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Effect of silver in thermal treatments of Fe-Mn-C degradable metals:Implications for stent processing

Bioactive Materials 2022年第6期7卷 30-41页

作者： sergio loffredo Sofia Gambaro Francesco Copes Carlo Paternoster Nicolas Giguere Maurizio Vedani Diego Mantovani Laboratory for Biomaterials and Bioengineering Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in SurgeryDepartment of Min-Met-Materials EngineeringResearch Center of CHU de QuebecDivision of Regenerative MedicineLaval UniversityQuebec CityQC G1V 0A6Canada Department of Mechanical Engineering Politecnico di MilanoMilan20156Italy National Research Council Institute of Condensed Matter Chemistry and Technologies for Energy CNR-ICMATEGenoa16149Italy Quebec Metallurgy Center CMQ Trois-RivieresQCG9A 5E1Canada

Twinning-induced plasticity(TWIP)steels are considered excellent materials for manufacturing products requiring extremely high mechanical properties for various applications including thin medical devices,such as biodegradable intravascular *** is also proven that the addition of Ag can guarantee an appropriate degradation while implanted in human body without affecting its bioactive *** order to develop an optimized manufacturing process for thin stents,the effect of Ag on the recrystallization behavior of TWIP steels needs to be *** is of major importance since manufacturing stents involves several intermediate recrystallization annealing *** this work,the recrystallization mechanism of two Fe-Mn-C steels with and without Ag was thoroughly investigated by microstructural and mechanical *** was observed that Ag promoted a finer microstructure with a different texture evolution,while the recrystallization kinetics resulted *** presence of Ag also reduced the effectiveness of the recrystallization *** behavior was attributed to the presence of Ag-rich second phase particles,precipitation of carbides and to the preferential development of grains possessing a{111}orientation upon thermal *** prominence of{111}grains can also give rise to premature twinning,explaining the role of Ag in reducing the ductility of TWIP steels already observed in other ***,in vitro biological performances were unaffected by *** findings could allow the design of efficient treatments for supporting the transformation of Fe-Mn-C steels alloyed with Ag into commercial products.

关键词： Twinning Recrystallization Biomaterials Silver Steels

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Correlates and Covariates of Type 2 Diabetes in an African American Population in the Washington DC Area

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Open Journal of Epidemiology 2022年第4期12卷 431-448页

作者： Jyothirmai J. Simhadri Christopher A. loffredo Tanmoy Mondal Zarish Noreen Thomas Nnanabu Ruth Quartey Charles Howell Brent Korba Gail Nunlee-Bland Somiranjan Ghosh Departments of Pediatrics and Child Health College of Medicine Howard University Washington DC USA Department of Oncology Georgetown University Washington DC USA Department of Healthcare Biotechnology National University of Sciences and Technology (NUST) Islamabad Pakistan Department of Biology Howard University Washington DC USA Department of Internal Medicine College of Medicine Howard University Washington DC USA Department of Microbiology & Immunology Georgetown University Washington DC USA

In the United States, type 2 diabetes mellitus (T2DM) disproportionately affects the African American (AA) community, which has not been systematically included in molecular studies of underlying mechanisms. As part of a gene expression study, we recruited cases with T2DM and matched, unaffected controls at an urban hospital in Washington, DC, with a majority AA population. Here we describe the profile of socio-demographic, behavioral, and health-related associations of the study population. Self-reported data were collected from cases with T2DM (N = 77) and age- and gender-matched controls (N = 80), ages 45 - 65 years. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI). As expected, obesity, hypertension, and cardiovascular disease were more prevalent in cases than in controls. Tobacco smoking and working alongside other tobacco smokers were also associated with T2DM. After adjusting for covariates, current tobacco smoking remained statistically associated with the disease (OR per half pack of cigarettes 1.43, 95% CI 1.04 - 1.95;p-value 0.027). HbA1c levels were elevated in T2DM cases who smoked more than a pack of cigarettes daily. These associations highlight the comorbid burdens of T2DM in an AA urban community setting and identify tobacco control as an unmet need for future prevention and control efforts.

