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Application of response surface methodology in optimization of bioleaching parameters for high-magnesium nickel sulfide ore

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Journal of Central South University 2022年第5期29卷 1488-1499页

作者： sun jian-zhi WU Biao CHEN Bo-wei WEN jian-kang GRINM Resources and Environment Tech.Co. Ltd.Beijing 101407China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China National Engineering Research Center for Environment-friendly Metallurgy in Producing Premium Non-ferrous Metals Beijing 100088China GRINM Group Co. Ltd.Beijing 100088China

The response surface methodology(RSM)was used to optimize the operating parameters during the bioleaching of Jinchuan high-magnesium nickel sulfide *** particle size,acid addition,pulp density and inoculation amount were chosen as the investigated *** maximize the leaching efficiency of nickel,copper,cobalt and minimize the dissolution of magnesium and iron ions,the model suggested a combination of optimal parameters of particles less than 0.074 mm being 72.11%,sulfuric acid addition being 300 kg/t,pulp density being 5%and inoculation amount being 12.88%.Under the conditions,the average results of three parallel experiments were 89.43%of nickel leaching efficiency,36.78%of copper leaching efficiency,84.07%of cobalt leaching efficiency,49.19%of magnesium leaching efficiency and 0.20 g/L of iron *** model indicated that the most significant factor in response of the leaching efficiency of valuable metal is the particle size,and the most significant factor in response to the leaching efficiency of harmful ions(Mg2+)is the amount of sulfuric acid *** according to the suggested models,no significance of the interaction effect between particle size and acid addition was *** the optimized parameters suggested by models,the valuable metals could be separated from harmful ions during the bioleaching process.

关键词： high-magnesium nickel sulfide ore bioleaching response surface methodology particle size acid consumption

Comparing minimally invasive and open transforaminal lumbar interbody fusion for treatment of degenerative lumbar disease： a meta-analysis

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Chinese Medical Journal 2013年第20期126卷 3962-3971页

作者： sun zhi-jian Li Wen-jing Zhao Yu Qiu Gui-xing Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Orthoped Beijing 100730 Peoples R China Peking Union Med Coll Beijing 100730 Peoples R China

Background Transforaminal lumbar interbody fusion （TLIF） through a minimally invasive approach （mTLIF） was introduced to reduce soft tissue injury and speed recovery. Studies with small numbers of patients have be... 详细信息

关键词： transforaminal lumbar interbody fusion degenerative lumbar disease," minimally invasive surgery," mini-open surgery," meta-analysis

Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan sun Lulin Li jian Luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of Care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation

Evaluation of diffusion weighted imaging of magnetic resonance imaging in small focal hepatic lesions:a quantitative study in 56 cases

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 406-409页

作者： Xian-Yue Quan, Xi-Jie sun, zhi-jian Yu and Ming Tang Imaging Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China Imaging Center Affiliated Zhujiang Hospital of Southern Medical University Guangzhou 510282 China. quanxianyue@***

Diffusion-weighted imaging (DWI) as a new technique of magnetic resonance imaging (MRI) is used to detect focal hepatic lesions. This study was designed to evaluate the significance of DWI to differentiate focal hepatic lesions less than 3 cm in diameter by the quantitation of apparent diffusion coefficient (ADC) values. METHODS:DWI using 1.5T MRI scanner unit was performed with a spin-echo single-shot echo planar imaging (EPI) in 56 cases of small focal hepatic lesions, including hepatocellular carcinoma (11), hepatic metastatic tumor (15 ), hepatic cavernous hemangioma (14), and hepatic cyst (16).The ADC values of these lesions were calculated respectively. The ratios of the ADC values of lesion/liver in hepatocellular carcinomas and hepatic metastatic tumors were also estimated. RESULTS:The mean ADC values (mm2/s) were (0.93±0.06) ×10-3 in hepatocellular carcinomas, (1.09±0.18)×10-3 in hepatic metastatic tumors,(1.95±0.38)×10-3 in hepatic cavernous hemangiomas, and (3.18±0.33) ×10-3 in hepatic cysts. The ratios of ADC values of lesion/liver were 0.90±0.06 and 1.15±0.14 in hepatocellular carcinoma and hepatic metastatic tumors respectively, which were significantly different (P<0.05). CONCLUSION:The measurement of ADC values and the ratios of ADC values of lesion/liver are helpful in MR diagnosis and differentiation of focal hepatic lesions.

关键词： quantitative study diffusion-weighted imaging apparent diffusion coefficient magnetic resonance imaging b value

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中国行政研究概念创新:一项学科发展新议程

江苏行政学院学报 2014年第1期 96-102页

作者：孙志建上海行政学院公共管理教研部上海200433

"概念"是理论创新与知识增长的基石。扎根于本土社会的事实且同国际理论接轨的概念创新乃是推进中国行政学蓬勃发展的重要一环。概念创新没有标准程式。中国行政学研究的概念创新亟需汲取国际行政学科发展历程中概念创新的基本经验(譬... 详细信息

"概念"是理论创新与知识增长的基石。扎根于本土社会的事实且同国际理论接轨的概念创新乃是推进中国行政学蓬勃发展的重要一环。概念创新没有标准程式。中国行政学研究的概念创新亟需汲取国际行政学科发展历程中概念创新的基本经验(譬如现象聚焦、锁定重大理论问题等),遵循概念创新的基本原则(包括精简性、客观性、中立性、开放性、平衡性以及情境性等原则)和科学思维(包括"领地"思维、"类型"思维、"类比"思维、"变量"思维、"特质"思维以及"关联"思维等),并将概念创新同公共行政的研究方法统筹把握。在关于中国行政学的研究中,有必要倡导一种基于现象聚焦(尤指"元现象")、锁定学科重大理论问题且以中层概念生产为取向的概念创新。

