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Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis

Chinese Journal of Natural Medicines 2018年第3期16卷 225-230页

作者： Umar Farooq Ajmal Khan sadia naz Abdur Rauf Haroon Khan Afsar Khan Irfan Ullah Syed Majid Bukhari Department of Chemistry COMSATS Institute of Information Technology UoN Chair of Oman's Medicinal Plants and Marine Natural Products University of Nizwa Department of Geology University of Swabi Anbar Department of Pharmacy Abdul Wali Khan University Department of Pharmacy Abasyn University

Two new sesquiterpenes, trivially named ricinusoids A(1) and ricinusoids B(2), were isolated from ethyl acetate fraction of Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic techniques, including 1 D-and 2 D-NMR, UV, IR spectroscopy, and mass spectrometry. The compounds(1-2) were also assessed for in-vivo sedative and analgesic like effects in open field and acetic acid induced writhing tests respectively at 5, 10, and 20 mg·kg^(–1) i.p. Pretreatment of both test compounds caused significant(P ≤ 0.05) reduction in locomotive activity like sedative agents and abdominal constrictions like analgesics. Both compounds(1-2) possessed marked sedative and antinociceptive effects in animal models.

关键词： Ricinus communis Sesquiterpenoids Euphorbiaceae Spectroscopic techniques Antinociceptive activity

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Three new anthraquinone derivatives isolated from Symplocos racemosa and their antibiofilm activity

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Chinese Journal of Natural Medicines 2017年第12期15卷 944-949页

作者： Umar Farooq Sara Khan sadia naz Ajmal Khan Afsar Khan Ayaz Ahmed Abdur Rauf Syed Majid Bukhari Shujaat Ali Khan Arfa Kamil Nadia Riaz Abdur Rahman Khan Department of Chemistry COMSATS Institute of Information Technology Abbottabad-22060 Pakistan Dr. Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological Sciences University of Karachi- 752 70 Pakistan Department of Geology University of Swabi Anbar-23430 KPK Pakistan Institute of Chemical Sciences University of Peshawar Peshawar 25120 Pakistan Department of Pharmaceutical Chemistry Faculty of Pharmacy Federal Urdu University of Arts Science and Technology Karachi Karachi 75300 Pakistan Department of Environmental Sciences COMSATS Institute of lnformation Technology Abbottabad-22060 Pakistan

Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C(Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses(UV, IR, Mass, ~1 H-and ^(13)C-NMR, and two-dimensional(2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·m L^(-1) against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis. Both compounds were further screened for anti-biofilm activity, which revealed promising activities at sub-MIC concentrations. None of the compounds were found to be active against Klebsiella pneumoniae.

关键词： Symplocos racemosa Substituted anthraquinone Antibiofilm activity

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Hydro-meteorological characteristics of Chitral River basin at the peak of the Hindukush range

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Natural Science 2013年第9期5卷 987-992页

作者： Salma Khalid Shafiq Ur Rehman Syed Mushtaq Ali Shah Alia naz Beena Saeed sadia Alam Farman Ali Hasina Gul Department of Agriculture Abdul Wali Khan University Mardan Pakistan Department of Agronomy University of Agriculture Peshawar Pakistan Department of Biotechnology Abdul Wali Khan University Mardan Pakistan Department of Environmental Sciences Abdul Wali Khan University Mardan Pakistan Department of Environmental Sciences University of Peshawar Peshawar Pakistan Regional Meteorological Centre Peshawar Pakistan

This paper presents the impact of mean maximum temperature on Chitral river basin situated at Chitral district and high altitude (>6000 m) peaks of the Hindukush range under changing climate in Pakistan. The analysis of Chitral River as one of the tributary of Kabul River—the second largest river of Pakistan—revealed that change in temperature has a profound influence on the snow/glacial melt in comparison to the mean monthly rainfall. This is because the studied river is faded by the snow and glacial melt and receives a lot of snowfall from winter (DecFeb) to pre-monsoon (April-May). In monsoon period (Jul-Sep), 30% of the time the discharge rate remains above the mean while 60% of the time the discharge is less than the mean in the pre-monsoon (April-May) period. It means that 10% of the time the discharge is in reach of 300% to 900% of the mean flow, showing a rise in water yield and river discharge rate due to increase in mean monthly maximum temperature. Due to this significant increase (p < 0.05), the glaciers start melting faster and disappear in early summer, hence, reducing their residency period to convert into ice. This shows the signals of changing climate transfer into hydrological changes in Pakistan. Our findings are important for agriculture, hydropower and water management sectors for future planning especially in dry season for sustainable food security and for operation of ydrological installations in the country.

关键词： Mean Maximum Temperature Mean Rainfall River Discharge Climate Change Chitral

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Contribution of soil and foliar fertilization of nitrogen and sulfur on physiological and quality assessment of wheat (<i>Triticum aestivum</i>L.)

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Natural Science 2013年第9期5卷 1012-1018页

作者： Beena Saeed Hasina Gul Farman Ali Amir Zaman Khan Shazma Anwar Nasrullah sadia Alam Salma Khalid Alia naz Hina Fayyaz Azra Department of Agriculture Abdul Wali Khan University Mardan Pakistan Department of Agronomy The University of Agriculture Peshawar Pakistan Department of Biotechnology Abdul Wali Khan University Mardan Pakistan Department of Environmental Sciences Abdul Wali Khan University Mardan Pakistan Department of Plant Breeding & Genetics The University of Agriculture Peshawar Pakistan Department of Plant Pathology The University of Agriculture Mardan Campus Pakistan Department of Soil Sciences The University of Agriculture Peshawar Pakistan

Nitrogen and sulfur supplies have a strong influence on the physical characteristics of crop as well as on the quality and quantity of wheat storage proteins, which play an important role in bread-making process. In order to evaluate the contribution of soil and foliar fertilization of nitrogen and sulfur on physiological and quality assessment of wheat, a field trail was carried out having randomized complete block design with four replications and eight different treatments of nitrogen and sulfur combinations were allotted to plots at different growth stages. Results indicated that highest protein content (12.82%), maximum moisture content (10.9%), maximum crop growth rate and maximum absolute growth rate were recorded when the wheat crop was fertilized with T8 [Nitrogen @ 60 kg·ha-1 at sowing + 40 kg·ha-1 at tillering + 10 kg·ha-1 at anthesis (spray) + 10 kg·ha-1 after anthesis (spray)] + [Sulfur @ 15 kg·ha-1 at sowing + 10 kg·ha-1 at anthesis (spray) + 5 kg·ha-1 after anthesis (spray)], while control practice resulted low moisture content, low protein, minimum crop growth rate and low absolute growth rate. Among physiological components of wheat cultivars, leaf area index was enhanced when fertilization was done with T5 (Sulfur @ 15 kg·ha-1 at sowing + 10 kg·ha-1 at anthesis + 5 kg·ha-1 after anthesis). In all the recorded observations,concerning experiment wheat cultivar Pirsabaq2005 showed appreciable response as compared with other variety (Khyber-87). Thus it is possible to obtain maximum physiological traits as well as bread-making quality of wheat through soil and foliar application of nitrogen and sulfur.

关键词： Absolute Growth Rate Crop Growth Rate Leaf Area Index Moisture and Protein Contents

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