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Acute development of collateral circulation and therapeutic prospects in ischemic stroke

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Neural Regeneration Research 2016年第3期11卷 368-371页

作者： Eri Iwasawa Masahiko Ichijo satoru Ishibashi Takanori Yokota Department of Neurology and Neurological Science Tokyo Medical and Dental University

In acute ischemic stroke,collateral circulation plays an important role in maintaining blood flow to the tissue that is at risk of progressing into ischemia,and in increasing the successful recanalization rate without hemorrhagic *** have reported that well-developed collateral circulation is associated with smaller infarct volume and better long-term neurological outcome,and it disappears promptly once the effective recanalization is *** to the belief that collateral vessels develop over time in chronic stenotic condition,there exists a phenomenon that collateral circulation develops immediately in acute stenosis or occlusion of the arteries and it seems to be triggered by fluid shear stress,which occurs between the territories of stenotic/occluded arteries and those fed by surrounding intact *** believe that this acute development of collateral circulation is a target of novel therapeutics in ischemic stroke and refer our recent attempt in enhancing collateral circulation by modulating sphingosine-1-phosphate receptor 1,which is a known shear-stress mechanosensing protein.

关键词： ischemic stroke collateral S1PR1 shear stress leptomeningeal arteries PCA laterality hyperintensive vessels

Micro-scale Additive Manufacturing Using the Optical Potential Generated by a Bessel Beam

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Nanomanufacturing and Metrology 2020年第4期3卷 292-298页

作者： Masaki Michihata Makoto Yokei Shotaro Kadoya satoru Takahashi Department of Precision Engineering The University of Tokyo7-3-1 HongoBunkyoTokyo 113-8654Japan Research Center for Advanced Science and Technology The University of Tokyo4-6-1 KomabaMeguroTokyo 153-8904Japan

In this study,we proposed a novel micro-scale additive manufacturing method based on the optical potential formed by a Bessel *** proposed technique is expected to show no deterioration in manufacturing resolution due to heat genera-tion,to be applicable to various materials,and to be able to be performed in an air *** basic principle of the proposed method involves accumulating and stacking particles dispersed in air by using optical radiation *** this paper,the trajectory of the accumulated particles was numerically estimated and experimentally *** numerical and experimental results agreed well;specfially,the back ground flow carried the particles to the optical axis of the Bessel beam,and then the particles were localized at the bottom of the optical potential valley on the ***,a pillar structure was fabricated with polystyrene particles having a diameter of 1 um,which indicated that the proposed technique was promising for practical applications.

关键词： Additive manufacturing Optical radiation pressure Optical trapping potential Bessel beam Nanoparticles

Frequent loss of heterozygosity in two distinct regions,8p23.1 and 8p22, in hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第7期13卷 1090-1097页

作者： Tomoe Lu Hiroshi Hano Keisuke Nagatsuma satoru Chiba Masahiro Ikegami Department of Pathology Jikei University School of Medicine Tokyo Japan

AIM： To identify the precise location of putative tumor suppressor genes （TSGs） on the short arm of chromosome 8 in patients with hepatocellular carcinoma （HCC）. METHODS： We used 16 microsatellite markers informative in Japanese patients, which were selected from 61 pub- lished markers, on 81：）, to analyze the frequency of loss of heterozygosity （LOH） in each region in 33 cases （56 lesions） of HCC. RESULTS： The frequency of LOH at 8p23.2-21 with at least one marker was 63% （20/32） in the informative cases. More specifically, the frequency of LOH at 8p23.2, 8p23.1, 8p22, and 8p21 was 6%, 52%, 47%, and 13% in HCC cases. The LOH was significantly more frequent at 8p23.1 and 8p22 than the average （52% vs 220, P = 0.0008; and 47% vs 22%, P = 0.004, respectively） or others sites, such as 8p23.2 （52% vs 60, P = 0.003; 47% vs 220, P = 0.004） and 8p21 （52% vs 13%, P = 0.001; 47% vs 13%, P = 0.005） in liver cancer on the basis of cases. Notably, LOH frequency was significantly higher at D85277, DSS503, DSS1130, DSS552, DSS254 and D8S258 than at the other sites. However, no allelic loss was detected at any marker on 8p in the lesions of nontumor liver tissues. CONCLUSION： Deletion of 8p, especially the loss of 8p23.1-22, is an important event in the initiation or promotion of HCC. Our results should be useful in identi- fying critical genes that might lie at 8p23.1-22.

