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Efficiency-Driven Custom Chatbot Development: Unleashing LangChain, RAG, and Performance-Optimized LLM Fusion

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Computers, Materials & Continua 2024年第8期80卷 2423-2442页

作者： s.Vidivelli Manikandan Ramachandran A.Dharunbalaji school of Computing SASTRA Deemed UniversityThanjavurTamilnadu613401India

This exploration acquaints a momentous methodology with custom chatbot improvement that focuses on pro-ficiency close by *** accomplish this by joining three key innovations:LangChain,Retrieval Augmented Generation(RAG),and enormous language models(LLMs)tweaked with execution proficient strategies like LoRA and *** takes into consideration fastidious fitting of chatbots to explicit purposes,guaranteeing engaged and important collaborations with ***’s web scratching capacities engage these chatbots to get to a tremendous store of data,empowering them to give exhaustive and enlightening reactions to *** recovered data is then decisively woven into reaction age utilizing LLMs that have been calibrated with an emphasis on execution *** combination approach offers a triple advantage:further developed viability,upgraded client experience,and extended admittance to *** become proficient at taking care of client questions precisely and productively,while instructive and logically pertinent reactions make a more regular and drawing in cooperation for *** last,web scratching enables chatbots to address a more extensive assortment of requests by conceding them admittance to a more extensive information *** digging into the complexities of execution proficient LLM calibrating and underlining the basic job of web-scratched information,this examination offers a critical commitment to propelling custom chatbot plan and *** subsequent chatbots feature the monstrous capability of these advancements in making enlightening,easy to understand,and effective conversational specialists,eventually changing the manner in which clients cooperate with chatbots.

关键词： LangChain retrieval augumental generation(RAG) fine tuning

Twinning aspects and their efficient roles in wrought Mg alloys:A comprehensive review

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Journal of Magnesium and Alloys 2024年第6期12卷 2201-2230页

作者： s.s.A.shah Manping Liu Azim Khan Farooq Ahmad M.R.Abdullah Xingquan Zhang shiwei Xu Zhen Peng school of Materials science and Engineering Jiangsu UniversityZhenjiang 212013China school of Mechanical Engineering Anhui University of TechnologyMáanshan 243002China College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China

Twinning is widely recognized as an effective and cost-efficient method for controlling the microstructure and properties of wrought magnesium(Mg)***,twins play a crucial role in initiating dynamic recrystallization(DRX),while twin regions experience rapid recrystallization during static recrystallization(sRX).The activation of twinning can lead to changes in lattice orientation,significantly impacting the final texture in Mg *** active roles of twinning are influenced by various factors during the activation process,and the mobility of twin boundaries(TB)can be amplified by stress effects,dislocation interactions,and thermal ***,annealing treatments that involve proper segregation or precipitation on TBs serve to stabilize them,restraining their *** such as segregation may also alter the twinning propensity in Magnesium-rare earth(Mg-RE)***{10–11}contraction twins(CT)and{10–11}-{10–12}double twins(DT)can promote dynamic recrystallization(DRX),they also pose a risk as potential sources of voids and ***,understanding the nucleation and growth mechanisms of twinning is crucial,and these aspects are briefly reviewed in this *** the factors mentioned above,this article summarizes the recent research progress in this field,shedding light on advancements in recent eras.

关键词： Mg alloys Twinning Recrystallization Texture Mechanical properties

Enhancing Multicriteria-Based Recommendations by Alleviating scalability and sparsity Issues Using Collaborative Denoising Autoencoder

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Computers, Materials & Continua 2024年第2期78卷 2269-2286页

作者： s.Abinaya K.Uttej Kumar school of Computer science&Engineering Vellore Institute of TechnologyChennaiTamilnadu600127India

