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Z-shaped incision without epithelial resection in pterygium surgery

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1262-1266页

作者： satoru Kase Shinki Chin Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan

AIM:To introduce a novel surgical technique using a Z-shaped incision without epithelial resection in ophthalmic ***:This was a prospective *** pterygium surgery,all proliferative tissues were separated from the cornea and conjunctiva without resection of the *** unaffected conjunctiva was incised in a *** upper(or lower)conjunctival flap was sutured to the lower(or upper)normal conjunctiva on the limbal sclera,while the proliferative tissue was sutured to the upper conjunctiva(or lower)near the ***:Ten patients with pterygia were eligible for this *** patients with primary pterygia and 2 with recurrent pterygia were *** age of patients at surgery ranged from 47 to 90y(average:71.9y).Five patients each showed right and left-sided *** postoperative follow-up periods were from 8 to 78mo(average:25.0mo).The surgery was successfully conducted and wounds were favorably reconstructed in all *** proliferative tissues sutured to the normal conjunctiva showed palor and attenuated neovessles,and never showed re-growth after *** patients did not show *** pterygium was noted in 1 patient,but additional treatments were not ***:The procedure involves the reconstruction of pterygial tissue and normal conjunctiva using a Z-shaped *** scleral limbal wound can be covered with nonaffected conjunctiva without any excision of conjunctival epithelia in patients with primary or recurrent pterygia.

关键词： pterygium surgery Z-shape non-resection

Fluorescence‑Based Calibration Model for In‑Situ Measurement of Micro‑scaled Lubricant Thickness Distribution at Indentation Interface

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Nanomanufacturing and Metrology 2024年第2期7卷 76-88页

作者： Motoya Yoshikawa Saeko Fujii Shotaro Kadoya Tatsuya Sugihara Masaki Michihata satoru Takahashi Department of Precision Engineering The University of TokyoHongo 7‑3‑1BunkyoTokyo 113‑8656Japan Department of Mechanical Engineering Osaka UniversityYamadaoka 2‑1SuitaOsaka 565‑0871Japan

This study proposes a model for the measurement of microscale liquid film thickness distribution using fluorescence *** interfacial conditions between the tool and the workpiece in mechanical machining are important for understanding these phenomena and *** this study,indentation tests with transparent tools were used to observe interfaces;however,it was challenging to obtain the signal from a thin fluorescent liquid film on smooth and steeply inclined ***,fluorescence-based measurement,such as laser-induced fluorescence,was *** measure the absolute thickness of the thin fluorescent film,calibration of the measurement system is ***,a theoretical model was proposed considering the multiple reflections of excitation light and fluorescence at the inclined surface between the indenter and *** measuring the profile of the surface topography of the indented workpiece and comparing the results with those measured by a surface profiler,the validity of the proposed calibration method and the performance of this measurement system were *** measured surface profiles,including scratches of 2–4μm,were in good agreement,demonstrating the validity of the proposed method.

关键词： Laser-induced fluorescence(LIF) Thickness distribution In-situ measurement Lubricant Mechanical machining

Improvement of histone deacetylase inhibitor efficacy by SN38 through TWIST1 suppression in synovial sarcoma

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Cancer Innovation 2024年第2期3卷 80-95页

作者： satoru Sasagawa Jun Kumai Toru Wakamatsu Yoshihiro Yui Molecular Biology Laboratory Research InstituteNozaki Tokushukai HospitalDaitoOsakaJapan Sarcoma Treatment Laboratory Research InstituteNozaki Tokushukai HospitalDaitoOsakaJapan Department of Musculoskeletal Oncology Service Osaka International Cancer InstituteOsakaJapan

