检索结果-南通市图书馆

Effects of telomere length on leukemogenesis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2020年第2期63卷 308-311页

作者： Shihui Ma Guohuan Sun shangda yang Zhenyu Ju Tao Cheng Hui Cheng State Key Laboratory of Experimental Hematology Institute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Center for Stem Cell Medicine Chinese Academy of Medical SciencesTianjin 300020China Department of Stem Cell and Regenerative Medicine Peking Union Medical CollegeTianjin 300020China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineJinan UniversityGuangzhou 510632China

Dear Editor,Most cancer cells maintain the length of their telomeres via telomerase(Günes and Rudolph,2013;Kim et al.,1994).However,in some cancers,telomeres are maintained not by telomerase but by alternative lengthening of telomeres(Bryan et al.,1997).Telomerase activity appears to be reduced in some bone marrow(BM)diseases,including chronic myeloid leukemia,acute myeloid leukemia(AML),and myeloproliferative neoplasms(MPN),leading to shortened telomeres that correlate with leukemogenesis(Bouillon et al.,2018;Engelhardt et al.,2000;Shay et al.,1996).Our current study aimed to determine the definitive roles of telomeres and telomerase in leukemogenesis.

关键词： al. neoplasms acute

p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2024年第11期15卷 840-857页

作者： Nini Wang shangda yang Yu Li Fanglin Gou Yanling Lv Xiangnan Zhao Yifei Wang Chang Xu Bin Zhou Fang Dong Zhenyu Ju Tao Cheng Hui Cheng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China CAMS Center for Stem Cell Medicine PUMC Department of Stem Cell and Regenerative MedicineTianjin 300020China The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)Department of Cell BiologyTianjin Medical UniversityTianjin 300270China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China

The maintenance of hematopoietic stem cells(HSCs)is a complex process involving numerous cell-extrinsic and-intrinsic *** first member of the cyclin-dependent kinase family of inhibitors to be identified,p21,has been reported to perform a wide range of critical biological functions,including cell cycle regulation,transcription,differentiation,and so *** the previous inconsistent results regarding the functions of p21 in HSCs in a p21-knockout mouse model,we employed p21-tdTomato(tdT)mice to further elucidate its role in HSCs during *** results showed that p21-tdT+HSCs exhibited increased self-renewal capacity compared to p21-tdT−***18,a transcriptional repressor,was upregulated in p21-tdT+HSCs,and its knockdown significantly impaired the reconstitution capability of ***,p21 interacted with ZBTB18 to co-repress the expression of cKit in HSCs and thus regulated the self-renewal of *** data provide novel insights into the physiological role and mechanisms of p21 in HSCs during homeostasis independent of its conventional role as a cell cycle inhibitor.

关键词： hematopoietic stem cells self-renewal p21 Zbtb18 cKit

Dual-ligand chiral MOFs exhibiting circularly polarized room temperature phosphorescence for anti-counterfeiting

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Hongrui Zheng Qingqing Wang Xinchao Wang Fei Wang shangda Li Jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fujian Key Laboratory of Polymer Materials College of Chemistry and Materials Science Fujian Normal University

Advanced chiral optical materials exhibiting circularly polarized room-temperature phosphorescence（CPRTP） possess significant research value. This study facilitates the synthesis of chiral metal-organic frameworks（CMOFs） with good CPRTP performance by implementing a dual-ligand strategy. By self-assembling the luminescent ligand H2BIIM with the chiral ligands L-or D-H2IDPA in the presence of Zn（II） ions, two robust three-dimensional（3D） CMOFs were successfully constructed. These complexes demonstrated intense fluorescence and exhibited prolonged yellow room-temperature phosphorescence（RTP） with a duration of up to 6 s. Notably, they exhibited both circularly polarized fluorescence(glum= ±7.57 × 10-3) and CPRTP(glum=±2.68 × 10-3). These unique properties were effectively utilized in the creation of multi-color anti-counterfeiting patterns,underscoring their promising potential for a wide range of applications.

关键词：

Magnetic molecular materials with paramagnetic lanthanide ions

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2009年第11期52卷 1739-1758页

作者： WANG BingWu JIANG shangda WANG XiuTeng GAO Song Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The diverse magnetic properties of lanthanide-based magnetic molecular materials are introduced in the following ***,the general aspects of magnetic molecular materials and electronic states of lanthanide ions are *** the structures and magnetic properties are described and analyzed for molecules with one lanthanide ion,4f-4f,4f-3d and 4f-p magnetic coupling *** each section,magnetic coupling,magnetic ordering and magnetic relaxation phenomenon are briefly reviewed using some ***,some possibilities of developing magnetic molecular materials containing lanthanide ions are discussed in the outlook part.

