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China Ocean Engineering 2024年第4期38卷 636-647页

作者： HOU Fu-heng jia Lu-sheng CHEN Yan-fei ZHANg Qi ZHONg Rong-feng WANg Chun-sha School of Mechanical and Transportation Engineering China University of PetroleumBeijingBeijing 102249China CNOOC Research Institute Ltd.Beijing 100028 China

A dent is a common type of defects for submarine *** submarine pipelines,high hydrostatic pressure and internal pressure are the main *** pipelines bend due to complex subsea conditions,the compression strain capacity may be *** into the local buckling failure and accurate prediction of the compressive strain capacity are important.A finite element model of a pipeline with a dent is *** buckling failure under a bending moment is investigated,and the compressive strain capacity is *** effects of different parameters on pipeline local buckling are *** results show that the dent depth,external pressure and internal pressure lead to different local buckling failure modes of the pipeline.A higher internal pressure indicates a larger compressive strain capacity,and the opposite is true for external *** the ratio of external pressure to collapse pressure of intact pipeline is greater than 0.1,the deeper the dent,the greater the compressive strain capacity of the *** as the ratio is less than 0.1,the opposite is *** the basis of these results,a regression equation for predicting the compressive strain capacity of a dented submarine pipeline is proposed,which can be referred to during the integrity assessment of a submarine pipeline.

关键词： submarine pipeline dent defect bending load local buckling compressive strain capacity

Analyzing the surface passivity effect of germanium oxynitride:a comprehensive approach through first principles simulation and interface state density

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Nuclear Science and Techniques 2024年第5期35卷 74-84页

作者： Sheng-Jie Du Xiu-Xia Li Yang Tian Yuan-Yuan Liu Ke jia Zhong-Zheng Tang jian-Ping Cheng Zhi Deng Yu-Lan Li Zheng-Cao Li sha.sha.Lv College of Nuclear Science and Technology Joint Laboratory of Jinping Ultra‑Low Radiation Background Measurement of Ministry of Ecology and Environment Key Laboratory of Beam Technology of Ministry of Education Beijing Normal UniversityBeijing Normal UniversityBeijing 100875China Joint Research Center Nuctech Company LimitedBeijing 100084China Department of Engineering Physics Key Laboratory of Particle&Radiation Imaging of Ministry of EducationTsinghua UniversityBeijing 100084China Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

High-purity germanium(HPge)detectors,which are used for direct dark matter detection,have the advantages of a low threshold and excellent energy *** surface passivation of HPge has become crucial for achieving an extremely low energy *** this study,first-principles simulations,passivation film preparation,and metal oxide semiconductor(MOS)capacitor characterization were combined to study surface *** calculations of the energy band structure of the -H,-OH,and -NH_(2) passivation groups on the surface of ge were performed,and the interface state density and potential with five different passivation groups with N/O atomic ratios were accurately analyzed to obtain a stable surface *** on the theoretical calculation results,the surface passivation layers of the ge_(2)ON_(2) film were prepared via magnetron sputtering in accordance with the optimum atomic ratio *** microstructure,C-V,and I-V electrical properties of the layers,and the passivation effect of the Al/ge_(2)ON_(2)/ge MOS were characterized to test the interface state *** mean interface state density obtained by the Terman method was 8.4×10^(11) cm^(-2) eV^(-1).The processing of germanium oxynitrogen passivation films is expected to be used in direct dark matter detection of the HPge detector surface passivation technology to reduce the detector leakage currents.

关键词： Surface passivation High purity germanium detector germanium nitrogen oxide Interface state density

RKKY interaction in helical higher-order topological insulators

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Chinese Physics B 2024年第7期33卷 587-593页

作者：金莎李健李清旭朱家骥 School of Science Chongqing University of Posts and TelecommunicationsChongqing 400065China Institute for Advanced Sciences Chongqing University of Posts and TelecommunicationsChongqing 400065China Southwest Center for Theoretical Physics Chongqing UniversityChongqing 401331Chin

