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Development of New Tumor Targeting 10B-carrier:Boron Cluster-Cyclic RGD Pentapeptide Conjugates for Boron Neutron Capture Therapy

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Development of New Tumor Targeting 10B-carrier:Boron Cluster...

作者： s.Kimura s.Ueda K.Okuda s.masunaga H.Nagasawa Laboratory of Medicinal & Pharmaceutical Chemistry Gifu Pharmaceutical University

INTRODUCTION:A neutron capture reaction in boron[B(n,α) Li]is,in principle,very effective in destroying tumors selectively,providing that sufficient amount of B can be accumulated in the target tumor. However one of the major limitations in boron neutron capture therapy(BNCT) is insufficient and heterogeneous delivery of B from currently clinical-used B carriers, such as sodium mercaptoundecahydrododecaborate-B (BsH) and L-4-boronophenylalanine-B(BPA),into the target *** augment the efficiency of BNCT,we developed new B carriers containing the Arg-Gly-Asp

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Optical imaging of Intratumor HIF-1 Activity to Optimize Treatment Regimen for the Combination of a HIF-1 Inhibitor with Radiation Therapy

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Optical imaging of Intratumor HIF-1 Activity to Optimize Tre...

作者： H.Harada s.Itasaka K.shibuya s.masunaga M.Hiraoka Department of Radiation Oncology and Image-applied Therapy Kyoto University Graduate School of Medicine

BACKGROUND & PURPOsE:Tumor cells in which the transcriptional activity of hypoxia-inducible factor 1 (HIF-1) is extremely high are recognized as potential targets in cancer therapy because HIF-1 has been strongly associated with not only tumor angiogenesis,invasion, metastasis but also poor prognosis after radiation therapy. Here,we performed a series of optical imaging experiments to clarify the postirradiation changes in intratumor HIF-1 *** on the information,we intended to optimize the protocol for the combination of a HIF-1 inhibitor, YC-1,with radiation therapy.

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Influence of Manipulating Hypoxia in solid Tumors on Radiation Dose-Rate Effect in Vivo,with Reference to That in Quiescent Tumor Cell Population

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Influence of Manipulating Hypoxia in Solid Tumors on Radiati...

作者： s.masunaga R.Hirayama A.Uzawa G.Kashino Y.sakurai H.Tanaka M.suzuki Y.Kinashi Y.Liu s.Koike K.Ando K.Ono National Institute of Radiological sciences Heavy Ion Medical Center Gunma University

BACKGROUNDs AND PURPOsEs:Intensity modulated radiotherapy(IMRT) and stereotactic irradiation have become common as a new radiotherapy technique for treatment of *** modalities generally use multiple arc or fixed-portal radiation beams,and radiation beams are exposed *** techniques often require 30 rain or a longer time in one treatment session for precise positioning of *** of irradiation time may reduce a radiation effect,and evokes a major concern for the dose rate ***,it is needed to clarify the

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Manipulating Hypoxia in solid Tumors Has the Potential to Influence Lung Metastases in vivo

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Manipulating Hypoxia in Solid Tumors Has the Potential to In...

作者： s.masunaga Y.Matsumoto R.Hirayama G.Kashino Y.sakurai H.Tanaka M.suzuki Y.Kinashi Y.Liu K.Ando K.Ono National Institute of Radiological sciences Heavy Ion Medical Center Gunma University

BACKGROUNDs AND PURPOsEs:Many cells in solid tumors are quiescent in situ but are still clonogenic .Quiescent(Q) tumor cells are more resistant to low-LET radiation because of their larger hypoxic fraction and greater capacity to recover from radiation -induced DNA damage than proliferating(P) tumor *** original method for selectively detecting the response of intratumor Q cells has made it possible to evaluate the usefulness of various modalities for cancer therapy in terms of effectiveness against intratumor Q

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Usefulness of Hexamethylenetetramine as an Adjuvant to Radiotherapy and Cisplatin Treatment for solid Tumors:its independency of p53 status

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Usefulness of Hexamethylenetetramine as an Adjuvant to Radio...

作者： s.masunaga K.Tano J.Nakamura M.Watanabe G.Kashino A.Takahashi H.Tanaka Y.sakurai M.suzuki K.Ohnishi Y.Kinashi Y.Liu T.Ohnishi K.Ono University of North Carolina at Chapel Hill USA Nara Medical University

BACKGROUNDs AND PURPOsEs:Formaldehyde preserves or fixes tissue or cells by irreversibly cross-linking primary amine groups in proteins with other nearby nitrogen atoms in protein or DNA through a -CH2- *** acid-dependent formaldehyde donor, hexamethylenetetramine(HMTA),has been used as an antiseptic for urinary tract infections and it has been supposed to be characterized as a non-carcinogen in animals. In the hypoxic condition in a solid tumor,pyruvate

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soil Development and Fertility Characteristics of Inland Valleys in the Rain Forest Zone of Nigeria: Mineralogical Composition and Particle-size Distribution

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Pedosphere 2009年第4期19卷 505-514页

作者： s. s. ABE G. O. OYEDIRAN T. masunaga s. YAMAMOTO T. HONNA T. WAKATsUKI Africa Rice Center (WARDA) Faculty of Agriculture Tottori University Department of Agronomy Ladoke Akintola University of Technology Ogbamoso (Nigeria) Faculty of Life and Environmental science Shimane University Faculty of Agriculture Kinki University

