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Treatment of Vulvovaginal candidiasis with A Strategy Based on Phototherapy (M.A.c.^® Scar Acceleration Method)

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Modern Research in Inflammation 2024年第1期13卷 1-7页

作者： Marcus Vinicius de Mello Pinto Karin Yuri Fernández Iturra Aline Ronis sampaio María Elena Silva Álvarez Esteban Fortuny celulare Institute Petrópolis Brazil Bienus clinic Santiago Chile Fisiocare Curicó Chile Universidad Finis Terrae Santiago Chile

candidiasis, also known as candidiasis vulvovaginitis, is an infection caused by different types of candida fungi, the most frequent being candida albicans. The present study reports an effective strategy, which opens new avenues for the treatment of this public health problem. The MAc® Methodology, conventional laser light-emitting (LLLT)/LED) methods are based on the biphasic response demonstrated many times in LLLT research and as with other forms of drugs, a “drug” (irradiation parameters) and a “dose” (irradiation times) and the “Arndt-Schulz Law” is often cited as a suitable model to describe the dose-dependent effects of LLLT. This method uses photopharmaceuticals, cell markers and the use of correct parameters for each case to induce the acceleration of tissue repair. The present study shows a case of a 32-year-old patient diagnosed with recurrent candidiasis 4 years ago. Eighteen sessions were performed (every other day) using a photoactivated component (Methylene blue 1% + clotrimazole 1%) and LED phototherapy (red, blue and violet) with emission times of 60 - 260 seconds for each applicator, according to the dose recommendations of the scar acceleration method (MAc®). At the sixth treatment session there was a noticeable decrease in the itching sensation reported by the patient. In session 11 she reported feeling a great improvement, indicating that she no longer felt itching in any area after 18 sessions. The present case demonstrates new methodologies to treat common problems in the population that have a positive impact on the quality of life. This methodology has a promising future because it is non-invasive and requires a great biological transformation for inflammatory, fungal and viral control.

关键词： Treatment of vulvovaginal candidiasis candidiasis candida M.A.c. MAc®

颅底骨折患者预防性使用抗生素预防脑膜炎的系统评价(英文)

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中国循证医学杂志 2006年第8期6卷 576-585页

作者： Ratilal B costa J sampaio c 陈耀龙（译）刁骧（审校） Department of Neurosurgery Hospital de Sāo José Rua José António Serrano Lisboa Portugal 1400-350 不详

目的评价颅底骨折患者预防性使用抗生素预防脑膜炎的效果。方法检索cochrane临床对照试验资料库（cENTRAL）（cochrane图书馆2005年第3期）、MEDLINE（1966～2005．09）、EMBASE（1974～2005．06）和LILAcS（1982～2005．09）。电子... 详细信息

目的评价颅底骨折患者预防性使用抗生素预防脑膜炎的效果。方法检索cochrane临床对照试验资料库（cENTRAL）（cochrane图书馆2005年第3期）、MEDLINE（1966～2005．09）、EMBASE（1974～2005．06）和LILAcS（1982～2005．09）。电子检索美国神经外科医师协会会议记录（1997～2005．09），手工检索神经外科学会欧洲联合会会议记录摘要（1995，1999，2003）。收集比较抗生素与安慰剂或空白对照的随机对照试验。同时对检出的非随机对照试验单独进行Meta分析以比较结果。至少由两名研究者独立评价每项试验的质量并提取数据。采用RevMan4．2软件进行Meta分析。结果纳入的5个随机对照试验和17个非随机对照试验比较了颅底骨折患者使用不同类型的预防性抗生素与安慰刹或空白对照的效果。但多数试验对方法学细节描述不充分。所有试验均将脑膜炎纳入其主要结局。共评价了符合Meta分析纳入标准的四个随机对照试验，共包括208例受试者。在降低脑膜炎的发生率、全因病死率、脑膜炎病死率和需要手术干预的脑脊液漏的发生率等方面，预防性抗生素组与对照组无显著差异。对伴或不伴脑脊液漏的患者进行亚组分析以评价其主要结局，并对所有检出的非随机对照试验（共包括2168例受试者）进行Meta分析，得出的结果与随机数据一致。结论现有的随机对照试验证据并不支持对颅底骨折患者预防性使用抗生素，无论其有无脑脊液漏的迹象。在更多的研究完成之前，尚无法确定颅底骨折患者使用抗生素的效果，因为迄今发表的研究均存在偏倚，尚需更多设计完善的大样本随机对照试验。

关键词：预防性抗生素脑膜炎颅底骨折系统评价

Electrical cardioversion for supraventricular arrhythmias in octagenarians

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Journal of Geriatric cardiology 2019年第12期16卷 902-904页

作者： Felipe L.Malafaia Patrícia O.Guimarães Márcio c.sampaio Pedro G.M.de Barros e Silva Renato D.Lopes Juliano V.custódio Miguel da S.Diniz Jose c.T.Garcia Valter Furlan Samaritano Paulista Hospital São PauloBrazil Duke clinical Research Institute Duke UniversityDurhamNCUnited States

Atrial fibrillation(AF)is the most common arrhythmia in the elderly and its incidence increases with aging.[1]Electrical cardioversion is used as a strategy for rhythm control in patients with supraventricular *** octagenarians,there are challenges associated with the indication for electrical cardioversion,such as the use of appropriate sedation and anticoagulant *** decisions in clinical practice for these patients derive from observational data and personal experience,since octagenarians represent a minority of patients included in randomized clinical *** evidence is available regarding the clinical context of electrical cardioversion in this vulnerable ***,we aimed to describe the clinical profile of octagenarians undergoing electrical cardioversion in a cardiology reference center from 2014 to 2018.

