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持续葡萄糖监测技术在糖尿病患者中的应用

中外医学研究 2024年第19期22卷 96-99页

作者：鄢赛高榕六盘水市人民医院贵州六盘水553000

目的:探究持续葡萄糖监测技术在糖尿病患者中的应用。方法:回顾性分析2023年1—12月六盘水市人民医院内分泌科住院及门诊就诊的180例糖尿病患者的临床资料。根据血糖监测方法的不同将其分为对照组和观察组,各90例。对照组实施指尖血糖监... 详细信息

目的:探究持续葡萄糖监测技术在糖尿病患者中的应用。方法:回顾性分析2023年1—12月六盘水市人民医院内分泌科住院及门诊就诊的180例糖尿病患者的临床资料。根据血糖监测方法的不同将其分为对照组和观察组,各90例。对照组实施指尖血糖监测,观察组实施持续葡萄糖监测技术。比较两组血糖水平,血糖达标情况,血糖波动情况,胰岛素用量,低血糖情况。结果:观察组午餐、晚餐前后血糖值均低于对照组,差异有统计学意义(P0.05);观察组四分位区间(IQR)、十分位数区间(IDR)均小于对照组,差异有统计学意义(P<0.05)。观察组日均胰岛素用量明显少于对照组,差异有统计学意义(t=4.849,P<0.001)。观察组低血糖发生率为18.89%,低于对照组的42.22%,差异有统计学意义(P<0.05)。结论:糖尿病患者实施持续葡萄糖监测的效果优于指尖血糖监测,血糖波动减少,胰岛素用量降低。

关键词：糖尿病指尖血糖监测持续葡萄糖监测血糖管理

电子在自旋-轨道耦合调制下磁受限半导体纳米结构中的传输时间及其自旋极化

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物理学报 2024年第11期73卷 377-384页

作者：温丽卢卯旺陈嘉丽陈赛艳曹雪丽张安琪桂林理工大学物理与电子信息工程学院桂林541004

通过考虑构筑在半导体GaAs/Al_(x)Ga_(1–x)As异质结上的磁受限半导体纳米结构中的塞曼效应和自旋-轨道耦合,本文采用理论分析和数值计算相结合的方法研究了电子的传输时间与自旋极化.利用矩阵对角化和改进的转移矩阵方法,数值求解电子... 详细信息

通过考虑构筑在半导体GaAs/Al_(x)Ga_(1–x)As异质结上的磁受限半导体纳米结构中的塞曼效应和自旋-轨道耦合,本文采用理论分析和数值计算相结合的方法研究了电子的传输时间与自旋极化.利用矩阵对角化和改进的转移矩阵方法,数值求解电子的薛定谔方程;采用***理论求电子的居留时间,并计算自旋极化率.由于塞曼效应与自旋-轨道耦合,电子的居留时间明显地与其自旋有关,因此可在时间维度上分离自旋、实现半导体中电子的自旋极化.因为半导体GaAs的有效g-因子很小,电子自旋极化主要源于自旋-轨道耦合,大约为塞曼效应引起的自旋极化的4倍.由于电子的有效势与自旋-轨道耦合的强度有关,电子的居留时间及其自旋极化可通过界面限制电场或应力工程进行有效调控.这些有趣的结果不仅对半导体自旋注入具有参考价值,而且还可为半导体自旋电子学器件应用提供时间电子自旋分裂器.

关键词：半导体自旋电子学磁调制半导体纳米结构自旋-轨道耦合居留时间

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面向自理型独居老人的智能化门厅设计

家具 2024年第4期45卷 19-23,63页

作者：刘树老闫赛华南师范大学美术学院广州510631

当今的各种社会原因导致大量独居老人出现,“居家养老”和“智能化养老”逐渐成为备受推广的养老模式,为提高居家老人生活质量,营造合理居家环境,有必要进行家居的适老化设计研究与实践,如何保障老年人的生活品质和健康状况受到家庭和... 详细信息

当今的各种社会原因导致大量独居老人出现,“居家养老”和“智能化养老”逐渐成为备受推广的养老模式,为提高居家老人生活质量,营造合理居家环境,有必要进行家居的适老化设计研究与实践,如何保障老年人的生活品质和健康状况受到家庭和社会的重视。在家居环境中,门厅空间是老年人使用频率较高的区域。通过对独居老人心理和生理特征的分析,结合独居老人对智能化门厅的需求,与智能家居技术结合,构建出适用于独居老人的智能、安全、便捷的门厅系统,为老年人构建良好的门厅环境,并为进一步推动我国居家养老产品的适老化设计提供一定参考。

关键词：自理型独居老人门厅设计门厅空间智能化智能化系统

Transport of a topologically protected photonic waveguide on-chip

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Photonics Research 2023年第6期11卷 1021-1028页

作者： sai yan JINGNAN yanG SHUSHU SHI ZHANCHUN ZUO CAN WANG XIULAI XU Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Topological Quantum Computation and School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China Songshan Lake Materials Laboratory Dongguan 523808China

We propose a design on integrated optical devices on-chip with an extra width degree of freedom by using a photonic crystal waveguide with Dirac points between two photonic crystals with opposite valley Chern *** such an extra waveguide,we demonstrate numerically that the topologically protected photonic waveguide retains properties of valley-locking and immunity to *** to the design flexibility of the width-tunable topologically protected photonic waveguide,many unique on-chip integrated devices have been proposed,such as energy concentrators with a concentration efficiency improvement of more than one order of magnitude,and a topological photonic power splitter with an arbitrary power splitting *** topologically protected photonic waveguide with the width degree of freedom could be beneficial for scaling up photonic devices,and provides a flexible platform to implement integrated photonic networks on-chip.

