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ESR2–HDA6 complex negatively regulates auxin biosynthesis to delay callus initiation in Arabidopsis leaf explants during tissue culture

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Plant Communications 2024年第7期5卷 200-214页

作者： Kyounghee Lee Hobin Yoon Ok-Sun Park Jongbu lim Sang-Gyu Kim Pil joon Seo Department of Chemistry Seoul National UniversitySeoul 08826Korea Research Institute of Basic Sciences Seoul National UniversitySeoul 08826Korea Interdisciplinary Program in Agricultural Biotechnology Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Department of Biological Sciences KAISTDaejeon 34141Korea

Plants exhibit an astonishing ability to regulate organ regeneration upon *** of leaf explants promotes the biosynthesis of indole-3-acetic acid(IAA),which is polar-transported to excised regions,where cell fate transition leads to root founder cell specification to induce de novo root *** regeneration capacity of plants has been utilized to develop in vitro tissue culture ***,we report that IAA accumulation near the wounded site of leaf explants is essential for callus formation on 2,4-dichlorophenoxyacetic acid(2,4-D)-rich callus-inducing medium(CIM).Notably,a high concentration of 2,4-D does not compensate for the action of IAA because of its limited efflux;rather,it lowers IAA biosynthesis via a negative feedback mechanism at an early stage of in vitro tissue culture,delaying callus *** auxin negative feedback loop in CIM-cultured leaf explants is mediated by an auxin-inducible APETALA2 transcription factor,ENHANCER OF SHOOT REGENERATION 2(ESR2),along with its interacting partner HISTONE DEACETYLASE 6(HDA6).The ESR2–HDA6 complex binds directly to,and removes the H3ac mark from,the YUCCA1(YUC1),YUC7,and YUC9 loci,consequently repressing auxin biosynthesis and inhibiting cell fate transition on 2,4-D-rich *** findings indicate that negative feedback regulation of auxin biosynthesis by ESR2 and HDA6 interferes with proper cell fate transition and callus initiation.

关键词： auxin biosynthesis negative feedback loop ESR2 HDA6 YUCCA chromatin modification

Compact piezoelectric X-Y positioner on a sample holder of scanning tunneling microscope

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Compact piezoelectric X-Y positioner on a sample holder of s...

Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

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作者： Min Jun LEE seong joon lim BeomYong HWANG Hwansoo SUH Jeong Hoon KWON young KUK Department of Physics and Astronomy Seoul National University

Piezo-scanner used in STMs has limited the scanning range up to several micrometers in two dimensions. Various two dimensional positioners have been tried to cover wider scanning range of STMs in order to locate the probing tip over a position of interest. However, existing positioners require entire modification of the previous STM system. Changing the original STM system is difficult because one should redesign the whole STM head and resize other parts. We constructed a X-Y piezoelectric positioner that requires only minor modification of the original STM system. It is designed to move a sample holder over a distance of some millimeters with a few nanometer steps on a plane. It has one X-aligned shear piezo stack and another Y-aligned shear piezo stack being orthogonal to the former one and its size is about 20×20×10 mm. Slip-stick motion could be realized by a contact consists of a stainless steel ball and a polished alumina surface. This X-Y positioner could be made by modifying only the sample holder and the electrical connection part between the STM head and new sample holder. We could expand scanning range to a few millimeters without modifying original STM system. Because only a slightly modification was needed, it was possible to use the original sample holder. For uniform samples we could use the original sample holder and for patterned samples or samples which have nano-structures, we could use our modified sample holder. Our observations are performed using optical microscope in the air at room temperature. We expect further improvement can be done by adjusting tension between a stainless steel ball and a polished alumina surface or by changing the combination of contact materials.

