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Elevated CXCL1 triggers dopaminergic neuronal loss in the substantia nigra of C57BL/6J mice: Evaluation of a novel Parkinsonian mouse model

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Zoological Research 2025年第01期 225-235页

作者： xi-Zhen Ma Guo-Rui Jia Meng-Yu Li Sheng-Han Zhang Zhao-xin Wang Ning song Ying-Juan Liu Jun-xia xie Institute of Brain Science and Disease School of Basic Medicine Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders Qingdao University College of Life Sciences and Health University of Health and Rehabilitation Science

Substantial evidence points to the early onset of peripheral inflammation in the development of Parkinson's disease(PD), supporting the “body-first” hypothesis. However,there remains a notable absence of PD-specific animal models induced by inflammatory cytokines. This study introduces a novel mouse model of PD driven by the proinflammatory cytokine CXCL1, identified in our previous research. The involvement of CXCL1 in PD pathogenesis was validated using subacute and chronic MPTP-induced mouse models. Based on these findings, 2-month-old C57BL/6J mice were intravenously administered CXCL1(20 ng/kg/day) for 2 weeks(5 days per week), successfully replicating motor deficits and pathological alterations in the substantia nigra observed in the chronic MPTP *** results demonstrate the potential of CXCL1-induced inflammation as a mechanism for PD modeling. The model revealed activation of the PPAR signaling pathway in CXCL1-mediated neuronal damage by CXCL1. Linoleic acid, a PPAR-γ activator, significantly mitigated MPTPand CXCL1-induced toxicity and reduced serum CXCL1levels. In addition, the CXCL1-injected mouse model shortened the timeline for developing chronic PD mouse model to 2 weeks, offering an efficient platform for studying inflammation-driven processes in PD. The findings provide critical insights into the inflammatory mechanisms underlying PD and identify promising therapeutic targets for intervention.

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Analysis of risk factors for bile leakage after laparoscopic exploration and primary suture of common bile duct

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 278-287页

作者： Qing-song Yang Meng Zhang Chang-song Ma Da Teng Ao Li Ji-Dong Dong xi-Fei Wang Fu-Bao Liu Department of Hepatopancreatobiliary Surgery Affiliated Chuzhou Hospital of Anhui Medical University(The First People’s Hospital of Chuzhou)Chuzhou 239001Anhui ProvinceChina Department of Hepatobiliary and Pancreatic Surgery General SurgeryThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina

BACKGROUND Bile leakage is a common complication following laparoscopic common bile duct exploration(LCBDE)with primary duct closure(PDC).Identifying and analyzing the risk factors associated with bile leakage is crucial for improving surgical *** To explore the value analysis of common risk factors for bile leakage after LCBDE and PDC,with a focus on strict adherence to *** Clinical data of 106 cases undergoing LCBDE+PDC in the Hepatobiliary and Pancreatic Surgery Department(Division 1)of Chuzhou First People’s Hospital from April 2019 to March 2024 were *** and multiple factor regression analysis were conducted on common risk factors for bile *** change in surgical time was analyzed using the cumulative summation(CUSUM)method,and the minimum number of cases required to complete the learning curve for PDC was obtained based on the proposed fitting curve by identifying the CUSUM maximum *** Multifactor logistic regression analysis showed that fibrinous inflammation and direct bilirubin/indirect bilirubin were significant independent high-risk factors for postoperative bile leakage(P<0.05).The time to drain removal and length of hospital stay in cases without bile leakage were significantly shorter than in cases with bile leakage(P<0.05),with statistical *** CUSUM method indicated that a minimum of 51 cases were required for the surgeon to complete the learning curve(P=0.023).CONCLUSION With a good assessment of duodenal papilla sphincter function,unobstructed bile-pancreatic duct convergence,exact stone clearance,and sufficient surgical experience to complete the learning curve,PDC remains the preferred method for bile duct closure and is worthy of clinical promotion.

