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Proportion and clinical features of never-smokers with non-small cell lung cancer

Chinese Journal of Cancer 2017年第2期36卷 81-87页

作者： Jaeyoung Cho Sun Mi Choi Jinwoo lee Chang-Hoon lee sang-Min lee Dong-Wan Kim Jae-joon Yim Young Tae Kim Chul-Gyu Yoo Young Whan Kim Sung Koo Han Young Sik Park Department of Internal Medicine Seoul National University HospitalSeoul 110-744Republic of Korea Department of Thoracic and Cardiovascular Surgery Seoul National University HospitalSeoul 110-744Republic of Korea

Background: The proportion of never?smokers with non?small cell lung cancer(NSCLC) is increasing, but that in Korea has not been well addressed in a large population. We aimed to evaluate the proportion and clinical features of never?smokers with NSCLC in a large single ***: We analyzed clinical data of 1860 consecutive patients who were newly diagnosed with NSCLC between June 2011 and December ***: Of the 1860 NSCLC patients, 707(38.0%) were never?smokers. The proportions of women(83.7% vs. 5.6%) and adenocarcinoma(89.8% vs. 44.9%) were higher among never?smokers than among ever?smokers. Significantly more never?smokers were diagnosed at a younger median age(65 vs. 68 years, P < 0.001) and earlier stage(stage I–II, 44.5% vs. 38.9%, P < 0.001) a= 0.015) compared with ever?smokers. Epidermal growth factor receptor mutations(57.8% vs. 24.4%, Pnd anaplastic lymphoma kinase rearrangements(7.8% vs. 2.8%, P < 0.001) were more common in never?smokers, whereas Kirsten rat sarcoma viral oncogene homolog mutations(5.8% vs. 9.6%, P ntly encountered in never?smokers than in ever?smokers. Never?smokers showed longer su= 0.021) were less frequervival after adjust?ing for the favorable effects of younger age, female sex, adenocarcinoma histology, better performance status, early stage disease, being asymptomatic at diagnosis, received antitumor treatment, and the presence of driver mutations(hazard ratio, 0.624; 95% confidence interval, 0.460–0.848; P = 0.003).Conclusions: More than one?third of the Korean patients with NSCLC were never?smokers. NSCLC in never?smokers had different clinical characteristics and major driver mutations and resulted in longer overall survival compared with NSCLC in ever?smokers.

关键词： Non-small cell lung carcinoma Never-smoker Epidermal growth factor receptor KRAS Prognosis

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Enhance of TiO_2 dopants incorporated reduced graphene oxide via RF magnetron sputtering for efficient dye-sensitised solar cells

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Rare Metals 2018年第11期37卷 919-928页

作者： Foo Wah Low Chin Wei Lai Kian Mun lee joon Ching Juan Nanotechnology and Catalysis Research Centre Institute Postgraduate Studies University of Malaya

In particular, the dye-sensitised solar cells(DSSCs) have a high potential in the rational energy conversion efficiency to secure our sustainable energy *** the present study, advanced radio frequency(RF) magnetron sputtering technique was applied to incorporate titanium dioxide(TiO) dopants into reduced graphene oxide(rGO) nanosheet for improving the power conversion efficiency(PCE) of DSSCs device. An optimum TiOcontent incorporated onto rGO nanosheet plays an important role in improving the PCE of DSSCs by minimising the recombination losses of photo-induced charge *** on the results obtained, 40-s sputtering duration for incorporating TiOdopants onto rGO nanosheet exhibits a maximum PCE of 8.78% than that of pure rGO film(0.68%). In fact, the presence of optimum content of TiOdopants within rGO nanosheet could act as mediators for efficient separation photo-induced charge carriers. However, the excessive of sputtering duration(e.g. 60 s) of TiOdopants onto rGO nanosheet results higher charge recombination and lowers the PCE of DSSCs(5.39%).