关键词： Atrial fibrillation Electrical cardioversion Octagenarians

Flotation of Brazilian and colombian coals Using a Negative Bias

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Journal of chemistry and chemical Engineering 2013年第2期7卷 170-174页

作者： Irineu Brum H. Villegas W. Banguero J. Guerrero c. sampaio J. Barraza Laboratorio de Processamento Mineral Centro de Tecnologia Universidad Federal Rio Grande do Sul Porto Alegre Brasil Escuela de Ingenierla Quimica Universidad del Valle Cali 25360 Colombia

Brazil and colombia have large reserves of coal. Those reserves in Brazil are located predominantly in the south and the main reserves in colombia are located in the north. Despite the relative ease of exploitation, these resources have been underestimated as a source of energy. currently, these countries are developing projects and partnerships aiming to qualify this mineral resource, adding quality to the final product of the processing plants. In this scenario, the processing of Brazilian and colombian coal in flotation columns appears as a promising alternative, having been successful in mineral systems containing fine particles. The paper aims to study the overall process of column flotation for a specific Brazilian coal and a specific colombian coal. The material used in this study consists of fine coal from Brazil （copelmi） and colombia （cerrejon）. The objective is to recover carbonaceous matter and reduce the ash and contaminants grade. The two coals were floated using a negative bias in a 5 cm diameter conventional flotation column of 5 m high. Flotation parameter investigated included air velocity in the range 0.6 to 1.5 cm/s. For all runs, a constant negative bias of-0.25 cm/s and a pulp concentration of 8% w/w were used. For cerrej6n coal, 300 g/ton of frother and 907 g/ton of collector was used, whereas for copelmi coal, 600 g/ton of frother and 1,815 g/ton of collector was employed. The frother was a commercial Aerofroth 65 （AF65）, whereas the collector was Kerosene. For the colombian coal, in general, yield, organic recovery, ash recovery and water recovery decreased with the increasing air rate. However, for Brazilian coal the air rate had no significant effect. For colombian coal, the highest yield （60% w/w） and organic recovery （69% w/w） were obtained at the lowest air rate （0.6 cm/s）.

关键词： Negative bias column flotation coal.

A toast to a zebrafish germ cell induction cocktail

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Science china(Life Sciences) 2024年第6期67卷 1314-1315页

作者： Mary c.Mullins Department of cell and Developmental Biology University of Pennsylvania Perelman School of MedicinePhiladelphia 19104USA

The zebrafish field is ringing in the new year with a publication from Yonghua Sun's laboratory(Wang et al.,2023)of a cocktail of germline factors that can induce all cells of the zebrafish embryo into primordial germ cells(PGcs)at phenomenal *** major advance is not only of great interest to germ cell biologists,but it has important applications to the entire zebrafish field,as shown in Wang et al.(2023).

关键词： fish zebra field

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Performance of evolutionary optimized machine learning for modeling total organic carbon in core samples of shale gas fields

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Petroleum 2024年第1期10卷 150-164页

作者： Leonardo Goliatt c.M.Saporetti L.c.Oliveira E.Pereira Department of computational and Applied Mechanics Federal University of Juiz de Fora Department of computational Modeling Polytechnic Institute Rio de Janeiro State University Petrobras Department of Stratigraphy and Paleontology Rio de Janeiro State University

Rock samples' TOc content is the best indicator of the organic matter in source rocks. The origin rock samples' analysis is used to calculate it manually by specialists. This method requires time and resources because it relies on samples from many well intervals in source rocks. Therefore, research has been done to aid this effort. Machine learning algorithms can estimate total organic carbon instead of well logs and stratigraphic studies. In light of these efforts, the current work present a study on automating the total organic carbon estimation using machine learning approaches improved by an evolutionary methodology to give the model flexibility and precision. Genetic algorithms, differential evolution, particle swarm optimization, grey wolf optimization, artificial bee colony, and evolution strategies were used to improve machine learning models to predict TOc. The six metaheuristics were integrated into four machine learning methods: extreme learning machine, elastic net linear model, linear support vector regression, and multivariate adaptive regression splines. core samples from the YuDong-Nan shale gas field, located in the Sichuan basin, were used to evaluate the hybrid strategy. The findings show that combining machine learning models with an evolutionary algorithms in a hybrid fashion produce flexible models that accurately predict TOc. The results show that, independent of the metaheuristic used to guide the model selection, optimized extreme learning machines attained the best performance scores according to six metrics. Such hybrid models can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic carbon Hybrid models Automated machine learning Evolutionary algorithms Geology

