KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression
KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression作者机构：Hepato-Biliary-Pancreatic Surgery DivisionDepartment of Surgery1Graduate School of Medicine the University of Tokyo 7-3-1 HongoIBunkyo-ku Tokyo 113-8655 Japan Department of Applied Biochemistry TokaiUniversity Hiratsuka Kanagawa 259-1292 Japan Department of Applied-Biochemistry andInstitute of Glycotechnology Tokai University HiratsukaKanagawa 259-1292 Japan
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2005年第11卷第35期
页 面：5450-5454页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Grants-in-aid From the Ministry of Education Science Sports and Culture of Japan and a grant for Hi-Tech Research from Tokai University
主 题：KL-6 mucin Carcinoma of the ampulla of Vater Invasion Metastasis Prognosis
摘 要：AIM： To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater. METHODS： Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS： Positive staining of ampullary carcinoma cells was observed in 26 （68.4%） cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis （P = 0.020）, pancreatic invasion （P = 0.016）, duodenal invasion （P = 0.034）, and advanced stage of TNM clinical classification （P = 0.010）. Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis （P = 0.029）. CONCLUSION： The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of cardnoma of the ampulla of Vater.
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