Usefulness of Hexamethylenetetramine as an Adjuvant to Radiotherapy and Cisplatin Treatment for Solid Tumors:its independency of p53 Status

作     者：S.Masunaga K.Tano J.Nakamura M.Watanabe G.Kashino A.Takahashi H.Tanaka Y.Sakurai M.Suzuki K.Ohnishi Y.Kinashi Y.Liu T.Ohnishi K.Ono 

作者单位：University of North Carolina at Chapel HillUSA Nara Medical University 

会议日期：2010年

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

摘      要：BACKGROUNDS AND PURPOSES:Formaldehyde preserves or fixes tissue or cells by irreversibly cross-linking primary amine groups in proteins with other nearby nitrogen atoms in protein or DNA through a -CH2- *** acid-dependent formaldehyde donor, hexamethylenetetramine(HMTA),has been used as an antiseptic for urinary tract infections and it has been supposed to be characterized as a non-carcinogen in animals. In the hypoxic condition in a solid tumor,pyruvate