Recent advances on bismuth oxyhalides for photocatalytic cO_(2)reduction

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Journal of Environmental Sciences 2024年第6期140卷 183-203页

作者： Liangpang Xu Jimmy c.Yu Ying Wang Department of chemistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong 999077China

Photocatalytic conversion of cO_(2)into fuels such as cO,cH_(4),and cH_(3)OH,is a promising approach for achieving carbon *** oxyhalides(BiOX,where X=cl,Br,and I)are appropriate photocatalysts for this purpose due to the merits of visible-light-active,efficient charge separation,and easy-to-modify crystal structure and surface *** practical applications,multiple strategies have been proposed to develop high-efficiency BiOX-based *** review summarizes the development of different approaches to prepare BiOX-based photocatalysts for efficient cO_(2)*** the review,the fundamentals of photocatalytic cO_(2)reduction are ***,several widely used modification methods for BiOX photocatalysts are systematacially discussed,including heterojunction construction,introducing oxygen vacancies(OVs),Bi-enrichment,heteroatom-doping,and morphology ***,the challenges and prospects in the design of future BiOX-based photocatalysis for efficient cO_(2)reduction are examined.

关键词： Bismuth oxyhalides Photocatalysis cO_(2)reduction Modification methods

Exercise immunology:Novel insights

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Journal of Sport and Health Science 2024年第3期13卷 277-279,I0001页

作者： David c.Nieman Human Performance Laboratory Appalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA

The coronavirus disease 2019(cOVID-19)pandemic heightened worldwide attention on the influence of exercise on the immune *** were raised about whether regular moderate-to-vigorous physical activity(MVPA)could help prevent cOVID-19 or mitigate symptoms when *** MVPA bolster immunity among those most prone to cOVID-19 including the elderly,obese,and immunocompromised patients?Does regular MVPA dampen systemic inflammation,thereby lessening the cOVID-19 cytokine storm?

关键词： immunity inflammation thereby

comparison of the systemic action of electroacupuncture and laserpuncture in experimental injuries on the back skin of Wistar rats(Rattus novergicus)

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Journal of Traditional chinese Medicine 2021年第5期41卷 779-788页

作者： Ivens Takechi Nakagawa Hamilton Ricardo Alonso Fabrício campos Kuroda JoséRoberto Passarini Junior Juan Guzman Quispe cabanillas Fernanda Aparecida sampaio Mendonça Gláucia Maria Tech dos Santos Andrea Aparecida de Aro Edson Rosa Pimentel Maria Esméria corezola do Amaral Marcelo Augusto Marretto Esquisatto Graduate Program in Biomedical Sciences University Center of Herminio Ometto Foundation-FHOAvenida Dr.Maximiliano Baruto500-Jardim UniversitarioArarasSao Paulo 13607-339Brazil Department of Structural and Functional Biology Institute of BiologyState University of Campinas-UNICAMPAvenida Bertrand Russels/n.Caixa Postal 6109CampinasSao Paulo 13083-865Brazil

OBJEcTIVE:To evaluate the systemic action of electroacupuncture and laserpuncture in the repair of excisional cutaneous injuries on the back of adult female Wistar ***:Ninety animals were divided into three experimental groups:c-control;E-treated with electroacupuncture[acupoints:Feishu(BL13),Geshu(BL17),Zusanli(ST36)];L-treated with laserpuncture(same acupoints)and euthanized on the 7 th,14 th and 21 st days for tissue removal and preparation for histomorphometric and biochemical(dosages,zymography and Western blotting)***:The number of fibroblasts in the E and L groups presented higher values than the c on the14 th and 21 st *** number of granulocytes was lower than c on the 21 st day in groups E and *** total number of newly formed vessels increased on the 21 st day and was higher in both treatments when compared to *** birefringent collagen fibers detected on the 21 st day was lower in groups E and L than group *** glycosaminoglycans and hydroxyproline amount was similar among groups throughout the experimental *** active isoform of matrixmetallo proteinase(MMP)-2 and the latent isoform of MMP-9 did not show any differences among all groups and experimental *** amount of collagenⅠpresented higher values in the L group on the 14 th day and in the E and L groups on the 21 st *** typeⅢcollagen,groups E and L presented values lower than c in all experimental *** amount of transforming growth factor-β1 in the E and L groups showed higher amounts than c on the 7 th day and lower on the 14 th and 21 st *** vascular endothelial growth factor,E and L groups presented similar and lower values than c on the 7 th and 14 th days,respectively,and similar on the 21 st ***:The therapies evaluated in this article stimulated fibroblast proliferation,neoangiogenesis and altered the reorganization of collagen fibers in the repair of excisional injuries in female adult rats.

关键词： wound healing electroacupuncture inflammation morphological and morphometric findings