检索结果-南通市图书馆

Neoadjuvant chemoradiotherapy for locally advanced gastric cancer with bulky lymph node metastasis:Five case reports

引用

World Journal of Clinical Cases 2020年第18期8卷 4177-4185页

作者： Eiji Nomura Hajime Kayano Takashi Machida Hideki Izumi Soichiro Yamamoto Akitomo sugawara Masaya Mukai Terumitsu Hasebe Department of Gastroenterological and General Surgery Tokai University Hachioji HospitalHachioji 192-0032TokyoJapan Department of Radiology Tokai University Hachioji HospitalHachioji 192-0032TokyoJapan

BACKGROUND Neoadjuvant chemoradiotherapy(NACRT)has not been accepted as a general therapy for gastric cancer because of its localized effect and toxicity for radiosensitive ***,if radiation therapy could compensate for the limited or inadequate treatment choices available for elderly patients and/or those at high risk,the available therapeutic options for advanced gastric cancer might *** this perspective,we present our experiences of five patients with advanced gastric cancer in whom we used NACRT therapy with interesting *** SUMMARY We admitted five patients with clinical Stage III gastric cancer and bulky lymph node metastasis or adjacent organ invasion at the time of diagnosis.A total of 50 Gy of preoperative intensity modulated radiation therapy was delivered to the patients in doses of 2.0 Gy/d,together with a regimen of concomitant chemotherapy comprising two courses of oral tegafur/gimeracil/oteracil(S-1;65 mg/m2 per day)for three consecutive weeks followed by two weeks of rest,starting at the same time as *** patients underwent no residual tumor resection and a pathological complete response of the primary tumors was achieved in two *** incidence of hematological toxicity was low,although the digestive toxicities of anorexia and diarrhea developed in three of the five patients,necessitating termination of radiation therapy at 30 Gy and S-1 at three ***,even 30 Gy of irradiation and half the dose of S-1 resulted in sufficient downstaging,indicating that even a reduced amount of NACRT could confer considerable *** Slightly reduced NACRT might be useful and safe for patients with locally advanced gastric cancer.

关键词： Advanced gastric cancer Neoadjuvant chemoradiotherapy Intensity modulated radiation therapy Tegafur/gimeracil/oteracil Curative resection Case report Gastrectomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Corticospinal excitability during motor imagery is diminished by continuous repetition-induced fatigue

引用

Neural Regeneration Research 2021年第6期16卷 1031-1036页

作者： Akira Nakashima Takefumi Moriuchi Daiki Matsuda Takashi Hasegawa Jirou Nakamura Kimika Anan Katsuya Satoh Tomotaka Suzuki Toshio Higashi Kenichi sugawara Department of Rehabilitation Juzenkai HospitalNagasakiJapan Graduate School of Biomedical Sciences Nagasaki UniversityNagasakiJapan School of Rehabilitation Kanagawa University of Human ServicesYokosukaJapan

Application of continuous repetition of motor imagery can improve the performance of exercise ***,there is a lack of more detailed neurophysiological evidence to support the formulation of clear standards for interventions using motor ***,identification of motor imagery intervention time is necessary because it exhibits possible central ***,the purpose of this study was to elucidate the development of fatigue during continuous repetition of motor imagery through objective and subjective *** study involved two *** experiment 1,14 healthy young volunteers were required to imagine grasping and lifting a 1.5-L plastic bottle using the whole *** participant performed the motor imagery task 100 times under each condition with 48 hours interval between two conditions:500 mL or 1500 mL of water in the bottle during the demonstration *** fatigue and a decrease in pinch power appeared under the 1500-mL *** were changes in concentration ability or corticospinal excitability,as assessed by motor evoked potentials,between each set with continuous repetition of motor imagery also under the 1500-mL ***,in experiment 2,12 healthy volunteers were required to perform the motor imagery task 200 times under the 1500-mL *** concentration ability and corticospinal excitability *** is the first study to show that continuous repetition of motor imagery can decrease corticospinal excitability in addition to producing mental *** study was approved by the Institutional Ethics Committee at the Nagasaki University Graduate School of Biomedical and Health Sciences(approval No.18121302)on January 30,2019.