关键词： X-Y positioner STM

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Oncology Research 2024年第4期32卷 615-624页

作者： HYUNG SUN KIM YUN SUN LEE SEUNG MYUNG DONG HYO JUNG KIM DA EUN LEE HYEON WOONG KANG MYEONG JIN KIM joon seong PARK Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome Co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been *** this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of *** found that N-WASP is markedly expressed in clinical patients with *** analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMT)via gene expression profile *** of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMT and invadopodia function were *** N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic *** results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMT and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in the development of therapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer Neural Wiskott-Aldrich syndrome protein(N-WASP)signaling Metastasis Epithelial-mesenchymal transition(EMT) Lysyl oxidase-like 2(LOXL2)

Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea,2010-2018

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World Journal of Gastroenterology 2024年第9期30卷 1154-1163页

作者： Seulji Kim Hyun Jung Lee Seung Woo Lee Sanghyun Park seong-joon Koh Jong Pil Im Byeong Gwan Kim Kyung-Do Han Joo Sung Kim Department of Internal Medicine Korea Institute of Radiological and Medical SciencesSeoul 01812South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea

BACKGROUND Inflammatory bowel disease(IBD)was previously regarded as a Western disease;however,its incidence is increasing in the *** epidemiology of IBD in Asia differs significantly from the patterns in the *** To comprehensively investigate the epidemiology of IBD in South Korea,inclu-ding its incidence,prevalence,medication trends,and *** We analyzed claims data from the Health Insurance Review and Assessment Service and Rare and Intractable Diseases(RIDs),operated by the National Health Insurance Service of South *** with IBD were identified based on the International Classification of Diseases,Tenth Revision,and RID diagnostic codes for Crohn’s disease(CD)and ulcerative colitis(UC)from 2010 to *** In total,14498 and 31409 patients were newly diagnosed with CD and UC,respectively,between 2010 and *** annual average incidence of CD was 3.11 cases per 105 person-years,and that of UC was 6.74 cases per 10^(5) *** 2014,the incidence rate of CD has been stable,while that of UC has steadily increased,shifting the peak age group from 50-year-olds in 2010 to 20-year-olds in *** CD and UC prevalence increased consistently over the study period;the use of 5-aminosali-cylates and corticosteroids gradually decreased,while that of immunomodulators and biologics steadily increased in both CD and *** clinical outcomes of IBD,such as hospitalization and surgery,decreased during the study *** The CD incidence has been stable since 2014,but that of UC has increased with a shift to a younger age at peak incidence between 2010 and *** clinical outcomes improved over time,with increased use of immunomodu-lators and biologics.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Incidence Prevalence

Research on the Path of Cultivating High-Level Technical and Skilled Talents in Vocational Undergraduate Colleges and Universities

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Journal of Contemporary Educational Research 2024年第7期8卷 150-157页

作者： Kan Su seong Pek lim Linli Yao Faculty of Education and Social Sciences Universiti Selangor40000 Shah AlamSelangorMalaysia School of Communication Chengdu Vocational University of The ArtsChengdu 610000Sichuan ProvinceChina

This paper explores strategies to cultivate high-level technical talents in vocational undergraduate colleges by analyzing their development,the essence of such talents,and proposing several key *** include optimizing professional settings and curricula,enhancing school-enterprise cooperation and the integration of industry-university-research,improving teaching staff quality and educational standards,and expanding international *** importance of policy support and funding and establishing robust quality assurance systems is emphasized for effectively cultivating skilled talents in vocational undergraduate colleges.

关键词： Vocational undergraduate colleges High-level technical talents Professional setting Innovation and entrepreneurship education

Zone 3 Relay Blocking Scheme to Prevent Cascaded Events

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Transactions of Tianjin University 2008年第2期14卷 97-105页

作者： lim seong-Il Department of Electrical Engineering Kyungnam UniversityMasanKorea

Defense systems are needed to prevent catastrophic failures of a power grid due to cascaded events. Cascaded events can be attributed to improper operations of protective relays. The most challenging problem for the design and implementation of a defense system is the performance in accuracy and speed in a real time environment. Protective devices are normally designed to operate fast in order to isolate the fault（s）. This paper proposes a new methodology to distinguish line overloads from actual faults for distance relays. In order to distinguish between line flow transfers from a line outage and an actual fault, the line outage distribution factor （LQDF） and generation shift factor （GSF） based power flow estimation method, and a secure peer to peer （P2P） communication structure are adopted. Computer simulations of cascaded events for a 6-bus system and the Korean power grid have been performed to establish the feasibility of the proposed scheme.

