Acute development of collateral circulation and therapeutic prospects in ischemic stroke

作     者：Eri Iwasawa Masahiko Ichijo Satoru Ishibashi Takanori Yokota 

作者机构：Department of Neurology and Neurological ScienceTokyo Medical and Dental University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第3期

页      面：368-371页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：Japan Society for the Promotion of Science  JSPS  (26282136) 

主　　题：ischemic stroke collateral S1PR1 shear stress leptomeningeal arteries PCA laterality hyperintensive vessels 

摘      要：In acute ischemic stroke,collateral circulation plays an important role in maintaining blood flow to the tissue that is at risk of progressing into ischemia,and in increasing the successful recanalization rate without hemorrhagic *** have reported that well-developed collateral circulation is associated with smaller infarct volume and better long-term neurological outcome,and it disappears promptly once the effective recanalization is *** to the belief that collateral vessels develop over time in chronic stenotic condition,there exists a phenomenon that collateral circulation develops immediately in acute stenosis or occlusion of the arteries and it seems to be triggered by fluid shear stress,which occurs between the territories of stenotic/occluded arteries and those fed by surrounding intact *** believe that this acute development of collateral circulation is a target of novel therapeutics in ischemic stroke and refer our recent attempt in enhancing collateral circulation by modulating sphingosine-1-phosphate receptor 1,which is a known shear-stress mechanosensing protein.