A Recommender system(Rs)is a crucial part of several firms,particularly those involved in *** conventional Rs,a user may only offer a single rating for an item-that is insufficient to perceive consumer ***,businesses in industries like e-learning and tourism enable customers to rate a product using a variety of factors to comprehend customers’*** the other hand,the collaborative filtering(CF)algorithm utilizing AutoEncoder(AE)is seen to be effective in identifying user-interested ***,the cost of these computations increases nonlinearly as the number of items and users *** triumph over the issues,a novel expanded stacked autoencoder(EsAE)with Kernel Fuzzy C-Means Clustering(KFCM)technique is proposed with two *** the first phase of offline,the sparse multicriteria rating matrix is smoothened to a complete matrix by predicting the users’intact rating by the EsAE approach and users are clustered using the KFCM *** the next phase of online,the top-N recommendation prediction is made by the EsAE approach involving only the most similar user from multiple *** the EsAE_KFCM model upgrades the prediction accuracy of 98.2%in Top-N recommendation with a minimized recommendation generation *** experimental check on the Yahoo!Movies(YM)movie dataset and TripAdvisor(TA)travel dataset confirmed that the EsAE_KFCM model constantly outperforms conventional Rs algorithms on a variety of assessment measures.

关键词： Recommender systems multicriteria rating collaborative filtering sparsity issue scalability issue stacked-autoencoder Kernel Fuzzy C-Means Clustering

Optimizing oncolytic virus design:a“swiss army knife”approach to create a systemically delivered therapeutic

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signal Transduction and Targeted Therapy 2024年第5期9卷 1791-1792页

作者： Carolina s.Ilkow John Cameron Bell Ottawa Hospital Research Institute 501 Smyth RoadOttawaONK1H 8L6Canada

In a recent paper published in Nature Biotechnology,Chen et al.1 describe a multiplex oncolytic virus platform that coupled with adoptive T cell therapy could solve the problem of repeat,systemic delivery of virus based *** is widely accepted that multi-targeted therapeutic approaches attacking several facets of cancer biology are necessary to effectively deal with the tumor heterogeneity that exists within and between patients.

关键词： therapeutic al. targeted

slags containing transition metal(chromium and vanadium)oxides——Conversion from ticking bombs to valuable resources:Collaborative studies between KTH and UsTB

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International Journal of Minerals,Metallurgy and Materials 2022年第4期29卷 750-757页

作者： seshadri seetharaman Lijun Wang Haijuan Wang Royal Institute of Technology(KTH) Stockholm 10044Sweden Collaborative Innovation Center of steel Technology University of Science and Technology BeijingBeijing 100083China school of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

As the steel industry expands worldwide,slag dumps with transition metals(especially chromium and vanadium)are becoming more common,posing a serious environmental *** the properties of slags containing transition metal oxides,as well as how to use the slags to recover and recycle metal values,is *** this end,the University of science and Technology Beijing(UsTB)and Royal Institute of Technology(KTH)have been collaborating on slags containing transition metals for *** research was carried out from a fundamental viewpoint to get a better understanding of the structure of these slags and their properties,as well as industrial *** research focused on the three“R”s,***,recovery,and *** present paper attempts to highlight some of the important achievements in these joint studies.

关键词： transition metals vanadium chromium recovery collaborative study

Transmission of amyloid-βpathology in humans:a perspective on clinical evidence

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Neural Regeneration Research 2024年第2期19卷 390-392页

作者： Celso s.G.Catumbela Rodrigo Morales Department of Neurology McGovern Medical SchoolThe University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Transmission of misfolded amyloid-β(Aβ)aggregates between human subjects:Protein misfolding disorders are a family of diseases characterized by the accumulation of misfolded protein *** proteinaceous structures,also known as amyloids,are key drivers of fatal neurodegenerative disorders such as prion diseases,Alzheimer’s disease(AD),Parkinson’s disease,and others.

关键词： amyloid diseases Aβ

Features of sampling stream sediments of large river valleys under cryolithogenesis conditions in the Balygychan-sugoy trough,North-East of Russia

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Acta Geochimica 2024年第4期43卷 638-660页

作者： Artem s.Makshakov Raisa G.Kravtsova A.P.Vinogradov Institute of Geochemistry Siberian Branch of the Russian Academy of SciencesFavorskiy Str 1AIrkutskRussia 664033

