检索结果-南通市图书馆

Fe_(2)Mn(μ_(3)-O)(COO)_(6) Cluster Based Stable MOF for Oxidative Coupling of Amines via Heterometallic Synergy

Chinese Journal of Chemistry 2021年第11期39卷 2983-2989页

作者： Ying-xia Wang Hui-Min Wang Pan Meng Dong-xia song Zhikai Qi xian-ming Zhang Key Laboratory of Magnetic Molecules and Magnetic Information Materials(Ministry of Education) Institute of Chemistry and CultureSchool of Chemistry and Material ScienceShanxi Normal UniversityLinfenShanxi041004 China College of Chemistry&Chemical Engineering Key Laboratory of Interface Science and Engineering in Advanced MaterialMinistry of EducationTaiyuan University of TechnologyNo.79 Yingze WestTaiyuanShanxi030024 China

The direct catalytic oxidative coupling of amines is one of the attracting methods for the synthesis of a variety of pharmaceutical or industrial needed *** earth-abundant manganese based salts,oxides,and complexes have been applied in this ***,these compounds suffered from difficult separation,large catalyst loading,complicated reactivation or indeterminate *** the facts that metal-organic frameworks(MOFs)with crystalline structure,precise composition,and enormous surface area have superior performance in heterogeneous catalytic reactions,herein,we introduced Mn into[Fe_(3)(μ_(3)-O)(CH_(3)COO)_(6)],one of the precursors for the preparation of stable MOFs,and got[Fe_(2)Mn(μ_(3)-O)(CH_(3)COO)_(6)]*** ligand replacement with biphenyl-3,4’,5-tricarboxylic acid(BPTC),heterometallic cluster-based[Fe_(2)Mn(μ_(3)-O)(BPTC)2(DMF)2(H_(2)O)](1)was *** expected,1 is stable and able to catalyze the homo-or cross-coupling of amines effectively and selectively with 0.9 mol%catalyst loading at room *** experiments indicated that the catalytic activity of 1 mainly stems from Mn sites and that Fe synergistically contributes to the ***,1 is recyclable and can be reused easily for at least 8 runs without obvious decrease in catalytic *** our knowledge,1 should be the first heterometallic cluster-based MOF with defined structure suitable for the synthesis of diverse imines from oxidative coupling of amines under mild conditions,which may shed light on the easy preparation of effective heterogeneous catalysts for organic synthesis.

关键词： Amines Metal-organic frameworks Manganese Oxidative coupling Heterometallic synergy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

苯基吡唑缩氨基胍衍生物的合成及其抗菌活性研究

引用

井冈山大学学报（自然科学版） 2018年第5期39卷 67-72页

作者：罗辉陈华斌梁焯李程程宋明霞井冈山大学医学部基础医学与药学学院江西吉安343009

目的设计合成一系列苯基吡唑缩氨基胍衍生物,用于抗菌活性的筛选。方法以苯乙酮与盐酸氨基脲为原料,经亲核加成反应、Vilsmeier-Haack反应、亲核取代反应和缩合反应得最终产物4a～4j和5a～5c。采用连续稀释法评价13个化合物对革兰氏阳... 详细信息

目的设计合成一系列苯基吡唑缩氨基胍衍生物,用于抗菌活性的筛选。方法以苯乙酮与盐酸氨基脲为原料,经亲核加成反应、Vilsmeier-Haack反应、亲核取代反应和缩合反应得最终产物4a～4j和5a～5c。采用连续稀释法评价13个化合物对革兰氏阳性菌和革兰氏阴性菌的抑制活性。结果部分化合物对革兰氏阳性菌和阴性菌显示出一定的抑制活性,其中化合物5c对各种测定菌株均显示出抑制活性,对枯草芽孢杆菌(CMCC 63501)的抑菌活性MIC值达到16μg/mL。结论本研究合成的苯基吡唑缩氨基胍衍生物对所选择的革兰氏阳性菌和阴性菌具有一定的抑制活性,虽然活性强度未能达到预期目的,但该研究进一步丰富了缩氨基胍衍生物的抗菌构效关系,为新的抗菌活性化合物乃至候选药物的发现奠定了基础。

关键词：缩氦基胍苯基吡唑合成抗菌活性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Immobilizing Triphenylamine with Photoredox Inert Sr^(2+)Forming Sr-MOF with Controlled Electron Migration for Photocatalytic Oxidation of Thiols to Disulfides