关键词： Diabetes Epidemiology Smoking African American

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Indoor Radon Concentrations in Dwellings of Ischia Island

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Journal of Environmental Protection 2013年第8期4卷 37-39页

作者： Mariagabriella Pugliese Maria Quarto Filomena loffredo Agostino Mazzella Vincenzo Roca 1Dipartimento di Fisica Università di Napoli Federico II Naples Italy 2Istituto Nazionale di Fisica Nucleare (INFN) Sezione di Napoli Naples Italy Dipartimento di Fisica Università di Napoli Federico II Naples Italy Liceo Statale Ischia Naples Italy

Indoor radon concentration measurements were performed in dwellings of Ischia island (South Italy) using commercial E-Perm devices in LST configuration. The average concentrations in the dwellings were found to vary from 125 to 865 Bq/m3 with an average of 354 ± 176 Bq/m3. This value is higher than Italian National average that is 75 Bq/m3 and Campanian average that is 95 Bq/m3. Correlation between indoor radon concentration measurements and floor level of monitored room was also studied.

关键词： Radon E-Perm Floor Level

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Endoscopic ultrasound-guided through-the-needle microforceps biopsy and needle-based confocal laser-endomicroscopy increase detection of potentially malignant pancreatic cystic lesions:A single-center study

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World Journal of Gastrointestinal Endoscopy 2022年第3期14卷 129-141页

作者： Carlos Robles-Medranda Juan I Olmos Miguel Puga-Tejada Roberto Oleas Jorge Baquerizo-Burgos Martha Arevalo-Mora Raquel Del Valle Zavala Joao Autran Nebel Daniel Calle loffredo Hannah Pitanga-Lukashok Gastroenterology and Endoscopy Division Instituto Ecuatoriano de Enfermedades DigestivasGuayaquil 090505Ecuador

BACKGROUND Currently,there is insufficient data about the accuracy in the diagnosing of pancreatic cystic lesions(PCLs),especially with novel endoscopic techniques such as with direct intracystic micro-forceps biopsy(mFB)and needle-based confocal laser-endomicroscopy(nCLE).AIM To compare the accuracy of endoscopic ultrasound(EUS)and associated techniques for the detection of potentially malignant PCLs:EUS-guided fine needle aspiration(EUS-FNA),contrast-enhanced EUS(CE-EUS),EUS-guided fiberoptic probe cystoscopy(cystoscopy),mFB,and *** This was a single-center,retrospective *** identified patients who had undergone EUS,with or without additional diagnostic techniques,and had been diagnosed with *** determined agreement among malignancy after 24-mo follow-up findings with detection of potentially malignant PCLs via the EUSguided techniques and/or EUS-guided biopsy when available(EUS malignancy detection).RESULTS A total of 129 patients were included, with EUS performed alone in 47/129. In 82/129 patients,EUS procedures were performed with additional EUS-FNA (21/82), CE-EUS (20/82), cystoscopy(27/82), mFB (36/82), nCLE (44/82). Agreement between EUS malignancy detection and the 24-mo follow-up findings was higher when associated with additional diagnostic techniques thanEUS alone [62/82 (75.6%) vs 8/47 (17%);OR 4.35, 95%CI: 2.70-7.37;P < 0.001]. The highestmalignancy detection accuracy was reached when nCLE and direct intracystic mFB were bothperformed, with a sensitivity, specificity, positive predictive value, negative predictive value andobserved agreement of 100%, 89.4%, 77.8%, 100% and 92.3%, respectively (P < 0.001 comparedwith EUS-alone).CONCLUSIONThe combined use of EUS-guided mFB and nCLE improves detection of potentially malignantPCLs compared with EUS-alone, EUS-FNA, CE-EUS or cystoscopy.

