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The effectiveness of local anesthetic and sodium hyaluronate injection for the posterior disc displacement: A case report

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Open Journal of Stomatology 2013年第3期3卷 223-225页

作者： Yui Mori Kenji Kakudo Hideya Haeniwa Motohiro Gotoh Hirohito Kubo Yuichi ohnishi Masahiro Nakajima Harumi Iwasaki Hironori Akiyama Yoritaka Yotsui Kimishige Shimizutani Department of Oral Radiology Osaka Dental University Osaka Japan Second Department of Oral and Maxillofacial Surgery Osaka Dental University Osaka Japan

Posterior disc displacement of the temporomandibular joint is rare. We present a unique treatment method and magnetic resonance (MR) images of this condition. The patient was a 43-year-old male with a chief complaint of abnormal occlusion. Regarding the present status, there was no occlusion on the right side. No temporomandibular joint pain, myalgia, or clicking were observed while mouth opening. On MR images, the posterior disc displacement without reduction on the right was observed and it was assumed that occlusal abnormality was due to this condition. We treated him with the following methods. After injection into the superior articular cavity with 2% lidocaine, a sodium hyaluronate preparation was injected followed by intermaxillary traction applied using rubber. The recovery of occlusion was confirmed in follow-up at 5 days after treatment. In the 13th days, the intermaxillary traction was removed. On MR images, the right disc condition was changed to anterior disc displacement with reduction. We consider our treatment methods are effective for this clinical condition.

关键词： Posterior Disc Displacement without Reduction Temporomandibular Joint Local Anesthetic with Sodium Hyaluronate Injection Intermaxillary Traction Magnetic Resonance Imaging.

Case of autoimmune hepatitis with markedly enlarged hepatoduodenal ligament lymph nodes

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World Journal of Gastroenterology 2013年第11期19卷 1834-1840页

作者： Hideki Fujii Naoki ohnishi Kazuho Shimura Masafumi Sakamoto Tohru Ohkawara Yoshihiko Sawa Koichi Nishida Yasuo Ohkawara Tatsuro Kobata Kanji Yamaguchi Yoshito Itoh Department of Internal Medicine Aiseikai Yamashina HospitalShichouno-choTakehanaYamashinakuKyoto 602-8086Japan Department of Gastroenterology and Hepatology Uji Tokushukai HospitalKyoto 611-0042Japan Molecular Gastroenterology and Hepatology Kyoto Prefectural University of MedicineGraduate School of Medical ScienceKyoto 602-8566Japan

Autoimmune hepatitis(AIH) is a necroinflammatory liver disease of unknown *** disease is characterized histologically by interface hepatitis,biochemically by increased aspartate aminotransferase and alanine aminotransferase levels,and serologically by increased autoantibodies and immunoglobulin G *** we discuss AIH in a previously healthy 37-year-old male with highly elevated serum levels of soluble interleukin-2 receptor and markedly enlarged hepatoduodenal ligament lymph nodes(HLLNs,diameter,50 mm).Based on these observations,the differential diagnoses were AIH,lymphoma,or Castleman's *** biopsy revealed the features of interface hepatitis without bridging fibrosis along with plasma cell infiltration which is the typical characteristics of acute *** node biopsy revealed lymphoid follicles with inflammatory lymphocytic infiltration;immunohistochemical examination excluded the presence of lymphoma ***,he was administered corticosteroid therapy:after 2 mo,the enlarged liver reached an almost normal size and the enlarged HLLNs reduced in *** could not find AIH cases with such enlarged lymph nodes(diameter,50 mm) in our literature ***,we speculate that markedly enlarged lymph nodes observed in our patient may be caused by a highly activated,humoral immune response in AIH.

关键词： Autoimmune hepatitis Humoral immune response Hepatoduodenal ligament lymph nodes Corticosteroid Hepatomegaly

Usefulness of Hexamethylenetetramine as an Adjuvant to Radiotherapy and Cisplatin Treatment for Solid Tumors:its independency of p53 Status

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Usefulness of Hexamethylenetetramine as an Adjuvant to Radio...

