Neoadjuvant chemoradiotherapy for locally advanced gastric cancer with bulky lymph node metastasis:Five case reports

作     者：Eiji Nomura Hajime Kayano Takashi Machida Hideki Izumi Soichiro Yamamoto Akitomo Sugawara Masaya Mukai Terumitsu Hasebe 

作者机构：Department of Gastroenterological and General SurgeryTokai University Hachioji HospitalHachioji 192-0032TokyoJapan Department of RadiologyTokai University Hachioji HospitalHachioji 192-0032TokyoJapan 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2020年第8卷第18期

页      面：4177-4185页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Tokai University Hachioji Hospital 

主　　题：Advanced gastric cancer Neoadjuvant chemoradiotherapy Intensity modulated radiation therapy Tegafur/gimeracil/oteracil Curative resection Case report Gastrectomy 

摘      要：BACKGROUND Neoadjuvant chemoradiotherapy(NACRT)has not been accepted as a general therapy for gastric cancer because of its localized effect and toxicity for radiosensitive ***,if radiation therapy could compensate for the limited or inadequate treatment choices available for elderly patients and/or those at high risk,the available therapeutic options for advanced gastric cancer might *** this perspective,we present our experiences of five patients with advanced gastric cancer in whom we used NACRT therapy with interesting *** SUMMARY We admitted five patients with clinical Stage III gastric cancer and bulky lymph node metastasis or adjacent organ invasion at the time of diagnosis.A total of 50 Gy of preoperative intensity modulated radiation therapy was delivered to the patients in doses of 2.0 Gy/d,together with a regimen of concomitant chemotherapy comprising two courses of oral tegafur/gimeracil/oteracil(S-1;65 mg/m2 per day)for three consecutive weeks followed by two weeks of rest,starting at the same time as *** patients underwent no residual tumor resection and a pathological complete response of the primary tumors was achieved in two *** incidence of hematological toxicity was low,although the digestive toxicities of anorexia and diarrhea developed in three of the five patients,necessitating termination of radiation therapy at 30 Gy and S-1 at three ***,even 30 Gy of irradiation and half the dose of S-1 resulted in sufficient downstaging,indicating that even a reduced amount of NACRT could confer considerable *** Slightly reduced NACRT might be useful and safe for patients with locally advanced gastric cancer.