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Hemogram-derived ratios as prognostic markers for major adverse cardiovascular events in patients with non-ST-segment elevation myocardial infarction

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World Journal of Methodology 2025年第2期15卷 125-136页

作者： Emir Bećirović Minela Bećirović SabinaŠegalo Amir Bećirović semir hadžić Kenana Ljuca Emsel Papić Lamija Ferhatbegović Malik Ejubović Amira JagodićEjubović Amila Kovčić ArminŠljivo Emir Begagić Department of intensive Care University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina Department of Nephrology University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina Department of Laboratory Technologies Faculty of Health SciencesUniversity of SarajevoSarajevo 71000Bosnia and Herzegovina Department of Endocrinology University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina School of Medicine University of TuzlaTuzla 75000Bosnia and Herzegovina Department for internal Diseases and Hemodialysis Canton Hospital ZenicaZenica 72000Bosnia and Herzegovina Department of internal Medicine Canton Hospital ZenicaZenica 72000Bosnia and Herzegovina Department of Radiotherapy University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina Department of Cardiology University Clinical Center SarajevoSarajevo 72000Bosnia and Herzegovina Department of General Medicine University of ZenicaSchool of MedicineZenica 72000Bosnia and Herzegovina

BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMi)poses significant challenges in clinical management due to its diverse *** the prognostic role of hematological parameters and derived ratios in NSTEMi patients could aid in risk stratification and improve patient *** To evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events(MACE)in NSTEMi patients,potentially improving clinical *** A prospective,observational cohort study was conducted in 2021 at the internal Medicine Clinic of the University Hospital in Tuzla,Bosnia and *** study included 170 patients with NSTEMi,who were divided into a group with MACE and a control group without ***,the MACE group was subdivided into lethal and non-lethal groups for prognostic *** hematological parameters,an additional 13 hematological-derived ratios(HDRs)were monitored,and their prognostic role was *** Hematological parameters did not significantly differ between non-ST segment elevation myocardial infarction(NSTEMi)patients with MACE and a control group at T1 and ***,significant disparities emerged in HDRs among NSTEMi patients with lethal and non-lethal outcomes ***,neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were elevated in lethal ***,C-reactive protein-to-lymphocyte ratio(CRP/Ly)at T1(>4.737)demonstrated predictive value[odds ratio(OR):3.690,P=0.024].Both NLR at T1(>4.076)and T2(>4.667)emerged as significant predictors,with NLR at T2 exhibiting the highest diagnostic performance,as indicated by an area under the curve of 0.811(95%Ci:0.727-0.859)and OR of 4.915(95%Ci:1.917-12.602,P=0.001),emphasizing its important role as a prognostic *** This study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMi *** follow-up,NLR,PLR,and CRP/Ly off

关键词： Hemogram-derived ratios Prognostic markers Neutrophil-to-lymphocyte ratio Myocardial infarction

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Diabetes-induced changes in cardiac voltage-gated ion channels

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World Journal of Diabetes 2021年第1期12卷 1-18页

作者： Nihal Ozturk Serkan Uslu semir Ozdemir Department of Biophysics Akdeniz University Faculty of MedicineAntalya 07058Turkey

Diabetes mellitus affects the heart through various mechanisms such as microvascular defects,metabolic abnormalities,autonomic dysfunction and incompatible immune ***,it can also cause functional and structural changes in the myocardium by a disease known as diabetic cardiomyopathy(DCM)in the absence of coronary artery *** DCM progresses it causes electrical remodeling of the heart,left ventricular dysfunction and heart *** changes in the diabetic heart contribute significantly to the incidence of arrhythmias and sudden cardiac death in diabetes mellitus *** recent studies,significant changes in repolarizing K+currents,Na+currents and L-type Ca^(2+)currents along with impaired Ca^(2+ )homeostasis and defective contractile function have been identified in the diabetic *** addition,insulin levels and other trophic factors change significantly to maintain the ionic channel expression in diabetic *** are many diagnostic tools and management options for DCM,but it is difficult to detect its development and to effectively prevent its *** this review,diabetes-associated alterations in voltage-sensitive cardiac ion channels are comprehensively assessed to understand their potential role in the pathophysiology and pathogenesis of DCM.

