Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models

作     者：Junqiong Huang Scot Leary Jim Xiang 

作者机构：Cancer Research ClusterSaskatchewan Cancer AgencySaskatoonSKCanada Department of OncologyCollege of MedicineUniversity of SaskatchewanSaskatoonSKCanada Department of Blood TransfusionAffiliated Hospital of Zunyi Medical UniversityZunyiGuizhouChina Department of BiochemistryMicrobiology and ImmunologyCollege of MedicineUniversity of SaskatchewanSaskatoonSKCanada 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2022年第19卷第10期

页      面：1073-1076页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：This work was supported by a research grant(#PJT153314)from the Canadian Institute of Health Research(CIHR) 

主　　题：FOXO1 immunity stimulation 

摘      要：CD8^(+)effector T(T_(E))cells play a critical role in immunity against *** response to a pathogenic stimulus,antigenpresenting cells(APCs)deliver three signals[via T-cell receptor(TCR),costimulation,and cytokines]to naive CD8^(+)T cells,stimulating their entry into a developmental program characterized by T-cell expansion followed by a contraction *** the contraction phase,90-95%of IL-7R^(-)CD62L^(-)KLRG1^(+)T_(E)cells undergo cell apoptosis.