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Real-time fluorescence image-guided gastrointestinal oncologic surgery:Towards a new era

World Journal of Gastrointestinal Oncology 2021年第9期13卷 1029-1042页

作者： Elías martínez-López Aleix martínez-Pérez sergio navarro-martínez Juan Carlos Sebastián-Tomás Nicola de'Angelis Eduardo García-Granero Department of Surgery University of ValenciaValencia 46010Spain Department of General and Digestive Surgery Hospital Universitario Doctor PesetValencia 46017Spain Faculty of Health Sciences Valencian International UniversityValencia 46002Spain Minimally Invasive and Robotic Digestive Surgery Unit Miulli HospitalAcquaviva delle Fonti 70021Italy Department of General and Digestive Surgery Hospital Universitario y Politécnico La FeValencia 46026Spain

Technological improvements are crucial in the evolution of ***-time fluorescence-guided surgery(FGS)has spread worldwide,mainly because of its usefulness during the intraoperative decision-making *** success of any gastrointestinal oncologic resection is based on the anatomical identification of the primary tumor and its regional lymph *** allows also to evaluate the blood perfusion at the gastrointestinal stumps after colorectal or esophageal ***,a reduction on the anastomotic leak rates has been postulated as one of the foreseeable benefits provided by the use of FGS in these *** the use of fluorescence in lymph node detection was initially described in breast cancer surgery,the technique is currently applied in gastric or splenic flexure cancers,as they both present complex and variable lymphatic *** allows also to perform intraoperative lymphograms or sentinel lymph node *** applications of FGS are being developed to assist in the detection of peritoneal metastases or in the evaluation of the tumor resection *** present review aims to provide a general overview of the current status of real-time FGS in gastrointestinal oncologic *** put a special focus on the different applications of FGS,discussing the main findings and limitations found in the contemporary literature and also the promising near future applications.

关键词： Surgery Colorectal cancer Esophageal cancer Fluorescence Image-guided surgery Anastomotic leak Lymph node

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Semiosic Translation:a Bayesian-heuristic theory of translation and translating

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Language and Semiotic Studies 2024年第2期10卷 167-202页

作者： sergio Torres-martínez Universidad de Antioquia Cll.67#53–108MedellínAntioquiaColombia

In the context of Semiosic Translation,two elements are essential for a translation to emerge:the body–brain–context interface(extended mind)and the sign systems making up a translation *** this paper,I explain how a renewed view of the body as a Bayesian-heuristic Semiotic Prior helps to understand in a more holistic manner the motivations and agentive character of translation,defined herein as a phenomenological grasp of the *** to the present proposal is the idea that bodily self-stabilization(homeostasis)and brain-driven correction(allostasis)provide translator-agents with maps of action upon the world that are semiotic in *** this occurs thanks to information weighing(Bayesian)and cue-driven(heuristic)types of inference whereby exteroceptive(exogenous)and interoceptive(inner-body)signals converge to create a sense of bodily awareness responsible for the construction of the symbolic persona(the translator-agent).

关键词： embodiment Bayesian semiosis heuristic semiosis semiotics Semiosic Translation translator-agents

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Performance of statistical and machine learning-based methods for predicting biogeographical patterns of fungal productivity in forest ecosystems

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Forest Ecosystems 2021年第2期8卷 278-291页

作者： Albert Morera Juan martínez de Aragón José Antonio Bonet Jingjing Liang sergio de-Miguel Department of Crop and Forest Sciences University of LleidaAv.Alcalde Rovira Roure 191E-25198 LleidaSpain Joint Research Unit CTFC-AGROTECNIO-CERCA Center Av.Rovira Roure 19125198 LleidaSpain Forest Science and Technology Centre of Catalonia Ctra.Sant Llorençde Morunys km 225280 SolsonaSpain Forest Advanced Computing and Artificial Intelligence Laboratory Department of Forestry and Natural ResourcesPurdue UniversityWest LafayetteIN 47907USA

Background:The prediction of biogeographical patterns from a large number of driving factors with complex interactions,correlations and non-linear dependences require advanced analytical methods and modeling *** study compares different statistical and machine learning-based models for predicting fungal productivity biogeographical patterns as a case study for the thorough assessment of the performance of alternative modeling approaches to provide accurate and ecologically-consistent ***:We evaluated and compared the performance of two statistical modeling techniques,namely,generalized linear mixed models and geographically weighted regression,and four techniques based on different machine learning algorithms,namely,random forest,extreme gradient boosting,support vector machine and artificial neural network to predict fungal *** evaluation was conducted using a systematic methodology combining random,spatial and environmental blocking together with the assessment of the ecological consistency of spatially-explicit model predictions according to scientific ***:Fungal productivity predictions were sensitive to the modeling approach and the number of predictors ***,the importance assigned to different predictors varied between machine learning modeling *** tree-based models increased prediction accuracy by more than 10%compared to other machine learning approaches,and by more than 20%compared to statistical models,and resulted in higher ecological consistence of the predicted biogeographical patterns of fungal ***:Decision tree-based models were the best approach for prediction both in sampling-like environments as well as in extrapolation beyond the spatial and climatic range of the modeling *** this study,we show that proper variable selection is crucial to create robust models for extrapolation in biophysically differentiated *** allows for reducing the dime

