黏液素核心蛋白的表达证明一些发生于乳晕部的Paget病是乳腺外Paget病组织学表现及多种疾病的一部分
Evidence from mucin core protein expression that some Paget's disease on areola can be of extramammary like histogenesis and part of multisite diseas e作者机构：Department of Dermatology Teikyo University School of Medicine 11- 1 Kaga- 2 Itabashi-ku Tokyo 17 3- 8605 Japan
出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)
年 卷 期：2005年第1卷第3期
页 面：49-50页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Paget病 乳腺外 黏液素 核心蛋白 乳房肿瘤 角蛋白 外科切除 腺管 腋部 免疫组化染色
摘 要：Triple extramammary Paget’s disease, which consists ordinarily of b ilateral axillary and genital lesions, is uncommon. Triple extramammary Paget’s diseas e involving other sites has never been reported, although solitary extramammary Paget’s disease can occur at various sites around the body, Erythematous plaqu es on the areola, axilla and genitalia of a 91- year-oldman were surgically r emoved under the clinical diagnosis of multiple extramammary Paget’s disease, Histology revealed that all three lesions consisted of intraepidermal nests of P aget cells and other isolated Paget cells scattered in the epidermis. Although a dnexal invasion was observed in the genital lesion, neither intraductal invasion nor underlying breast carcinomawas detected in the areolar lesion. Immunohistoc hemically, the Paget cells in all lesions expressed simple epithelial cytokerati ns (CK8, 18 and 19), mucin (MUC)1 and MUC5AC, but neither CK20 nor MUC2. From th e histological findings, the present case was interpreted as triple extramammary Paget’s disease rather than synchronous mammary and extramamma ry Paget’s disease. Furthermore, the mucin core protein expression pattern, wh ich was identical to that observed in extramammary Paget’s disease, supported the above interpretation.
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