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Effects of solar variability on thermosphere density from CHAMP accelerometer data

2020年

作者： (美)塞恩·d.卡斯特拉恩(sean d. Casterline)，(美)小罗伯特·G.耶特曼(Robert G. Yetman Jr.)

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Effects of solar variability on thermosphere density from CH...

WONCA研究论文摘要汇编(七)——轻度认知受损有氧运动效应:对照试验

中国科学院地质与地球物理研究所2007学术年会

作者：郭建鹏 Jeffrey M.Forbes Eric Sutton R.Steven Nerem T.N.Woods sean Bruinsma Institute of Geology and Geophysics Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences department of Aerospace Engineering Sciences University of ColoradoBoulderColoradoUSA Laboratory for Atmospheric and Space Physics University of ColoradoBoulderColoradoUSA department of Terrestrial and Planetary Geodesy Centre National d'Etudes SpatialesToulouseFrance

Thermosphere densities near 410 km altitude inferred from accelerometer measurements on the Challenging Minisatellite Payload(CHAMP) satellite are analyzed for solar irradiance variability effects during the period *** between the densities and the solar irradiances for different spectral lines and wavelength ranges reveal significantly different *** density correlates remarkably well with all the selected solar irradiances except the lower chromospheric OⅠ(130.4 nm) *** the chosen solar proxies,the MgⅡcore-to-wing ratio index,EUV (30-120 nm) and F10.7 show the highest correlations with the density for short-term (d) *** both long-term(>～27 d) and short-term variations,linear correlation coefficients exhibit a decreasing trend from low latitudes toward high latitudes. The density variability can be effectively modeled(capturing 71%of the variance) using multiple solar irradiance indices,including F10.7,S(the EUV 30-120 nm index),and S(the FUV 120-193 nm index),in which a lag time of 1 d was used for both F10.7 and S,and 5 d for *** our regression formulation,S has the largest contribution to the density variation(40%),with the F10.7 having the next largest contribution(32%) and S accounting for the rest(28%).Furthermore,a pronounced period of about 27.2 d(mean period of the Sun’s rotation) is present in both density and solar irradiance data of 2003 and 2004,and a pronounced period of about 54.4 d (doubled period of the solar rotation) is also revealed in ***,soft X-ray and FUV irradiances did not present a pronounced 54.4-d period in 2004,in spite of their high correlation with the *** Ap index also shows 54-d periodicities in 2004, and magnetic activity,together with solar irradiance,affects the 54-d variation in density *** addition,NRLMSISE00,dTM-2000,and JB2006 model predictions are compared with density measurements from CHAMP to assess their accuracy,and the results

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中国全科医学 2010年第10期13卷 1102-1102页

作者： Laura d.Baker Laura L.Frank Karen foster-Schubert 周淑新中国石油中心医院

目的检测有氧运动对认知和其他生物标记物相关的阿尔茨海默病病理,轻度认知受损老年人的作用,并评估作为反应预测指标的性别角色。设计6个月随机对照临床试验。机构:华盛顿西雅图后备军人事务Puget Sound健康照顾系统,临床研究所。参试... 详细信息

目的检测有氧运动对认知和其他生物标记物相关的阿尔茨海默病病理,轻度认知受损老年人的作用,并评估作为反应预测指标的性别角色。设计6个月随机对照临床试验。机构:华盛顿西雅图后备军人事务Puget Sound健康照顾系统,临床研究所。参试者:33名(17名女性)遗忘性轻度认知受损者,年龄55－85岁(平均78岁)。干预将参试者随机分配至高强度有氧运动或伸展运动对照组。[第一段]

关键词：轻度认知受损有氧运动 WONCA 对照试验运动效应论文摘要随机对照临床试验汇编

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颅内囊性脑动脉瘤血管内治疗的报道标准

国际脑血管病杂志 2009年第12期17卷 889-901页

作者： Philip M. Meyers Christian Schumacher Randall T. Higashida Colin P. derdeyn Gary M. Nesbit david Sacks Lawrence R. Wechsler Joshua B. Bederson sean d. Lavine Peter Rasmussen 廖煜君(译) 宋冬雷(译) From the Columbia University College of Physicians and Surgeons Neurological Institute of New York NY Saul R. Korey department of Neurology Division of Vascular Neurology and Neurocritical Care Albert Einstein College of Medicine Bronx NY University of Califomia San Francisco Mallinckrodt Institute of Radiology Washington University School of Medicine St. Louis Mo Oregon Health and Science University Portland Ore Advanced Interventional Radiology Reading Hospital and Medical Center Reading Pa University of Pittsburgh Medical Center Pa department of Neurological Surgery Mount Sinai Medical Center New York NY Cleveland Clinic Foundation Ohio 复旦大学附属华山医院神经外科上海200040