Background:Synovial sarcoma(SS)is an SS18-SSX fusion gene-driven soft tissue sarcoma with mesenchymal characteristics,associated with a poor prognosis due to frequent metastasis to a distant organ,such as the *** deacetylase(HDAC)inhibitors(HDACis)are arising as potent molecular targeted drugs,as HDACi treatment disrupts the SS oncoprotein complex,which includes HDACs,in addition to general HDACi *** provide further molecular evidence for the advantages of HDACi treatment and its limitations due to drug resistance induced by the microenvironment in SS cells,we examined cellular responses to HDACi treatment in combination with two-dimensional(2D)and 3D culture ***:Using several SS cell lines,biochemical and cell biological assays were performed with romidepsin,an HDAC1/2 selective ***38 was concomitantly used as an ameliorant drug with romidepsin ***,apoptosis induction,and MHC class I polypeptide-related sequence A/B(MICA/B)induction were monitored to evaluate the drug *** addition to the conventional 2D culture condition,spheroid culture was adopted to evaluate the influence of cell-mass microenvironment on ***:By monitoring the cellular behavior with romidepsin and/or SN38 in SS cells,we observed that responsiveness is diverse in each cell *** the apoptotic inducible cells,co-treatment with SN38 enhanced cell *** nonapoptotic inducible cells,cytostasis and MICA/B induction were observed,and SN38 improved MICA/B induction *** a novel efficacy of SN38,we revealed TWIST1 suppression in SS *** the spheroid(3D)condition,romidepsin efficacy was severely restricted in TWIST1-positive *** demonstrated that TWIST1 downregulation restored romidepsin efficacy even in spheroid form,and concomitant SN38 treatment along with romidepsin reproduced the ***:The current study demonstrated the benefits and concerns of using HDACi for SS treatment in 2D and

关键词： HDAC inhibitor MICA/B SN38 spheroid synovial sarcoma TWIST1

Efficacy of incremental loads of cow's milk as a treatment for lactose malabsorption in Japan

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World Journal of Clinical Cases 2023年第4期11卷 797-808页

作者： Matsuri Hasegawa Kazuko Okada satoru Nagata Shigetaka Sugihara Department of Pediatrics Tokyo Women's Medical University Medical Center EastDepartment of PediatricsTokyo Women’s Medical University Medical Center EastArakawa-ku 116-8561TokyoJapan Department of Pediatrics Okada Pediatric ClinicShinjuku-ku 169-0072TokyoJapan Department of Pediatrics Tokyo Women’s Medical UniversityShinjuku-ku 162-8666TokyoJapan

BACKGROUND Lactose intolerance(LI)is commonly seen in East Asian *** studies showed that lactose or milk loading has been used as a treatment for lactose malabsorption(LM)in Western countries,but there have been no reports regarding this type of treatment in *** lactose or milk loading requires ingestion of large amounts of lactose within a short period,this is considered to be too harsh for Japanese people because of their less habitual milk consumption(175 mL per day in average)than Western *** this study,we demonstrated lactose tolerance acquisition in a suitable way for *** To examine the efficacy of lactose(cow’s milk)loading treatment in patients with *** Individuals with abdominal symptoms induced by milk or dairy products(LI symptoms)were identified with a questionnaire.A 20 g lactose hydrogen breath test(LHBT)was carried out to confirm LM diagnosis and to evaluate co-existence of small intestinal bacterial overgrowth(SIBO).Respondents diagnosed with LM were selected as study subjects and were treated with incremental loads of cow’s milk,starting from 30 mL and increasing up to 200 mL at 4-7 d *** the treatment,changes in symptoms and LM diagnostic value of 20 g LHBT were *** samples pre-and post-treatment were examined for changes in intestinal microbiota using 16S rRNA *** consent was obtained prior to each stage of the *** In 46 subjects with LI symptoms(10-68 years old,mean age 34 years old)identified with the questionnaire,35(76.1%)were diagnosed with LM by 20 g LHBT,and 6 had co-existing *** treatment with incremental cow’s milk was carried out in 32 subjects diagnosed with LM(14-68 years old,median age 38.5 years old).The mean period of the treatment was 41±8.6 *** of symptoms was observed in 29(90.6%;95%confidence interval:75.0%-98.0%)*** 20 g LHBT indicated that 10(34.5%)subjects had improved diagnostic value of LM,no change was

关键词： Lactose Intolerance Lactose Malabsorption lactose loading treatment Intestinal bacterial flora Fecal microbiota

Promising role of D-amino acids in irritable bowel syndrome

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World Journal of Gastroenterology 2022年第31期28卷 4471-4474页

作者： Yuka Ikeda Kurumi Taniguchi Haruka Sawamura Ai Tsuji satoru Matsuda Department of Food Science and Nutrition Nara Women's UniversityNara 630-8506Japan

Irritable bowel syndrome(IBS)is an important health care *** in the microbiota of the gut-brain axis may be linked to the pathophysiology of *** dietary intake could contribute to produce various metabolites including Damino acids by the fermentation by the gut microbiota.D-amino acids are the enantiomeric counterparts of L-amino acids,in general,which could play key roles in cellular physiological processes against various oxidative ***,the presence of D-amino acids has been shown to be linked to the protection of several organs in the *** particular,the gut microbiota could play significant roles in the stability of emotion via the action of D-amino ***,we would like to shed light on the roles of D-amino acids,which could be used for the treatment of IBS.

