Elevated CXCL1 triggers dopaminergic neuronal loss in the substantia nigra of C57BL/6J mice:Evaluation of a novel Parkinsonian mouse model

作     者：Xi-Zhen Ma Guo-Rui Jia Meng-Yu Li Sheng-Han Zhang Zhao-Xin Wang Ning Song Ying-Juan Liu Jun-Xia Xie Xi-Zhen Ma;Guo-Rui Jia;Meng-Yu Li;Sheng-Han Zhang;Zhao-Xin Wang;Ning Song;Ying-Juan Liu;Jun-Xia Xie

作者机构：Institute of Brain Science and DiseaseSchool of Basic MedicineShandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological DisordersQingdao UniversityQingdaoShandong 266071China College of Life Sciences and HealthUniversity of Health and Rehabilitation ScienceQingdaoShandong 266113China 

出 版 物：《Zoological Research》 (动物学研究(英文))

年 卷 期：2025年第46卷第1期

页      面：225-235页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (32471049,32170984,32471188,32200802) Natural Science Foundation of Shandong Province (ZR2023QH110) 

主　　题：Parkinson’s disease Mouse model CXCL1 Inflammation PPAR signaling pathway 

摘      要：Substantial evidence points to the early onset of peripheral inflammation in the development of Parkinson s disease(PD),supporting the“body-first***,there remains a notable absence of PD-specific animal models induced by inflammatory *** study introduces a novel mouse model of PD driven by the proinflammatory cytokine CXCL1,identified in our previous *** involvement of CXCL1 in PD pathogenesis was validated using subacute and chronic MPTP-induced mouse *** on these findings,2-month-old C57BL/6J mice were intravenously administered CXCL1(20 ng/kg/day)for 2 weeks(5 days per week),successfully replicating motor deficits and pathological alterations in the substantia nigra observed in the chronic MPTP *** results demonstrate the potential of CXCL1-induced inflammation as a mechanism for PD *** model revealed activation of the PPAR signaling pathway in CXCL1-mediated neuronal damage by *** acid,a PPAR-γactivator,significantly mitigated MPTPand CXCL1-induced toxicity and reduced serum *** addition,the CXCL1-injected mouse model shortened the timeline for developing chronic PD mouse model to 2 weeks,offering an efficient platform for studying inflammation-driven processes in *** findings provide critical insights into the inflammatory mechanisms underlying PD and identify promising therapeutic targets for intervention.