关键词： Loss of heterozygosity Chromosome Hepatocarcinogenesis Hepatocellular carcinoma 8p

Diagnostics of Rovibrational Distribution of H_2 in Low Temperature Plasmas by Fulcher-α band Spectroscopy - on the Reaction Rates and Transition Probabilities

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Plasma Science and Technology 2005年第2期7卷 2773-2776页

作者：肖炳甲 Shinichiro Kado Shin Kajita Daisuge Yamasaki satoru Tanaka Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031China High temperature plasma research center the university of Tokyo Yayoi 2-11-16Bunkyo-kuTokyoJapan 113-0030 Graduate school of engineering department of quantum engineering and systems sciences the university of Tokyo

A novel fitting procedure is proposed for a better determination of H2 rovibrational distribution from the Fulcher-α band spectroscopy. We have recalculated the transition probabilities and the results show that they deviate from Franck-Condon approximation especially for the non-diagonal transitions. We also calculated the complete sets of vibrationally resolved cross sections for electron impact d3Ⅱu-X3Σg transition based on the semi-classical Gryzinski theory. An example of experimental study confirms that current approach provides a tool for a better diagnostics of H2 rovibrational distribution in electronic ground state.

关键词： Fulcher-a band rovibronic excitation hydrogen molecule

Growth and low-energy electron microscopy characteri- zation of monolayer hexagonal boron nitride on epitaxial cobalt

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Nano Research 2013年第5期6卷 335-347页

作者： Carlo M. Orofeo satoru Suzuki Hiroyuki Kageshima Hiroki Hibino NTT Basic Research Laboratories NTT Corporation A tsugi Kanagawa 243-0198 Japan

Low-energy electron microscopy （LEEM） has been used to study the structure, initial growth orientation, growth progression, and the number of layers of atomically thin hexagonal boron nitride （h-BN） films. The h-BN films are grown on heteroepitaxial Co using chemical vapor deposition （CVD） at low pressure. Our findings from LEEM studies include the growth of monolayer film having two, oppositely oriented, triangular BN domains commensurate with the Co lattice. The growth of h-BN appears to be self-limiting at a monolayer, with thicker domains only appearing in patches, presumably initiated between domain boundaries. Reflectivity measurements of the thicker h-BN films show oscillations resulting from the resonant electron transmission through quantized electronic states of the h-BN films, with the number of minima scaling up with the number of h-BN layers. First principles density functional theory （DFT） calculations show that the positions of oscillations are related to the electronic band structure of h-BN.

关键词： chemical vapor deposition cobalt domain boundaries hexagonal boron nitride low-energy electronmicroscopy (LEEM)

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中国高铁与日本新干线技术比较（英文）

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2015年第10期16卷 769-780页

作者： satoru SONE Kogakuin University

本文主要从技术的角度对日本和中国的高速铁路技术进行比较。首先介绍日中两国高速铁路的发展简史,并用数字说明两国在高速铁路运营里程、旅客发送量和高速列车数量等方面的现状。其次,比较分析日中两国高速铁路在高速列车设计理念、自... 详细信息

本文主要从技术的角度对日本和中国的高速铁路技术进行比较。首先介绍日中两国高速铁路的发展简史,并用数字说明两国在高速铁路运营里程、旅客发送量和高速列车数量等方面的现状。其次,比较分析日中两国高速铁路在高速列车设计理念、自动过电分相、电磁兼容、再生制动列车导入后的相平衡措施和列车轻量化等技术方面上的差异,并侧重阐述日本在轻量化和编组动拖比优化等方面取得的成功经验。其三,介绍英国、法国和德国的高速铁路技术,并以日本为比较对象,从受流、列车超速防护、列车长度、运行图、动力方式和转向架结构等方面说明法国高速铁路技术的特点。其四,分析中日两国高速列车采用相同的动力分散方式背后的不同原因以及中国引进日欧技术导致多种技术并存的优点和缺点。其五,提出中日两国今后应重点讨论的几个技术问题,如编组动拖比优化、制动系统设计、安全和可靠性设计以及车载列控系统设计等。最后,从日中两国中速铁路和市郊铁路存在明显差异的角度,分析日中两国铁路的特殊性,提出两国在高速铁路、中速铁路以及城市轨道交通领域相互取长补短的具体方法。

关键词：高速铁路中速铁路城市轨道交通动力分散动力集中编组动拖比电流集中电磁兼容性问题安全性和可靠性协调性

Effectiveness and adverse effects of hormonal therapy for prostate cancer： Japanese experience and perspective

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Asian Journal of Andrology 2012年第3期14卷 451-457,I0007,I0008页

作者： Mikio Namiki satoru Ueno Yasuhide Kitagawa Takashi Fukagai Hideyuki Akaza Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-8640 Japan Department of Urology Showa University School of Medicine Tokyo 142-8666 Japan Research Center for Advanced Science and Technology University of Tokyo Tokyo 153-8903 Japan

