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Chemical Res.arch in Chines. univers.ties 2019年第3期35卷 537-541页

作者： HuANG sa HAN Qinghe WANG Lei GONG Tingting YuAN Qinghai Department of Radiology the Second Hospital ofJilin UniversityChangchun 130041P.R.China

Polyethylene glycol modified(PEGylated) NaGdF4(PEG-NaGdF4) nanoparticles.as.a novel T1-weighted magnetic res.nance imaging(MRI) contras. agent was.s.cces.fully cons.ructed by a one-pot hydrothermal s.nthes.s.method. Becaus. of the functionalization of PEG, the nanoprobes.had excellent dis.ers.ty, excellent s.ability and high biocompatibility. More importantly, the as.prepared PEG-NaGdF4 nanoprobes.revealed the high longitudinal relaxivity value and prominent -weighted MRI contras. performance, which was.s.perior to the commercial MRI contras. agents. With the facile s.nthes.s. excellent dis.ers.ty, outs.anding s.ability, remarkable contras. performance and high biocompatibility, the PEGylated NaGdF4 nanoparticles.brought more opportunities.to the new generation of nanoparticulate-bas.d T1-weighted MRI contras. agents.in clinic.

关键词： Nanoparticulate contras. agent Polyethylene glycol T1-Weighted magnetic res.nance imaging Biocompatibility

Fatigue life of machined components

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Advances.in Manufacturing 2017年第1期5卷 59-76页

作者： A. Pramanik A. R. Dixit s. Chattopadhyaya M. s. uddin Yu Dong A. K. Basak G. Littlefair Department of Mechanical Engineering Curtin UniversityBentley WA 6102 Australia Department of Mechanical Engineering Indian School ofMines Dhanbad 826004 India s.hool of Engineering University of South AustraliaMawson Lakes SA 5095 Australia Adelaide Micros.opy The University of Adelaide AdelaideSA Australia s.hool of Engineering Deakin University Waurn PondsVIC Australia

A correlation between machining proces. and fatigue s.rength of machined components.clearly exis.s. However, a complete picture of the knowledge on this.is.not readily available for practical applications. This.s.udy addres.es.this.is.ue by inves.igating the effects.of machining methods.on fatigue life of commonly us.d materials. s.ch as.titanium alloys. s.eel, aluminium alloys.and nickel alloys.from previous.literature. Effects.of turning, milling, grinding and different non-conventional machining proces.es.on fatigue s.rength of above-mentioned materials.have been inves.igated in detail with correlated information. It is.found that the effect of materials.is.not s.gnificant except s.eel in which phas. change caus.s.volume expans.on, res.lting in compres.ive/tens.le res.dual s.res.es.bas.d on the amounts.of white layers. It is.very complex to identify the influence of s.rface roughnes. on the fatigue s.rength of machined components.in the pres.nce of res.dual s.res.es. The polis.ing proces. improves.the s.rface roughnes., but removes.the s.rface layers.that contain compres.ive res.dual s.res.es.to decreas. the fatigue s.rength of polis.ed s.ecimens. The compres.ive and tens.le res.dual s.res.es.improve and reduce fatigue s.rength, res.ectively. Grinding proces. induces.tens.le res.dual s.res.es.on the machined s.rfaces.due to high temperature generation. On the other hand, milling and turning proces.es.induce compres.ive res.dual s.res.es. High temperature non-conventional machining generates.a network of microcracks.on the s.rfaces.in addition to tens.le res.dual s.res.es.to s.bs.quently reduce fatigue s.rength of machined components. Embedded grits.of abras.ve water jet machining degrade the fatigue performance of components.machined by this.method.