关键词： Pancreatic cysts Endoscopic ultrasound-guided fine-needle aspiration Confocal microscopy Image-guided biopsy

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服务质量变成新焦点

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电子设计技术 1995年第4期 53-55页

作者： Susan loffredo

电子产业为用户服务的质量是不是在逐步提高?回答是一个令人满意的“是”。电子产业中一些部门所属的公司已经找到了有效的,有些是革新的办法来提高服务质量,但与其同时,仍有更多的公司依然落后于用户的需求。总的来说,服务工作包含着... 详细信息

电子产业为用户服务的质量是不是在逐步提高?回答是一个令人满意的“是”。电子产业中一些部门所属的公司已经找到了有效的,有些是革新的办法来提高服务质量,但与其同时,仍有更多的公司依然落后于用户的需求。总的来说,服务工作包含着罗万象的各种活动。这些活动有助于用

关键词：设备公司用户满意程度加利福尼亚州工业自动化质量

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Treatment of a patient with congenital analbuminemia with atorvastatin and albumin infusion

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World Journal of Clinical Cases 2013年第1期1卷 44-48页

作者： Maria Del Ben Francesco Angelico Lorenzo loffredo Francesco Violi Clinica Medica I Sapienza University 00161 Rome Italy

Congenital analbuminemia is a rare autosomic recessive inherited disorder characterized by low plasma albumin and hypercholesterolemia, which may increase cardiovascular risk. Patients are essentially asymptomatic, apart from ease of fatigue, minimal ankle oedema and hypotension. There is no accepted strategy for safely treating both hypercholesterolemia and analbuminemia in order to eventually decrease the atherosclerotic risk. We report a case of congenital analbuminemia(1.0 g/dL) in a 38-year-old male with hypercholesterolemia(range: 406-475 mg/dL) and severe arterial dysfunction [no brachial artery flow-mediated dilation(FMD)]. Long-term, cholesterol-lowering treatment with atorvastatin was associated with the appearance of peripheral edema. Twomonths of infusion with albumin improved FMD(7%) and reduced serum cholesterol(273 mg/dL), supporting the hypothesis of a compensatory role of hypercholesterolemia. Statin treatment, together with periodical albumin infusions, may contribute to the safe reduction of cardiovascular risk.

关键词： Analbuminemia Hypercholesterolemia Atorvastatin Albumin infusion Endothelial dysfunction

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Modern approach to the clinical management of non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第26期20卷 8341-8350页

作者： Maria Del Ben Licia Polimeni Francesco Baratta Daniele Pastori Lorenzo loffredo Francesco Angelico Department of Internal Medicine and Medical Specialities Department of Public Health and Infectious Diseases Sapienza University

Non-alcoholic fatty liver disease(NAFLD)is the most common and emerging form of chronic liver disease *** includes a wide spectrum of liver diseases ranging from simple fatty liver to steatohepatitis,which may progress to cirrhosis,liver cancer,and liver *** metabolic diseases,which are well established cardiovascular risk factors,have been associated to NAFLD and cardiovascular disease is the single most important cause of morbidity and mortality in this patient *** pathogenesis of NAFLD appears multifactorial and many mechanisms have been proposed as possible causes of fatty liver *** of fatty liver has become a major challenge to healthcare systems as the consequence of the increasing rates of obesity ***-line management focuses on lifestyle *** weight reduction either by dietary restriction or by increased habitual physical activity is safe and highly *** therapeutic interventions have been *** include insulin sensitizer agents,lipid lowering drugs,antioxidants such as vitamin E and supplementation of vitamin ***,therapeutic strategies have been largely empirical so far,and experimental trials have mostly been carried out in uncontrolled settings with small sample *** conditions such as diabetes mellitus,obesity,hypertension and hyperlipidemia,should be strongly considered and a multidisciplinary approach should be personalized for individual *** of co-morbidities should be regarded as of paramount importance in the management of these *** purpose of this review is to examine different approaches for the clinical management of non-alcoholic fatty liver disease.

关键词： Non-alcoholic fatty liver disease Nonalcoholic ste

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Conotruncal heart malformations in Egypt: An epidemiological study

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Open Journal of Epidemiology 2013年第4期3卷 169-176页

作者： Doa’a A. Saleh Sameera Ezzat Hala Hamza Mohamed Abdel-Hamid Karen S. Kuehl Christopher A. loffredo Cairo University Cairo Egypt Children’s National Medical Center Washington DC USA Georgetown University Washington DC USA Menoufiya University Shibin El Kom Egypt Minia University Minia Egypt