A Phase II Study of Erlotinib in Patients with Previously Treated Non-Small Cell Lung Cancer

作者： S.Masunaga K.Tano J.Nakamura M.Watanabe G.Kashino A.Takahashi H.Tanaka Y.Sakurai M.Suzuki K.ohnishi Y.Kinashi Y.Liu T.ohnishi K.Ono University of North Carolina at Chapel Hill USA Nara Medical University

BACKGROUNDS AND PURPOSES:Formaldehyde preserves or fixes tissue or cells by irreversibly cross-linking primary amine groups in proteins with other nearby nitrogen atoms in protein or DNA through a -CH2- *** acid-dependent formaldehyde donor, hexamethylenetetramine(HMTA),has been used as an antiseptic for urinary tract infections and it has been supposed to be characterized as a non-carcinogen in animals. In the hypoxic condition in a solid tumor,pyruvate

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Advances in Lung Cancer 2014年第1期3卷 10-20页

作者： Tetsuya Kubota Yoshio Okano Mizu Sakai Takashi Yamane Naoki Shiota Hiroshi ohnishi Hisanori Machida Nobuo Hatakeyama Eiji Takeuchi Tomoyuki Urata Fumitaka Ogushi Akihito Yokoyama Department of Hematology and Respiratory Medicine School of Medicine Kochi University Kochi Japan Division of Pulmonary Medicine Kochi Medical Center Kochi Japan Division of Pulmonary Medicine Kochi Red Cross Hospital Kochi Japan Division of Pulmonary Medicine NHO Kochi Hospital Kochi Japan

Background: Erlotinib has been reported to be effective for the treatment of non-small cell lung cancer (NSCLC). To evaluate the efficacy and safety of erlotinib under conditions similar to daily clinical practice, a phase II trial was conducted in Japanese patients with previously treated NSCLC. Methods: The eligibility criteria were stage IIIB/IV NSCLC, a performance status (PS) of 0 - 2, and previous treatment with 1 - 2 non-EGFR-TKI regimens. Patients received erlotinib (150 mg/day) orally until disease progression or intolerable toxicity occurred. The primary endpoint was the objective response rate (ORR). In addition, the disease control rate (DCR), progression-free survival (PFS), overall survival (OS), safety, and EGFR gene mutation status were evaluated. Results: Thirty-eight patients were enrolled, and 37 patients were evaluated. The median age was 69 years (range, 50 - 80 years). Patient characteristics were as follows: 26 were male and 11 were female;12 had a PS of 0, 20 had a PS of 1, and 5 had a PS of 2;and 26 had adenocarcinoma, and 11 had non-adenocarcinoma histology. The ORR and DCR were 21.6% (95% confidence interval [CI], 11.4% - 37.2%) and 54.1% (95% CI, 35.9% - 66.6%), respectively. Twenty-seven patients could be evaluated for EGFR gene status (12, mutated;15, wild-type). The ORR for EGFR-mutated patients was 41.7%, while that for patients with wild-type EGFR was 13.3%. The median PFS was evaluated as 4.4 months (95% CI, 2.2 - 10.7 months). The median OS was 14.9 months (95% CI, 9.2 months - not reached). Common adverse events were tolerable skin toxicities, diarrhea, and stomatitis. In addition, interstitial lung disease occurred in 8.1% of patients. Conclusion: As efficacy and safety were similar to previous studies, erlotinib was found to be effective for Japanese patients with previously treated NSCLC in clinical practice.