关键词： Irritable bowel syndrome D-amino acid Gut microbiota Colitis Probiotics Fecal microbiota transplantation

A case of conjunctival intraepithelial neoplasia with spheroidal degeneration:a clinicopathological study

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1401-1403页

作者： Shoichiro Ota satoru Kase Takayuki Tanaka Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan

Dear Editor,I am Shoichiro Ota from Hokkaido University hospital,*** intraepithelial neoplasia(CIN)is a disease concept that includes dysplasia and carcinoma in ***,CIN is characterized by tumor cell proliferation located within the epithelium with preservation of the basement membrane[1].In addition to histological diagnosis,anterior segment optical coherence tomography(ASOCT)plays an important role in clinical diagnosis,showing diffuse epithelial thickening with homogeneous high-intensity reflection in case of CIN[2-3].

关键词： diagnosis degeneration neoplasia

Atezolizumab plus bevacizumab and tremelimumab plus durvalumab: how should we choose these two immunotherapy regimens for advanced hepatocellular carcinoma?

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Hepatobiliary Surgery and Nutrition 2022年第6期11卷 927-930页

作者： Takeshi Hatanaka Atsushi Naganuma Yutaka Yata satoru Kakizaki Department of Gastroenterology Gunma Saiseikai Maebashi HospitalMaebashiJapan Department of Gastroenterology National Hospital Organization Takasaki General Medical CenterTakasakiJapan Department of Gastroenterology Hanwa Memorial HospitalOsakaJapan Department of Clinical Research National Hospital Organization Takasaki General Medical CenterTakasakiJapan

We read with interest the manuscript(1)by Bruix et *** a European Association for the Study of the Liver(EASL)position paper on the systemic treatment of hepatocellular carcinoma(HCC).Systemic treatment options for ad... 详细信息

关键词： hepatocellular regimen

Analysis of in-bore balloting and control of jump variability

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Defence Technology（防务技术） 2019年第5期15卷 721-734页

作者： satoru Shoji Wakayama-dai ShimamotoOsakaJapan21-104

The variability of projectile jump is the long-term issue to improve weapon *** we have many simulation codes to predict ***,these codes cannot explain explicitly how the variability of jump *** aims of this paper are,(1)to give fundamental explanations for the variability of Jump,and (2)to offer design factors to make the variability of Jump *** model presented here was formulated in accordance with the transition of the system in reverse way commencing from the target impact stage to the chambering *** of the simulation are generic 120mm smooth bore and long rod system which are extremely simplified to the vibration of tube,the spring effect by sabot,and the free-ends beam of *** calculations clarified that high Jump-variability is generated only when the last rebound is on the muzzle *** particular state of rebound is achieved by many combinations of *** map named JV-Chart is proposed to show the high Jumpvariability zone.

关键词： Jump variability Coupled vibration In-bore balloting Cantilever tube

Efficacy of probiotics on the modulation of gut microbiota in the treatment of diabetic nephropathy

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World Journal of Diabetes 2022年第3期13卷 150-160页

作者： Nozomi Nagase Yuka Ikeda Ai Tsuji Yasuko Kitagishi satoru Matsuda Department of Food Science and Nutrition Nara Women's UniversityNara 630-8506Japan

Diabetic nephropathy(DN)is a major cause of end-stage renal disease,and therapeutic options for preventing its progression are *** number of patients with DN has been increasing in Asian countries because of westernization of dietary lifestyle,which may be associated with the following changes in gut *** in the gut microbiota composition can lead to an imbalanced gastrointestinal environment that promotes abnormal production of metabolites and/or inflammatory *** microenvironments of the gut could be changed in the different stages of *** particular,altered levels of short chain fatty acids,D-amino acids,and reactive oxygen species biosynthesis in the gut have been shown to be relevant to the pathogenesis of the *** far,evidence suggests that the gut microbiota may play a key role in determining networks in the development of *** directing the gut microbiota deserve further investigation as a new protective therapy in *** this review,we discuss the potential roles of the gut microbiota and future perspectives in the protection and/or treatment of kidneys.

关键词： Diabetic nephropathy Short chain fatty acids Superoxide dismutase Reactive oxygen species D-amino acids Gut microbiota Diabetes mellitus Renal disease