背景和目的本文旨在为颅内脑动脉瘤的放射学评价和血管内治疗的报道标准、术语和书面定义提供共识性推荐意见。这些标准旨在设计临床试验，为患者的合理选择和分层提供统一的定义，并且允许对报道的数据进行分析和汇总分析。方法本文是... 详细信息

背景和目的本文旨在为颅内脑动脉瘤的放射学评价和血管内治疗的报道标准、术语和书面定义提供共识性推荐意见。这些标准旨在设计临床试验，为患者的合理选择和分层提供统一的定义，并且允许对报道的数据进行分析和汇总分析。方法本文是由技术评价委员会、神经介入外科学会、介入放射学学会、美国神经外科医师协会和神经外科医师大会的脑血管神经外科联合分会以及美国神经病学学会卒中和介入神经病学分会组成的联合写作组起草完成的。对1991年1月-2007年12月美国国立医学图书馆文献数据库（PubMed）进行计算机检索，以确定已发表的涉及脑动脉瘤的评价和血管内治疗的脑血管介入治疗数据，以此作为质量评价的基准。我们设法确定那些可能影响操作成功和并发症风险的相关危险因素。本文针对脑动脉瘤血管内治疗临床试验设计方面的重要因素，提供了各种临床和技术方面的基本原则。本指南还包含了对这类临床试验统一报道标准的建议。这些定义和标准主要用于研究目的；不过，它们对于临床实践也应有所帮助，并且适用于所有出版物。结论脑动脉瘤的评价和治疗常常涉及多个医学专业。为制定破裂和未破裂脑动脉瘤的临床处理指南，美国心脏协会最近发辰的综述已对相关医学文献进行了回顾。尽管努力综合了脑动脉瘤评价和治疗方面的现有认识，但在以研究和报道为目的的术语和定义方面仍存在明显的不一致性。这些可操作的定义是由一个多学科写作组一致选择的，用来使涉及脑动脉瘤的临床试验和观察性研究中的影像学相关报道一致。这些定义应有助于不同组织发表能够直接进行比较的研究结果。

关键词：动脉瘤方法学神经放射学神经外科报道标准

direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle

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Nano Research 2015年第10期8卷 3307-3315页

作者： daniela P. Lobo Alan M. Wemyss david J. Smith Anne Straube Kai B. Betteridge Andrew H. J. Salmon Rebecca R. foster Hesham E. Elhegni Simon C. Satchell Haydn A. Little Raul Pacheco-Gomez Mark J. Simmons Matthew R. Hicks david O. Bates Alison Rodger Timothy R. dafforn Kenton P. Arkill departmentofChemistryandWarwickAnalyticalScienceCentre UniversityofWarwickCoventryCV47ALUK MOACdoctoralTrainingCentre UniversityofWarwickCoventryCV47ALUK Mathematics UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK CentreforMechanochemicalCellBiology WarwickMedicalSchoolUniversityofWarwickCoventryCV47ALUK PhysiologyandPharmacology UniversityofBristolUniversityWalkBristolBS81TDUK ClinicalSciences WhitsonStreetUniversityofBristolBristolBS13NYUK SchoolofChemistry UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK Biosciences UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK ChemicalEngineering UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK SchoolofMedicine UniversityofNottinghamQueen'sMedicalCentreNottinghamNG27UHUK Biochemistry UniversityofBristolUniversityWalkBristolBS81TDUK

The wall shear stress （WSS） that a moving fluid exerts on a surface affects many processes including those relating to vascular function. WSS plays an important role in normal physiology （e.g. angiogenesis） and affects the microvasculature＇s primary function of molecular transport. Points of fluctuating WSS show abnormalities in a number of diseases; however, there is no established technique for measuring WSS directly in physiological systems. All current methods rely on estimates obtained from measured velocity gradients in bulk flow data. In this work, we report a nanosensor that can directly measure WSS in microfluidic chambers with sub-micron spatial resolution by using a specific type of virus, the bacteriophage M13, which has been fluorescently labeled and anchored to a surface. It is demonstrated that the nanosensor can be calibrated and adapted for biological tissue, revealing WSS in micro-domains of cells that cannot be calculated accurately from bulk flow measurements. This method lends itself to a platform applicable to many applications in biology and microfluidics.