关键词： Dye-sensitised solar cell RF magnetron sputtering Titanium dioxide Reduced graphene oxide

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Role of computed tomographic colonoscopy of postoperative surveillance in patient with gastric cancer

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World Journal of Gastroenterology 2007年第11期13卷 1646-1651页

作者： Dae Won Jun Oh Young lee Hyun Chul Lim Sung joon Kwon Hang Lak lee Byung Chul Yoon Ho Soon Choi joon Soo Hahm Min Ho lee Dong Hoo lee Department of Internal Medicine Hanyang University College of Medicine Seoul Korea Department of Radiology Hanyang University College of Medicine Seoul Korea Department of General Surgery Hanyang University College of Medicine Seoul Korea

AIM： TO examine the diagnostic yield of colorectal neoplasia at computed tomographic colonoscopy （CTC） as well as the feasibility of contrast enhanced CTC in patients with gastric cancer. METHODS： To examine the incidence of colon polyp we selected postoperative 188 gastric cancer patients, which we refer to as the ‘colon polyp survey group’. To examine the feasibility of CTC for early detection of colon cancer or advanced colon adenoma, we selected 47 gastric cancer patients （M：F 29：18, mean age 53.8 years）, which we call the ‘CT colonoscopy group’. All the 47 patients underwent successive CTC and colonoscopy on the same day. RESULTS： Totally 109 colon polyps were observed from 59 out of 188 gastric cancer patients, the inddence rate of colon polyps in gastric cancer patients being 31.4%. The sensitivity of CTC in detecting individuals with at least 1 lesion of any size was 57.1%, the specificity was 72.7%, the positive predictive value was 47.1%, and the negative predictive value was 71.9%. When the cutoff size was decreased to 6 mm, the sensitivity and specificity were 80.0% and 92.9%, respectively, with positive and negative predictive values of 57.1% and 97.5%, respectively. Only one patient was classified as false negative by virtual colonoscopy. CONCLUSION： The diagnostic yield of colorectal polyp was 31.4% in patients with gastric cancer, and contrast enhanced CTC is an acceptable tool for the detection of synchronous colorectal advanced adenoma and postoperative surveillance of gastric cancer patients.

关键词： Stomach cancer Colon cancer Computed tomocjraphic colonoscopy

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Implementation of an 8ch GbE Multiplexing Transponder

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光学学报 2003年第S1期23卷 651-652页

作者： joon Ki lee Hyunjae lee Yool Kwon Electronics and Telecommunications Research Institute 161 Gajeong-dong Yuseong-gu Daejeon 305-350 KoreaElectronics and Telecommunications Research Institute 161 Gajeong-dong Yuseong-gu Daejeon 305-350 KoreaElectronics and Telecommunications Research Institute 161 Gajeong-dong Yuseong-gu Daejeon 305-350 Korea

We report the implementation of a transponder to transmit eight channels of a Gigabit Ethernet signal transparently in an Optical Transport Network(OTN). This transponder is based on framing technologies for Ethernet ... 详细信息

关键词： of on for OTN Implementation of an 8ch GbE Multiplexing Transponder into WDM

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Activation of non-basal ＜c + a> slip in multicomponent Mg alloys

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Journal of Magnesium and Alloys 2022年第2期10卷 585-597页

作者： Hyo-Sun Jang Jong-Kwan lee Antonio Jo?o Seco Ferreira Tapia Nack joon Kim Byeong-Joo lee Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Graduate Institute of Ferrous Technology Pohang University of Science and Technology (POSTECH)

Activating non-basal slip is a key method to improve room temperature ductility and formability of Mg alloys. However, the detailed criterion for activation of the slip in multicomponent Mg alloys, which can be utilized in commercial Mg alloys, requires further understanding. The present authors investigated the mechanism and criterion using a molecular statics simulation on dislocation behaviors in multicomponent Mg alloys. We found that if multicomponent Mg alloys have an equivalent dislocation binding intensity to associated binary Mg alloys that are optimized to minimize the critical resolved shear stress anisotropy and thus activate the slip,then the critical resolved shear stress anisotropy between slip systems of the multicomponent Mg alloys can also be minimized, resulting in activation of the slip. The activation is maximized in multicomponent Mg alloys when alloying a large amount of weak dislocation binding elements. It was confirmed through experiments that the multicomponent Mg alloys satisfying the above criterion show higher room-temperature tensile elongation and formability than other alloys.