Conotruncal malformations of the heart are a major category of birth defects. No previous epidemiological studies on these malformations have been carried out in Egypt;therefore our study aimed to describe associations with maternal and infant factors in order to identify possible risk factors. Cases (N = 255) were children up to two years of age whose heart malformations were confirmed by echocardiography;they were enrolled at the Cardiology Department of the Pediatric Hospital of Cairo University. Controls (N = 155) were free of congenital heart malformations, matched to the cases by age, and recruited from outpatients of the same hospital. Mothers of cases (97%) and controls (89%) provided consent to participate in an interview about their medical, familial, and occupational histories. Odds ratios (OR) and exact 95% confidence intervals (CI) assessed the magnitude and statistical significance of case-control differences. Cases were divided into two groups based on the presence of d-transposition of the great arteries (TGA): there were 139 with TGA and 116 with normally-related great arteries (NGA). Maternal diabetes prevalence was elevated in both the TGA (OR = 3.4) and NGA (OR = 5.5) subgroups. Several agricultural factors were associated with increased risk: raising animals (for TGA: OR = 2.4, 95% CI 1.2-4.6), raising poultry (for NGA: OR = 1.8, 95% CI 1.1-3.2), and using chemical rodenticides (for all conotruncal cases: OR = 3.2, 95% CI 1.1-13.2). These results are consistent with previous studies of associations of maternal diabetes and pesticide exposure with conotruncal malformations. Further research is warranted to explore such associations and determine avenues for prevention.

关键词： Congenital Heart Disease Cardiovascular Malformations Conotruncal Malformations Epidemiology Environmental Factors Diabetes

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精心协调

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世界农药 1993年第3期 6-8页

作者： Douglas loffredo 赵祖培

由于消费者需求提高和家畜生产技术的发展,动物健康管理的市场将有稳定增长。根据生产者的需求,维生素、抗生素和氨基酸的使用将紧随着工业的更精细化而发展。另一方面,对激素所增加的市场份额,人们也可看到随着FDA的认可,其增长势头非... 详细信息

由于消费者需求提高和家畜生产技术的发展,动物健康管理的市场将有稳定增长。根据生产者的需求,维生素、抗生素和氨基酸的使用将紧随着工业的更精细化而发展。另一方面,对激素所增加的市场份额,人们也可看到随着FDA的认可,其增长势头非常猛,但是管理过程相对缓慢。目前为争取市场份额而进行的竞争仅限于已经上市的产品或熟悉的新产品。

关键词：美元美国研究所普朗克动物本位币美利坚合众国北美洲抗微生物制剂维生素市场促生长素生产者销售额市场份额饲料添加剂特种饲料

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Estimates of the Prevalence of Tobacco Smoking in Egypt

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Open Journal of Epidemiology 2015年第2期5卷 129-135页

作者： Christopher A. loffredo Ghada Nasr Radwan Eman M. Eltahlawy Maged El-Setouhy Laurence Magder Mohamed Hassan Hussein Georgetown University Washington DC USA Cairo University Cairo Egypt National Research Center Cairo Egypt Jazan University Jazan Saudi Arabia Ain Shams University Cairo Egypt University of Maryland Baltimore USA

The use of tobacco products constitutes the leading cause of preventable deaths in the world. In Egypt, data on the national prevalence of cigarette and waterpipe smoking are lacking, yet such data are vital to tobacco control efforts. We designed and implemented a sampling method to generate population-based prevalence estimates for tobacco smoking in Egypt. In 2005, a total of 3369 adults ages 18 and above, including 1867 females and 1502 males, participated in the survey. Among males, the national prevalence of former cigarette smoking was 18.1%, and 27.5% reported current smoking. Exclusive current waterpipe smoking was reported by 7.2% of adult males, and a further 3.4% reported smoking both waterpipes and cigarettes. Tobacco smoking was rarely reported by females;among them the national prevalence of current cigarette smoking was 0.3%. This study produced the first robust estimate of the national prevalence of cigarette and waterpipe smoking in Egypt based on a rigorous probability sample. Along with the more recent Global Adult Tobacco Survey, carried out by the World Health Organization in 2009, the results will be useful in assessing smoking trends in Egypt and in evaluating the impacts of recent tobacco control laws.

关键词： Egypt Smoking Tobacco Waterpipe Shisha Survey

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