关键词： waveguide protected valley

Freezing the conductance of platinum(Ⅱ)complexes by quantum interference effect

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Chinese Chemical Letters 2022年第6期33卷 3263-3266页

作者： sai-sai yan Jin-Yun Wang Zi-You Pan Da-Sheng Zheng Qian-Chong Zhang Zhong-Ning Chen Fujian Normal University Fuzhou 350007China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

Understanding the impact of substituents on the quantum interference effect at single molecule scale is of great importance for the design of molecular *** this work,three platinum(Ⅱ)complexes with–H,–NH_(2)and–NO_(2)groups on conductive backbones were designed and ***-molecule conductance,which was measured using scanning tunnelling microscope break junction(STM-BJ)technique,demonstrated a conductance freeze phenomenon under the variation of *** study revealed that,despite the electronic effect of the substituents shifting the energy level of molecular orbital,the quantum interference effect vanished the influence of electronic effect on the conductance and eventually leaded to the conductance freeze.

关键词： Platinum(Ⅱ)complex Electronic effect Single-molecule conductance Quantum interference Magic ratio rule

An improved defect recognition framework for casting based on DETR algorithm

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Journal of Iron and Steel Research(International) 2023年第5期30卷 949-959页

作者： Long Zhang sai-fei yan Jun Hong Qian Xie Fei Zhou Song-lin Ran Anhui Province Key Laboratory of Metallurgical Engineering&Resources Recycling Anhui University of TechnologyMa’anshan 243002AnhuiChina School of Metallurgical Engineering Anhui University of TechnologyMa’anshan 243002AnhuiChina Technical Department Anhui Highly Precision Casting Co.Ltd.Ma’anshan 238100AnhuiChina Anhui Engineering Laboratory for Intelligent Applications and Security of Industrial Internet Anhui University of TechnologyMa’anshan 243032AnhuiChina

The current casting surface defect detection algorithms suffer from poor small target defect recognition and imbalance between detection performance and detection *** improved algorithmic framework for casting defect detection was proposed based on the DEtection TRansformer(DETR)*** algorithm takes ResNet with an efficient channel attention(ECA)-Net module as the backbone *** addition,based on the original algorithm architecture,dynamic anchor boxes,improved multi-scale deformable attention module,and SIoU loss function are introduced to improve the sensitivity of transformer structure to input location information and scale size,and the small target defect detection performance is effectively *** recognition performance of the algorithm in a self-built casting defect dataset was *** improved DETR algorithm has 97.561% accuracy in recognizing two defects,namely sandinclusion and notch,with the detection rate being improved by 65.854% and 17.073% compared with the original DETR and you only look once(Yolo)-V5,*** algorithm verifies the applicability of the transformer architecture target detection algorithm for casting defect detection tasks and provides new ideas for detecting other similar application scenarios.

关键词： Casting defect recognition DEtection TRansformer Small target detection Deep learning Attention mechanism

基于《内经》“肌肉枯,气道涩”理论以健脾活血化痰法中药治疗老年失眠症的临床研究

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广州中医药大学学报 2024年第7期41卷 1730-1737页

作者：王朝梅建强闫赛强张珣刘澳游晓艳成立河北中医药大学研究生院河北石家庄050091 河北中医药大学第一附属医院河北石家庄050010 平山县人民医院河北石家庄050400

【目的】探讨基于《黄帝内经》(简称《内经》)“肌肉枯,气道涩”理论,以健脾活血化痰法中药治疗老年失眠症的临床疗效。【方法】将120例老年失眠症患者随机分为观察组和对照组,每组各60例。对照组给予口服右佐匹克隆片治疗,观察组给予... 详细信息