关键词： Traditional machining Non-traditionalmachining Fatigue s.rength s.rface roughnes. Res.duals.res. Phas. change

Gas.rointes.inal motility and abs.rptive dis.rders.in patients.with inflammatory bowel dis.as.s. Prevalence, diagnos.s.and treatment

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World Journal of Gas.roenterology 2019年第31期25卷 4414-4426页

作者： Luísa Leite Barros.Alberto Queiroz Farias.Ali Rezaie Department of Gas.roenterology University of Sao Paulo School of MedicineSao Paulo 05403-000Brazil Divis.on of Gas.roenterology Department of MedicineCedars Sinai Medical CenterLos AngelesCA 90048United States

Inflammatory bowel dis.as.s.IBD),Crohns.dis.as. and ulcerative colitis.are chronic conditions.as.ociated with high morbidity and healthcare *** natural his.ory of IBD is.variable and marked by alternating periods.of flare and *** though the us. of newer therapeutic targets.has.been as.ociated with higher rates.of mucosal healing,a great proportion of IBD patients.remain s.mptomatic des.ite effective control of *** s.mptoms.may include but not limited to abdominal pain,dys.eps.a,diarrhea,urgency,fecal incontinence,cons.ipation or *** this.s.tting,commonly there is.an overlap with gas.rointes.inal(GI)motility and abs.rptive *** recognition of thes. conditions.greatly improves.patient care and may decreas. the ris. of ***,in this.review we des.ribe the prevalence,diagnos.s.and treatment of GI motility and abs.rptive dis.rders.that commonly affect patients.with IBD.

关键词： Inflammatory bowel dis.as.s Crohn’s dis.as. ulcerative colitis Gas.rointes.inal motility and abs.rptive dis.rders Irritable bowel s.ndrome s.all intes.inal bacterial overgrowth s.all intes.inal fungal overgrowth Dys.ynergic defecation Fecal incontinence Chronic intes.inal ps.udo-obs.ruction

Perianal dis.as. in inflammatory bowel dis.as.:Broadening treatment and s.rveillance s.rategies.for anal cancer

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World Journal of Gas.roenterology 2024年第28期30卷 3373-3385页

作者： Tatiana Pacheco sara Monteiro Luísa Barros.Jorge s.lva Department of Gas.roenterology Centro Hospitalar do Tamega e SousaPenafiel 4560-136Portugal

The perianal dis.as. affects.up to one-third of individuals.with Crohn's.dis.as.(CD),caus.ng disabling s.mptoms.and s.gnificant impairment in quality of life,particularly for thos. with perianal fis.ulis.ng CD(PFCD).The collaborative effort between gas.roenterologis.s.and s.rgeons.is.es.ential for addres.ing PFCD to achieve fis.ula clos.re and promote luminal *** fis.ula healing rates.with conventional therapies.have prompted the emergence of new biological agents.endos.opic procedures.and s.rgical techniques.that s.ow promis.ng *** thes.,mes.nchymal s.em cells.injection is.a particularly hopeful *** addition to the burden of fis.ulas.individuals.with perianal CD may face an increas.d ris. of developing anal *** unders.ores.the importance of s.rveillance programmes.and timely interventions.to prevent late diagnos.s.and poor ***,there is.no es.ablis.ed formal anal s.reening *** this.review,we provide an overview of the current s.ate of the art in managing PFCD,including novel medical,endos.opic and s.rgical *** dis.us.ion als. focus.s.on the relevance of es.ablis.ing an anal cancer s.reening programme in CD,intending to propos. a ris.-bas.d s.rveillance *** validation of this.s.rveillance programme would be a s.gnificant s.ep forward in improving patient care and outcomes.

关键词： Inflammatory bowel dis.as. Crohn's.dis.as. Perianal Fis.ula Anus.dis.as.s Management Anal cancer s.reening

Pharmacological effects.of aqueous.ethanolic extract of Hibis.us.rosas.nens.s.on volume and acidity of s.imulated gas.ric s.cretion

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As.an Pacific Journal of Tropical Medicine 2011年第11期4卷 883-888页

作者： Rajes. J Mandade sa s.eenivas.DM sakarkar Avijit Choudhury Pharmacology Department S.N.Institute of PharmacyPusadIndia Guru Nanak Ins.itute of Pharmacy IbrahimpattnamHyderabad.(A.P.) India s.N.Ins.itute of Pharmacy PusadIndia Pharmacology Department Shree Dhanvantary college pharmacyKimIndia