关键词： central nervous system concentration continuous repetition of motor imagery corticospinal excitability mental fatigue motor evoked potential motor imagery muscle fatigue neurophysiology transcranial magnetic stimulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical significance of subcellular localization of KL-6 mucin in primary colorectal adenocarcinoma and metastatic tissues

引用

World Journal of Gastroenterology 2006年第1期12卷 54-59页

作者： Qian Guo Wei Tang Yoshinori Inagaki Yutaka Midorikawa Norihiro Kokudo Yasuhiko sugawara MunehiroNakata Toshiro Konishi Hirokazu Nagawa Masatoshi Makuuchi Hepatobiliary-Pancreatic Surgery Division Department of Surgery GraduateSchool of Medicine the University of Tokyo 7-3-1 HongoBunkyo-ku Tokyo 113-8655 Japan Department of Applied Biochemistry and Institute of Glycotechnology Tokai University Hiratsuka Kanagawa 259-1292 Japan Kanto Medical Center NTT EC 5-9-22 Higashigotanda Shinagawa-ku Tokyo 141-8625 Japan Surgical Oncology Division Department of Surgery Graduate School of Medicine the University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan

AIM： To assess subcellular localization of KL-6 mucin and its clinicopathological significance in colorectal carcinoma as well as metastatic lymph node and liver tissues. METHODS： Colorectal carcinoma tissues as well as metastatic lymph node and liver tissues were collected from 82 patients who underwent colorectomy or hepatectomy. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS： Of the 82 colorectal carcinoma patients, 6 showed no staining, 29 showed positive staining only in the apical membrane, and 47 showed positive staining in the circumferential membrane and/or cytoplasm. Positive staining was not observed in non-cancerous colorectal epithelial cells surrounding the tumor tissues. The five-year survival rate was significantly lower in cases showing positive staining in the circumferential membrane and/or cytoplasm （63.0%） than those showing positive staining only in the apical membrane （85.7%） and those showing no staining （100%）. Statistical analysis between clinicopathological factors and subcellular localization of KL-6 mucin showed that KL-6 localization in the circumferential membrane and/or cytoplasm was significantly associated with the presence of venous invasion （P = 0.0003）, lymphatic invasion （P 〈 0.0001）, lymph node metastasis （P〈0.0001）, liver metastasis （P = 0.058）, and advanced histological stage （P〈 0.0001）. Positive staining was observed in all metastatic lesions tested as well as in the primary colorectal carcinoma tissues. CONCLUSION： The subcellular staining pattern of KL-6 in colorectal adenocarcinoma may be an important indicator for unfavorable behaviors such as lymph node and liver metastasis, as well as for the prognosis of patients.

关键词： KL-6 mucin Colorectal carcinoma Metasta-sis Prognosis Immunohistochemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Multi-Section Quantum-Dot Semiconductor Optical Amplifier for Ultrabroad-Band Gain-Flattened Low-Noise Amplification

引用

光学学报 2003年第S1期23卷 459-460页

作者： Tomoyuki Akiyama Mitsuru sugawara Koji Otsubo Hiroji Ebe Nobuaki Hatori Yasuhiko Arakawa Fujitsu Ltd. Kanagawa JapanUniversity of Tokyo Tokyo JapanFujitsu Ltd. Kanagawa JapanUniversity of Tokyo Tokyo JapanUniversity of Tokyo Tokyo JapanUniversity of Tokyo Tokyo Japan

We propose an ultrabroad-band 1R regenerator utilizing a multi-section quantum-dot semiconductor optical amplifier. Due to the reduced electron states, quantum dot is beneficial in broadening the gain spectrum and lowering the noise figure. Combining this with a multi-section structure drastically improves the gain equality among the different bound states, leading to an increase in the maximum output power and an improvement of the noise figure.