关键词： Mg–Zn–Ca alloy Molecular statics simulation Ductility Formability

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Characterization of focal hypermetabolic thyroid incidentaloma: An analysis with F-18 fluorodeoxyglucose positron emission tomography/computed tomography parameters

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World Journal of Clinical Cases 2022年第1期10卷 155-165页

作者： Haejun lee Yoo Seung Chung joon-Hyop lee Ki-Young lee Kyung-Hoon Hwang Department of Nuclear Medicine Gachon University College of MedicineGil Medical CenterIncheon 21565South Korea Department of Endocrine Surgery Gachon University College of MedicineGil Medical CenterIncheon 21565South Korea Department of Endocrinology and Metabolism Gachon University College of MedicineGil Medical CenterIncheon 21565South Korea

BACKGROUND Incidentally found thyroid tumor(thyroid incidentaloma,TI)on F-18 fluorodeoxyglucose(FDG)positron emission tomography-computed tomography(PETCT)is reported in 2.5%-5%of patients being investigated for non-thyroid *** to 50%of these cases have been diagnosed to be malignant by cytological/histological ***(US)and fine-needle aspiration cytology are recommended for thyroid nodules with high FDG uptake(hypermetabolism)that are 1 cm or greater in *** is important to accurately determine whether a suspicious hypermetabolic TI is malignant or *** To distinguish malignant hypermetabolic TIs from benign disease by analyzing F-18 FDG PET-CT parameters and to identify a cut-off *** Totally,12761 images of patients who underwent F-18 FDG PET-CT for nonthyroid purposes at our hospital between January 2016 and December 2020 were retrospectively reviewed,and 339 patients[185 men(mean age:68±11.2)and 154 women(mean age:63±15.0)]were found to have abnormal,either focal or diffuse,thyroid FDG *** a thorough review of their medical records,US,and cytological/histological reports,46 eligible patients with focal hypermetabolic TI were included in this *** TIs were categorized as malignant and benign according to the cytological/histological reports,and four PET parameters[standardized uptake value(SUV)max,SUV_(peak),SUV_(mean),and metabolic tumor volume(MTV)]were measured on FDG *** lesion glycolysis(TLG)was calculated by multiplying the SUV_(mean) by *** parametric and non-parametric methods were used to compare the five parameters between malignant and benign *** operating characteristic(ROC)curve analysis was performed to identify a cut-off *** Each of the 46 patients[12 men(26.1%;mean age:62±13.1 years)and 34 women(73.9%;mean age:60±12.0 years)]with focal hypermetabolic TIs had one focal hypermetabolic *** them,26(56.5%)were malignant and 20(43.5%)were ***_(max

关键词： Thyroid incidentaloma Malignancy Fluorodeoxyglucose positron emission tomography/computed tomography Standardized uptake value Cut-off

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Biliary drainage for obstructive jaundice caused by unresectable hepatocellular carcinoma: the endoscopic versus percutaneous approach

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Hepatobiliary & Pancreatic Diseases International 2012年第6期11卷 636-642页

作者： Jongkyoung Choi Ji Kon Ryu sang Hyub lee Dong-Won Ahn Jin-Hyeok Hwang Yong-Tae Kim Yong Bum Yoon joon Koo Han Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea Department of Internal Medicine National Medical Center Seoul Korea Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Korea Department of Internal Medicine Seoul National University Boramae Medical Center Seoul Korea Department of Radiology Seoul National University College of Medicine Seoul Korea

BACKGROUND: For palliative treatment of the obstructive jaundice associated with unresectable hepatocellular carcinoma (HCC), percutaneous transhepatic biliary drainage (PTBD) or endoscopic retrograde biliary drainage (ERBD) has been performed. PTBD is preferred as an initial procedure. Little is known about the better option for patients with obstructive jaundice caused by unresectable HCC. METHODS: Sixty patients who had received ERBD or PTBD for the palliative treatment of obstructive jaundice caused by unresectable HCC between January 2006 and May 2010 were included in this retrospective study. Successful drainage, drainage patency, and the overall survival of patients were evaluated. RESULTS: Univariate analysis revealed that the overall frequency of successful drainage was higher in the ERBD group (22/29, 75.9%) than in the PTBD group (15/31, 48.4%) (P=0.029); but multivariate analysis showed marginal significance (P=0.057). The duration of drainage patency was longer in the ERBD group than in the PTBD group (82 vs 37 days, respectively, P=0.020). Regardless of what procedure was performed, the median survival time of patients who had a successful drainage was much longer than that of the patients who did not have a successful drainage (143 vs 38 days, respectively, P<0.001).CONCLUSION: Besides PTBD, ERBD may be used as the initial treatment option to improve obstructive jaundice in patients with unresectable HCC if there is a longer duration of drainage patency after a successful drainage.