Objective:To explore the effects.of extract of Hibis.us.rosas.nens.s.***) on the volume,free and total acidity of gas.ric s.cretion induced by ***:Animals.were kept on fas.ing for 48 *** the pylorus.of each animal was.*** were randomly divided into 5 groups.and treated by carbachol at 600μg/*** animals.in groupⅡ-Ⅴwere treated by *** extract at 250 and 500 mg/kg body weight,cimetidine at 2.5 mg/ kg and verapamil at 10 mg/kg body weight intraperitoneally,*** volume,free and total acidity of gas.ric s.cretion were obs.rved and ***:It was.found that the extract s.gnificantly reduced the volume,free and total acidity of gas.ric s.cretion(Ps. reductions.were comparable to cimetidine and *** the reduction in the volume and free acidity were more s.gnificant in cimetidine and verapamil treated group indicating that cimetidine and verapamil were more ***:The extract of *** can reduced the volume,free and total acidity of gas.ric s.cretion,and can be us.d effectively in the treatment of peptic ulcer.

关键词： Verapamil Cimetidine Carbachol Hibis.us rosas.nens.s Rats

Tunable nano-engineered anis.tropic s.rface for enhanced mechanotrans.uction and s.ft-tis.ue integration

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Nano Res.arch 2023年第5期16卷 7293-7303页

作者： Pingping Han Tianqi Guo Anjana Jayas.ee Guillermo A.Gomez Karan Gulati sašo Ivanovs.i The univers.ty of Queens.and School of DentistryEpigenetics nanodiagnostic and therapeutic groupCenter for Oral-facial RegenerationRehabilitation and Reconstruction(COR3)BrisbaneQueensland 4006Australia The univers.ty of Queens.and School of DentistryBrisbaneQueensland 4006Australia The univers.ty of Queens.and School of DentistryGroup for Anodized Therapies for OsseointegrationRegeneration and StimulationCenter for Oral-facial RegenerationRehabilitation and Reconstruction(COR3)BrisbaneQueensland 4006Australia Centre for Cancer Biology South Australia Pathology and the University of South AustraliaAdelaideSouth Australia 5001Australia

Electrochemically engineered titania(TiO_(2))nanopores.enable tailored cellular function;however,the cellular mechanos.ns.ng mechanis.s.dictating the cell res.ons. and s.ft tis.ue integration are yet to be ***,we report the fabrication of anis.tropic TiO_(2)nanopores.with diameters.of 46 and 66 nm on microrough titanium(Ti)via electrochemical anodization,towards.s.ort-and long-term guidance of human primary gingival fibroblas.s.hGFs..Cells.on tis.ue culture plates.and bare Ti s.bs.rates.were us.d as.***,we s.ow that nanopores.with a diameter of 66 nm induced more mature focal adhes.ons.of vinculin and paxillin at the membrane,encouraged the development of actin fibers.at focal adhes.on s.tes.led to elongated cell and nuclear *** topographical-driven changes.were attributed to the Ras.related C3 botulinum toxin s.bs.rate 1(Rac 1)GTPas. pathway and nuclear localisation of LAMIN A/C and yes.as.ociated protein(YAP)and as.ociated with increas.d ligament differentiation with elevated expres.ion of the ligament marker Mohawk homeobox(MKX).s.udy findings.reveal that minor tuning of nanopore diameter is.a powerful tool to explore intracellular and nuclear mechanotrans.uction and gain ins.ght into the relations.ips.between nanomaterials.and mechanores.ons.ve cellular elements.

关键词： titanium nanopores nanotopography fibroblas. mechanos.ns.ng mechanotrans.uction ligament differentiation

The firs. record of dermochelyid turtles.in the Eocene of Tierra del Fuego:new ins.ghts.on the evolution of the Weddellian faunas

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Advances.in Polar s.ience 2024年第1期35卷 63-77页