关键词： for in of be it A Multi-Section Quantum-Dot Semiconductor Optical Amplifier for Ultrabroad-Band Gain-Flattened Low-Noise Amplification MOP SOA NF dBm QDs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Applications of quantum computing for investigations of electronic transitions in phenylsulfonyl-carbazole TADF emitters

引用

npj Computational Materials 2021年第1期7卷 619-627页

作者： Qi Gao Gavin O.Jones Mario Motta Michihiko sugawara Hiroshi CWatanabe Takao Kobayashi Eriko Watanabe Yu-ya Ohnishi Hajime Nakamura Naoki Yamamoto Mitsubishi Chemical Corporation Science&Innovation CenterYokohamaJapan Quantum Computing Center Keio UniversityYokohamaJapan IBM Quantum IBM Research-AlmadenSan JoseCAUSA Materials Informatics Initiative Yokkaichi Research CenterJSR CorporationYokkaichiMieJapan IBM Research-Tokyo TokyoJapan Department of Applied Physics and Physico-Informatics Keio UniversityYokohamaJapan

A quantum chemistry study of the first singlet(S_(1))and triplet(T_(1))excited states of phenylsulfonyl-carbazole compounds,proposed as useful thermally activated delayed fluorescence(TADF)emitters for organic light emitting diode(OLED)applications,was performed with the quantum Equation-Of-Motion Variational Quantum Eigensolver(qEOM-VQE)and Variational Quantum Deflation(VQD)algorithms on quantum simulators and *** quantum simulations were performed with double zeta quality basis sets on an active space comprising the highest occupied and lowest unoccupied molecular orbitals(HOMO,LUMO)of the TADF *** differences in energy separations between S_(1) and T_(1)(ΔEST)predicted by calculations on quantum simulators were found to be in excellent agreement with experimental *** of 17 and 88 mHa with respect to exact energies were found for excited states by using the qEOM-VQE and VQD algorithms,respectively,to perform simulations on quantum devices without error *** utilizing state tomography to purify the quantum states and correct energy values,the large errors found for unmitigated results could be improved to differences of,at most,4 mHa with respect to exact ***,excellent agreement could be found between values ofΔEST predicted by quantum simulations and those found in experiments.

关键词： quantum excited occupied

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A high quality surface finish grinding process to produce total reflection mirror for x-ray fluorescence analysis

引用

International Journal of Extreme Manufacturing 2020年第1期2卷 156-162页

作者： Hitoshi Ohmori Shinjiro Umezu Yunji Kim Yoshihiro Uehara Hiroshi Kasuga Teruko Kato Nobuhide Itoh Syuhei Kurokawa Takayuki Kusumi Yugo sugawara Shinsuke Kunimura Materials Fabrication Laboratory RIKENSaitama 351-0198Japan Department of Modern Mechanical Engineering Waseda UniversityTokyo 169-8555Japan Department of Mechanical Systems Engineering Ibaraki UniversityIbaraki 316-8511Japan Department of Mechanical Engineering Kyushu UniversityFukuoka 819-0395Japan New technology developments Akita Industrial Technology CentreAkita 010-1623Japan Department of Industrial Chemistry Tokyo University of ScienceTokyo 162-8601Japan

Total reflection x-ray fluorescence analysis is applied to trace element detection in liquid for effective environmental *** analytical approach requires x-ray total reflection *** order to achieve high sensitivity element detection,the mirrors require high surface quality for high x-ray *** finishing for x-ray mirrors is typically conducted through a series of abrasive processes,such as grinding and polishing,and is thus time *** purpose of this study is to streamline and enhance the surface finishing process based on unique high quality grinding techniques for the production of x-ray total reflection mirrors.

关键词： grinding finishing x-ray mirror

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of Models for Excess Mortality of Influenza Applied to Japan

引用

Journal of Biosciences and Medicines 2019年第6期7卷 13-23页

作者： Tamie sugawara Yasushi Ohkusa Infectious Disease Surveillance Center National Institute of Infectious Diseases Shinjuku Tokyo Japan