The particle-size distribution and mineralogical composition of the clay （〈 2 μm） and fine-sand （0.25-0.10 mm） fractions in soils of two inland valleys in Abakaliki and Bende, southeast Nigeria, were investigated to provide basic information on soil-forming processes and agricultural potentials. These soils were silty or clayey, deriving from Cretaceous or Tertiary shale materials. The particle-size distribution and its computation on a clay-free basis revealed relatively remarkable lithologic breaks in a couple of pedons. The effect of lithologic discontinuities on soil mineralogical composition was not, however, conspicuous. Petrographic investigation revealed that quartz predominantly comprised the fine-sand fraction in the soils at both study sites. Nevertheless, the clay mineralogical composition of the soils was a mixture of kaolinite, irregularly interstratified smectite-illite intergrades （s/I）, hydroxyl-A1 interlayered 2：1 type clays （HICs）, vermiculite, smectite, halloysite and illite along with fine-sized quartz in Abakaliki. The soils of Bende predominantly contained smectite, which was partially interlayered with hydroxyl-A1 and kaolinite. It is suggested that seasonal floodwater has slowed the disintegration of weatherable clay minerals inherited from the shale, while quartz originating from the sandstone is predominant in the fine-sand fraction. Additionally, a possible soil-forming process observed at the both study sites was ferrolysis, which was indicated by a clear decreasing pattern of HICs downward in the soil profiles, The entry of s/I and vertical distribution patterns for a couple of clay minerals in the pedon suggested that the soils in Abakaliki have developed under the significant influence of aeolian dust delivered by the Harmattan. The findings might describe a site-specific deposition pattern of Harmattan dusts as well as hydromorphic soil-forming processes in the wetlands of the inland valleys.

关键词： aeolian dust ferrolysis hydromorphic soil hydroxyl-A1 interlayered 2:1 type clays southeast Nigeria

Derivation of salt content in salinized soil from hyperspectral reflectance data: A case study at Minqin Oasis, Northwest China

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Journal of Arid Land 2019年第1期11卷 111-122页

作者： QIAN Tana Atsushi TsUNEKAWA PENG Fei Tsugiyuki masunaga WANG Tao LI Rui Arid Land Research Center Tottori University Life and Environmental science Shimane University Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences state Key Laboratory of Remote sensing science Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences

soil salinization is a serious ecological and environmental problem because it adversely affects sustainable development worldwide, especially in arid and semi-arid regions. It is crucial and urgent that advanced technologies are used to efficiently and accurately assess the status of salinization processes. Case studies to determine the relations between particular types of salinization and their spectral reflectances are essential because of the distinctive characteristics of the reflectance spectra of particular salts. During April 2015 we collected surface soil samples(0–10 cm depth) at 64 field sites in the downstream area of Minqin Oasis in Northwest China, an area that is undergoing serious salinization. We developed a linear model for determination of salt content in soil from hyperspectral data as follows. First, we undertook chemical analysis of the soil samples to determine their soluble salt contents. We then measured the reflectance spectra of the soil samples, which we post-processed using a continuum-removed reflectance algorithm to enhance the absorption features and better discriminate subtle differences in spectral features. We applied a normalized difference salinity index to the continuum-removed hyperspectral data to obtain all possible waveband pairs. Correlation of the indices obtained for all of the waveband pairs with the wavebands corresponding to measured soil salinities showed that two wavebands centred at wavelengths of 1358 and 2382 nm had the highest sensitivity to salinity. We then applied the linear regression modelling to the data from half of the soil samples to develop a soil salinity index for the relationships between wavebands and laboratory measured soluble salt content. We used the hyperspectral data from the remaining samples to validate the model. The salt content in soil from Minqin Oasis were well produced by the model. Our results indicate that wavelengths at 1358 and 2382 nm are the optimal wavebands for monitoring the

关键词： salinity index soil salt content spectral reflectance waveband pairs arid regions

starbase:A Potential Modern Company Town

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空中英语教室（高级版．彭蒙惠英语） 2021年第9期 32-34,47,48页

作者： samantha masunaga 不详

The secluded Texas beachside community of Boca Chica Village was once a haven for retirees,snowbirds and outdoorsy ***,traffic backs up the lone highway out of the unincorporated area that’s now home to only about half a dozen residents-and spaceX’s starship *** test launches,residents receive a notice suggesting they temporarily evacuate for safety.

关键词： base beach haven

FUZZY MODEL FOR TWO-DIMENsIONAL RIVER WATER QUALITY sIMULATION UNDER sUDDEN POLLUTANTs DIsCHARGED

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Journal of Hydrodynamics 2007年第4期19卷 434-441页

作者： LI Ru-zhong sHIGEKI masunaga HONG Tian-qiu QIAN Jia-zhong school of Resources and Environmental Engineering Hefei University of Technology Hefei 230009 China Graduate school of Environment and Information sciences Yokohama National University Yokohama 240-8501 Japan

Based on the fuzziness and impreciseness of water environmental system, the fuzzy arithmetic was used to simulate the fuzzy and imprecise relations in modeling river water quality. By defining the parameters of water quality model as symmetrical triangular fuzzy numbers, a two-dimensional fuzzy water quality model for sudden pollutant discharge is established. From the fuzzy model, the pollutant concentrations, corresponding to the specified confidence level of a, can be obtained by means of the a-cut technique and arithmetic operations of triangular fuzzy numbers. study results reveal that it is feasible in theory and reliable on calculation applying triangular fuzzy numbers to the simulation of river water quality.

关键词： fuzzy water quality simulation model triangular fuzzy number membership function a-cut technique