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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan xiuqin Rao Yue lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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多力场耦合条件下T型圆管通道内流体热混合机理研究

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西安交通大学学报 2025年第1期59卷 78-92页

作者：李桉琦苏博林梅王秋旺西安交通大学能源与动力工程学院西安710049

针对海洋动力平台和船舶动力装置中T型圆管通道内冷热流体间的热混合机理尚不清楚的问题,利用大涡模拟方法,对不同支管布置方式高温高压工况下(运行压力为10 MPa,进口流体温差为275 K,摇摆雷诺数为41 500)的多力场耦合T型圆管通道内流... 详细信息

针对海洋动力平台和船舶动力装置中T型圆管通道内冷热流体间的热混合机理尚不清楚的问题,利用大涡模拟方法,对不同支管布置方式高温高压工况下(运行压力为10 MPa,进口流体温差为275 K,摇摆雷诺数为41 500)的多力场耦合T型圆管通道内流体热混合机理进行数值研究。利用提出的混合系数定量评价了不同布置方式下T型圆管通道内流体混合效果,利用均方根温度定量评价了不同布置方式下T型圆管通道管壁处温度脉动情况。结果表明:剪切层和尾迹区内涡结构与温度场存在时间和空间上的协同机制,且涡脱落频率和温度脉动频率基本相同,脱落频率为19.3 Hz;附加惯性力引起T型圆管通道内涡结构和温度场在时间和空间上周期性变化,加速了流体混合过程,削弱了浮升力和重力引起的热分层现象,同时增大了流体域内温度波动,长度约为10.2 D(D为主管内径);与对应的静止工况相比,支管竖直向上、水平和竖直向下布置时,摇摆条件下混合系数分别增大了10.8%、18.3%和27.8%;摇摆条件竖直向下布置时,管壁处温度均方根峰值最大为0.16,约为静止工况的2倍。因此,支管竖直向上布置时,热混合效果最好,热分层现象最弱,在实际应用中应被优先考虑。

关键词： T型圆管通道浮升力摇摆条件热混合机理大涡模拟

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WIDE-BAND LASER CLADDING: WEAR AND CORROSION RESISTANCE OF A Ni-BASED ALLOY

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Acta Metallurgica Sinica(English Letters) 1997年第5期10卷 445-452页

作者： Pan, Q.Y. Huang, W.D. Li, Y.M. lin, x. Zhou, Y.H. Yang, x.C. Northwestern Polytechnical Univ Xi'an China

A novel wide-band laser cladding system, with high rate of cladding, has been developed in the present work. The system mainly consisted of a 5kW CO2 laser, an automatic powder feeder and a wide-band scanning rotative polygon mirror which can produce a linear or rectangular focused laser beam. Using this system, a Ni-Cr-Si-B alloy powder was cladded on the surface of type 321 austenitic stainless steel in order to improve its wear and corrosion resistance. The pitting corrosion, high temperature oxidation and wear tests were conducted in order to evaluate the properties of the laser cladded layer. The results demonstrated that the cladded layer can significantly improve the adhesive wear and pitting corrosion resistance of the substrate. Moreover, the cladded layer exhibited good oxidation resistance, which is almost the same as that of GMR-235D Ni-based superalloy.

关键词： Boron Chromium alloys Cladding (coating) Laser applications Nickel alloys Silicon alloys Wear resistance

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Projective Hilbert modules and sequential approximations

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Science China Mathematics 2025年第1期 137-168页

作者： Lawrence G.Brown Huaxin lin Department of Mathematics Purdue University Department of Mathematics East China Normal University Department of Mathematics University of Oregon Shanghai Institute for Mathematics and Interdisciplinary Sciences

We show that when A is a separable C*-algebra,every countably generated Hilbert A-module is projective（with bounded module maps as morphisms）.We also study the approximate extensions of bounded module *** the case where A is a σ-unital simple C*-algebra with strict comparison,and every strictly positive lower semicontinuous affine function on quasitraces can be realized as the rank of an element in the Cuntz semigroup,we show that the Cuntz semigroup is equivalent to unitarily equivalent classes of countably generated Hilbert A-modules if and only if A has stable rank one.

