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Comparison of two supplemental oxygen methods during gastroscopy with propofol mono-sedation in patients with a normal body mass index

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World Journal of Gastroenterology 2020年第43期26卷 6867-6879页

作者： liu-Jia-Zi shao Yi Zou Fu-Kun liu Lei Wan shao-hua liu Fang-Xiao Hong Fu-Shan Xue Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Hypoxemia due to respiratory depression and airway obstruction during upper gastrointestinal endoscopy with sedation is a common *** Wei nasal jet tube(WNJT)is a new nasopharyngeal airway with the ability to provide supraglottic jet ventilation and oxygen insufflation via its built-in wall *** available evidence indicates that with a low oxygen flow,compared with nasal cannula,the WNJT does not decrease the occurrence of hypoxemia during upper gastrointestinal endoscopy with propofol *** date,there has been no study assessing the performance of WNJT for supplemental oxygen during upper gastrointestinal endoscopy with sedation when a moderate oxygen flow is *** To determine whether the WNJT performs better than the nasal prongs for the prevention of hypoxemia during gastroscopy with propofol mono-sedation when a moderate oxygen flow is provided in patients with a normal body mass *** This study was performed in 291 patients undergoing elective gastroscopy with propofol *** were randomized into one of two groups to receive either the WNJT(WNJT group,n=147)or the nasal cannula(nasal cannula group,n=144)for supplemental oxygen at a 5-L/min flow during *** lowest SpO2 during gastroscopy was *** primary endpoint was the incidence of hypoxemia or severe hypoxemia during *** The total incidence of hypoxemia and severe hypoxemia during gastroscopy was significantly decreased in the WNJT group compared with the nasal cannula group(P=0.000).The lowest median SpO2 during gastroscopy was significantly higher(98%;interquartile range,97-99)in the WNJT group than in the nasal cannula group(96%;interquartile range,93-98).Epistaxis by device insertion in the WNJT group occurred in 7 patients but stopped naturally without any *** two groups were comparable in terms of the satisfaction of physicians,anesthetists and *** With a moderate oxygen flow,the WNJT

关键词： Gastroscopy Hypoxemia Wei nasal jet tube Nasal cannula Supplemental oxygen Adverse outcomes

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What Moved into the Lung?An Unusual Case of Foreign Body Migration

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Chinese Medical Sciences Journal 2013年第4期28卷 248-249页

作者： Yan-ting Wang Xiao-dong Yang shao-hua liu Yan-hua huang Department of Respiratory Medicine West China Hospital of Sichuan University

FOREIGN body migration into the lung is a rare complication that can cause various symptoms. In adults, however, foreign body deposited in the luna can be tolerated and remain undetected fora long time. Delayed diagnosis and subsequent delayed treatment is usually associated with atypical complications. In this article, we describe a case of foreign body migration into the tracheobronchial tree. After a long time delay diagnosis, the foreign body was ultimately removed by operation.

关键词： tracheobronchial foreign body migration

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PROTECTION OF CARBON MONOXIDE INHALATION ON LIPOPOLY-SACCHARIDE-INDUCED MULTIPLE ORGAN INJURY IN RATS

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Chinese Medical Sciences Journal 2007年第3期22卷 169-176页

作者： shao-hua liu Xin-rong Xu Ke Ma Bing Xu Intensive Care Unit the First Affiliated Hospital of Nanjing Medicial University Nanjing 210029