关键词： Laparoscopic common bile duct exploration Primary duct closure Bile leakage Risk factor analysis Cumulative summation

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建筑机械加工轴承表面缺陷光学识别模型

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机械设计与制造 2025年第1期407卷 214-217,221页

作者：焦宏涛赵嵩郑州铁路职业技术学院河南郑州450052 河南大学河南郑州450046

建筑机械加工轴承表面缺陷识别技术的表面缺陷识别效果不佳,影响工业生产的安全性。为了解决这一问题,提出建筑机械加工轴承表面缺陷光学识别模型构建方法。获取多角度机械加工轴承表面图像,将建筑机械加工轴承表面展开,再进行二维图像... 详细信息

建筑机械加工轴承表面缺陷识别技术的表面缺陷识别效果不佳,影响工业生产的安全性。为了解决这一问题,提出建筑机械加工轴承表面缺陷光学识别模型构建方法。获取多角度机械加工轴承表面图像,将建筑机械加工轴承表面展开,再进行二维图像拼接,获得建筑机械加工轴承表面没有重复且完整的二维图像;通过局部与全部相结合的平滑策略构建光流误差轨迹模型,在光流求解策略的基础上,构建建筑机械加工轴承表面缺陷光学识别模型,计算建筑机械加工轴承表面二维图像的光流值,根据计算结果对建筑机械加工轴承表面缺陷情况进行判定,实现建筑机械加工轴承表面缺陷的识别。实验结果表明,所提方法的轴承表面缺陷识别率高、识别用时明显提升。

关键词：机械加工轴承表面缺陷识别图像展开图像拼接

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Genome-wide investigation of defensin genes in apple(Malus×domestica Borkh.) and in vivo analyses show that MdDEF25 confers resistance to Fusarium solani

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Journal of Integrative Agriculture 2025年第1期24卷 161-175页

作者： Mengli Yang Jian jiao Yiqi Liu Ming Li Yan xia Feifan Hou Chuanmi Huang Hengtao Zhang Miaomiao Wang Jiangli Shi Ran Wan Kunxi Zhang Pengbo Hao Tuanhui Bai Chunhui song Jiancan Feng xianbo Zheng College of Horticulture Henan Agricultural UniversityZhengzhou 450046China Zhengzhou Fruit Research Institute Chinese Academy of Agricultural SciencesZhengzhou 450009China

Apple replant disease is a complex soil syndrome that occurs when the same fields are repeatedly utilized for apple orchard *** can be caused by various pathogens,and Fusarium solani is the main *** solani disrupts the structure and function of the orchard soil ecosystem and inhibits the growth and development of apple trees,significantly impacting the quality and yield of *** this study,we conducted a transcriptome comparison between uninoculated apple saplings and those inoculated with F:*** differentially expressed genes were mainly enriched in processes such as response to symbiotic *** defensins are antimicrobial peptides,but their roles during *** infection remain *** performed a genome-wide identification of apple defensin genes and identified 25 genes with the conserved motif of eight cysteine *** wildtype apple rootstock inoculated with ***,the root surface cells experienced severe damage,and showed significant differences in the total root length,total root projection area,root tips,root forks,and total root surface area compared to the control ***-PCR analysis revealed that MdDEF3 and MdDEF25 were triggered in response to *** infection in *** localization showed specific expression of the MdDEF3-YFP and MdDEF25-YFP proteins on the cell *** theMdDEF25-YFP fusiongene enhanced resistance against *** in apple,providing a new strategy for the future prevention and biological control of apple replantdisease.

关键词： apple Fusarium solani defensin resistance replant disease

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Tailoring Cathode-Electrolyte Interface for High-Power and Stable Lithium-Sulfur Batteries

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Nano-Micro Letters 2025年第4期17卷 181-211页

作者： Mengting Liu Ling-jiao Hu Zhao-Kun Guan Tian-Ling Chen xin-Yu Zhang Shuai Sun Ruoli Shi Panpan Jing Peng-Fei Wang Center of Nanomaterials for Renewable Energy State Key Laboratory of Electrical Insulation and Power EquipmentSchool of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049People’s Republic of China Low-Dimensional Materials and Photo/Electrochemical Technology Lab School of Materials Science and EngineeringShaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic MaterialsShaanxi University of Science&TechnologyXi’an 710021People’s Republic of China

Global interest in lithium-sulfur batteries as one of the most promising energy storage technologies has been sparked by their low sulfur cathode cost,high gravimetric,volumetric energy densities,abundant resources,and environmental ***,their practical application is significantly impeded by several serious issues that arise at the cathode-electrolyte interface,such as interface structure degradation including the uneven deposition of Li_(2)S,unstable cathode-electrolyte interphase(CEI)layer and intermediate polysulfide shuttle ***,an optimized cathode-electrolyte interface along with optimized electrodes is required for overall ***,we comprehensively outline the challenges and corresponding strategies,including electrolyte optimization to create a dense CEI layer,regulating the Li_(2)S deposition pattern,and inhibiting the shuttle effect with regard to the solid-liquid-solid pathway,the transformation from solid-liquid-solid to solid-solid pathway,and solid-solid pathway at the cathode-electrolyte *** order to spur more perceptive research and hasten the widespread use of lithium-sulfur batteries,viewpoints on designing a stable interface with a deep comprehension are also put forth.