关键词： lanthanide coordination compound magnetic coupling magnetic ordering magnetic relaxation single-molecule magnet single-chain magnet single-ion magnet

High sensitivity artificial synapses using printed high-transmittance ITO fibers for neuromorphic computing

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第12期35卷 234-238页

作者： shangda Qu Yiming Yuan Xu Ye Wentao Xu Institute of Photoelectronic Thin Film Devices and Technology Key Laboratory of Photoelectronic Thin Film Devices and Technology of TianjinCollege of Electronic Information and Optical EngineeringEngineering Research Center of Thin Film Photoelectronic Technology of Ministry of EducationSmart Sensing Interdisciplinary Science CenterNankai UniversityTianjin 300350China Shenzhen Research Institute of Nankai University Shenzhen 518000China

Artificial synapses are essential building blocks for neuromorphic ***,solid polymer electrolyte-gated artificial synapses(EGASs)were fabricated using ITO fibers as channels,which possess an ultra-high sensitivity of 5 m V and a long-term memory time exceeding 3 ***,digitally printed ITO-fiber arrays exhibit an ultra-high transmittance of approximately 99.67%.Biological synaptic plasticity,such as excitatory postsynaptic current,paired-pulse facilitation,spike frequency-dependent plasticity,and synaptic potentiation and depression,were successfully mimicked using the *** on the synaptic properties of the EGASs,an artificial neural network was constructed to perform supervised learning using the Fashion-MNIST dataset,achieving high pattern recognition rate(82.39%)due to the linear and symmetric synaptic *** work provides insights into high-sensitivity artificial synapses for future neuromorphic computing.

关键词： Solid polymer electrolyte ITO fibers Artificial synapses Synaptic plasticity Neuromorphic computing

Design of protective and high sensitivity encapsulation layers in wearable devices

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2023年第1期66卷 223-232页

作者： WANG XiuFeng HUANG JieLong LIU yangChengYi TAN JinYuan CHEN shangda AVILA Raudel XIE ZhaoQian School of Materials Science and Engineering Xiangtan UniversityXiangian 41105China Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsDalian University of TechnologyDalian116024China

Elastomeric encapsulation layers are widely used in soft, wearable devices to physically isolate rigid electronic components from external environmental stimuli(e.g., stress) and facilitate device sterilization for reusability. In devices experiencing large deformations, the stress-isolation effect of the top encapsulation layer can eliminate the damage to the electronic components caused by external forces. However, for health monitoring and sensing applications, the strain-isolation effect of the bottom encapsulation layer can partially block the physiological signals of interest and degrade the measurement accuracy. Here, an analytic model is developed for the strain-and stress-isolation effects present in wearable devices with elastomeric encapsulation layers. The soft, elastomeric encapsulation layers and main electronic components layer are modeled as transversely isotropicelastic mediums and the strain-and stress-isolation effects are described using isolation indexes. The analysis and results show that the isolation effects strongly depend on the thickness, density, and elastic modulus of both the elastomeric encapsulation layers and the main electronic component layer. These findings, combined with the flexible mechanics design strategies of wearable devices, provide new design guidelines for future wearable devices to protect them from external forces while capturing the relevant physiological signals underneath the skin.

关键词： strain-isolation effect stress-isolation effect elastomeric encapsulation transversely isotropic medium wearable devices

An introduction to molecular spintronics

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2012年第6期55卷 867-882页

作者： JIANG shangda GOB Karin CERVETTI Christian BOGANI Lapo Physikalisches Institut Universitiit Stuttgart Pfaffenwaldring 57 70550 Stuttgart Germany Max Planck lnstitut fiir Festkoerperforschung Heisenbergstrasse 1 70569 Stuttgart Germany

We review the progress and future possibilities in the emerging area of molecular spintronics. We first provide an overview of the different transport regimes in which electronic nanodevices can operate, then briefly overview the important characteristics of molecular magnetic materials that can be useful for application in spintronics and we eventually present several schemes to include such systems into spintronic nanodevices. We hightlight the importance of a chemical approach to the area, and in the last section we showcase some approaches to the creation of hybrids made of carbon nanostructures and molecular magnets, which are gaining increasing attention.

关键词： carbon nanostructures molecular spintronics molecular magnetism quantum transport electronicnanodevices

ATOMIC-LIKE ORBITS AND LANTHNIDE CONTRACTION

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 1989年第10期6卷 436-439页

作者： LI Yongping XIA shangda ZHANG Haifeng Department of Physics University of Science and Technology of ChinaHefei

The high order momentums of radial wavefunctions for 4f-series were calculated using atomic-like Gaussian *** lanthnide contraction and some comparisons were concluded.

关键词： momentum contraction radial

Organic ionic plastic crystal as electrolyte for lithium-oxygen batteries

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2019年第6期30卷 1289-1292页

作者： Shaokang Tian Bowen Shao Zhiqun Wang shangda Li Xiangyu Liu Yibo Zhao Lei Li School of Chemistry and Chemical Engineering Shanghai Key Lab of Electrical Insulation and Thermal Aging Shanghai Jiao Tong University Shanghai 200240 China Shanghai Electrochemical Energy Devices Research Center School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China

Organic ionic plastic crystals (OIPCs) composed of 1-ethyl-1-methyl pyrrolidinium bis(fluorosulfonyl) imide (P12FSI) and lithium bis(fluorosulfonyl)imide (LiFSI) was used as electrolyte for lithium-oxygen batteries. Since P12FSI-LiFSI electrolyte exhibited high ionic conductivity, good chemical stability and wide electrochemical window, the battery showed good rate capability, excellent cycling stability and can be operated stably for 320 cycles under a fixed capacity of 500 mAh/gcarbon. The use of OIPCs electrolyte could provide a new avenue for the development of high-performance Li-O2 batteries.

关键词： Organic ionic plastic crystal Electrolyte Lithium-oxygen batteries Long life Chemical stability