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Mechanisms of tigecycline resistance in Gram-negative bacteria:A narrative review

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Engineering Microbiology 2024年第3期4卷 54-61页

作者： Wenya su Wenjia Wang ling Li Mengge Zhang Hai Xu Chengzhang Fu Xiuhua Pang Mingyu Wang State Key Laboratory of Microbial Technology Microbial Technology InstituteShandong UniversityQingdao 266237PR China Helmholtz Institute for Pharmaceutical Research Saarland(HIPS) Helmholtz Centre for Infection Research(HZI)and Department of PharmacySaarland UniversitySaarbrücken 66123Germany

Tigecycline serves as a critical“final-resort”antibiotic for treating bacterial infections caused by multidrug-resistant bacteria for which treatment options are severely *** increasing prevalence of tigecycline resistance,particularly among Gram-negative bacteria,is a major *** mechanisms have been iden-tified as contributors to tigecycline resistance,including upregulation of nonspecific Resistance Nodulation Divi-sion(RND)efflux pumps due to mutations in transcriptional regulators,enzymatic modification of tigecycline by monooxygenase enzymes,and mutations affecting tigecycline binding *** review aims to consolidate our understanding of tigecycline resistance mechanisms in Gram-negative bacteria and offer insights and perspectives for further drug development.

关键词： Gram-negative bacteria Tigecycline Tigecycline resistance Resistance mechanisms RND efflux pump

Recent advances in structural modification on graphitic carbon nitride(g-C_(3)N_(4))-based photocatalysts for high-efficiency photocatalytic H_(2)O_(2)production

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Nano Research Energy 2024年第1期3卷 101-151页

作者： Feng Ming Yap Grayson Zhi Sheng ling Brenden Jing su Jian Yiing Loh Wee-Jun Ong School of Energy and Chemical Engineering Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia Center of Excellence for NaNo Energy&Catalysis Technology(CONNECT) Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia State Key Laboratory of Physical Chemistry of Solid surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Gulei Innovation Institute Xiamen UniversityZhangzhou 363200China Shenzhen Research Institute of Xiamen University Shenzhen 518057China

To date,extensively high demand for hydrogen peroxide(H_(2)O_(2))has been predominantly supplied by the anthraquinone process for several worldwide applications,encompassing wastewater treatment,environmental remediation,and chemical ***,the compacted manufacturing,massive energy input and the release of tremendous wastes have restricted commercialization *** to mitigate such issues,the photocatalytic H_(2)O_(2)production by utilizing g-C_(3)N_(4)catalysts has endowed a greener,sustainable and promising alternative,considering that it involves water and oxygen as reactants in the present of sunlight as energy ***,we have manifested a comprehensive overview of the research progress for g-C_(3)N_(4)-based semiconductors for photocatalytic H_(2)O_(2)*** review has systematically elucidated state-of-the-art development of different modifications on g-C_(3)N_(4)to unravel the fundamental mechanism of H_(2)O_(2)evolution via oxygen reduction reaction(ORR)and water oxidation reaction(WOR).In addition,the contribution made by vacancy introduction,doping,heterogenization,and co-catalyst passivation with respect to photoefficiency enhancement have been ***,the current challenges and perspective of future development directions on photocatalytic H_(2)O_(2)production have also been *** such,g-C_(3)N_(4)stands as the next step toward advancement in the configuration and modulation of high-efficiency photocatalysts.

关键词： photocatalysis g-C_(3)N_(4) H_(2)O_(2)production structural modification

Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons

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Biomedical and Environmental Sciences 2024年第5期37卷 479-493页

作者： LI Yang LIN Dan ZHANG Xiu Qin JU Guang Xiu su Ya ZHANG Qian DUAN Hai Ping YU Wei Sen WANG Bing ling PANG Shu Tao Department of Epidemiology and Health Statistics School of Public HealthQingdao UniversityQingdao 266021ShandongChina Department of Environmental Health Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Physicochemical Laboratory Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Section of Child Health Care Huangdao Maternity and Child Health Care Hospital of QingdaoQingdao 266499ShandongChina Qingdao Blood Center Qingdao 266071ShandongChina

Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal *** Liquid chromatography-tandem mass spectrometry was used to determine ten hydroxyl metabolites of PAHs(OH-PAHs)in 36-month-old ***,37 children were categorized into low-and high-exposure groups based on the sum of the ten ***-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify non-targeted metabolites in the urine ***,fecal flora abundance was assessed by 16S rRNA gene sequencing using Illumina *** The concentrations of 21 metabolites were significantly higher in the high exposure group than in the low exposure group(variable importance for projection>1,Psure in young children affected metabolic homeostasis,particularly that of certain gut microbiota-derived *** investigation is needed to explore the potential influence of PAHs on the gut microbiota and their possible association with neurodevelopmental outcomes.