关键词： hepatocellular carcinoma obstructive jaundice endoscopic retrograde biliary drainage percutaneous transhepatic biliary drainage

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Electrophoretic Deposition of Oxide Nanoparticles for Electron Emission Enhancement

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Journal of Materials Science & Technology 2010年第11期26卷 1032-1036页

作者： Jong Rok Ahn Gil Seon Kang Hwack Joo lee Chang joon Park Korea Research Institute of standards and Science

Four oxide nanoparticles,such as yttrium oxide,lanthanum oxide,cerium oxide and zirconium oxide were coated on rhenium filaments by an electrophoretic deposition *** oxide coatings were examined by scanning electron microscopy,and electron emission characteristics of the oxide-coated rhenium were studied to find alternative oxide materials for replacing the hazardous thorium *** four oxides tested in this work,yttrium oxide and lanthanum oxide coated rhenium showed enhanced electron emission compared with an uncoated ***,lanthanum oxide coating evaporated too quickly in a vacuum chamber,and hence yttrium oxide was found to be the only alternative material for use in a routine mass *** optimum coating thickness of the yttrium oxide and lanthanum oxide was around 20 μm.

关键词： Electrophoretic deposition Oxide nanoparticles Scanning electron microscopy (SEM) Electron emission

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Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression

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World Journal of Gastroenterology 2018年第16期24卷 1708-1724页

作者： Yu-Min Choi So-Young lee Bum-joon Kim Department of Microbiology and Immunology Biomedical Sciences Liver Research Institute and Cancer Research Institute Seoul National University College of Medicine

The annual number of deaths caused by hepatitis B virus(HBV)-related disease, including cirrhosis and hepatocellular carcinoma(HCC), is estimated as 887000. The reported prevalence of HBV reverse transcriptase(RT) mutation prior to treatment is varied and the impact of preexisting mutations on the treatment of na?ve patients remains controversial, and primarily depends on geographic factors, HBV genotypes, HBe Ag serostatus, HBV viral loads, disease progression, intergenotypic recombination and co-infection with HIV. Different sensitivity of detection methodology used could also affect their prevalence results. Several genotype-dependent HBV RT positions that can affect the emergence of drug resistance have also been reported. Eight mutations in RT(rtL80I, rtD134N, rtN139K/T/H, rtY141F, rtM204I/V, rtF221Y, rtI224V, and rtM309K) are significantly associated with HCC progression. HBe Ag-negative status, low viral load, and genotype C infection are significantly related to a higher frequency and prevalence of preexisting RT mutations. Preexisting mutations are most frequently found in the A-B interdomain of RT which overlaps with the HBs Ag "a" determinant region, mutations of which can lead to simultaneous viral immune escape. In conclusion, the presence of baseline RT mutations can affect drug treatment outcomes and disease progression in HBVinfected populations via modulation of viral fitness and host-immune responses.

关键词： polymerase hepatocellular carcinoma reverse transcriptase preexisting mutations hepatitis B virus

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Low-Programmable-Voltage Nonvolatile Memory Devices Based on Omega-shaped Gate Organic Ferroelectric P(VDF-TrFE) Field Effect Transistors Using p-type Silicon Nanowire Channels

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Nano-Micro Letters 2015年第1期7卷 35-41页

作者： Ngoc Huynh Van Jae-Hyun lee Dongmok Whang Dae joon Kang Department of Physics Institute of Basic SciencesSungkyunkwan University School of Advanced Materials Science and Engineering SKKU Advanced Institute of Nanotechnology Sungkyunkwan University

A facile approach was demonstrated for fabricating high-performance nonvolatile memory devices based on ferroelectric-gate field effect transistors using a p-type Si nanowire coated with omega-shaped gate organic ferroelectric poly(vinylidene fluoride-trifluoroethylene)(P(VDF-Tr FE)). We overcame the interfacial layer problem by incorporating P(VDF-Tr FE) as a ferroelectric gate using a low-temperature fabrication process. Our memory devices exhibited excellent memory characteristics with a low programming voltage of ±5 V, a large modulation in channel conductance between ON and OFF states exceeding 105, a long retention time greater than 3 9 104 s, and a high endurance of over 105 programming cycles while maintaining an ION/IOFFratio higher than 102.

关键词： Si nanowires Field effect transistor Ferroelectric memory

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