Polymeric and biological membranes for organ-ona-chip devices
作者机构：School of Engineering and ScienceTecnológico de MonterreyAve.Eugenio Garza Sada 2501Monterrey 64849Mexico
出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)
年 卷 期：2023年第9卷第4期
页 面：19-43页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：The literature facilities provided by Tecnológico de Monterrey in Mexico are thankfully acknowledged
摘 要：Membranes are fundamental elements within organ-on-a-chip(OOC)platforms,as they provide adherent cells with support,allow nutrients(and other relevant molecules)to permeate/exchange through membrane pores,and enable the delivery of mechanical or chemical *** OOC platforms,physiological processes can be studied in vitro,whereas OOC membranes broaden knowledge of how mechanical and chemical cues affect cells and *** with membranes are in vitro microfluidic models that are used to replace animal testing for various applications,such as drug discovery and disease *** this review,the relevance of OOCs with membranes is discussed as well as their scaffold and actuation roles,properties(physical and material),and fabrication methods in different organ *** purpose was to aid readers with membrane selection for the development of OOCs with specific applications in the fields of mechanistic,pathological,and drug testing *** stimulation from liquid flow and cyclic strain,as well as their effects on the cell’s increased physiological relevance(IPR),are described in the first *** review also contains methods to fabricate synthetic and ECM(extracellular matrix)protein membranes,their characteristics(e.g.,thickness and porosity,which can be adjusted depending on the application,as shown in the graphical abstract),and the biological materials used for their *** discussion section joins and describes the roles of membranes for different research purposes and their advantages and challenges.
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