Objective To observe the protection of carbon monoxide （CO） inhalation on lipopolysaccharide （LPS）-induced rat multiple organ injury. Methods Sprague-Dawley rats with multiple organ injury induced by 5 mg/kg LPS intravenous injection were exposed to room air or 2.5 × 10 ^-4 （V/V） CO for 3 hours. The lung and intestine tissues of rats were harvested to measure the expression of heme oxygenase-1 （ HO-1 ） with reverse transcription-polymerase chain reaction, the levels of pulmonary tumor necrosis factor-or （ TNF-α）, interleukin-6 （ IL-6）, and intestinal platelet activator factor （ PAF）, intercellular adhesion molecule-1 （ICAM-1） with enzyme-linked immunosorbent assay, the content of maleic dialdehyde （MDA） and the activity of myeloperoxidase （MPO） with chemical method, the cell apoptosis rate with flow cytometry, and the pathological changes with light microscope. Results CO inhalation obviously up-regulated the expression of HO-1 in lung （5.43 ± 0. 92） and intestine （6. 29 ± 1.56） in LPS ＋ CO group compared with （ 3.08 ± 0. 82） and （ 3.97 ± 1.16 ） in LPS group （ both P 〈 0. 05 ）. The levels of TNF-ot, IL-6 in lung and PAF, ICAM-1 in intestine ofLPS ＋ CO group were 0. 91 ±0. 25,0. 64 ±0.05, 1. 19 ± 0. 52, and 1.83 ±0. 35 pg/mg, respectively, significantly lower than the corresponding values in LPS group （ 1.48 ± 0. 23, 1.16 ± 0. 26, 1.84 ± 0. 73, and 3.48 ± 0. 36 pg/mg, all P 〈 0. 05 ）. The levels of MDA, MPO, and cell apoptosis rate in lung and intestine of LPS ＋ CO group were 1.02 ± 0. 23 nmol/mg, 1.74 ± 0. 17 nmol/mg, 7.18 ± 1.62 U/mg, 6. 30 ±0. 97 U/mg, 1.60% ±0. 34%, and 30. 56% ±6. 33%, respectively, significantly lower than the corresponding values in LPS group （ 1.27 ± 0. 33 nmol/mg, 2. 75 ± 0. 39 nmol/mg, 8. 16 ± 1.49 U/mg, 7. 72 ± 1.07 U/mg, 3.18% ±0. 51%, and 41.52% -＋3.36%, all P 〈0.05）. In addition, injury of lung and intestine induced by LPS was attenuated at presence of CO inhalation. Conclusion CO inhalation protects rat lung and intestine from LP

关键词： carbon monoxide lung intestine multiple organ injury

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Effect of low high-density lipoprotein levels on mortality of septic patients: A systematic review and meta-analysis of cohort studies

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World Journal of Emergency Medicine 2020年第2期11卷 109-116页

作者： shao-hua liu Huo-yan Liang Hong-yi Li Xian-fei Ding Tong-wen Sun Jing Wang General ICU the First Affi liated Hospital of Zhengzhou UniversityHenan Key Laboratory of Critical Care MedicineZhengzhou 450052China Department of Respiratory Critical Care Medicine the First Affi liated Hospital of Zhengzhou UniversityZhengzhou 450052China

BACKGROUND:An increase in high-density lipoprotein(HDL)is well associated with a decreased cardiovascular risk,especially *** studies suggest that lower levels of HDL may also be associated with an increased risk of sepsis and an increased rate of mortality in septic ***,this conclusion remains ***:MEDLINE,EMBASE,and CENTRAL databases were searched from inception to September 30,*** studies were conducted to evaluate the correlation of lipoprotein levels and the risk and outcomes of sepsis in adult *** primary outcomes were the risk and mortality of ***:Seven studies comprising 791 patients were *** levels of HDL had no marked relevance with the risk of sepsis(odds radio[OR]for each 1 mg/dL increase,0.94;95%CI 0.86–1.02;P=0.078),whereas lower HDL levels were related to an increased mortality rate in septic patients(OR for below about median HDL levels,2.00;95%CI 1.23–3.24;P=0.005).CONCLUSION:This meta-analysis did not reveal a signifi cant association between lower HDL levels and an increase in the risk of sepsis,whereas it showed that lower HDL levels are associated with a higher mortality rate in septic adult *** findings suggest that HDL may be considered as a promising factor for the prevention and treatment of sepsis in the future.