关键词： Modeling Regression Biogeography Climate Forest Fungi Mushrooms

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Advancing towards accurate phenotyping based on metabolic and fibrosis risk in metabolic-dysfunction associated steatotic liver disease:one step closer to personalized care

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 128-131页

作者： sergio Muñoz-martínez Alba Jiménez-Masip Juan M.Pericàs Liver Unit Vall d’Hebron Hospital UniversitariVall d’Hebron Institut de Recerca(VHIR)Vall d’Hebron Barcelona Hospital CampusBarcelonaSpain Universitat de Barcelona BarcelonaSpain Universitat Autònoma de Barcelona BellaterraBarcelonaSpain Centros de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas(CIBERehd)MadridSpain

Relevance of liver fibrosis amongst diabetic patients with metabolic-dysfunction associated steatotic liver disease(MASLD)and knowledge gaps Insulin resistance is paramount in the crosstalk between intrahepatic and extrahepatic pathophysiological mechanisms leading to MASLD(1),hence gaining special relevance in patients diagnosed with type 2 diabetes(T2D).MASLD is the term that was recently endorsed by an international multidisciplinary consensus panel to replace non-alcoholic fatty liver disease[as non-alcoholic steatohepatitis(NASH)was replaced by metabolic dysfunction-associated steatohepatitis(MASH)](2).

关键词： Metabolic-dysfunction associated steatotic liver disease(MASLD) advanced fibrosis type 2 diabetes(T2D) non-invasive tests(NITs)

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Ultrasonic spray pyrolysis deposition of SnSe and SnSe_2 using a single spray solution

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Journal of Semiconductors 2013年第1期34卷 12-15页

作者： Jorge sergio Narro-Rios Manoj Ramachandran Dalia martínez-Escobar Aarón Snchez-Jurez Centro de investigación en Energía UNAMP.O.Box 3462580 TemixcoMorelosMxico

Thin films of SnSe and SnSe2 have been deposited using the ultrasonic spray pyrolysis（USP） *** the best of our knowledge this is the first report of the deposition of SnSe and SnSe2 thin films using a single spray *** use of a single spray solution for obtaining both a p-type material,SnSe,and an n-type material,SnSe2,simplifies the deposition *** SnSe2 thin films have a bandgap of 1.1 eV and the SnSe thin films have a band gap of 0.9 *** Hall measurements were used to determine the resistivity of the thin *** SnSe2 thin films show a resistivity of 36.73 Ωcm and n-type conductivity while the SnSe thin films show a resistivity of 180 Ωcm and p-type conductivity.

关键词： SnSe SnSe2 ultrasonic spray pyrolysis technique

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Superattracting cycles for some Newton type iterative methods

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Science China Mathematics 2011年第3期54卷 539-544页

作者： AMAT sergio BUSQUIER Sonia navarro Emilie PLAZA sergio Departamento de Matemtica Aplicada y Estadistica Universidad Politécnica de Cartagena Ecole Généraliste d'Ingénieurs de Marseille (EGIM) Departamento de Matemticas Facultad de Ciencias Universidad de Santiago de Chile

The paper is devoted to the analysis of certain dynamical properties of a family of iterative Newton type methods used to find roots of non-linear equations. We present a procedure for constructing polynomials in such a way that superattracting cycles of any prescribed length occur when these iterative methods are applied. This paper completes the study begun in Amat, Bermúclez, Busquier, et al., (2009).

关键词： iterative methods (super)attracting cycles dynamics

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Yield models for predicting aboveground ectomycorrhizal fungal productivity in Pinus sylvestris and Pinus pinaster stands of northern Spain

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Forest Ecosystems 2019年第4期6卷 414-426页

作者： Mariola Sánchez-González sergio de-Miguel Pablo martin-Pinto Fernando martínez-Pe?a María Pasalodos-Tato Juan Andrés Oria-de-Rueda Juan martínez de Aragón Isabel Ca?ellas José Antonio Bonet Spanish National Institute for Agricultural and Food Research and Technology (INIA)

Background: Predictive models shed light on aboveground fungal yield dynamics and can assist decision-making in forestry by integrating this valuable non-wood forest product into forest management planning. However, the currently existing models are based on rather local data and, thus, there is a lack of predictive tools to monitor mushroom yields on larger ***: This work presents the first empirical models for predicting the annual yields of ectomycorrhizal mushrooms and related ecosystem services in Pinus sylvestris and Pinus pinaster stands in northern Spain, using a long-term dataset suitable to account for the combined effect of meteorological conditions and stand *** were fitted for the following groups of fungi separately: all ectomycorrhizal mushrooms, edible mushrooms and marketed mushrooms. Our results show the influence of the weather variables(mainly precipitation) on mushroom yields as well as the relevance of the basal area of the forest stand that follows a right-skewed unimodal curve with maximum predicted yields at stand basal areas of 30–40 m2·***: These models are the first empirical models for predicting the annual yields of ectomycorrhizal mushrooms in Pinus sylvestris and Pinus pinaster stands in northern Spain, being of the highest resolution developed to date and enable predictions of mushrooms productivity by taking into account weather conditions and forests’ location, composition and structure.