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A facile and green preparation of durian shell-derived carbon electrodes for electrochemical double-layer capacitors

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Progress in Natural Science:Materials International 2012年第6期22卷 624-630页

作者： L.K.Ong A.Kurniawan A.C.Suwandi C.x.lin x.S.Zhao S.Ismadji Department of Chemical Engineering Widya Mandala Surabaya Catholic UniversityKalijudan 37Surabaya 60114.Indonesia School of Chemical Engineering The University of Queensland.St.Lucia 4072.QldAustralia Department of Chemical Engineering Widya Mandala Surabaya Catholic University.Kaliludan 37.Surabaya 60114Indonesia

A facile and green preparation of high surface area activated carbons with mixed microporosity and mesoporosity from durian shell waste is reported in this *** pore structure and surface chemistry of the parent carbon were modified by the combination of ultrasonication and microwave irradiation *** effects of temperature and time in the ultrasonication treatment and power output and time in the microwave irradiation were studied. The electrochemical performance of carbon electrodes for supercapacitors was tested by cyclic voltammeter(CV) and galvanostatic *** results show that the capacitive energy storage of electrodes is critically dependent on the microporosity and surface chemistry of activated *** highest electrode capacitance in this work was 103.6 F/g that prepared from activated carbon modified at an ultrasonication temperature of 323.15 K for 10 min and microwave power output of 900 W for 10 min.

关键词： Durian shell Activated carbon Ultrasonication Microwave irradiation EDLC

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Surfing the nano-wave:Emerging trends in cancer diagnostics and therapy

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Nano Research 2025年第1期18卷 520-544页

作者： Genping Fu Yuting Weng Yunfan Li Carl Ho Yiyu Fu Wenxuan Wang Songbin Fu Wenjing Sun Jie lin xiaoyu Fan Binbin Jia Mengdi Cai linlin Li Laboratory of Medical Genetics Harbin Medical UniversityHarbin 150081China Key Laboratory of Preservation of Human Genetics Resources and Disease Control in China(Harbin Medical University) Ministry of EducationHarbin 150081China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Washington University School of Medicine in St.Louis St.LouisMO 63110USA Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Aix-Marseille College Wuhan University of TechnologyWuhan 430070China

Facing the growing global challenge posed by cancer,the quest for more accurate and potent cancer diagnostic and therapeutic strategies continues to require a multidisciplinary integration *** review firstly summarizes various types of nanoparticles in cancer ***,it offers a comprehensive overview of signalenhancing techniques for visualizing in situ tumors,along with multimodal diagnostic methods for detecting *** for tumor therapy,cutting-edge drug delivery methods that can cross biological barriers and the pinpoint targeting of tumor lesions for precise medical intervention are *** the domain of therapeutic diagnostics,we elucidate the theoretical underpinnings and structural paradigms that underlie a spectrum of advanced diagnostic and therapeutic ***,we present a compendium of publications delineating the clinical applications of each nano-based theragnostic integration ***,this comprehensive review discusses the safety concerns pertaining to the clinical application of nanoparticles and proposes some strategic recommendations to enhance the precision and safety of theragnostic-guided,nanotechnology-based clinical practices.A deeper understanding of nanomaterials,together with intimate interdisciplinary collaborations,nano-wave will most probably guide human beings to win the battle against cancers.

关键词： nanoparticles drug delivery gastric cancer glioma glioblastoma

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An Efficient Operator-Splitting Method for Noise Removal in Images

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Communications in Computational Physics 2006年第5期1卷 847-858页

作者： D.Krishnan P.lin x.-C.Tai Department of Mathematics National University of SingaporeSingapore 117453 Department of Mathematics University of BergenJohannes Brunsgate 12BergenN-5008Norway

In this work,noise removal in digital images is *** importance of this problem lies in the fact that removal of noise is a necessary pre-processing step for other image processing tasks such as edge detection,image segmentation,image compression,classification problems,image registration etc.A number of different approaches have been proposed in the *** this work,a non-linear PDE-based algorithm is developed based on the ideas proposed by Lysaker,Osher and Tai[IEEE *** Process.,13(2004),1345-1357].This algorithm consists of two steps:flow field smoothing of the normal vectors,followed by image *** propose a finite-difference based additive operator-splitting method that allows for much larger *** results in an efficient method for noise-removal that is shown to have good visual *** energy is studied as an objective measure of the algorithm performance.

关键词： Noise removal nonlinear PDEs additive operator splitting(AOS)

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DEGRADATION BEHAVIORS OF NEW TYPE TiV-BASED HYDROGEN STORAGE ELECTRODE ALLOYS

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Acta Metallurgica Sinica(English Letters) 2006年第1期19卷 68-74页

作者： x.Z. Sun Y. F. Zhu Y. lin R. Li M.x. Gao H. G. Pan Department of Materials Science and Engineering Zhejiang University Hangzhou310027 China