We theoretically investigate the Ruderman–Kittel–Kasuya–Yosida(RKKY) interaction in helical higher-order topological insulators(HOTIs), revealing distinct behaviors mediated by hinge and Dirac-type bulk carriers. Our findings show that hinge-mediated interactions consist of Heisenberg, Ising, and Dzyaloshinskii–Moriya(DM) terms, exhibiting a decay with impurity spacing z and oscillations with Fermi energy εF. These interactions demonstrate ferromagnetic behaviors for the Heisenberg and Ising terms and alternating behavior for the DM term. In contrast, bulk-mediated interactions include Heisenberg, twisted Ising, and DM terms, with a conventional cubic oscillating decay. This study highlights the nuanced interplay between hinge and bulk RKKY interactions in HOTIs, offering insights into designs of next-generation quantum devices based on HOTIs.

关键词： magnetic impurity interactions magnetic ordering spintronics topological phases

Development and validation of an immunogenic cell death-related prognostic model, and landscape of the tumor immune microenvironment in glioblastoma

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genes & Diseases 2024年第3期11卷 72-74页

作者： sha.Yang Mei Deng Yunbiao Xiong Bing Xiong Junwu Fu jia Wang Jiqin Zhang guoqiang Han jian Liu Ying Tan guizhou University Medical College GuiyangGuizhou 550025China Department of Neurosurgery Guizhou Provincial People's HospitalGuiyangGuizhou 550002China Department of Anesthesiology Guizhou Provincial People's HospitalGuiyangGuizhou 550002China Department of Neurosurgery Chongqing Emergency Medical CenterChongqing400000China

The important role of immunogenic cell death(ICD)in many tumors is increasingly being ***,its mechanisms and potential as a biomarker and therapeutic target in glioblastoma(gBM)have not been well *** obtained gBM samples from the Cancer genome Atlas(TCgA)and gene Expression Omnibus(gEO)databases,as well as the immunotherapy cohort from the IMvigor210 *** used unsupervised clustering to obtain two ICDrelated clusters,corresponding to the ICD-low and ICD-high subtypes respectively,and the tumor immune microenvironment and prognosis of the two subtypes were significantly different.

关键词： immune Cancer prognosis

Stay in touch with the endoplasmic reticulum

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Science China(Life Sciences) 2024年第2期67卷 230-257页

作者： sha.Sun gan Zhao Mingkang jia Qing jia.g Shulin Li Haibin Wang Wenjing Li Yunyun Wang Xin Bian Yan g.Zhao Xun Huang ge Yang Huaqing Cai Jose C.Pastor-Pareja Liang ge Chuanmao Zhang Junjie Hu National Laboratory of Biomacromolecules Institute of BiophysicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China The Ministry of Education Key Laboratory of Cell Proliferation and Differentiation College of Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Laboratory of Computational Biology&Machine Intelligence School of Artificial IntelligenceUniversity of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin 300071China Brain Research Center Department of BiologySchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Neurosciences Consejo Superior de Investigaciones Científicas-Universidad Miguel HernándezSan Juan de Alicante 03550Spain

The endoplasmic reticulum(ER),which is composed of a continuous network of tubules and sheets,forms the most widely distributed membrane system in eukaryotic *** a result,it engages a variety of organelles by establishing membrane contact sites(MCSs).These contacts regulate organelle positioning and remodeling,including fusion and fission,facilitate precise lipid exchange,and couple vital signaling ***,we systematically review recent advances and converging themes on ER-involved organellar *** molecular basis,cellular influence,and potential physiological functions for ER/nuclear envelope contacts with mitochondria,golgi,endosomes,lysosomes,lipid droplets,autophagosomes,and plasma membrane are summarized.

关键词： endoplasmic reticulum nuclear envelope mitochondria golgi apparatus endosome lysosome lipid droplets autophagosome plasma membrane membrane contact site

Nasal congestion caused by long-term retention of a nasal foreign body near the orbit:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4331-4336页

作者： Dan Wang Qing Liu Hui Liu jia-sha.Wei Department of Rhinology Zibo Central HospitalZibo 255000Shandong ProvinceChina