关键词： Non-Small Cell Lung Cancer Phase II Study Erlotinib Previously Treated

Study of Factors Affecting Medical Incident: 3. Medicine Inspection

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Pharmacology & Pharmacy 2020年第1期11卷 9-16页

作者： Yuka Miyachi Chika Nakayama Takashi Horiba Tomoaki Hino Kazuyo Nagashiba Miki Kato Masafumi ohnishi Hiroko Saito Masato Isogai Nami Sugiura Keiko Matsuura Taeyuki Oshima College of Pharmacy Kinjo Gakuin University Nagoya Japan

It is the responsibility of pharmacists to ensure the safety of patients as pharmacist’s professional duties expand into diverse directions. In recent years, the use of automated dispensing systems has increased;however, the inspection by pharmacists is the most important step in the prevention of medical errors. Comparing the inspection of hospital and community pharmacists may lead to an increased awareness of incident countermeasures. Therefore, eye tracking was performed for hospital and community pharmacists who conduct inspection, and the results revealed the factors that affect dispensing errors. One of the factors was the size of the dispensing space, especially if the space was small and the items needed were not easily accessible. In addition, differences in the inspection procedures among pharmacists were presumed to lead to possible dispensing errors due to oversights. Moreover, it was suggested that any subsequent work would flow more smoothly if a pharmacist checked the prescription and medication history management records at the beginning. Furthermore, it was thought that keeping a history of checks, such as recording any prescription checks in writing, would speed up finding the cause in the unlikely event that a dispensing error occurred. Accordingly, creating an environment in which one can concentrate without distractions during the inspections can lead to the prevention of dispensing error.

关键词： Medicine Inspection Dispensing Error Eye Tracking Pharmacist

Antarctic Macroalgae Palmaria decipiens (Rhodophyta, Palmariales) Extracts Present Antioxidant and Antitumor Activity against Colorectal Cancer

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Advances in Biological Chemistry 2022年第6期12卷 274-291页

作者： Marina Della Giustina Rafaele Frassini Sidnei Moura Fernando Joel Scariot Sérgio Echeverrigaray Vanessa sayuri Osaki Franciane M. Pellizari Pio Colepicolo João Antonio Pêgas Henriques Janaina da Silva Crespo Mariana Roesch-Ely Laboratory of Applied Toxicology and Bioproducts University of Caxias do Sul Rio Grande do Sul RS Brazil Laboratory of Biosynthetic and Natural Products University of Caxias do Sul Rio Grande do Sul RS Brazil Laboratory of Applied Microbiology Biotechnology Institute University of Caxias do Sul Rio Grande do Sul RS Brazil Laboratory of Phytology and Quality of Marine Water Paraná State University Paranaguá Campus PR Brazil Laboratory of Biochemistry and Molecular Biology of Algae University of S&#227 o Paulo S&#227 o Paulo SP Brazil Exact Sciences and Engineering Area University of Caxias do Sul Rio Grande do Sul RS Brazil

Despite therapeutic advances in recent decades, colorectal cancer is still the third most frequent neoplasm worldwide, with significant morbidity and mortality in young and middle-aged adults. Therefore, advance in treatment options for patients who are afflicted with tumor subtypes without effective therapies is needed. Antarctica macroalgae are substances-producing organisms with important biological activities, in which antitumor properties are investigated, showing promising cytotoxic results. There are no reports so far showing antitumor activity of macroalgae Palmaria decipiens extracts against colorectal tumors. This study aims to evaluate the effect of macroalgae P. decipiens extract from Antarctic on tumor cell HCT-116 and non-tumor cell HaCaT lines. The phenolic compounds present were identified by high performance liquid chromatography. The antioxidant activity of the extracts was determined by the DPPH radical inhibition method and cytotoxicity was evaluated through MTT assay. Cell death events were identified using dual staining with acridine orange/ethidium bromide and flow cytometry. The quantification of phenolic compounds present in the extracts identified the presence of three main compounds among them is kaempferol. The metanolic extract showed inhibition within 72 h of treatment in HCT-116 and potential antioxidant activity. The results presented in this study point out an imbalance in the redox metabolism and also a loss of mitochondrial membrane potential integrity, most likely inducing cell death mechanisms after 72 h exposure to treatment with metanolic extract. These events could be observed by penetration of propidium iodide through membrane damage. The results indicate that the extract of the Antarctic macroalgae P. decipiens interferes in the mechanisms of action of colorectal cancer tumor cells, acting as a potential antitumor and antioxidant agent.