关键词： High-density lipoprotein Sepsis Mortality Meta-analysis

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Three new diterpenoids from Leonurus japonicus

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Chinese Chemical Letters 2014年第5期25卷 677-679页

作者： Zhi-Ke liu Da-Rong Wu Yi-Ming Shi Ting Zeng shao-hua liu Xue Du Yong-Jun Dang Wei-Lie Xiao Han-Dong Sun State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences University of Chinese Academy of Sciences Chengdu No. 1 Pharmaceutical Group Co. Ltd. Key Laboratory of Molecular Medicine Ministry of Educationand Department of Biochemistry and Molecular BiologyFudan University Shanghai Medical College

Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid,leojaponin A（1）,characterized by a C4–C7oxa-bridge,and two new labdane diterpenoids,leojaponins B（2） and C（3）.The structures of these new compounds were determined based on extensive 1D and 2D NMR spectroscopic *** the best of our knowledge,compound 1 is the first clerodane diterpenoid obtained from *** of them were evaluated for their cytotoxicity.

关键词： Leonurus japonicus Leojaponin A Leojaponin B Leojaponin C

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Synthesis, insecticidal activity and molecular docking study of clothianidin analogues with hydrazide group

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Chinese Chemical Letters 2014年第7期25卷 1017-1020页

作者： shao-hua liu Wei Peng Yan-Yan Qu Dan Xu Hong-Yue Li Dun-Lun Song Hong-Xia Duan Xin-Ling Yang Department of Applied Chemistry College of ScienceChina Agricultural University Department of Entomology College of Agriculture and BiotechnologyChina Agricultural University

A series of novel neonicotinoid analogues were designed and synthesized by introducing a hydrazide group into clothianidin. Their structures were confirmed by IR, 1H NMR, and HRMS （ESI）. Preliminary bioassay showed that some compounds, Sb and Sg, exhibited good activity against soybean aphids （Aphis glycines） at 100 mg L ^-1. In addition, molecular docking with receptor was carried out to explain their different activity from clothianidin.

关键词： Clothianidin analogues Hydrazide group Insecticidal activity Molecular docking

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Different distributions of interstitial cells of Cajal and platelet-derived growth factor receptor-α positive cells in colonic smooth muscle cell/interstitial cell of Cajal/plateletderived growth factor receptor-α positive cell syncytium in mice

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World Journal of Gastroenterology 2018年第44期24卷 4989-5004页

作者： Chen Lu Xu huang Hong-Li Lu shao-hua liu Jing-Yu Zang Yu-Jia Li Jie Chen Wen-Xie Xu Department of Physiology Shanghai Jiao Tong University School of Medicine Department of Anesthesiology Ren Ji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Pediatric Surgery Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

AIM To investigate the distribution and function of interstitialcells of Cajal(ICCs) and platelet-derived growth factor receptor-α positive(PDGFRα+) cells in the proximal and distal *** The comparison of colonic transit in the proximal and distal ends was performed by colonic migrating motor complexes(CMMCs). The tension of the colonic smooth muscle was examined by smooth muscle spontaneous contractile experiments with both ends of the smooth muscle strip tied with a silk thread. Intracellular recordings were used to assess electrical field stimulation(EFS)-induced inhibitory junction potentials(IJP) on the colonic smooth muscle. Western blot analysis was used to examine the expression levels of ICCs and PDGFRα in the colonic smooth *** Treatment with NG-nitro-L-arginine methyl ester hydrochloride(L-NAME) significantly increased the CMMC frequency and spontaneous contractions, especially in the proximal colon, while treatment with MRS2500 increased only distal CMMC activity and smooth muscle contractions. Both CMMCs and spontaneous contractions were markedly inhibited by NPPB, especially in the proximal colon. Accordingly, CyPPA sharply inhibited the distal contraction of both CMMCs and spontaneous contractions. Additionally, the amplitude of stimulationinduced nitric oxide(NO)/ICC-dependent slow IJPs(sIJPs) by intracellular recordings from the smooth muscles in the proximal colon was larger than that in the distal colon, while the amplitude of electric field stimulationinduced purinergic/PDGFRα-dependent fast IJPs(fIJPs) in the distal colon was larger than that in the proximal colon. Consistently, protein expression levels of c-Kit and anoctamin-1(ANO1) in the proximal colon were much higher, while protein expression levels of PDGFRα and small conductance calcium-activated potassium channel 3(SK3) in the distal colon were much *** The ICCs are mainly distributed in the proximal colon and there are more PDGFRα+ cells are in the dis