To elucidate the social effects of an influenza outbreak, the World Health Organization recommends a concept for excess mortality attributable to an influenza outbreak. However, because several models exist to estimate excess mortality, we would like to ascertain the most appropriate of three models: the Center for Disease Control and Prevention (CDC) model, the seasonal autoregressive integrated moving average (SARIMA) model, and the National Institution of Infectious Diseases (NIID) model. Excess mortality is defined as the difference between the actual number of deaths and the epidemiological threshold. The epidemiological threshold is defined as upper bound of 95% confidence interval (CI) of the baseline. The actual number of deaths might be less than the baseline, which implies inconsistent with the definition of baseline. Especially, actual deaths fewer than the lower bound of 95% CI of baseline suggest the inappropriateness of a model of excess mortality. Among 123 months during epidemic periods, the NIID model found excess mortality in 56 months, CDC model in 31 months, and SARIMA model in 35 months. Conversely, the NIID model found negative excess mortality in only 2 months, but the CDC model and SARIMA model found it respectively for 10 and 33 months. Negative excess mortality represents the logical inconsistency of the model. Therefore, NIID model might be the best among the three models considered.

关键词： CDC Model Excess Mortality Influenza NIID Model SARIMA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression

引用

World Journal of Gastroenterology 2005年第35期11卷 5450-5454页

作者： Wei Tang Yoshinori Inagaki Norihiro Kokudo Qian Guo Yasuji Seyama Munehiro Nakata Hiroshi Imamura Keiji Sano Yasuhiko sugawara Masatoshi Makuuchi Hepato-Biliary-Pancreatic Surgery Division Department of Surgery1Graduate School of Medicine the University of Tokyo 7-3-1 HongoIBunkyo-ku Tokyo 113-8655 Japan Department of Applied Biochemistry TokaiUniversity Hiratsuka Kanagawa 259-1292 Japan Department of Applied-Biochemistry andInstitute of Glycotechnology Tokai University HiratsukaKanagawa 259-1292 Japan

AIM： To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater. METHODS： Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS： Positive staining of ampullary carcinoma cells was observed in 26 （68.4%） cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis （P = 0.020）, pancreatic invasion （P = 0.016）, duodenal invasion （P = 0.034）, and advanced stage of TNM clinical classification （P = 0.010）. Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis （P = 0.029）. CONCLUSION： The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of cardnoma of the ampulla of Vater.

关键词： KL-6 mucin Carcinoma of the ampulla of Vater Invasion Metastasis Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ionic Debye Screening in Dense Liquid Plasmas Observed for Li+p,d Reactions with Liquid Li Target

引用

原子核物理评论 2009年第S1期26卷 44-48页

作者： J.Kasagi H.Yonemura Y.Toriyabe A.Nakagawa T.sugawara Laboratory of Nuclear Science Tohoku University

Thick target yields of α particles emitted in the 6Li(d,α)4He and 7Li(p,α)4He reactions were measured for Li target in the solid and liquid phase. Observed reaction rates for the liquid Li are always larger than those for the solid. This suggests that the stopping power of hydrogen ion in the liquid Li metal might be smaller than in the solid. Using the empirically obtained stopping power for the liquid Li,we have deduced the screening potentials of the Li+p and Li+d reactions in both phases. The deduced screening potential for the liquid Li is about 500 eV larger than for the solid. This difference is attributed to the effect of liquefied Li+ ions. It is concluded that the ionic screening is much stronger than the electronic screening in a low-temperature dense plasmas.

关键词： low energy nuclear reaction Li+p and Li+d reaction in liquid Li liquid metal Li screening energy.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Introduction of Human Resource Development of Rehabilitation Project

Introduction of Human Resource Development of Rehabilitation...

引用

中国康复医学会首届儿童康复学术会议暨中国残疾人康复协会第八届小儿脑瘫学术会议

作者： Yoko sugawara Japan International Cooperation Agency.The Project for Human Resources Development of Rehabilitation Professionals

We would like to introduce the Project in China Rehabilitation Research Center that began from November, 2001. The purpose of this Project is to develop curriculums meeting international standards of Physical therapy and Occupational therapy, to produce highly qualified teaching professionals and to prepare teaching materials and educational equipment. From last year, Chinese counterparts who studied in Japan had started to teach about special course. From this year, separated special course of Physical therapy and Occupational therapy had opened for students. We will explain about specific action of experts of Japan and counterparts in China.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：