关键词： Antarctic Seaweeds Antitumor Activity Colorectal Cancer Antioxidant Activity

Magnetic Field Configuration Effect and New ECRISs for RIKEN RIBF Project

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Chinese Physics C 2007年第S1期31卷 133-136页

作者： T.Nakagawa M.Kidera Y.Higurasi J.ohnishi T.Kageyama T.Aihara A.Goto Y.Yano Nishina Center for Accelerator Based Science RIKENHirosawa 2-1WakoSaitama 351-0198Japan) SAS Ltd Ohsaki 1-17-6Sinagawa-kuTokyo141-0032Japan Nishina Center for Accelerator Based Science RIKENHirosawa 2-1WakoSaitama 351-0198Japan

We measured the main plasma parameters(density of electron,temperature of electron and ion confinement time)and beam intensity of various heavy ions as a function of B_(min).The B_(min) strongly affects the field gradient at the resonance zone,consequently the plasma parameters and beam intensity are changed. Based on these experimental results,we started to construct new 18GHz ECRIS and make a detailed design of the 28GHz SC-ECRIS for RIKEN RI beam factory project.

关键词： magnetic field configuration B_(min) superconducting ECRIS

在免眼中进行经瞳孔阈值下温热疗法的组织学效应和蛋白表达

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美国医学会眼科杂志（中文版） 2005年第3期17卷 185-186页

作者： Yoshihiro Morimura Annabelle A. Okada Atsushi Hayashi sayuri Fujioka Sumie Kawahara Tetsuo Hida 李扬（译）

目的：研究阈值下经瞳孔温热疗法（TTT）对视网膜组织学的效应。方法：对正常视网膜色素的兔眼进行TTT，通过1个810nm激光二极管产生直径为1．2mm能量为50mW的光斑，持续时间为15、30和60秒。4周后进行荧光血管造影并摘除眼球，通过电... 详细信息

目的：研究阈值下经瞳孔温热疗法（TTT）对视网膜组织学的效应。方法：对正常视网膜色素的兔眼进行TTT，通过1个810nm激光二极管产生直径为1．2mm能量为50mW的光斑，持续时间为15、30和60秒。4周后进行荧光血管造影并摘除眼球，通过电子显微镜和免疫组化染色来检查。

关键词：经瞳孔温热疗法组织学效应蛋白表达阈值视网膜色素荧光血管造影免疫组化染色激光二极管电子显微镜

黏液素核心蛋白的表达证明一些发生于乳晕部的Paget病是乳腺外Paget病组织学表现及多种疾病的一部分

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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 49-50页

作者： ohnishi T. Shibuya S. Nemoto I. 崔荣 Department of Dermatology Teikyo University School of Medicine 11- 1 Kaga- 2 Itabashi-ku Tokyo 17 3- 8605 Japan

Triple extramammary Paget’s disease, which consists ordinarily of b ilateral axillary and genital lesions, is uncommon. Triple extramammary Paget’s diseas e involving other sites has never been reported, although solitary extramammary Paget’s disease can occur at various sites around the body, Erythematous plaqu es on the areola, axilla and genitalia of a 91- year-oldman were surgically r emoved under the clinical diagnosis of multiple extramammary Paget’s disease, Histology revealed that all three lesions consisted of intraepidermal nests of P aget cells and other isolated Paget cells scattered in the epidermis. Although a dnexal invasion was observed in the genital lesion, neither intraductal invasion nor underlying breast carcinomawas detected in the areolar lesion. Immunohistoc hemically, the Paget cells in all lesions expressed simple epithelial cytokerati ns (CK8, 18 and 19), mucin (MUC)1 and MUC5AC, but neither CK20 nor MUC2. From th e histological findings, the present case was interpreted as triple extramammary Paget’s disease rather than synchronous mammary and extramamma ry Paget’s disease. Furthermore, the mucin core protein expression pattern, wh ich was identical to that observed in extramammary Paget’s disease, supported the above interpretation.

关键词： Paget病乳腺外黏液素核心蛋白乳房肿瘤角蛋白外科切除腺管腋部免疫组化染色