关键词： microfluidics nanoparticle M13 bacteriophage wall shear stress fluorescent microscopy

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总统的女儿里根家事 1版

Electroosmotic Water Vapor Transport across Novel, Smart, Functionalized Conducting Polymer Microporous Membranes in Active Mode at Very High Rates, with Concomitant Chemical Warfare (CW) Agent Blocking

1987年

作者：（美）戴维斯（davis P.）（美）福斯特（foster M.S.）之援等译

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Advances in Materials Physics and Chemistry 2013年第4期3卷 217-237页

作者： Prasanna Chandrasekhar Petar Pirgov Brian J. Zay david Lawrence sean Morefield Tilghman L. Rittenhouse Salvatore G. Clementi Quoc Truong Russell R. Greene Ashwin-Ushas Corporation Marlboro NJ USA Chemical and Biological Technologies directorate US Defense Threat Reduction Agency (DTRA) Fort Belvoir VA USA Hazardous Materials Research Center (HMRC) Battelle Columbus Laboratories Battelle Memorial Institute Columbus OH USA US Army Engineer Research and development Center Construction Engineering Research Laboratory (ERDC-CERL) Champaign IL USA Warrior Science Technology and Applied Research Directorate US Army Natick Soldier Research Development and Engineering (RD&E) Center Natick MA USA

Electroosmotic water vapor transport (WVT) across very thin, flexible, functionalized conducting polymer (CP) microporous (μP) membranes at a very high rate is reported. Both passive and active (6 VdC applied) WVT are reported, the latter for the first time ever. WVT occurs with concomitant, effective blocking of chemical warfare (CW) agents, again demonstrated for the first time ever. Initial active liquid||membrane||liquid interface studies demonstrated WVT rates of >1.7 × 10-5g .mm-2s-1, >3 × the highest prior reported values of 5 × ***-2s-1. Subsequent vapor||membrane|| vapor interface studies using industry-standard methods (including ASTM E96B Upright Cup (“WVT”), ASTM F2298 (“dynamic Moisture Permeation Cell”) and ASTM F1868 (“Sweating Guard Hotplate”) were done at independent, external labs for independent corroboration. These yielded, e.g., WVT values of2564.4 g.m2.d-1 (passive) and3706.7 g.m2d-1 (active), to be compared with the highest (passive) value ever reported previously,984.8 g.m2.d-1 for a μP-Nylon membrane. More than 15 different membrane configurations, porosities and types were studied, including membranes with CP + organophosphate hydrolase (OPH), an enzyme reactive to CW agents. Efficient blocking of the actual CW agents GB, Hd, VX is also reported, using the TOP-8-2-501standard. Membranes also passed all Industry-standard durability tests, e.g. ASTM d2261 (Tearing), ASTM d5034 (Breaking), ASTM d3886 (Abrasion), ASTM F392 (Gelbo Flex). Incorporation into smart soldiers’ garments was demonstrated;power consumption was -2. Mechanisms of enhanced WVT and CW agent blocking in the membranes are discussed.

关键词： Electroosmotic Transport Smart Microporous Membrane Conducting Polymer Functionalized

Create Value through Investment in Science A Business Overview of New drug R＆d

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中国医药技术经济与管理 2014年第4期8卷 76-82页

作者： Xi-Yong (sean) Fu

This article is based on an invited presentation given at the opening ceremony of SAPA-GP Liaison Office at CPTTC Beijing Office on 25May2014. The author would like to thank Mr. Guozhong Rui and other CPTTC collaborat... 详细信息

关键词：医疗卫生行业发展现状医学研究创新

disruption of drug Effects (dopamine, Nicotine, Pilocarpine, κ-Opioid) in Planarians by UV Light

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Pharmacology & Pharmacy 2012年第3期3卷 358-363页

作者： Robert B. Raffa Christopher S. Tallarida Aruj Choudhry Nadia Sanni-Adam sean McGonigle Michael Baron Zhuo L. Chen Scott M. Rawls Ronald J. Tallarida department of Pharmaceutical Sciences Temple University School of Pharmacy Philadelphia PA U.S.A. department of Pharmacology Temple University School of Medicine and Center for Substance Abuse Research Temple University Philadelphia PA U.S.A.

Based on previous work, it has been hypothesized that the energetics of ultraviolet (UV) light disrupts effects induced by receptor-binding ligands. If this hypothesis is true, then UV light should (i) disrupt a broad variety of endpoints and (ii) disrupt effects produced by ligands that bind to diverse receptor types. This was tested directly in the present study by using ligands selective for four different receptors (one ionotropic, three metabotropic) and three different behavioral endpoints. The selective dopamine d2 receptor antagonist (–)sulpiride (0.1 uM) dose-relatedly decreased spontaneous locomotor velocity, the selective nicotinic acetylcholine receptor agonist nicotine (1, 3, 5 mM) and the selective muscarinic acetylcholine receptor agonist pilocarpine (20, 30, 50 mM) induced seizure-like activity, and the selective-opioid receptor agonist U-50,488H (10 uM) produced physical dependence (manifested as abstinence-induced withdrawal) in planarian models. Each of these diverse ligand and receptor-mediated effects were attenuated by UV light (254 nm = 7.83 × 10–19 J = 4.89 eV). These findings provide further evidence that UV light disrupts ligand-receptor mediated interactions and that UV light might provide a useful tool for examining drug-receptor interactions.

关键词： UV Light drug-Receptor Interaction Locomotor Activity Seizure Physical dependence Planarian