The degradation behaviors of the TiV-based multiphase hydrogen storage alloy Ti0.8Zr0.2V3.2Mn0.64 Cr0.96Ni1.2 during electrochemical cycling in alkaline electrolyte have been studied by xRD, SEM, EIS and AES measurements. xRD analysis indicates that the alloy consists of a C14-type Laves phase and a V-based solid solution. The lattice parameters of both phases are increased after discharged with cycling, which indicates that more irreversible hydrogen remains not discharged in the alloy. It shold be responsible for the decrease of discharge capacity. SEM micrographs show that after 10 electrochemical cycles, a large number of cracks can be observed in the alloy, existing mainly in the V-based solid solution phase. Moreover, after 30 cycles, the alloy particles are obviously pulverized due to the larger expansion and shrinkage of cell volumes during hydrogen absorption and desorption, which induces the fast degradation of the TiV-based hydrogen storage alloys. EIS and AES measurements indicate that some passive oxide film has been formed on the surface of alloy electrode, which has higher charge-transfer resistance, lower hydrogen diffusivity, and less electro-catalytic activity. Therefore it can be concluded that the pulverization and oxidation of the alloy are the main factors responsible for the fast degradation of the TiV-hased hydrogen storage alloys.

关键词： metal hydrides hydrogen storage alloy pulverization degradation

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初中生认知控制对替代性攻击行为的影响:激惹和触发的情境边界条件

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心理学报 2025年第1期57卷 36-57页

作者：林爽程塨渌刘文白学军天津师范大学心理学部天津300387 辽宁师范大学心理学院大连116029 广西师范大学教育学部桂林541004

本研究通过3个实验探索了初中生认知控制对替代性攻击行为的影响以及认知控制影响替代性攻击行为的激惹和触发情境边界条件。实验1考察了一般性认知控制对替代性攻击行为的影响,结果发现一般性认知控制不能有效降低替代性攻击行为的攻... 详细信息

本研究通过3个实验探索了初中生认知控制对替代性攻击行为的影响以及认知控制影响替代性攻击行为的激惹和触发情境边界条件。实验1考察了一般性认知控制对替代性攻击行为的影响,结果发现一般性认知控制不能有效降低替代性攻击行为的攻击比例。实验2探讨了特异性认知控制对替代性攻击行为的有效抑制作用,结果发现无论在高激惹情境还是低激惹情境,主动控制和反应性控制启动条件下的替代性攻击行为均显著低于基线水平。实验3则探究了特异性认知控制抑制替代性攻击行为的激惹和触发情境边界条件,结果发现特异性认知控制、激惹情境、触发情境三者的交互作用显著,激惹和触发情境能够有效调节特异性认知控制对替代性攻击行为的影响。而且,在高激惹高触发和高激惹低触发情境下,主动性控制减基线的攻击比例显著高于反应性控制减基线,但在低激惹高触发和低激惹低触发情境下主动性控制减基线的攻击比例与反应性控制减基线不存在显著差异。此外,高激惹高触发情境下主动性控制减基线的攻击比例是所有条件下最高的。以上结果说明,特异性认知控制能够有效抑制初中生的替代性攻击行为,其中主动性控制的情境边界出现在高激惹高触发情境。

关键词：认知控制替代性攻击行为激惹情境触发情境情境边界条件

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FEM SIMULATION FOR LASER FORMING PROCESSING

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Acta Metallurgica Sinica(English Letters) 2004年第3期17卷 317-322页

作者： L.Q.Li Y.B.Chen x.Y Wang S.Y lin State Key Laboratory of Advanced Welding Production Technology Harbin Institute of Technology Harbin 150001 China Harbin Research Institute of Welding Harbin 150001 ChinaState Key Laboratory of Advanced Welding Production Technology Harbin Institute of Technology Harbin 150001 China Harbin Research Institute of Welding Harbin 150001 ChinaHarbin Research Institute of Welding Harbin 150001 ChinaHarbin Research Institute of Welding Harbin 150001 China

Laser forming involves heating sheet metal workpiece along a certain path with adefocused laser beam directed irradiate to the surface. During laser forming, a tran-sient temperature fields is caused by the irradiation and travelling of a laser beam.Consequently, thermal expansion and contraction take place, and allows the thermal-mechanical forming of complex shapes. This is a new manufacturing technique thatforming metal sheet only by thermal stress. Therefore, the analysis of temperaturefields and stress fields are very useful for studying the forming mechanism and con-trolling the accuracy of laser forming. The non--liner finite element solver, MARC, isemployed to solve the thermal--mechanical analysis. Using this model, the stress andstrain distribution of pure aluminum plate with different thickness are analyzed. Theinfluence of scanning speed on temperature fields and plastic strain of metal sheet un-der the condition of constant line energy are also presented. Numerical results agreewell with the experimental results.

关键词： laser forming FEM simulation temperature fields stress distributton

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