引用

Chinese Journal of Chemistry 2024年第10期42卷 1093-1099页

作者： Ying-xia Wang Fang Zheng Dong-xia song Bao-Yue Niu Lu-Qian Deng xian-ming Zhang Key Laboratory of Magnetic Molecules and Magnetic Information Materials(Ministry of Education) Schoolof Chemistry and Materials ScienceShanxi Normal UniversityTaiyuanShanxi 030006China Key Laboratory of Interface Science and Engineering in Advanced Material(Ministry of Education) College of ChemistryTaiyuan University of TechnologyTaiyuanShanxi 030024China

The photocatalytic oxidative coupling of thiols is one of the most popular methods to synthesize the *** and its derivatives(TPAs)are promising for the above reaction,but suffer from the easy polymerization and difficult *** overcome these obstacles while controlling the photogenerated electrons transfer directly to target substrates,herein,we constructed one TPA-based metal-organic framework(MOF),(Me_(2)NH_(2))[Sr(TCBPA)]·DMA·3H_(2)O(1),by direct self-assembly of tris(4′-carboxybiphenyl)amine(H_(3)TCBPA)and photoredox inert strontium ion(Sr^(2+)).DFT calculations revealed that the valence band maximum(VBM)and the conduction band minimum(CBM)are mainly located on TCBPA^(3-),successfully inhibiting the undesirable electron migration to metal *** results indicated that 1 displays superior performance than homogeneous H_(3)TCBPA,which may result from the abundant π…π and C—H…π interactions between the well-arranged TCBPA^(3-)and the build-in electric field between the anionic framework and the Me_(2)NH^(2+).This work highlights that immobilizing TPAs into MOFs is one promising approach to designing heterogeneous photocatalysts for the synthesis of disulfides by oxidative coupling of thiols.

关键词： Triphenylamine Metal-organic frameworks Strontium Photooxidation Thiols Disulfides

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of processed Chinese medicinal materials using DNA mini-barcoding

引用

Chinese Journal of Natural Medicines 2017年第7期15卷 481-486页

作者： song ming DONG Gang-Qiang ZHANG Ya-Qin LIU xia SUN Wei Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China School of Chemistry Chemical Engineering and Life Sciences Wuhan University of Technology Wuhan 430070 China Amway (China) Botanical Research and Development Center Wuxi 214145 China

Most of Chinese medicinal herbs are subjected to traditional processing procedures, including stir-frying, charring, steaming, boiling, and calcining before they are released into dispensaries. The marketing and identification of processed medicinal materials is a growing issue in the marketplace. However, conventional methods of identification have limitations, while DNA mini-barcoding, based on the sequencing of a short-standardized region, has received considerable attention as a new potential means to identify processed medicinal materials. In the present study, six DNA barcode loci including ITS2, psb A-trn H, rbc L, mat K, trnL(UAA) intron and its P6 loop, were employed for the authentication of 45 processed samples belonging to 15 species. We evaluated the amplification efficiency of each locus. We also examined the identification accuracy of the potential mini-barcode locus, of trnL(UAA) intron P6 loop. Our results showed that the five primary barcode loci were successfully amplified in only 8.89%——20% of the processed samples, while the amplification rates of the trnL(UAA) intron P6 loop were higher, at 75.56% successful amplification. We compared the mini-barcode sequences with Genbank using the Blast program. The analysis showed that 45.23% samples could be identified to genus level, while only one sample could be identified to the species level. We conclude that trnL(UAA) p6 loop is a candidate mini-barcode that has shown its potential and may become a universal mini-barcode as complementary barcode for authenticity testing and will play an important role in medicinal materials control.

关键词： DNA barcoding trnL(UAA)intron P6 loop Identification Processed medicinal materials Mini-barcode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Electro-acupuncture on Expression of IRS-1/PI3K/GLUT4 Pathway in Ovarian Granulosa Cells of Infertile Patients with Polycystic Ovary Syndrome-Insulin Resistance of Phlegm-Dampness Syndrome

引用

Chinese Journal of Integrative Medicine 2021年第5期27卷 330-335页

作者： xiaNG Shan xia ming-feng song Jing-yan LIU Dan-qi LIAN Fang Gynecology of Traditional Chinese Medicine the First Clinical CollegeShandong University of Traditional Chinese MedicineJinan 250355China Reproductive and Genetic Center of Integrated Traditional and Western Medicine the Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250011China Experimental Center Shandong University of Traditional Chinese MedicineJinan 250355China

