A combination treatment of entecavir and early-phase corticosteroid in severe exacerbation of chronic hepatitis B

作     者：Kazuyuki Matsumoto Yasuhiro Miyake Hirokazu Miyatake Masahiro Takahara Takayuki Imada Satoru Yagi Tatsuya Toyokawa Morihito Nakatsu Masaharu Ando Mamoru Hirohata 

作者机构：Department of Internal MedicineMitoyo General Hospital Department of Molecular HepatologyOkayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2009年第15卷第13期

页      面：1650-1652页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Acute exacerbation Chronic hepatitis B Corticosteroid Entecavir Hepatitis B virus Hepaticcoma 

摘      要：Of patients with severe exacerbation of chronic hepatitis B accompanied by jaundice and coagulopathy,20%-30%have a fatal *** this report,we describe 2 cases of severe exacerbation of chronic hepatitis B with jaundice and coagulopathy who were successfully treated with a combination of entecavir and *** both cases,rapid reductions in serum hepatitis B virus(HBV)-DNA levels were observed,and corticosteroid was stopped after serum HBV-DNA levels became *** treatment was ***,entecavir treatment reduced serum HBV-DNA levels rapidly,although the improvement in liver function was delayed by a few *** this time lag,liver cell injury continued and the disease *** suppressed the excessive host immune response and was useful for stopping progressive deterioration.A combination of entecavir and early-phase corticosteroid may be a useful treatment in severe exacerbation of chronic hepatitis B.