关键词： Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile

UNIFORM ERROR BOUNDS OF A CONSERVATIVE COMPACT FINITE DIFFERENCE METHOD FOR THE QUANTUM ZAKHAROV SYSTEM IN THE suBSONIC LIMIT REGIME

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Journal of Computational Mathematics 2024年第1期42卷 289-312页

作者： Gengen Zhang Chunmei su School of Mathematics and Statistics Yunnan UniversityKunming 650504China Yau Mathematical Sciences Center Tsinghua UniversityBeijing 100084China

In this paper,we consider a uniformly accurate compact finite difference method to solve the quantum Zakharov system(QZS)with a dimensionless parameter 0<ε≤1,which is inversely proportional to the acoustic *** the s... 详细信息

In this paper,we consider a uniformly accurate compact finite difference method to solve the quantum Zakharov system(QZS)with a dimensionless parameter 0subsonic limit regime,i.e.,when 0sults are reported to verify the error behavior.

关键词： Quantum Zakharov system subsonic limit Compact finite difference method Uniformly accurate Error estimate

Hybrid Block Diagonalization Precoding for Multi-User Weighted sum-Rate Maximization

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China Communications 2024年第8期21卷 127-141页

作者： su Xiaofeng Jiang Yi Key Laboratory for Information Science of Electromagnetic Waves(MoE) Department of Communication Science and EngineeringFudan UniversityShanghai 200433China

This paper studies large-scale multi-input multi-output(MIMO)orthogonal frequency division multiplexing(OFDM)communications in a broadband frequency-selective channel,where a massive MIMO base station(BS)communicates with multiple users equipped with *** develop a hybrid precoding design to maximize the weighted sum-rate(WSR)of the users by optimizing the digital and the analog precoders *** the digital part,we employ block-diagonalization to eliminate inter-user interference and apply water-filling power allocation to maximize the *** the analog part,the optimization of the PSN is formulated as an unconstrained problem,which can be efficiently solved by a gradient descent *** results show that the proposed block-diagonal hybrid precoding algorithm can outperform the existing works.

关键词： block-diagonal gradient descent hybrid precoding iterative optimization MIMO-OFDM multi-user water-filling power allocation weighted sum-rate maximization

A real-world study of the differences in Traditional Chinese Medicine diagnosis and treatment rules for coronavirus disease 2019 between Northern and Southern China

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Journal of Traditional Chinese Medicine 2024年第4期44卷 822-829页

作者： su Rui su Youzhu WANG Shuo FAN Jie LIU Qingquan LIU Mifeng Department of infectious diseases Capital Medical University Beijing Hospital of Traditional Chinese MedicineBeijing 100010China

OBJECTIVE:To explore the differences in Traditional Chinese Medicine(TCM)diagnosis and treatment rules for coronavirus disease 2019(COVID-19)between Northern and Southern China based on the real-world data from 982 COVID-19 ***:All consecutive cases of COVID-19 admitted to the TCM department of designated COVID-19 hospitals in eight provinces and cities were retrospectively *** were divided into a Northern and a Southern group according to the location of the admitting *** symptoms,syndrome elements,syndrome distribution and herbal treatments were *** core prescriptions were extracted using the multiscale backbone-based network comparison algorithm(msbNC).REsuLTS:The distribution of syndrome elements showed that dampness was common in Northern and Southern China,wind and heat were more often present in the South,while fire toxin and spleen deficiency were more often encountered in the *** distribution of syndromes showed that the South was dominated by heat dampness accumulating in the lung(55.69%),while the North was dominated by dampness-toxin stagnating in the lung(44.90%).The results of core prescription mining showed that dispelling dampness,dispersing wind,clearing heat and strengthening spleen were the common treatment methods in Northern and Southern *** mild cases,Jinyinhua(Flos Lonicerae)and Lianqiao(Fructus Forsythiae suspensae)were often used in the South to clear heat and relieve exterior symptoms,while Chaihu(Radix Bupleuri Chinensis)and Huangqin(Radix Scutellariae Baicalensis)were often used in the North to relieve muscles by expelling *** moderate cases,Chaihu(Radix Bupleuri Chinensis),Qinghao(Herba Artemisiae Annuae),and Shigao(Gypsum Fibrosum)were often used to clear heat of Tri-jiao Channel and stomach in the South,while Fuling(Poria),Chenpi(Pericarpium Citri Reticulatae),and Dangshen(Radix Codonopsis)were often used to invigorate spleen and remove dampness in the *** severe cases

关键词： COVID-19 medicine,Chinese traditional North-South difference core prescription syndrome retrospective studies

