Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis

作     者：Umar Farooq Ajmal Khan Sadia Naz Abdur Rauf Haroon Khan Afsar Khan Irfan Ullah Syed Majid Bukhari 

作者机构：Department of Chemistry COMSATS Institute of Information Technology UoN Chair of Oman's Medicinal Plants and Marine Natural Products University of Nizwa Department of Geology University of Swabi Anbar Department of Pharmacy Abdul Wali Khan University Department of Pharmacy Abasyn University 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2018年第16卷第3期

页      面：225-230页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：financially supported by the Higher Education Commission of Pakistan(No.2003) 

主　　题：Ricinus communis Sesquiterpenoids Euphorbiaceae Spectroscopic techniques Antinociceptive activity 

摘      要：Two new sesquiterpenes, trivially named ricinusoids A(1) and ricinusoids B(2), were isolated from ethyl acetate fraction of Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic techniques, including 1 D-and 2 D-NMR, UV, IR spectroscopy, and mass spectrometry. The compounds(1-2) were also assessed for in-vivo sedative and analgesic like effects in open field and acetic acid induced writhing tests respectively at 5, 10, and 20 mg·kg^(–1) i.p. Pretreatment of both test compounds caused significant(P ≤ 0.05) reduction in locomotive activity like sedative agents and abdominal constrictions like analgesics. Both compounds(1-2) possessed marked sedative and antinociceptive effects in animal models.