关键词： Lithium-sulfur batteries Shuttle effect Cathode-electrolyte interface Structural enhancement Reaction pathway

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Combined anisotropic and cyclic constitutive model for laser powder bed fusion fabricated aluminum alloy

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Chinese Journal of Aeronautics 2025年第1期38卷 165-184页

作者： Fei-Fan LI Jihong ZHU Weihong ZHANG Shifeng WEN Jingwen song Jun MA Gang FANG State IJR Center of Aerospace Design and Additive Manufacturing School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi'an 710072China Department of Mechanical and Industrial Engineering Norwegian University of Science and TechnologyTrondheim 7491Norway State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China

This study presents new methods to effectively model the anisotropic yielding and hardening behavior of laser powder bed fusion fabricated aluminum alloy under both monotonic and cyclic loading *** proposed model combines the yield surface-interpolation method to accurately describe the anisotropic hardening rates in various directions,with the Chaboche kinematic hardening rule to precisely reflect the cyclic *** numerical implementation of the combined anisotropic and cyclic constitutive model,a fully implicit stress integration algorithm based on return mapping method is ***,the multiple parameters associated with the model are categorized and identified in an uncoupled *** isotropic and cyclic hardening parameters are determined by an inverse method,and the stability of the optimization outcomes is validated by applying different starting points for the ***,the back-stress effect on the identification of anisotropic parameters associated with the stress invariant-based Hill48 yield function is considered for the first *** consideration leads to an improved prediction accuracy compared to the identification of anisotropic parameters without considering back-stress *** combined anisotropic and cyclic constitutive model,along with the calibrated parameters,are proven capable of accurately reproducing the intricate deformation behavior of laser powder bed fusion fabricated AlSi10Mg.

关键词： Constitutive models Anisotropy Kinematic hardening Laser powder bed fusion Aluminum alloys

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Imperative for long-term management and surveillance in Kawasaki disease

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World Journal of Clinical Cases 2025年第4期13卷 61-63页

作者： Yan Pan Fu-Yong jiao Department of Pediatrics The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Shaanxi Kawasaki Disease Diagnosis and Treatment Center Children’s HospitalShaanxi Provincial People’s Hospital of Xi’an Jiaotong UniversityXi’an 710000Shaanxi ProvinceChina

Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery *** the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical *** editorial emphasizes the critical need for long-term management and regular surveillance to prevent such *** drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.

关键词： Kawasaki disease Long-term management Coronary artery aneurysm Surveillance Preventive care

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Brain Functional Networks with Dynamic Hypergraph Manifold Regularization for Classification of End-Stage Renal Disease Associated with Mild Cognitive Impairment

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Computer Modeling in Engineering & Sciences 2023年第6期135卷 2243-2266页

作者： Zhengtao xi Chaofan song Jiahui Zheng Haifeng Shi Zhuqing jiao School of Microelectronics and Control Engineering Changzhou UniversityChangzhou213164China School of Computer Science and Artificial Intelligence Changzhou UniversityChangzhou213164China Department of Radiology Changzhou Second People’s Hospital Affiliated to Nanjing Medical UniversityChangzhou213003China

The structure and function of brain networks have been altered in patients with end-stage renal disease(ESRD).Manifold regularization(MR)only considers the pairing relationship between two brain regions and cannot represent functional interactions or higher-order relationships between multiple brain *** solve this issue,we developed a method to construct a dynamic brain functional network(DBFN)based on dynamic hypergraph MR(DHMR)and applied it to the classification of ESRD associated with mild cognitive impairment(ESRDaMCI).The construction of DBFN with Pearson’s correlation(PC)was transformed into an optimization *** convolution and hyperedge convolution superposition were adopted to dynamically modify the hypergraph structure,and then got the dynamic hypergraph to form the manifold regular terms of the dynamic *** DHMR and L_(1) norm regularization were introduced into the PC-based optimization model to obtain the final DHMR-based DBFN(DDBFN).Experiment results demonstrated the validity of the DDBFN method by comparing the classification results with several related brain functional network construction *** work not only improves better classification performance but also reveals the discriminative regions of ESRDaMCI,providing a reference for clinical research and auxiliary diagnosis of concomitant cognitive impairments.