Objective:To evaluate the effect of electro-acupuncture(EA)in infertile patients with phlegmdampness polycystic ovary syndrome-insulin resistance(PCOS-IR).Methods:Seventy-six PCOS-IR patients who underwnet in vitro fertilization and embryo transfer(IVF-ET)were equally assigned to two groups according to a random digital table:the EA group and the control group,with 38 cases in each *** undergoing IVF,the two groups were treated with EA or pseudo-acupuncture,respectively,for 3 menstrual *** intervention was 25 min twice a week until the day of oocyte *** selected acupoints were Zhongwan(RN 12),Tianshu(ST 25),Daheng(SP 15),Daimai(GB 26),Qihai(CV 6),Guanyuan(CV 4),and bilateral points including Xuehai(SP 10),Fenglong(ST 40),Zusanli(ST 36),and Yinlingquan(SP 9).Evaluation of phlegm-dampness syndrome score and IR score were carried out before and after ***,the number of oocytes retrieved,transplantable embryo rate,high-quality embryo rate,clinical pregnancy rate and live birth rate were compared between the two ***-time polymerase chain reaction analysis was used to monitor the m RNA expression of the insulin receptor substrate(IRS-1),phosphatidylinositiol 3-kinase(PI3 K)and glucose transport factor 4(GLUT4)in ovarian granulosa ***:EA treatment reduced the phlegm-dampness syndrome score as well as the IR scores compared with the control group(P0.05).Moreover,the transplantable embryo rate[49.0%(284/580)vs.41.9%(273/652)],high-quality embryo rate[36.6%(104/284)vs.27.8%(76/273)],and live birth rate[50%(19/38)vs.26.3%(10/38)]in the EA group were significantly higher than in the control group(P<0.05).Gene expression analyses revealed significantly elevated IRS-1,PI3 K and GLUT4 m RNA in ovarian granulosa cells of the EA group compared with the control group(P<0.05).Conclusions:EA may ameliora

关键词： polycystic ovary syndrome phlegm-dampness syndrome electro-acupuncture insulin resistance granulosa cells mechanism of action

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

柿子叶有效部位的抗肿瘤活性研究

引用

井冈山大学学报（自然科学版） 2021年第6期42卷 25-29页

作者：刘彬宋明霞李东妮牛佳晓邓先清井冈山大学附属医院江西吉安343000 井冈山大学医学部江西吉安343009 井冈山大学中药资源和功能分子研究中心江西吉安343009

以柿子叶为研究对象,采用70%乙醇回流提取柿子叶的有效成分。提取物浓缩后加水搅拌,依次用石油醚、二氯甲烷、乙酸乙酯、正丁醇四种溶剂进行梯度萃取,浓缩各相,加上乙醇粗提物共得到六种干燥浸膏。采用CCK试剂检测法,测定六种浸膏对两... 详细信息

以柿子叶为研究对象,采用70%乙醇回流提取柿子叶的有效成分。提取物浓缩后加水搅拌,依次用石油醚、二氯甲烷、乙酸乙酯、正丁醇四种溶剂进行梯度萃取,浓缩各相,加上乙醇粗提物共得到六种干燥浸膏。采用CCK试剂检测法,测定六种浸膏对两组癌细胞人宫颈癌细胞Hela、肺癌细胞A549和正常细胞人肾上皮细胞293的生长抑制作用。结果表明,六种浸膏均具有较强抗肿瘤活性,其中二氯甲烷层和正丁醇层对Hela细胞抑制活性最好,其IC_(50)分别为0.24、0.26 mg/mL,A549细胞则对乙酸乙酯层更为敏感,其IC_(50)值低至0.03 mg/mL。此外,六种浸膏对正常人肾上皮细胞293也显示出明显的抑制作用,尤其是乙酸乙酯层,IC_(50)值达到0.93 mg/mL。研究证实了柿子叶具有明显抗肿瘤活性,且其活性成分复杂,在各相中均有分布,但又对不同细胞株活性各有差异,提示在后续的活性追踪中可以根据活性需求,选择恰当的柿子叶有效部位进行研究。

关键词：柿子叶提取物有效部位抗肿瘤活性 CCK法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

哺乳动物抗菌肽的生物信息学预测与分析

引用

广东农业科学 2015年第3期42卷 131-133,139页

作者：王艳丁雪赵晶宋明霞杜丰平周晓馥吉林师范大学生命科学学院吉林四平136000

抗菌肽(Antimicrobial peptides,AMPs)是能够抵抗病源微生物的小分子多肽,广泛分布于动植物、细菌、真菌等各种生物中,其在天然免疫中起着重要的作用。利用生物信息学方法,结合两大生物信息学门户网站ExPASy和NCBI,对截至2013年4月27日N... 详细信息

