Characterization of focal hypermetabolic thyroid incidentaloma: An analysis with F-18 fluorodeoxyglucose positron emission tomography/computed tomography parameters

作     者：Haejun Lee Yoo Seung Chung Joon-Hyop Lee Ki-Young Lee Kyung-Hoon Hwang 

作者机构：Department of Nuclear MedicineGachon University College of MedicineGil Medical CenterIncheon 21565South Korea Department of Endocrine SurgeryGachon University College of MedicineGil Medical CenterIncheon 21565South Korea Department of Endocrinology and MetabolismGachon University College of MedicineGil Medical CenterIncheon 21565South Korea 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第1期

页      面：155-165页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Thyroid incidentaloma Malignancy Fluorodeoxyglucose positron emission tomography/computed tomography Standardized uptake value Cut-off 

摘      要：BACKGROUND Incidentally found thyroid tumor(thyroid incidentaloma,TI)on F-18 fluorodeoxyglucose(FDG)positron emission tomography-computed tomography(PETCT)is reported in 2.5%-5%of patients being investigated for non-thyroid *** to 50%of these cases have been diagnosed to be malignant by cytological/histological ***(US)and fine-needle aspiration cytology are recommended for thyroid nodules with high FDG uptake(hypermetabolism)that are 1 cm or greater in *** is important to accurately determine whether a suspicious hypermetabolic TI is malignant or *** To distinguish malignant hypermetabolic TIs from benign disease by analyzing F-18 FDG PET-CT parameters and to identify a cut-off *** Totally,12761 images of patients who underwent F-18 FDG PET-CT for nonthyroid purposes at our hospital between January 2016 and December 2020 were retrospectively reviewed,and 339 patients[185 men(mean age:68±11.2)and 154 women(mean age:63±15.0)]were found to have abnormal,either focal or diffuse,thyroid FDG *** a thorough review of their medical records,US,and cytological/histological reports,46 eligible patients with focal hypermetabolic TI were included in this *** TIs were categorized as malignant and benign according to the cytological/histological reports,and four PET parameters[standardized uptake value(SUV)max,SUV_(peak),SUV_(mean),and metabolic tumor volume(MTV)]were measured on FDG *** lesion glycolysis(TLG)was calculated by multiplying the SUV_(mean) by *** parametric and non-parametric methods were used to compare the five parameters between malignant and benign *** operating characteristic(ROC)curve analysis was performed to identify a cut-off *** Each of the 46 patients[12 men(26.1%;mean age:62±13.1 years)and 34 women(73.9%;mean age:60±12.0 years)]with focal hypermetabolic TIs had one focal hypermetabolic *** them,26(56.5%)were malignant and 20(43.5%)were ***_(max