关键词： Interstitial cells of Cajal Platelet-derived growth factor receptor-α positive cells Smooth muscle cell/interstitial cell of Cajal/platelet-derived growth factor receptor-α positive cell syncytium Nitric oxide Purine

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A review of use of metallurgical slag for its carbonation products:processes,crystallization behavior,and application status

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Journal of Iron and Steel Research International 2023年第12期30卷 2341-2365页

作者： Ya-jun Wang Meng-jie Tao Jun-guo Li Jian-bao Zhang Song Qin shao-hua liu Li-jie Peng Xiao-pei Zhang Xi Zhang Ya-nan Zeng College of Metallurgy and Energy North China University of Science and TechnologyTangshan063210HebeiChina

In response to the pressing global issue of reducing carbon emissions and the crucial technical challenges of fully utilizing steel slag,researchers have been studying an accelerated carbonation process that entails the carbonation of basic oxides in steel slag to store CO_(2).However,despite its promising potential,the process has yet to see widespread industrial *** latest research progress in the area of mineral carbonation processes,both direct and indirect,that are used to capture,utilize,and store carbon in steel slag are *** the limited scale of steel slag carbonation and the underutilized products that can be derived from it,a new research focus is proposed for examining the regulation of calcium carbonate crystal forms during carbonation using the Ca source in steel *** control of synthesis variables will help to ensure accurate control of calcium carbonate precipitation in the carbonation process.A summary of the effects of synthesis variables on CaCO_(3)crystal form and the latest research findings on controlling aragonite morphology are *** review is concluded with a discussion of the potential applications and future development prospects of CaCO_(3)whiskers.

关键词： Steel slag Carbonation CaCO3 Crystallization Aragonite morphology

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Three minor new compounds from the aerial parts of Leonurus japonicus

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Chinese Chemical Letters 2015年第8期26卷 1000-1003页

作者： Wei-Mao Zhong Zhao-Meng Cui Zhi-Ke liu Yan Yang Da-Rong Wu shao-hua liu Hui Long Han-Dong Sun Yong-Jun Dang Wei-Lie Xiao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Molecular Medicine Ministry of Education and Department of Biochemistry and Molecular Biology Fudan University Shanghai Medical College Chengdu No.1 Pharmaceutical Group Co. Ltd.

Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one new labdane diterpenoid, leojaponin D （1） and two new ionone derivatives, leojaponones A and B （2 and 3）, together with seven known diterpenoids （4-10）. Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and by comparison with data reported in the literature. Selected isolates were evaluated their effects on lurkat IL2 secretino.

关键词： Leonurus japonicus Diterpenoid lonone derivative Jurkat IL2 secretion

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A rare case of circumferential intramural dissection of thoracic esophagus with contained esophageal perforation

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Chinese Medical Journal 2011年第20期124卷 3433-3435页

作者： WANG shao-hua RUAN Zheng liu Fa-bing huaNG Hai-long ZHENG Jian SONG Kang-sheng Department of Thoracic Surgery the First Affiliated People＇sHospital Shanghai Jiao Tong University Shanghai 200080 China

In this report, a full account of an extremely rare case on esophageal intramural dissection （EID） is presented. A 56-year-old female patient, misdiagnosed as esophageal mediastinal fistula under endoscopic view, was diagnosed correctly as EID with contained esophageal perforation in the operation and cured by thoracic esophagectomy.

关键词： esophageal intramural dissection esophageal perforation esophagectomy

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