关键词： blackouts cascaded events defense system distance relay Zone 3 relay

A Study on the Impact of Cheerleading on the Psychological Health of Female College Students

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Journal of Contemporary Educational Research 2024年第3期8卷 43-48页

作者： Haojun Zhao seong Pek lim Zhuozhuo Xin Lincoln University College 47301 Petaling JayaSelangorMalaysia Shandong Communication&Media College Jinan 250200Shandong ProvinceChina

This study investigates the effects of technical cheerleading and dance cheerleading on the psychological health of female college students by utilizing the Symptom Checklist-90(SCL-90),the Comprehensive Diagnostic Scale for Interpersonal Relationships,and the Social Adaptability Diagnostic *** findings indicate the following:(1)Technical cheerleading has a highly significant impact on sensitivity in interpersonal relationships,paranoia,and psychoticism,and a significant effect on anxiety and hostility;dance cheerleading has a highly significant effect on paranoia;(2)Both technical and dance cheerleading have minimal impact on the overall score distribution of interpersonal relationships among female college students,but the dimensions of their effects differ;(3)The impact of technical cheerleading on the social adaptability of female college students is more pronounced than that of dance cheerleading.

关键词： Technical cheerleading Dance cheerleading Female college students Psychological health

The Impact of Sports Games on the Psychological Health of Middle School Students

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Journal of Contemporary Educational Research 2024年第3期8卷 95-100页

作者： Zhuozhuo Xin seong Pek lim Haojun Zhao Lincoln University College 47301 Petaling JayaSelangorMalaysia Qilu Normal University Jinan 250200Shandong ProvinceChina

This study conducted a 16-week comparative experiment with 160 students from Jinan No.5 Middle School in Shandong Province as the experimental *** the implementation of the experiment,the subjects were divided into two groups:an experimental group and a control *** experimental group was subjected to physical exercise interventions using sports game teaching methods during physical education class,while the control group followed traditional physical education teaching *** results showed that the psychological health status of the students in the experimental group was significantly better than that of the control group after the *** application of sports games helps to improve the psychological health of middle school students in the course of physical education,promoting a positive and forward direction in student psychology and is an effective means to enhance the psychological health level of middle school students.

关键词： Sports games Physical education Middle school students Psychological health

Ultimate strength of single shear bolted connections with cold-formed ferritic stainless steel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第2期14卷 120-136页

作者： Jin-seong lim Tae-soo KIM Seung-hun KIM Department of Architectural Engineering Hanbat National UniversityDaejeon 305-719Korea

This paper is focused on the structural behavior of the single shear bolted connections with thin-walled ferritic stainless *** purpose of this study is to investigate the ultimate behaviors,such as ultimate strength and fracture mode of the single shear bolted connections of thin-walled ferritic stainless steel(low cost steel) rather than austenitic stainless steel(high cost steel).Bolt arrangement and end distance parallel to the direction of applied load are considered as main variables of the test specimens for bolted *** have a constant dimension of edge distance perpendicular to the loading direction,bolt diameter,pitch,and gauge.A monotonic tensile test for specimens has been carried out and some bolted connections with long end distance showed curling(out of plane deformation) occurrence which led to strength *** ultimate behaviors such as fracture mode,ultimate strength are compared with those predicted by current design ***,conditions of curling occurrence and the strength reduction due to curling are investigated and modified strength equations are suggested considering the curling effect.

关键词： Cold-formed ferritic stainless steel Bolted connection Bolt arrangement End distance Curling Strength reduction