Recently, novel anti-androgens and inhibitors of androgen biosynthesis have been developed through the elucidation of mechanisms of castration resistance of prostate cancer. We believe that these new developments will improve hormonal therapy. On the other hand, there has been an increase in criticism of hormonal therapy, because hormonal therapy is supposed to induce adverse effects such as cardiovascular disease. In this review, we have introduced the Japanese experience of hormonal therapy, because we believe that there may be ethnic differences between Caucasians and Asian people in the efficacy and adverse effects of hormonal therapy. First, we showed that primary hormonal therapy can achieve long-term control of localized prostate cancer in some cases and that quality of life of patients receiving hormonal therapy is rather better than previously thought. Neoadjuvant and adjuvant hormonal therapy in cases undergoing radical prostatectomy or radiotherapy are very useful for high-risk or locally advanced prostate cancer. Further clinical trials are required to confirm the efficacy of neoadjuvant or adjuvant hormonal therapy. We showed that the death from cardiovascular dis- eases in Japanese patients receiving hormonal therapy was not higher than that in the general population. However; efforts should be made to decrease the adverse effects of hormonal therapy, because life-style change may increase the susceptibility to adverse effects by hormonal therapy even in Japan. Managements of endocrine and metabolic dysfunction, such as diabetes mellitus, are essential. New hormonal compounds such as selective androgen receptor modulators capable of specifically targeting prostate cancer are expected to be developed.

关键词： adverse effects androgen deprivation therapy hormonal therapy prostate cancer

Efficacy of incremental loads of cow's milk as a treatment for lactose malabsorption in Japan

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World Journal of Clinical Cases 2023年第4期11卷 797-808页

作者： Matsuri Hasegawa Kazuko Okada satoru Nagata Shigetaka Sugihara Department of Pediatrics Tokyo Women's Medical University Medical Center EastDepartment of PediatricsTokyo Women’s Medical University Medical Center EastArakawa-ku 116-8561TokyoJapan Department of Pediatrics Okada Pediatric ClinicShinjuku-ku 169-0072TokyoJapan Department of Pediatrics Tokyo Women’s Medical UniversityShinjuku-ku 162-8666TokyoJapan

BACKGROUND Lactose intolerance(LI)is commonly seen in East Asian *** studies showed that lactose or milk loading has been used as a treatment for lactose malabsorption(LM)in Western countries,but there have been no reports regarding this type of treatment in *** lactose or milk loading requires ingestion of large amounts of lactose within a short period,this is considered to be too harsh for Japanese people because of their less habitual milk consumption(175 mL per day in average)than Western *** this study,we demonstrated lactose tolerance acquisition in a suitable way for *** To examine the efficacy of lactose(cow’s milk)loading treatment in patients with *** Individuals with abdominal symptoms induced by milk or dairy products(LI symptoms)were identified with a questionnaire.A 20 g lactose hydrogen breath test(LHBT)was carried out to confirm LM diagnosis and to evaluate co-existence of small intestinal bacterial overgrowth(SIBO).Respondents diagnosed with LM were selected as study subjects and were treated with incremental loads of cow’s milk,starting from 30 mL and increasing up to 200 mL at 4-7 d *** the treatment,changes in symptoms and LM diagnostic value of 20 g LHBT were *** samples pre-and post-treatment were examined for changes in intestinal microbiota using 16S rRNA *** consent was obtained prior to each stage of the *** In 46 subjects with LI symptoms(10-68 years old,mean age 34 years old)identified with the questionnaire,35(76.1%)were diagnosed with LM by 20 g LHBT,and 6 had co-existing *** treatment with incremental cow’s milk was carried out in 32 subjects diagnosed with LM(14-68 years old,median age 38.5 years old).The mean period of the treatment was 41±8.6 *** of symptoms was observed in 29(90.6%;95%confidence interval:75.0%-98.0%)*** 20 g LHBT indicated that 10(34.5%)subjects had improved diagnostic value of LM,no change was

关键词： Lactose Intolerance Lactose Malabsorption lactose loading treatment Intestinal bacterial flora Fecal microbiota

Fabrication of Transparent Sintered Silica Glass with SiO2-PVA Nanocomposite

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Fabrication of Transparent Sintered Silica Glass with SiO2-P...

作者： satoru Akiyama 上海交通大学

学位级别：硕士

Silica glass is utilized in many fields because of its excellent ***,ordinary method to fabricate bulk silica glass needs high temperature（above 1600°C）to melt the material so low energy process is *** this research,we fabricated silica glass by powder sintering *** method doesn’t have melting process so it needs relatively low *** first,we fabricate SiO

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