关键词： Mushrooms Fungi Non-wood forest products Mixed models Hurdle models

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Architecture as device:Estrangement theory from literature to architecture

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Frontiers of Architectural Research 2022年第1期11卷 1-12页

作者： Qirui Wan sergio martín Blas Department of Architectural Design ETSAMUniversidad Politécnica de MadridMadrid28040Spain

What is the estrangement of architecture?The concept has been incessantly mentioned by academics while there seems to be a lack of discussion systematically sorting out the significance,influence,and origins of estrangement asanarchitectural *** aims to discern the meaning of estrangement from the beginning and its process of entering the field of *** first part is expected to answer the following questions:what is estrangement’s original meaning in the field of literature and its variantions?The second part determines what estrangement is in architecture and in what form estrangement is represented according to these *** third part points out the difference during this translation fromliterature to architecture and demonstrates the reasonable inference thatmay actually compose the possibleway of applying the estranging technique in architecture.

关键词： Estrangement Architectural strategy Literature concept Decontextualization Anthropopathic architecture

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Polymeric and biological membranes for organ-ona-chip devices

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Microsystems & Nanoengineering 2023年第4期9卷 19-43页

作者： Kendra Corral-Nájera Gaurav Chauhan sergio OSerna-Saldívar sergio Omartínez-Chapa Mohammad Mahdi Aeinehvand School of Engineering and Science Tecnológico de MonterreyAve.Eugenio Garza Sada 2501Monterrey 64849Mexico

Membranes are fundamental elements within organ-on-a-chip(OOC)platforms,as they provide adherent cells with support,allow nutrients(and other relevant molecules)to permeate/exchange through membrane pores,and enable the delivery of mechanical or chemical *** OOC platforms,physiological processes can be studied in vitro,whereas OOC membranes broaden knowledge of how mechanical and chemical cues affect cells and *** with membranes are in vitro microfluidic models that are used to replace animal testing for various applications,such as drug discovery and disease *** this review,the relevance of OOCs with membranes is discussed as well as their scaffold and actuation roles,properties(physical and material),and fabrication methods in different organ *** purpose was to aid readers with membrane selection for the development of OOCs with specific applications in the fields of mechanistic,pathological,and drug testing *** stimulation from liquid flow and cyclic strain,as well as their effects on the cell’s increased physiological relevance(IPR),are described in the first *** review also contains methods to fabricate synthetic and ECM(extracellular matrix)protein membranes,their characteristics(e.g.,thickness and porosity,which can be adjusted depending on the application,as shown in the graphical abstract),and the biological materials used for their *** discussion section joins and describes the roles of membranes for different research purposes and their advantages and challenges.

关键词： testing replace porosity

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Identification of human papillomavirus in esophageal squamous papillomas

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World Journal of Gastroenterology 2008年第46期14卷 7107-7111页

作者： Olga L Bohn Leticia navarro Jesus Saldivar sergio Sanchez-Sosa Department of Pathology UPAEP University Hospital

AIM： To investigate the presence of human papillomavirus （HPV） in esophageal squamous papilloma （ESP） and determine p16, p53 and Ki67 expression in a Mexican cohort. METHODS： Nineteen cases diagnosed as ESP, corresponding to 18 patients were reviewed; nineteen cases of normal esophageal mucosa were used as negative controls. HPV detection was performed by ,amplified chromogenic in situ hybridization （ACISH） using a wide spectrum-cocktail probe and PCR. RESULTS： The average age at presentation was 46.3 years （range 28-72 years）. Patients included four （22.22%） males and 14 （77.77%） females. The most frequent location was upper third （11 cases）, followed by middle third （3 cases） and unknown site （5 cases）. Immunohistochemistry （IHC） revealed basal and focal p53 expression in 17 cases （89%）; p16 was expressed in eight cases （42.10%） and the Ki67 index ranged from 10% to 30%. HPV was detected in 14 out of 16 cases （87.5%） by ACISH： Twelve showed diffuse nuclear patterns and two showed granular patterns. HPV DNA was identified by PCR in 12 out of 14 cases （85.7%）. Low-risk HPV types were detected in the most of the cases. CONCLUSION： This study provides identification of HPV infection in almost 80% of ESP using either ACISH or PCR; overall, all of these lesions show low expression of cell-cycle markers. We suggest ACISH as an alternative diagnostic tool for HPV detection in ESR .

关键词： Human papillomavirus Esophageal papilloma Papillomatosis Esophageal neoplasm Immunohistochemistry Cell cycle

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