抗菌肽(Antimicrobial peptides,AMPs)是能够抵抗病源微生物的小分子多肽,广泛分布于动植物、细菌、真菌等各种生物中,其在天然免疫中起着重要的作用。利用生物信息学方法,结合两大生物信息学门户网站ExPASy和NCBI,对截至2013年4月27日NCBI上所有的哺乳动物抗菌肽条目的上述性质进行了详细分类,并对其氨基酸长度、平均疏水性、跨膜结构、信号肽、亚细胞定位等特征进行预测及分析。

关键词：哺乳动物抗菌肽生物信息学预测分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Theoretical Study on Photoisomerization of 2-Methylfuran to 3-Methylfuran

引用

Chinese Journal of Structural Chemistry 2006年第6期25卷 681-688页

作者： WANG Yan-xia YE song Department of Chemistry Yunnan University Kunming 650091 China

In the present work, the photoisomerization of 2-methylfuran to 3-methylfuran is investigated with the complete active space SCF （CASSCF） molecular orbital method. Geometries of minima and transition states on the excited and ground states are fully optimized at the CAS level with a 6-3 IG＊ basis set. A multireference MP2 algorithm that has been implemented in Gaussian is used to correct the energetics for dynamic correlation. The topology and reaction funnels of the singlet, triplet （S0, T1, T2） and potential energy surfaces have been characterized along the reaction coordinates corresponding to the mechanism. The reaction proceeds via two diradical intermediates, one intermediate product and four transition states. The two diradical S 1/T2 and T1/S0 energy surface crossing points are located along the reaction path and a T1/T2 conical intersection is also located. From this point the reaction soon returns to T1 surface. It is the most reasonable that the intersystem crossing from T1 to S0 takes place.

关键词： CASSCF photoisomerization intersystem crossing point reaction path

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Theoretical Study on the Triplet-sensitized Photolysis of 2,5-Dimethylfuran

引用

Chinese Journal of Structural Chemistry 2005年第10期24卷 1145-1151页

作者： WANG Yan-xia YE song Department of Chemistry Yunnan University Kunming 650091 China

In the present work, the triplet-sensitized photolysis of 2,5-dimethylfuran has been investigated with the complete active space SCF （CASSCF） molecular orbital method. Two different reaction routes through diradical and carbene intermediates respectively have been systematically studied, and the reaction via carbene intermediate is the major part well compatible with experiment. Geometries of minima and transition states on S0T1 surface were fully optimized at the CAS level with a 6-31G^＊ basis set. A multireference MP2 algorithm that has been implemented in Gaussian was used to correct the energetics for dynamic correlation. Four intersystem crossing points have been located and discussed, and two of them are efficient. Our computation indicates that the reaction must occur on the triplet-excited state.

关键词： CASSCF photolysis intersystem crossing point reaction path

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

半枝莲抗菌活性及其有效部位研究

引用

井冈山大学学报（自然科学版） 2018年第4期39卷 76-80页

作者：郑丽娟刘兵彭姣阳谭雨琪宋明霞井冈山大学医学院江西吉安343009

目的研究半枝莲不同粗提物的体外抗菌活性,并初步确定其抗菌活性有效部位。方法采用甲醇冷浸法、乙醇热回流法及微波萃取法提取粗提物,96孔板培养法测定不同粗提物对的体外抑菌活性;将提取物分别用石油醚、乙酸乙酯和水萃取得到不同极... 详细信息

目的研究半枝莲不同粗提物的体外抗菌活性,并初步确定其抗菌活性有效部位。方法采用甲醇冷浸法、乙醇热回流法及微波萃取法提取粗提物,96孔板培养法测定不同粗提物对的体外抑菌活性;将提取物分别用石油醚、乙酸乙酯和水萃取得到不同极性的萃取物组分,通过比较其抑菌活性初步确定半枝莲的抗菌有效部位。结果三种提取方法中,微波萃取法浸膏得出率最高;半枝莲的各粗提物对普通菌在2 mg/mL下未见抑制活性,但对耐甲氧西林金葡菌(ATCC33591和43300)半数抑制浓度(MIC值)达到2mg/mL;粗提物的萃取组分尤其是乙酸乙酯相,表现出广谱抗菌活性,其对各种菌株的半数抑制浓度大多在0.5～2 mg/mL范围,石油醚相对变异链球菌的抑菌活性较强,MIC值达到0.125 mg/mL。结论半枝莲具有广谱的抗菌活性,尤其是对耐药菌表现出较好的抗菌活性,并且初步确定抗菌有效部位为乙酸乙酯相,这为半枝莲抗菌应用的下一步研究奠定了基础。

关键词：半枝莲粗提物抗菌活性耐药菌有效部位

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：