BACKgROUND Nasal trauma presents a risk of foreign body invasion into the nasal ***,in the early treatment stage of nasal trauma,patients and doctors are not always aware of possible foreign body invasion,resulting in delayed *** describe the case of an adult patient admitted to the hospital due to left nasal congestion accompanied by yellow,purulent,and bloody *** SUMMARY Consultation with the patient revealed a history of nasal trauma 30 years prior that did not receive thorough examinations and imaging during treatment,resulting in a glass fragment retained in the nasal cavity adjacent to the *** admission,computerized tomography(CT)confirmed the presence of the foreign body in the patient’s left nasal–maxillary *** nasal foreign body led to symptoms such as chronic sinusitis,nasal polyps,fungal infection,and deviated nasal *** foreign body was successfully removed by nasal endoscopy,polypectomy,sinus fungal removal,left middle turbinate conchoplasty,fenestration via the right inferior meatus,nasal endoscopic maxillary sinus cystectomy,and *** operation was successful and without any *** CT scans should be performed in addition to necessary debridement sutures to avoid possible foreign body invasion during nasal *** planning should be tailored to the patient’s specific *** surgical method should be carefully selected,and sufficient preparation should be undertaken before the surgery to avoid possible displacement of the nasal foreign body.

关键词： Nasal foreign body Nasal endoscopic surgery Adult patients Nasal trauma Case report

Molecular mechanism of hypoxia and alpha-ketoglutaric acid on collagen expression in scleral fibroblasts

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1780-1790页

作者： Yun Sun Zhuo-Zheng Li Jing Yang Ya-Ru sha.Xin-Yu Hou Hong Fu jia-Yin Li Shu-Chang Bai Yong-Fang Xie guo-Hui Wang School of Life Science and Technology Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina

AIM:To investigate the molecular mechanisms underlying the influence of hypoxia and alpha-ketoglutaric acid(α-Kg)on scleral collagen ***:Meta-analysis and clinical statistics were used to prove the changes in choroidal thickness(ChT)during *** establishment of a hypoxic myopia model(HYP)for rabbit scleral fibroblasts through hypoxic culture and the effects of hypoxia andα-Kg on collagen expression were demonstrated by Sirius red *** analysis was used to verify the genes and pathways that hypoxia andα-Kg affect collagen ***,real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR)was used for reverse ***:Meta-analysis results aligned with clinical statistics,revealing a thinning of ChT,leading to scleral *** red staining indicated lower collagen expression in the HYP group and higher collagen expression in the HYP+α-Kg group,showed that hypoxia reduced collagen expression in scleral fibroblasts,whileα-Kg can elevated collagen expression under HYP *** analysis unveiled the related genes and signaling pathways of hypoxia andα-Kg affect scleral collagen expression and the results were verified by ***:The potential molecular mechanisms through which hypoxia andα-Kg influencing myopia is unraveled and three novel genes TLCD4,TBC1D4,and EPHX3 are *** findings provide a new perspective on the prevention and treatment of myopia via regulating collagen expression.

关键词： sclera scleral collagen expression hypoxia alpha-ketoglutaric acid myopia

A complete reference genome assembly for foxtail millet and Setaria-db, a comprehensive database for Setaria

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Molecular Plant 2024年第2期17卷 219-222页

作者： Qiang He Chunchao Wang Qiang He Jun Zhang Hongkai Liang Zefu Lui Kun Xie sha.Tang Yuhan Zhou Bin Liu Hui Zhi guanqing jia.ganggang guo Huilong Du Xianmin Diao State Key Laboratory of Crop gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China School of Life Sciences Institute of Life Sciences and Green DevelopmentHebei UniversityBaoding 071000China State Key Laboratory of Rice Biology&Breeding Zhejang Provincial Key Laboratory of Crop GermplasmThe Advanced Seed InstituteZhejiang UniversityHangzhouChina

Dear Editor,,Foxtail millet(Setaria italica)and its wild ancestor green foxtail(***),are two C4 genetic model plants known for their desirable traits,such as small size,short life cycle,ease of transformation,and a compact genome size(~420 Mb)(He et al.,2023).Foxtail millet stands out as the only cultivated species within the Setaria *** a foundational crop for ancient east Asian agriculture civilization,it possesses remarkable drought and soil-nutrient deficiency tolerance.