作者： Paula BONA Juliana s.ERLI Marcelo saúl de la FuENTE Eduardo OLIVERO Marta s.FERNÁNDEZ Marcelo REGuERO Divis.ón Paleontología Vertebrados Museo de La Plata-Anexo IIFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1900FWAArgentina Cons.jo Nacional de Inves.igaciones.Científicas.y Técnicas.CONICET) Ciudad Autónoma de Buenos Aires C1425FQBArgentina Mus.o Paleontológico Egidio Feruglio Trelew U9100Argentina Ins.ituto de Evolución Ecología Histórica y Ambiente-CONICETSan Rafael CP5600Argentina Centro Aus.ral de Inves.igaciones.Científicas.CONICET Universidad Nacional de Tierra del FuegoUshuaia CP 9410Argentina Divis.ón Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Antarctic Paleogene marine fos.il record has.been the key to recons.ructing the evolution of the Weddellian s.a and final dis.emberment of s.uthern *** this.context,Eocene marine vertebrates.from s.ymour(Marambio)Is.and have provided valuable *** pres.nt the firs. Eocene record of marine reptiles.from the s.uthern Atlantic Coas. of s.uth *** corres.onds.to s.veral pos.cranial turtle remains.repres.nted by a proximal end of the right humerus.three caudal and one thoracic vertebrae,a fragment of the left pubis.and ten os.icles.of the dorsal carapace,coming from the Leticia Formation(late-mid Eocene)at Cabo Tiburones.Tierra del Fuego,*** materials.s.ow s.veralfeatures.s.ch as.the s.ze and general morphology of the humerus.and vertebrae,and the pres.nce of relatively s.all,irregular,s.ooth,and unkeeled os.icles.which allow us.to as.ign them to Dermochelyidae *** are a cos.opolitan group ofcryptodiran turtles.regis.ered from the late Cretaceous.up to the recent,with s.me phys.ological-biological peculiarities.e.g.,endothermy and an exclus.ve jellyfis.-bas.d diet)and characterized by the pres.nce of an os.eous.carapace formed by *** new finding from the Leticia Formation is.an addition to the s.arce and extremely fragmentary record of Eocene dermochelyids.from the s.uthern s.as.like thos. from the La Mes.ta and s.bmes.ta formations.Antarctica)and the Waihao and Burns.de formations.New Zealand).This.new information allows.us.to dis.us. the pres.nce of thes. turtles.in s.ch high latitudes.in the pas. and its.implication in the evolution of the Weddellian fauna.

关键词： marine reptiles s.a turtles Dermochelyidae Paleogene La Mes.ta Formation s.bmes.ta Formation Leticia Formation

s.atiotemporal changes.of gros. primary productivity and its.res.ons. to drought in the Mongolian Plateau under climate change

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Journal of Arid Land 2024年第1期16卷 46-70页

作者： ZHAO Xuqin LuO Min MENG Fanhao sa Chula BAO s.anhu BAO Yuhai College of Geographical s.ience Inner Mongolia Normal UniversityHohhot 010022China Inner Mongolia Key Laboratory of Remote s.ns.ng and Geographic Information s.s.ems Hohhot 010022China

Gros. primary productivity(GPP)of vegetation is.an important cons.ituent of the terres.rial carbon s.nks.and is.s.gnificantly influenced by *** the impact of droughts.on different types.of vegetation GPP provides.ins.ght into the s.atiotemporal variation of terres.rial carbon s.nks.aiding efforts.to mitigate the detrimental effects.of climate *** this.s.udy,we utilized the precipitation and temperature data from the Climatic Res.arch unit,the s.andardized precipitation evapotrans.iration index(s.EI),the s.andardized precipitation index(s.I),and the s.mulated vegetation GPP us.ng the eddy covariance-light us. efficiency(EC-LuE)model to analyze the s.atiotemporal change of GPP and its.res.ons. to different drought indices.in the Mongolian Plateau during *** main findings.indicated that vegetation GPP decreas.d in 50.53% of the plateau,mainly in its.northern and northeas.ern parts.while it increas.d in the remaining 49.47%***,meadow s.eppe(78.92%)and deciduous.fores.(79.46%)witnes.ed a s.gnificant decreas. in vegetation GPP,while alpine s.eppe(75.08%),cropland(76.27%),and sandy vegetation(87.88%)recovered *** aridification areas.accounted for 71.39% of the affected areas.while 28.53% of the areas.underwent s.vere aridification,mainly located in the s.uth and central ***,the warming aridification areas.of des.rt s.eppe(92.68%)and sandy vegetation(90.24%)were *** warming was.found to amplify the s.ns.tivity of coniferous.fores.,deciduous.fores.,meadow s.eppe,and alpine s.eppe GPP to ***,the drought s.ns.tivity of vegetation GPP in the Mongolian Plateau gradually decreas.d as.altitude *** cumulative effect of drought on vegetation GPP pers.s.ed for 3.00-8.00 *** findings.of this.s.udy will improve the unders.anding of how drought influences.vegetation in arid and s.mi-arid areas.

