Effects of telomere length on leukemogenesis

作     者：Shihui Ma Guohuan Sun Shangda Yang Zhenyu Ju Tao Cheng Hui Cheng Shihui Ma;Guohuan Sun;Shangda Yang;Zhenyu Ju;Tao Cheng;Hui Cheng

作者机构：State Key Laboratory of Experimental HematologyInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Center for Stem Cell MedicineChinese Academy of Medical SciencesTianjin 300020China Department of Stem Cell and Regenerative MedicinePeking Union Medical CollegeTianjin 300020China Key Laboratory of Regenerative Medicine of Ministry of EducationInstitute of Aging and Regenerative MedicineJinan UniversityGuangzhou 510632China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2020年第63卷第2期

页      面：308-311页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(2016YFA0100600,2017YFA0103400) the National Natural Science Foundation of China(81421002,81730006,81430004,81870086,8181101081) CAMS Initiative for Innovative Medicine(2017-I2M-3-009,2016-I2M-1-017) the CAMS Fundamental Research Funds for Central Research Institutes(2018PT31005) 

主　　题：al. neoplasms acute 

摘      要：Dear Editor,Most cancer cells maintain the length of their telomeres via telomerase(Günes and Rudolph,2013;Kim et al.,1994).However,in some cancers,telomeres are maintained not by telomerase but by alternative lengthening of telomeres(Bryan et al.,1997).Telomerase activity appears to be reduced in some bone marrow(BM)diseases,including chronic myeloid leukemia,acute myeloid leukemia(AML),and myeloproliferative neoplasms(MPN),leading to shortened telomeres that correlate with leukemogenesis(Bouillon et al.,2018;Engelhardt et al.,2000;Shay et al.,1996).Our current study aimed to determine the definitive roles of telomeres and telomerase in leukemogenesis.