关键词： Diabetes Action potential Cardiac ion channels L-type Ca^(2+)channels Potassium channels Sodium channels

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PartLabeling:A label management framework in 3D space

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Virtual Reality & intelligent Hardware 2023年第6期5卷 490-508页

作者： semir ELEZOViKJ Jianqing JiA Chiu CTAN Haibin LiNG Department of Computer and information Sciences Temple UniversityPhiladelphiaPA 19122USA Department of Mathematics Syracuse UniversitySyracuseNY 13244USA Department of Computer Science Stony Brook UniversityStony BrookNY 11794USA

Background in this work,we focus on the label layout problem:specifying the positions of overlaid virtual annotations in Virtual/Augmented Reality *** Designing a layout of labels that does not violate domain-specific design requirements,while at the same time satisfying aesthetic and functional principles of good design,can be a daunting task even for skilled visual *** the annotations in 3D object space instead of projection space,allows for the preservation of spatial and depth *** results in stable layouts in dynamic environments,since the annotations are anchored in 3D *** in this paper we make two major ***,we propose a technique for managing the layout and rendering of annotations in Virtual/Augmented Reality scenarios by manipulating the annotations directly in 3D *** this,we make use of Artificial Potential Fields and use 3D geometric constraints to adapt them in 3D ***,we introduce PartLabeling:an open source platform in the form of a web application that acts as a much-needed generic framework allowing to easily add labeling algorithms and 3D *** serves as a catalyst for researchers in this field to make their algorithms and implementations publicly available,as well as ensure research *** PartLabeling framework relies on a dataset that we generate as a subset of the original PartNet dataset consisting of models suitable for the label management *** dataset consists of 10003D models with part annotations.

关键词： Label layout 3D object space labels

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Trace elements in diabetic cardiomyopathy:An electrophysiological overview

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World Journal of Diabetes 2013年第4期4卷 92-100页

作者： Nihal Ozturk Yusuf Olgar semir Ozdemir Department of Biophysics Akdeniz University Faculty of Medicine

There is a growing body of evidence that Diabetes Mellitus leads to a specific cardiomyopathy apart from vascular disease and bring about high morbidity and mortality throughout the *** clinical and experimental studies have extensively demonstrated that this cardiomyopathy causes impaired cardiac performance manifested by early diastolic and late systolic *** impaired cardiac performance most probably have emerged upon the expression and activity of regulatory proteins such as Na+/Ca2+exchanger,sarcoplasmic reticulum Ca2+-ATPase,ryanodine receptor and *** years many therapeutic strategies have been recommended for treatment of diabetic ***,inorganic elements have been suggested to have anti-diabetic effects due to their suggested ability to regulate glucose homeostasis,reduce oxidative stress or suppress *** findings have shown that trace elements exert many biological effects including insulin-mimetic or antioxidant activity and in this manner they have been recommended as potential candidates for treatment of diabetes-induced cardiac complications,an effect based on their modes of *** of these trace elements are known to play an essential role as component of enzymes and thus modulate the organ function in physiological and pathological ***,they can also manipulate redox state of the channels via antioxidant properties and thus contribute to the regulation of [Ca2+]i homeostasis and cardiac ion *** account of little information about some trace elements,we discussed the effect of vanadium,selenium,zinc and tungstate on diabetic heart complications.

关键词： Diabetic cardiomyopathy Electrophysiology Trace elements insulin-mimetic Antioxidant

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Effect of sodium tungstate on visual evoked potentials in diabetic rats

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international Journal of Ophthalmology(English edition) 2016年第5期9卷 677-681页

作者： Mehmet Bulut Bariszgür Dnmez Nihai ztürk Gksum Basaranlar Ceren Kencebay Manas Narin Derin semir zdemir Department of Ophthalmology Antalya Education and Research Hospital Department of Nutrition and Dietetics School of HealthAkdeniz University Department of Biophysics Faculty of MedicineAkdeniz University

AiM： To evaluate the effect of sodium tungstate on visual evoked potentials（VEPs） in diabetic rats.· METHODS： Wistar rats were randomly divided into three groups as normal control, diabetic control and diabetic rats treated with sodium tungstate. Diabetes was induced by single intraperitoneal injection of streptozotocin（50 mg/kg）. Sodium tungstate [40 mg/（kg·d）]was administered for 12 wk and then VEPs were ***, thiobarbituric acid reactive substance（TBARS） levels were measured in brain tissues.·RESULTS： The latencies of P1, N1, P2, N2 and P3 waves were significantly prolonged in diabetic rats compared with control group. Diabetes mellitus caused an increase in the lipid peroxidation process that was accompanied by changes in VEPs. However, prolonged latencies of VEPs for all components returned to control levels in sodium tungstate-treated group. The treatment of sodium tungstate significantly decreased brain TBARS levels and depleted the prolonged latencies of VEP components compared with diabetic control group.· CONCLUSiON： Sodium tungstate shows protective effects on visual pathway in diabetic rats, and it can be worthy of further study for potential use.

