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Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models

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Cellular & Molecular Immunology 2022年第10期19卷 1073-1076页

作者： Junqiong Huang scot Leary Jim Xiang Cancer Research Cluster Saskatchewan Cancer AgencySaskatoonSKCanada Department of Oncology College of MedicineUniversity of SaskatchewanSaskatoonSKCanada Department of Blood Transfusion Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhouChina Department of Biochemistry Microbiology and ImmunologyCollege of MedicineUniversity of SaskatchewanSaskatoonSKCanada

CD8^(+)effector T(T_(e))cells play a critical role in immunity against *** response to a pathogenic stimulus,antigenpresenting cells(APCs)deliver three signals[via T-cell receptor(TCR),costimulation,and cytokines]to naive CD8^(+)T cells,stimulating their entry into a developmental program characterized by T-cell expansion followed by a contraction *** the contraction phase,90-95%of IL-7R^(-)CD62L^(-)KLRG1^(+)T_(e)cells undergo cell apoptosis.

关键词： FOXO1 immunity stimulation

Fungal dysbiosis predicts the diagnosis of pediatric Crohn's disease

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World Journal of Gastroenterology 2018年第39期24卷 4510-4516页

作者： Mohammad I el Mouzan Kirill S Korolev Mohammad A Al Mofarreh Rajita Menon Harland S Winter Ahmad A Al Sarkhy scot e Dowd Ahmad M Al Barrag Asaad A Assiri Department of Pediatrics King Saud UniversityRiyadh 11461Saudi Arabia Department of Pediatrics Supervisor of Prince Abdullah Bin Khalid Celiac Disease Research ChairKing Saud UniversityRiyadh 11461Saudi Arabia Bioinformatics Program Boston UniversityBostonMA 02215United States Al Mofarreh PolyClinic Riyadh 11423Saudi Arabia MassGeneral Hospital for Children BostonMA 02114United States MRDNA ShallowaterTX 79363United States Department of Microbiology King Saud UniversityRiyadh 11461Saudi Arabia

AIM To investigate the accuracy of fungal dysbiosis inmucosa and stool for predicting the diagnosis of Crohn's disease(CD). MeTHODS Children were prospectively enrolled in two medical centers: one university hospital and one private gastroenterology clinic in the city of Riyadh, Kingdom of Saudi Arabia. The children with confirmed diagnosis of CD by standard guidelines were considered cases, and the others were considered non-inflammatory bowel disease controls. Mucosal and stool samples were sequenced utilizing Illumina MiSeq chemistry following the manufacturer's protocols, and abundance and diversity of fungal taxa in mucosa and stool were analyzed. Sparse logistic regression was used to predict the diagnosis of CD. The accuracy of the classifier was tested by computing the receiver operating characteristic curves with 5-fold stratified cross-validation under 100 permutations of the training data partition and the mean area under the curve(AUC) was calculated. ReSULTS All the children were Saudi nationals. There were 15 children with CD and 20 controls. The mean age was 13.9(range: 6.7-17.8) years for CD children and 13.9(3.25-18.6) years for controls, and 10/15(67%) of the CD and 13/20(65%) of the control subjects were boys. CD locations at diagnosis were ileal(L1) in 4 and colonic(L3) in 11 children, while CD behavior was non-stricturing and non-penetrating(B1) in 12 and stricturing(B2) in 3 children. The mean AUC for the fungal dysbiosis classifier was significantly higher in stools(AUC = 0.85 ± 0.057) than in mucosa(AUC = 0.71 ± 0.067)(P ecies were significantly more depleted in stools than mucosal samples, except for Saccharomyces cerevisiae and S. bayanus, which were significantly more abundant. Diversity was significantly more reduced in stools than in mucosa. CONCLUSION We found high AUC of fungal dysbiosis in fecal samples of children with CD, suggesting high accuracy in predicting diagnosis of CD.