关键词： comprehensive soil cultivated

Combination of p-Coumaric acid and lactoferrin ameliorates cognitive deficits through suppressing C/EBPβ/AEP pathway and modulating intestinal flora in APP/PS1 mice

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Food Science and Human Wellness 2024年

作者： Yan Zhou Yi-Tian Sun Hui guo Yan-Zi Liang Si-Yuan Zhu Yu sha.Zhong-Xiao Wan jia-Ying Xu jian-Rong jia.g Li-Qiang Qin Yun-Hong Li Department of Nutrition and Food Hygiene， School of Public Health， jia.gsu Key Laboratory of Preventive and Translational Medicine for geriatric Diseases， MOE Key Laboratory of geriatric Diseases and Immunology， Suzhou Medical college of Soochow University Department of Medical Technology， Suzhou Vocational Health College State Key Laboratory of Radiation Medicine and Protection， School of Radiation Medicine and Protection， Suzhou Medical college of Soochow University Suzhou Municipal Center for Disease Control and Prevention

Alzheimer's disease （AD） has become an important public health issue worldwide. P-Coumaric acid （CA） and lactoferrin （Lf） possessed antioxidant， anti-inflammatory， and anti-AD activities. Herein， we hypothesized that a combination treatment of CA and Lf would synergistically improve AD symptoms and studied its mechanisms. Twelve-week-old APP/PS1 mice were treated with CA， Lf， or both CA and Lf for 8 weeks. Results showed that individual and combined treatments could ameliorate cognitive deficits to varying degrees， with stronger effects for combined intervention than for CA or Lf alone. Specifically， combined treatment was most effective in improving nesting ability and reducing Aβ1-42deposition in mice. Moreover， combined treatment was more effective in suppressing APP， BACE1， and inflammation; it inhibited the CCAAT-enhancer-binding protein （C/EBPβ）/asparagine endopeptidase （AEP） signaling pathway in the hippocampus and colon and upregulated the expression of tight junction protein ZO-1 in the colon; it also decreased the F/B ratio at the phylum level and increased the relative abundance of Prevotellaceae， Lachnospira， and Eubacterium at the genus level. Overall， the combination of CA and Lf may ameliorate cognitive deficits in APP/PS1 mice by improving inflammation and inhibiting the C/EBPβ/AEP signaling pathway via modulating gut microbiome.

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人参上市药品研究进展

中国中药杂志 2024年第7期49卷 1717-1724页

作者：覃思意赖嘉敏贾彬王乐琪李莎莎严诗楷肖雪广东药科大学、广东省代谢病中西医结合研究中心(中医药研究所) 广东广州510006 国家药品监督管理局药品快速检验技术重点实验室(广东省药品检验所) 广东广州510663 广州中医药大学第二附属医院广东广州510120 上海交通大学药学院上海200240

人参被誉为“百草之王”,是一种重要的药用植物,其药用部位包括根、茎叶、花和果实,以根部最为常用。人参的主要活性成分包括三萜皂苷、多糖和多肽及挥发油等,人参化学成分及其活性代谢物赋予其多种药理作用,应用于治疗疾病和发挥保健... 详细信息

人参被誉为“百草之王”,是一种重要的药用植物,其药用部位包括根、茎叶、花和果实,以根部最为常用。人参的主要活性成分包括三萜皂苷、多糖和多肽及挥发油等,人参化学成分及其活性代谢物赋予其多种药理作用,应用于治疗疾病和发挥保健功能。人参作为传统中药资源,现已有多种人参制剂获得药品注册并上市,包括人参片、人参口服液、人参注射液等,在调节免疫功能、辅助治疗肿瘤、抗疲劳、延缓衰老、改善糖脂代谢、治疗心血管疾病及抗炎镇痛各方面展现出良好的临床疗效,相关药品的生产工艺和质量标准对保证其药效具有重要意义。该文基于人参“大补元气,补脾益肺,生津止渴、安神益智”的理论指导,较为系统地总结了药用植物人参及源于人参的相关上市药品的临床应用进展,同时关注人参上市药品及相关制品的再开发,为进一步挖掘人参的药用价值和保健功能提供参考。综述以上内容,作为深度开发人参及人参相关上市药的重要基础,为拓展人参的应用提供更多可能性。

关键词：人参上市药品临床应用研究进展潜在价值