关键词： diabetes retinopathy sodium tungstate visual evoked potentials lipid peroxidation

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Chronic hepatitis B virus infection in Eastern Ethiopia:Clinical characteristics and determinants of cirrhosis

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World Journal of Hepatology 2024年第7期16卷 995-1008页

作者： Nejib Y ismael semir A Usmael Nega B Belay Hailemichael Desalegn Mekonen Asgeir Johannessen Stian MS Orlien Haramaya University College of Health and Medical SciencesHarar 252Ethiopia Aklilu Lemma institute of Pathobiology Addis Ababa UniversityAddis Ababa 1000Ethiopia Regional Centre for imported and Tropical Diseases Oslo University HospitalOslo 0450UllevålNorway internal Medicine Gastroenterology and Hepatology UnitSaint Paul’s Hospital Millennium Medical CollegeAddis Ababa 1000Ethiopia Department of infectious Disease Vestfold Hospital TrustTønsberg 3103Norway institute of Clinical Medicine Oslo UniversityOslo 0318Norway Department of PediatricsOslo UniversityOslo 0450UllevålNorway

BACKGROUND Chronic hepatitis B(CHB)virus infection is a major cause of liver-associated morbidity and mortality,particularly in low-income countries.A better understanding of the epidemiological,clinical,and virological characteristics of CHB will guide appropriate treatment strategies and improve the control and management of CHB in *** To investigate the characteristics of CHB in Eastern Ethiopia and assess the efficacy and safety of antiviral *** This cohort study included 193 adults who were human immunodeficiency virus-negative with CHB between June 2016 and December *** assessments included chemistry,serologic,and viral markers.χ^(2) tests,Mann-Whitney U tests,and logistic regression analyses were used to identify the determinants of *** disoproxil fumarate(TDF)was initiated using treatment criteria from the Ethiopian CHB pilot *** A total of 132 patients(68.4%)were men,with a median age of 30 years[interquartile range(iQR):24-38].At enrollment,60(31.1%)patients had cirrhosis,of whom 35(58.3%)had decompensated *** use,hepatitis B envelope antigen positivity,and a high viral load were independently associated with ***,66 patients(33.4%)fulfilled the treatment criteria and 59(30.6%)started *** 29 patients who completed 24 months of treatment,the median aspartate aminotransferase to platelet ratio index declined from 1.54(iQR:0.66-2.91)to 1.10(iQR:0.75-2.53)(P=0.002),and viral suppression was achieved in 80.9%and 100%of patients after 12 months and 24 months of treatment,*** the treated patients,12(20.3%)died within the first 6 months of treatment,of whom 8 had decompensated *** This study highlights the high prevalence of cirrhosis,initial mortality,and the efficacy of TDF *** up measures to prevent and control CHB infections in Ethiopia is crucial.

关键词： Chronic hepatitis B Cirrhosis Cohort study Resource-limited settings Sub-Saharan Africa

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Low T3 vs low T3T4 euthyroid sick syndrome in septic shock patients:A prospective observational cohort study

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World Journal of Critical Care Medicine 2024年第3期13卷 53-62页

作者： Mirza Kovacevic Visnja Nesek-Adam semir Klokic Ekrema Mujaric Department of Anesthesiology Resuscitation and Intensive CareCantonal HospitalZenica 72000Bosnia and Herzegovina Department of Anesthesiology Resuscitation and Intensive CareClinical Hospital Sveti DuhZagreb 10000Croatia Gruppenpraxis General Practitioner's OfficeLaufen 4242Switzerland Department of internal Diseases Cantonal HospitalZenica 72000Bosnia and Herzegovina

BACKGROUND Both phases of euthyroid sick syndrome(ESS)are associated with worse prognosis in septic shock *** there are still no indications for supplementation therapy,there is no evidence that both phases(initial and prolonged)are adaptive or that only prolonged is maladaptive and requires *** To analyze clinical,hemodynamic and laboratory differences in two groups of septic shock patients with *** A total of 47 septic shock patients with ESS were divided according to values of their thyroid hormones into low T3 and low T3T4 *** analysis included demographic data,mortality scores,intensive care unit stay,mechanical ventilation length and 28-day survival and laboratory with *** The Simplified Acute Physiology Score ii score(P=0.029),dobutamine(P=0.003)and epinephrine requirement(P=0.000)and the incidence of renal failure and multiple organ failure(MOF)(P=0.000)were significantly higher for the low ***(P=0.047),neutrophilia(P=0.038),lymphopenia(P=0.013)and lactatemia(P=0.013)were more pronounced on T2 for the low T3T4 group compared to the low T3 *** blood pressure at T0(P=0.017)and T1(P=0.007),as well as mean arterial pressure at T0(P=0.037)and T2(P=0.033)was higher for the low T3 *** The low T3T4 population is associated with higher frequency of renal insufficiency and MOF,with worse laboratory and hemodynamic *** findings suggest potentially maladaptive changes in the chronic phase of septic shock.