关键词：挽救现象元现象概念创新中层概念行政学想象力

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基于独立分量分析的降噪技术

电子科技大学学报 2005年第3期34卷 296-299页

作者：张智林皮亦鸣孙志坚电子科技大学电子工程学院成都610054 青岛理工大学理学院山东青岛266033

介绍了新兴的独立分量分析技术的基本概念和原理,以及具有代表性的算法,即FastICA算法、EASI算法、非线性PCA算法和基于自然梯度的最大似然估计算法。通过降噪仿真实验,并采用均方误差作为降噪的性能指数,对这些算法与传统的自适应信号... 详细信息

介绍了新兴的独立分量分析技术的基本概念和原理,以及具有代表性的算法,即FastICA算法、EASI算法、非线性PCA算法和基于自然梯度的最大似然估计算法。通过降噪仿真实验,并采用均方误差作为降噪的性能指数,对这些算法与传统的自适应信号处理算法进行比较。所得实验结果表明,独立分量分析算法在降噪上的效果优于自适应信号处理算法。因此在降噪上具有较大的应用价值。

关键词：独立分量分析降噪自适应信号处理非线性PCA最大似然估计

Distribution of serum prostate-specific antigen in Chinese healthy men： a population-based study

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Chinese Medical Journal 2011年第8期124卷 1189-1192页

作者： YUAN Xiao-dong DONG zhi-gang ZHANG Hui LIN Hai-yan SONG Xin-hong NIU zhi-hong FU Qiang LIU Shuai sun zhi-jian LU Jia-ju Department of Urology Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China Department of Health Examination Center Provincial Hospital Affiliated toShandong University Jinan Shan_dong 250021 China

Background The morbidity and mortality of prostate cancer have been increasing rapidly in recent China. There were few studies investigating prostate-specific antigen （PSA） values ranges in the healthy Chinese population. We performed this study to determine the distribution of serum PSA in a large healthy Chinese *** From January 2001 to May 2008, 11 150 healthy Chinese men aged 30-79 years came to our hospital for routine health check-up. All subjects without a previous diagnosis of prostate cancer, a history of prostate surgery, or urogenital tract infection were proposed to undergo systematic serum PSA measurement and digital rectal examination （DRE）. Men with normal DRE and PSA ≤4.0 ng/ml and those PSA ＞4.0 ng/ml or abnormal DRE but without adverse findings on prostate biopsy were included （n=9358）. Age and serum PSA concentration were recorded and correlated through Logistic regression *** The 95th percentile serum PSA concentration was 1.89 ng/ml for men aged 30 to 39 years, 2.19 ng/ml for men aged 40 to 49 years, 2.88 ng/ml for men aged 50 to 59 years, 4.42 rng/ml for men aged 60 to 69 years, and 6.52 ng/ml for men aged 70 to 79 years. The serum PSA concentration correlated with age （P ＜0.0001） with an annual increase of 0.97% for men in 40 years, 1.58% for men in 50 years, 3.04% for men in 60 years, and 3.99% for men in 70 *** The serum PSA level correlates directly with age in Chinese men older than 40 years, not in Chinese men younger than 40 years old. Chinese men have lower PSA level compared with white men above 60 years of age, not in those under 60 years of age.

关键词： Asian Caucasian Chinese prostate-specific antigen reference ranges

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镁二次电池硅酸盐正极材料研究进展

电源技术 2013年第6期37卷 1075-1078页

作者：孙建之德州学院山东省高校配位化学与功能材料重点实验室山东德州253023

镁二次电池作为一种很有潜力的大负荷蓄电池逐渐受到研究者的关注。通过形貌控制和表面修饰提高材料的电导率是提高正极材料电化学性能的主要途径。对硅酸盐正极材料MgMSiO4(M=Mn,Fe,Co,Ni)进行了系统评述,重点对材料的合成方法、表面... 详细信息

镁二次电池作为一种很有潜力的大负荷蓄电池逐渐受到研究者的关注。通过形貌控制和表面修饰提高材料的电导率是提高正极材料电化学性能的主要途径。对硅酸盐正极材料MgMSiO4(M=Mn,Fe,Co,Ni)进行了系统评述,重点对材料的合成方法、表面改性、结构及充放电机理等方面进行了阐述,综合分析了各种合成方法的优缺点及性能和机理研究上的难点,分析并展望了亟待解决的问题和未来可能的发展方向。

关键词：镁二次电池硅酸盐合成方法电化学性能

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单分散微米磷酸锂的制备

化工矿物与加工 2008年第8期37卷 4-5页

作者：孙建之德州学院化学系

以提锂后的尾液为原料,与Na2CO3和Na3PO4.12H2O反应,在较为温和的水热条件下（120;50℃）、较短的反应时间内（3;0 h）制得了单分散的球形Li3PO4颗粒,粒径约5;μm,产率达到90%以上。该方法是一种环境友好的绿色化学制备方法,全过程接近... 详细信息

以提锂后的尾液为原料,与Na2CO3和Na3PO4.12H2O反应,在较为温和的水热条件下（120;50℃）、较短的反应时间内（3;0 h）制得了单分散的球形Li3PO4颗粒,粒径约5;μm,产率达到90%以上。该方法是一种环境友好的绿色化学制备方法,全过程接近污染物零排放,不仅解决了尾液的环境污染问题,而且还提高了盐湖资源的综合利用率。

关键词：水热合成磷酸锂卤水制备