关键词： Fungiome Mycobiome Crohn’s disease Inflammation Saudi children

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多样性红利

作者： (美)斯科特·佩奇(scot e. Page)

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e＆P资产评价、开发和决策的一种现代方法

国外石油动态 2005年第24期 6-10页

作者： scot evans 谢力（译）

油气资产的开发可能是现代商业世界中最资本密集的行业之一。最大的能源项目可能需要花费150多亿美元。油气资产通常具有较长的经济寿命，与其他行业的投资相比，它们在历史上以低回报率著称。据最近全球知名的投资银行Goldman Sachs报... 详细信息

油气资产的开发可能是现代商业世界中最资本密集的行业之一。最大的能源项目可能需要花费150多亿美元。油气资产通常具有较长的经济寿命，与其他行业的投资相比，它们在历史上以低回报率著称。据最近全球知名的投资银行Goldman Sachs报告，大油公司财产的平均寿命为21年，但在资本投资方面只有10％的现金回报率。

关键词：资产评价现代方法开发资本投资决策经济寿命平均寿命回报率行业油气

French Validation of the Screen for Cognitive Impairment in Psychiatry (SCIP-F)

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Open Journal of Psychiatry 2016年第1期6卷 107-118页

作者： Smadar Valérie Tourjman Miriam H. Beauchamp Akram Djouini Mathilde Neugot-Cerioli Charlotte Gagner Philippe Baruch Serge Beaulieu Florence Chanut Andrée Daigneault Robert-Paul Juster Sonia Montmayeur Stéphane Potvin scot Purdon Suzanne Renaud evens Villenneuve Institut Universitaire en Santé Mentale de Montréal Montreal Canada Centre de Recherche de l’H?pital Ste-Justine Montreal Canada Institut Universitaire en Santé Mentale de Québec Quebec Canada Douglas Mental Health University Institute Montreal Canada Centre Hospitalier Universitaire de Montréal Montreal Canada Faculté de Pharmacie d’Angers Université Angers Angers France Department of Psychiatry University of Alberta Edmonton Canada

Background: Measuring cognition in clinical practice is clearly essential to the appropriate characterisation of patients’ clinical status and to the development of a personalised care plan. The Screen for Cognitive Impairment in Psychiatry (SCIP) has been developed in order to provide a brief and accessible tool allowing the evaluation of cognitive function in psychiatric conditions. Objective: We present a validation of a French version of the SCIP. Method: Translation from english into French is carried out using the accepted back-translation method. Seventy-two healthy volunteers are characterised by demographic questionnaires and a neuropsychological battery. The French version of the SCIP is then administered on two separate occasions separated by at least a one-week interval. Results: High internal consistencies as well as strong correlations with comparable neuropsychological tests are obtained. A normalised Cronbach’s α = 0.66 is obtained. Conclusions: The French version of the SCIP (SCIP-F) yields results comparable to the english version. The SCIP represents an essential tool for the preliminary evaluation of cognition. Its characteristics, brevity and the lack of need for a technological platform, allow for its integration into clinical practice. Further testing of SCIP-F in various psychiatric conditions will yield valuable information on its potential in clinical settings.

关键词： Screen for Cognitive Impairment in Psychiatry Cognitive Deficits Neuropsychological Assessment Cognitive Screening Patient-Centered Approaches

使用不散瞳数码相机和标准的眼底彩照观测年龄相关性黄斑变性

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美国医学会眼科杂志（中文版） 2005年第3期17卷 188-188页

作者： Ronald Klein Stacy M. Meuer scot e. moss Barbara e. K. Klein Michael W. Neider Jennifer Reinke 韩亮（译）

目的：应用数码和眼底立体照象技术比较与老年黄斑变性相关的病变区的分级。设计：仪器确认研究。研究对象：62名患者（124只眼）伴有不同程度的AMD，其中也包括无AMD者。