关键词： Septic shock Euthyroid sick syndrome Low T3 Low T3T4 intensive care unit

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物联网时代:边缘计算与云计算的新融合

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中国电子商情(基础电子) 2018年第10期 13-14页

作者： semir haddad 瑞萨电子株式会社

英国作家罗伯特·史蒂文生在其经典小说《化身博士》中,讲述了一个拥有双重人格的人物的故事:温文尔雅的杰基尔博士和邪恶且反社会的海德先生,如果只遇见其中一种人格,人们会把他们看作两个完全不同的人,但他们又确实是同一个人的两个... 详细信息

英国作家罗伯特·史蒂文生在其经典小说《化身博士》中,讲述了一个拥有双重人格的人物的故事:温文尔雅的杰基尔博士和邪恶且反社会的海德先生,如果只遇见其中一种人格,人们会把他们看作两个完全不同的人,但他们又确实是同一个人的两个面孔。在计算领域也是如此,人们可能看到的是两种相对立的方法 -边缘计算和云计算,它们都在解决物联网(ioT)中那些类似的问题,但这些计算方案就

关键词：终端节点解决方案云计算物联网

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艺术创造力与大脑

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世界科学 2002年第6期 13-14页

作者： semir Zeki 张淑香伦敦大学

在《物种起源》一书中查尔斯·达尔文 (CharlesDarwin)谈到 ,作为决定进化的主要因素之一 ,可变性在进化最快的组织中是最大的。人类的大脑是进化最快、可变性最大的器官。目前 ,我们不能将这种可变性归于大脑中某一确定组织或部分。然... 详细信息

在《物种起源》一书中查尔斯·达尔文 (CharlesDarwin)谈到 ,作为决定进化的主要因素之一 ,可变性在进化最快的组织中是最大的。人类的大脑是进化最快、可变性最大的器官。目前 ,我们不能将这种可变性归于大脑中某一确定组织或部分。然而 ,我们可以通过智力、敏感创造力和技能等之间的巨大差异推断这种可变性。艺术是可变性的一种表现 ,所以研究艺术的神经学将不仅阐明主观性最丰富的来源 ,而且还解释了创造和欣赏的可变性的决定因素 ,从而阐明人类大脑的一个最重要的特征。

关键词：大脑神经学可变性神经生物学艺术创造力

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Dietary Fat intake, Micronutritient and Obesity among Adolescent in Tlemcen (Western Algeria)

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Food and Nutrition Sciences 2015年第10期6卷 860-868页

作者： Meryem Allioua Rabah Djaziri Moustafa Yassine Mahdad semir Bechir Suheil Gaouar Harek Derradji Boumediene Moussa Boudjemaa Slimane Belbraouet Laboratory of Applied Microbiology in Food in Biomedical and Environmental (LAMAABE) Department of Biology Faculty of Natural Science and Life University of Tlemcen Tlemcen Algeria Laboratory of Antibiotic and Antifungal Physico-Chemistry Synthesis and Biological Activity (LAPSAB) Department of Biology Faculty of Natural Science and Life University of Tlemcen Tlemcen Algeria Laboratory of Pathophysiology and Biochemistry of Nutrition (PPABiONUT) Department of Biology Faculty of Natural Science and Life University of Tlemcen Tlemcen Algeria National institute of Agronomic Research (iNRA) Algiers Algiers Algeria Ecole de Nutrition Université de Moncton Moncton Canada

Background: A number of epidemiological studies around the world have shown that the occurred and the high prevalence of some chronic diseases such as diabetes, obesity, cardiovascular disease, etc. are mainly caused by a high calorie and unbalanced diet associate with reduced physical activity. in Algeria, as in many emerging countries to improve the standard of living of the population and changes in lifestyle, more westernized characterized by abundant food and sedentary lifestyle especially among young people contribute to the increased incidence of these chronic diseases. Objectives: This work consists of a dietary survey conducted among adolescent boys and girls in Tlemcen (Algeria). Subject and Methods: This is a descriptive cross-sectional study of dietary intake of adolescent aged 10 - 17 years and anthropometric parameters: weight, height, body mass index. Results: increased fat intake was associated with increased body mass index in both sexes, increased obesity and abdominal obesity in girls, boys are more active than girls and we observed decreased intake of sugar, the nutritient adequacy ratio of folate, niacin, vitamin B6, iron, magnesium. Conclusion: The early prevention of obesity in children and adolescents is essential in the prevention of chronic diseases in adults. We recommended adolescent by healthy diets towards helps regulate their body weight and reduces the risk of cardiovascular disease and some types of cancer and especially the girls by lifestyle more active.

关键词： Adolescents Fat intake Micronutrient Body Mass index Obesity

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