关键词： End-stage renal disease mild cognitive impairment brain functional network dynamic hypergraph manifold regularization classification

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缬沙坦对小鼠能量代谢的影响及机制初探

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首都医科大学学报 2025年第1期46卷 106-114页

作者：纪文怡宋丽妮曹曦北京市糖尿病研究所北京100730 首都医科大学附属北京同仁医院内分泌科北京100730

目的研究血管紧张素Ⅱ受体拮抗剂(angiotensinⅡreceptor blocker,ARB)对小鼠能量代谢的影响及可能机制。方法①选用雄性6周龄C57BL/6N小鼠,分别以普通饲料(normal diet,ND)、高脂饲料(high-fat diet,HFD)喂养6周,诱导糖尿病肥胖小鼠,... 详细信息

目的研究血管紧张素Ⅱ受体拮抗剂(angiotensinⅡreceptor blocker,ARB)对小鼠能量代谢的影响及可能机制。方法①选用雄性6周龄C57BL/6N小鼠,分别以普通饲料(normal diet,ND)、高脂饲料(high-fat diet,HFD)喂养6周,诱导糖尿病肥胖小鼠,测定小鼠体质量、空腹血糖;②将高脂饮食诱导的糖尿病肥胖小鼠采用数字表法随机分为对照组(control,Con)、药物处理组(ARB),分别以每日3 mg/kg的0.9%(质量分数)氯化钠注射液(以下简称生理盐水)和缬沙坦灌胃处理6周后进行小鼠体质量、体温测定、葡萄糖耐量实验、呼吸代谢检测、脂肪组织苏木精-伊红染色(hematoxylin-eosin,HE)及棕色脂肪组织产热相关基因表达情况检测;③以雄性6周龄Leptin receptor基因敲除的糖尿病肥胖小鼠模型(db/db小鼠)为实验对象,同样分别以每日3 mg/kg的生理盐水和缬沙坦灌胃处理5周后进行小鼠体质量、空腹血糖及体温测定。结果高脂饮食成功诱导了糖尿病肥胖小鼠(HFD小鼠)模型,缬沙坦灌胃处理能显著降低HFD小鼠体质量增长率及db/db小鼠体质量。在HFD小鼠中,缬沙坦增加4℃冷处理环境中HFD小鼠体温,提高HFD小鼠能量消耗,但对HFD小鼠糖代谢无明显改善作用。在db/db小鼠中,与对照组相比,缬沙坦处理后db/db小鼠空腹血糖明显降低,4℃冷处理2 h和3 h体温有上升趋势,但差异无统计学意义。此外,在HFD小鼠中,缬沙坦处理使棕色脂肪组织(brown adipose tissue,BAT)、皮下脂肪组织(subcutaneous adipose tissue,SUB)以及性腺旁脂肪组织(epididymal adipose tissue,EP)细胞体积明显减小,并且在mRNA水平,缬沙坦促进了BAT中UCP1的表达,Prdm16、PGC1α、AP2表达无明显改变。结论缬沙坦可改善肥胖小鼠能量代谢,其机制可能与ARB对BAT产热功能的促进作用有关。

关键词：血管紧张素Ⅱ受体拮抗剂糖脂代谢棕色脂肪组织产热功能

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基于系统权变组织理论的县级公立中医医院治理

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中国医院 2025年第3期29卷 51-54页

作者：尹然焦楠杨子涵谭曦北京中医药大学机关党委北京市朝阳区100029 北京中医药大学国家中医药高等教育研究院北京市朝阳区100029 北京中医药大学管理学院北京市朝阳区100029 北京中医药大学深圳医院(龙岗) 广东省深圳市518172

县级公立中医医院作为卫生医疗体系中的一环,起到承接大型综合医院和引领乡镇医院的重要作用。因此,县级公立中医医院的独特定位及学科特性要求其具有一定“韧性”,以面对外界风险和不确定性。作者基于系统权变组织理论,从物理韧性维度... 详细信息

县级公立中医医院作为卫生医疗体系中的一环,起到承接大型综合医院和引领乡镇医院的重要作用。因此,县级公立中医医院的独特定位及学科特性要求其具有一定“韧性”,以面对外界风险和不确定性。作者基于系统权变组织理论,从物理韧性维度、组织结构韧性维度、经济技术韧性维度、社会心理韧性维度和管理韧性维度5个方面表现为县级公立中医医院韧性治理的维度,并提出相应韧性治理路径,以期提升县级公立中医医院应对风险挑战和复杂环境的能力,进而实现县级中医医院高质量发展。

关键词：韧性治理系统权变理论公立医院县级中医医院

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