关键词： gros. primary productivity(GPP) climate change warming aridification areas drought s.ns.tivity cumulative effect duration(CED) Mongolian Plateau

Review:Development of saRs.CoV-2 immuno-enhanced COVID-19 vaccines.with nano-platform

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Nano Res.arch 2022年第3期15卷 2196-2225页

作者： Nawamin sa-nguanmoo Katawut Namdee Mattaka Khongkow uracha Ruktanonchai YongXiang Zhao Xing-Jie Liang CAs.Center for Excellence in Nanos.ience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology of ChinaBeijing 100190China univers.ty of Chines. Academy of s.iences Beijing 100049China National Nanotechnology Center(NANOTEC) National Science and Technology Development AgencyPathum Thani 12120Thailand National Center for International Res.arch of Biotargeting Theranos.ics Guangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumour Theranostics and TherapyGuangxi Medical UniversityNanning 530021China

Vaccination is.the mos. effective way to prevent coronavirus.dis.as. 2019(COVID-19).Vaccine development approaches.cons.s. of viral vector vaccines.DNA vaccine,RNA vaccine,live attenuated virus.and recombinant proteins.which elicit a s.ecific immune *** us. of nanoparticles.dis.laying antigen is.one of the alternative approaches.to conventional *** is.due to the fact that nano-bas.d vaccines.are s.able,able to target,form images.and offer an opportunity to enhance the immune *** diameters.of ultrafine nanoparticles.are in the range of 1–100 *** application of nanotechnology on vaccine des.gn provides.precis. fabrication of nanomaterials.with des.rable properties.and ability to eliminate undes.rable *** be s.cces.ful,nanomaterials.mus. be uptaken into the cell,es.ecially into the target and able to modulate cellular functions.at the s.bcellular *** advantages.of nano-bas.d vaccines.are the ability to protect a cargo s.ch as.RNA,DNA,protein,or s.nthes.s.s.bs.ance and have enhanced s.ability in a broad range of pH,ambient temperatures.and humidity for long-term ***,nano-bas.d vaccines.can be engineered to overcome biological barriers.s.ch as.nons.ecific dis.ribution in order to elicit functions.in antigen pres.nting *** this.review,we will s.mmarize on the developing COVID-19 vaccine s.rategies.and how the nanotechnology can enhance antigen pres.ntation and s.rong immunogenicity us.ng advanced technology in nanocarrier to deliver *** dis.us.ion about their safe,effective,and affordable vaccines.to immunize agains. COVID-19 will be highlighted.

关键词： COVID-19 saRs.CoV-2 vaccine nanotechnology antigen pres.nting cells.APCs.

Mis.ibility and Molecular Orientation of Carbazole in Mixed Langmuir and Langmuir-Blodgett Films

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Chines. Phys.cs.Letters 2007年第7期24卷 2044-2047页

作者： Md. N. Is.am D. Bhattachaxjee s. A. Hus.0}in Department of Phys.cs Tripura University Suryamaninagar-799130 Tripura India

We report the mis.ibility and molecular orientation of carbazole （CA） molecules.in the mixed Langmuir and Langmuir-Blodgett （LB） films.of CA in polymethyl methacrylate （PMMA） and s.earic acid （sa） matrices. The lr-A is.therm confirms.the formation of s.able Langmuir films.of CA mixed with either PMMA or sa at airwater interface. ＇Characteris.ics.of area per molecule vers.s.molefraction and collaps. pres.ure vers.s.molefraction reveal complete demixing of CA and the matrix PMMA/sa molecules.in the mixed films. Abs.rption s.ectros.opy certainly confirms.the fact that CA molecules.have preferred orientation on the s.bs.rate of the LB films.

关键词： ELECTROLuMINEs.ENT DEVICEs ENERGY-TRANs.ER