Comprehensive research has been implemented to raise the efficiency of the geochemical survey of stream sediments(sss)that formed under the cryolithogenesis *** authors analysed the composition,structure and specific features of the formation of exogenous anomalous geochemical fields(AGFs)identified through sss of large river valleys of IV *** our case,these were the valleys of Maly Ken,Ken and Tap *** rivers are located in the central and southern parts of the Balygychan-sugoy trough enclosed in the Magadan region,North-East of *** authors proposed a new technique to sample loose alluvium of sss in the large river valleys along the *** profiles were located across the *** AGFs of Au,Ag,Pb,Zn,sn,Bi,Mo and W were *** between elements have been *** elements are the main indicator elements of Au-Ag,Ag-Pb,sn-Ag,Mo-W and sn-W mineralization occurring on the sites under *** results obtained were compared with the results of geochemical surveys of *** is concluded that the AGFs recognized along the profiles reflect the composition and structure of eroded and drained ore zones,uncover completely and precisely the pattern of element distribution in loose sediments of large water *** alluvium fractionseems to be most significant in a practical sense,as it concentrated numerous ore *** of this fraction in the river valleys of IV order does not cause any difficulty,for this kind of material is *** developed technique of alluvium sampling within large river valleys is efficient in searching for diverse mineralization at all stages of prognostic *** is applicable for geochemical survey of sss performed at different scales both in the North-East of Russia,as well as other regions with similar climatic conditions,where the sss are formed under the cryolithogenesis conditions.

关键词： stream sediments Large river valleys Geochemical fields Mineralization Indicator elements Geochemical survey

On the Geometry of the Anti-canonical Bundle of the Bott–samelson–Demazure–Hansen Varieties

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Acta Mathematica sinica,English series 2024年第8期40卷 1920-1940页

作者： Indranil BIsWAs s.senthamarai KANNAN Pinakinath sAHA school of Mathematics Tata Institute of Fundamental Research1 Homi Bhabha RoadMumbai 400005India Chennai Mathematical Institute Plot H1SIPCOT IT ParkSiruseriKelambakkam603103India

Let G be a semi-simple simply connected algebraic group over the field C of complex *** T be a maximal torus of G,and let W be the Weyl group of G with respect to *** Z(w,i)be the Bott–samelson–Demazure–Hansen variety corresponding to a tuple i associated to a reduced expression of an element w∈*** prove that for the tuple i associated to any reduced expression of a minuscule Weyl group element w,the anti-canonical line bundle on Z(w,i)is globally *** consequence,we prove that Z(w,i)is weak *** that G is a simple algebraic group whose type is different from *** s={α1,...,αn}be the set of simple *** w be such that support of w is equal to *** prove that Z(w,i)is Fano for the tuple i associated to any reduced expression of w if and only if w is a Coxeter element and w^(−1)(Σ_(t=1)^(n)α_(t))∈−s.

关键词： Bott-samelson-Demazure-Hansen variety Coxeter element anti-canonical line bundle Fano weak Fano

Targeting gut microbiota in osteoporosis:impact of the microbial based functional food ingredients

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Food science and Human Wellness 2024年第1期13卷 1-15页

作者： Pauline Duffuler Khushwant s.Bhullar Jianping Wu Department of Agricultural Food&Nutritional science University of AlbertaEdmonton T6G 2P5Canada

Osteoporosis is the most common bone disorder,characterized by low bone mineral density and microarchitectural deterioration of the bone tissue,which increases the susceptibility to *** the past decade,emerging research findings reported the implication of gut microbiota on bone health and osteoporosis *** patients or individuals with a lower bone mineral density exhibit an alteration of the gut microbiota at several taxonomic *** reports demonstrate that gut microbiota regulates bone metabolism through the modulation of the gut function(mineral availability and absorption,gut integrity),the immune system,and the endocrine ***,based on the vital role of gut microbiota on bone health,it has emerged as a novel therapeutic target for the prevention of bone loss and the treatment of ***-based functional food ingredients,such as probiotics,prebiotics,synbiotics,and fermented foods,have been developed to alter the gut microbiota composition and function and thus,to provide benefits to the host bone *** promising initial results,microbial-based therapies are still under ***,additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.

关键词： Dysbiosis Bone health Probiotic Prebiotic Fermented food synbiotic