关键词：年龄相关性黄斑变性眼底彩照数码相机观测标准散瞳老年黄斑变性不同程度研究对象

Pretty Good Privacy PGP for Personal Privacy 5.0——发送安全的e-mail

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电子与电脑 1997年第11期 39-39页

作者： scot Finnie ,唐宏

显然,大家都不愿意让不相干的人阅读自己的信件,使用e-mail当然同样也不愿冒这样的险,Pretty Good Privacy的PGP for Personal Privacy 5.0就是针对用户的这类需求而研制的产品。它可以方便地对用户的e-mail进行加密,从而使其变得安全... 详细信息

显然,大家都不愿意让不相干的人阅读自己的信件,使用e-mail当然同样也不愿冒这样的险,Pretty Good Privacy的PGP for Personal Privacy 5.0就是针对用户的这类需求而研制的产品。它可以方便地对用户的e-mail进行加密,从而使其变得安全可靠。从Web网点下载该产品仅需50美元,定价很合理。 PGP可以对几乎所有e-mail软件包生成的e-mail信息和附件进行加密。除了标准的RSA算法外,对那些要求苛刻的用户,PGP还提供了另一种可选的加密算法:DSS/DiffieHellman。

关键词： PGP 用户 Pretty Good Privacy PGP for Personal Privacy 5.0 e-mail

eXAMPLeS OF ReCeNT ADVANCeS IN SeISMIC STRUCTURAL TeSTS

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EXAMPLES OF RECENT ADVANCES IN SEISMIC STRUCTURAL TESTS

2007年全国砌体结构基本理论与工程应用学术会议

作者： Allen J.Clark Rod Larson Tony Y.Yang Bozidar Stojadinovic Jack P.Moehle Robert Tremblay Nilolay Velev Sina Merzouq Martin Leclerc Pierre Leger Bruno Massicotte Caroline Blais Colin Rogers M.Pangiotou Jose I.Restrepo Robert e.englekirk Nathan Johnson M.Saiid Saiidi David Sanders Richard T.Ranf Marc eberhard Andrei M.Reinhorn Mettupalayam V.Sivaselvan Zach Liang Mark Pittman scot Weinreber MTS Systems Corporation Department of Civil and environmental engineering University of California at Berkeley Group for Research and Studies in Structural engineering.Department of Civil Geological and Mining engineering.ecole Polytechnique Department of Civil engineering and Applied Mechanics McGill University Department of Structural engineering University of California at San Diego englekirk Partners Consulting Structural engineers Inc. University of Nevada University of Washington Department of Civil Structural and environmental engineering University of Buffalo

＜正＞earthquake damage of property and loss and injury of human life *** many laboratories worldwide have increased their abilities to mitigate the hazards of these reoccurring natural *** paper presents new experimental techniques and applications from five laboratories,one in Canada,and four in the United *** new techniques and technologies range from combining computational analyses with structural testing with strong wall and strong floor at the University of California at Berkelely, a new technique for increasing the capability of a medium size uniaxial shaking table at ecole Polytechnique,a description of the world’s highest capacity outdoor shaking table at the University of California at San Diego,testing with multiple biaxial shaking tables at the University of Reno,Nevada,and finally,the combination of strong wall dynamic structural actuators with a shaking table and real time computational sub-structuring computations at the University at Buffalo（SUNY）.These new capabilities allow the researcher to increase the size of the specimens of interest,allowing much better results to study nonlinear behaviors and failure mechanisms.

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技术的社会建构——兼论若干相关的哲学问题

哲学分析 2023年第3期14卷 156-175,199页

作者： [荷]韦博·e.比克武晨箫(译) 徐秋石(校) 不详中共中央党校(国家行政学院)哲学教研部南方科技大学创新创意设计学院

就技术的社会建构(scot)的哲学基础和影响而言,其重要方面包括:科学与技术的区别、技术的能动性、对称性原则、权力关系的作用、物质性与本体论、结构与行动者、理论的作用、相对主义以及技术的规范性与政治性等。

关键词：技术的社会建构(scot) 技术元勘对称性原则相对主义物质性