Perianal disease in inflammatory bowel disease:Broadening treatment and surveillance strategies for anal cancer
作者机构：Department of GastroenterologyCentro Hospitalar do Tamega e SousaPenafiel 4560-136Portugal
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2024年第30卷第28期
页 面：3373-3385页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Inflammatory bowel disease Crohn's disease Perianal Fistula Anus diseases Management Anal cancer Screening
摘 要：The perianal disease affects up to one-third of individuals with Crohn s disease(CD),causing disabling symptoms and significant impairment in quality of life,particularly for those with perianal fistulising CD(PFCD).The collaborative effort between gastroenterologists and surgeons is essential for addressing PFCD to achieve fistula closure and promote luminal *** fistula healing rates with conventional therapies have prompted the emergence of new biological agents,endoscopic procedures and surgical techniques that show promising *** these,mesenchymal stem cells injection is a particularly hopeful *** addition to the burden of fistulas,individuals with perianal CD may face an increased risk of developing anal *** underscores the importance of surveillance programmes and timely interventions to prevent late diagnoses and poor ***,there is no established formal anal screening *** this review,we provide an overview of the current state of the art in managing PFCD,including novel medical,endoscopic and surgical *** discussion also focuses on the relevance of establishing an anal cancer screening programme in CD,intending to propose a risk-based surveillance *** validation of this surveillance programme would be a significant step forward in improving patient care and outcomes.
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