Diabetes-induced changes in cardiac voltage-gated ion channels

作     者：Nihal Ozturk Serkan Uslu Semir Ozdemir 

作者机构：Department of BiophysicsAkdeniz University Faculty of MedicineAntalya 07058Turkey 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2021年第12卷第1期

页      面：1-18页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Diabetes Action potential Cardiac ion channels L-type Ca^(2+)channels Potassium channels Sodium channels 

摘      要：Diabetes mellitus affects the heart through various mechanisms such as microvascular defects,metabolic abnormalities,autonomic dysfunction and incompatible immune ***,it can also cause functional and structural changes in the myocardium by a disease known as diabetic cardiomyopathy(DCM)in the absence of coronary artery *** DCM progresses it causes electrical remodeling of the heart,left ventricular dysfunction and heart *** changes in the diabetic heart contribute significantly to the incidence of arrhythmias and sudden cardiac death in diabetes mellitus *** recent studies,significant changes in repolarizing K+currents,Na+currents and L-type Ca^(2+)currents along with impaired Ca^(2+ )homeostasis and defective contractile function have been identified in the diabetic *** addition,insulin levels and other trophic factors change significantly to maintain the ionic channel expression in diabetic *** are many diagnostic tools and management options for DCM,but it is difficult to detect its development and to effectively prevent its *** this review,diabetes-associated alterations in voltage-sensitive cardiac ion channels are comprehensively assessed to understand their potential role in the pathophysiology and pathogenesis of DCM.