Effect of male HBV infection on the outcomes of IVF/ICSI cycles:a retrospective cohort study based on propensity score matching

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Asian Journal of Andrology 2024年第4期26卷 415-420页

作者： su-Qin Zhu Xiu-Hua Liao Wen-Wen Jiang Yan sun Hui-ling Xu Xiao-Jing Chen Bei-Hong Zheng Fujian Provincial Reproductive Medicine Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics and Gynecology and PediatricsFujian Medical UniversityFuzhou 350001China Fujian Key Laboratory of Prenatal Diagnosis and Birth Defect Fuzhou 350001China Fujian Maternal-Fetal Clinical Medicine Research Center Fuzhou 350001China.

This study aimed to investigate the effects of male hepatitis B virus(HBV)infection on male fertility,embryonic development,and in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)*** performed a retrospective cohort study that included 3965 infertile couples who received fresh embryo transfer cycles for the first time at the Fujian Maternity and Child Health Hospital(Fuzhou,China)from January 2018 to January *** couples were categorized based on their HBV infection status into the HBV group(HBV-positive men and HBV-negative women)and the control group(HBV-negative couples).A 1:1 propensity score matching was performed with relatively balanced *** characteristics,semen parameters,laboratory outcomes,clinical outcomes,and obstetric and neonatal outcomes were compared between *** propensity score matching,821 couples were included in each *** groups had similar semen parameters and obstetric and neonatal *** HBV group showed a significantly lower live birth rate than the control group(P<0.05).The HBV group had a significantly higher abortion rate than the control group(P<0.05).The rates of high-quality embryos and blastocyst formation were significantly lower in the HBV group than those in the control group(both P<0.05).In conclusion,in couples who undergo IVF/ICSI,male HBV infection reduces the live birth rate and increases the risk of ***,the incidence of low birth weight in women with IVF/ICSI does not increase with male HBV infection.

关键词： hepatitis B virus in vitro fertilization intracytoplasmic sperm injection live birth rate propensity score matching

Parity-dependent skin effects and topological properties in the multilayer nonreciprocal su−Schrieffer−Heeger structures

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Frontiers of physics 2024年第3期19卷 115-133页

作者： Jia-Rui Li Cui Jiang Han su Di Qi Lian-Lian Zhang Wei-Jiang Gong College of Sciences Northeastern UniversityShenyang 110819China Basic Department Shenyang Institute of EngineeringShenyang 110136China

We concentrate on the skin effects and topological properties in the multilayer non-Hermitian su−Schrieffer−Heeger (SSH) structure, by taking into account the nonreciprocal couplings between the different sublattices in the unit cells. Following the detailed demonstration of the theoretical method, we find that in this system, the skin effects and topological phase transitions induced by nonreciprocal couplings display the apparent parity effect, following the increase of the layer number of this SSH structure. On the one hand, the skin effect is determined by the parity of the layer number of this SSH system, as well as the parity of the band index of the bulk states. On the other hand, for the topological edge modes, such an interesting parity effect can also be observed clearly. Next, when the parameter disorders are taken into account, the zero-energy edge modes in the odd-layer structures tend to be more robust, whereas the other edge modes are easy to be destroyed. In view of these results, it can be ascertained that the findings in this work promote to understand the influences of nonreciprocal couplings on the skin effects and topological properties in the multilayer SSH lattices.

关键词： multilayer SSH lattice nonreciprocal couplings band structure skin effect

Friction and Deformation Behavior of Human Skin During Robotic Sliding Massage Operation

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Journal of Bionic Engineering 2024年第4期21卷 1892-1904页

作者： Jingmei Zhai Rixing Li Ziqing su School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou510000China

This study investigates the friction and deformation behavior of the skin in contact with a rigid massage ball and its influencing *** and stretching experiments were conducted using a collaborative robot experimental *** experiments encompassed a loading normal force range of 2 N to 18 N and a sliding speed range of 10 mm/s to 20 mm/*** friction response curve exhibits two different stages:static stick state and dynamic stick-slip stage,both of which have been mathematically *** analyzing the experimental data,we analyzed the effects of elastic modulus,sliding speed and normal loading force on skin tangential friction and tensile *** results indicate that as the normal load increases,both friction and deformation exhibit an ***,they decrease with an increase in elastic ***,while deformation diminishes with higher sliding speed,friction force remains relatively unaffected by *** observation can be attributed to the strain rate sensitivity resulting from the viscoelastic characteristics of the skin under substantial *** study advances the understanding of friction and deformation behavior during skin friction,offering valuable insights to enhance the operational comfort of massage robots.

关键词： Human skin Friction sliding Deformation Robotic massage Stereo image