【目的】探讨基于《黄帝内经》(简称《内经》)“肌肉枯,气道涩”理论,以健脾活血化痰法中药治疗老年失眠症的临床疗效。【方法】将120例老年失眠症患者随机分为观察组和对照组,每组各60例。对照组给予口服右佐匹克隆片治疗,观察组给予口服健脾活血化痰中药汤剂治疗,疗程均为4周。观察2组患者治疗前后匹兹堡睡眠质量指数(PSQI)评分、失眠严重程度指数(ISI)评分、多导睡眠图(PSG)相关参数[包括总睡眠时间(TST)、觉醒次数(AN)、睡眠潜伏期(SL)]、大脑动脉[包括大脑前动脉(ACA)、大脑中动脉(MCA)、大脑后动脉(PCA)]平均血流速度以及血清5-羟色胺(5-HT)、褪黑素(MT)水平的变化情况,并评价2组患者的临床疗效和安全性。【结果】(1)治疗4周后,观察组的总有效率为93.33%(56/60),略高于对照组的90.00%(54/60),但差异无统计学意义(P>0.05)。(2)治疗后,2组PSQI量表各项评分及总分均较治疗前降低(P0.05);停药4周后,观察组PSQI量表的各项评分均较治疗后继续降低(P0.05)。(3)治疗后,2组ISI评分均较治疗前降低(P0.05)。(4)治疗后,2组的TST、AN、SL等PSG相关参数均较治疗前改善(P0.05);组间比较,观察组对ACA、MCA、PCA平均血流速度的改善程度均明显优于对照组(P0.05)。【结论】基于《内经》“肌肉枯,气道涩”理论,以健脾活血化痰中药治疗老年失眠症疗效确切,可有效改善患者睡眠质量和日间功能,提高睡眠效率,增加睡眠时间,减少觉醒次数,降低失眠严重程度,改善脑功能,调节神经递质水平,远期疗效显著且安全可靠。

关键词： “肌肉枯,气道涩”理论老年失眠症健脾活血化痰方多导睡眠图脑血流 5-羟色胺褪黑素

Humanin对鱼藤酮诱导的多巴胺神经元毒性的保护作用研究

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陆军军医大学学报 2024年第7期46卷 670-677页

作者：单耀辉张启夫程晋叶枫张玺余文珮王晓刚赵远鹏但国蓉陈明亮赛燕陆军军医大学(第三军医大学)军事预防医学系防化医学教研室重庆400038

目的探讨Humanin(HN)对鱼藤酮(rotenone,Rot)诱导的多巴胺神经元毒性损伤的保护作用和机制。方法构建Rot染毒PC12细胞模型,实验设对照组、Rot染毒组、HN预处理Rot染毒组、单独HN处理组。采用ELISA检测Rot染毒细胞内外HN的含量,CCK-8法... 详细信息

目的探讨Humanin(HN)对鱼藤酮(rotenone,Rot)诱导的多巴胺神经元毒性损伤的保护作用和机制。方法构建Rot染毒PC12细胞模型,实验设对照组、Rot染毒组、HN预处理Rot染毒组、单独HN处理组。采用ELISA检测Rot染毒细胞内外HN的含量,CCK-8法检测细胞活性,ATP检测试剂盒检测细胞内ATP含量,DCFH-DA探针检测细胞内ROS水平,Western blot分别检测线粒体自噬调控蛋白Pink1、Parkin、p-Parkin、p62、LC3,线粒体生物发生调控蛋白PGC1α和分裂/融合调控蛋白OPA1、MFN2、DRP1、p-DRP1以及抗氧化应激调控蛋白Keap1、Nrf2的表达。采用HBAD-mcherry-EGFP-LC3腺病毒转染细胞观察自噬体和自噬溶酶体的数量。结果Rot染毒组PC12细胞内HN浓度显著高于对照组(P<0.05);与对照组比较,Rot染毒组PC12细胞活性下降,ATP含量下降,ROS的生成增加,Rot染毒后PC12细胞内Pink1、p-Parkin表达升高,LC3Ⅱ/LC3Ⅰ比值升高,p62表达下降,细胞线粒体生物发生蛋白PGC1α和线粒体融合蛋白MFN2、OPA1表达下降,而线粒体分裂蛋白p-DRP1表达升高,抗氧化应激蛋白Keap1和Nrf2表达下降(P均<0.05);与对照组比较,Rot染毒组PC12细胞中自噬体和自噬溶酶体数量增多(P<0.05),而20μmol/L HN预处理可以改善Rot染毒引起的上述变化(P<0.05)。结论HN通过抑制线粒体自噬和线粒体分裂、促进线粒体生物发生和融合以及抗氧化应激,改善Rot诱导的多巴胺神经元毒性损伤。

关键词： Humanin 鱼藤酮多巴胺神经元线粒体

Predicting submerged vegetation drag with a machine learning-based method

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Journal of Hydrodynamics 2024年第3期36卷 534-545页

作者： Meng-yang Liu Hong-wu Tang sai-yu Yuan Jing yan College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China Key Laboratory of Hydrologic-Cycle and Hydrodynamic-System of Ministry of Water Resources Hohai UniversityNanjing210098China

Accurate estimation of the drag forces generated by vegetation stems is crucial for the comprehensive assessment of the impact of aquatic vegetation on hydrodynamic processes in aquatic *** coupling relationship between vegetation layer flow velocity and vegetation drag makes precise prediction of submerged vegetation drag forces particularly *** present study utilized published data on submerged vegetation drag force measurements and employed a genetic programming(GP)algorithm,a machine learning technique,to establish the connection between submerged vegetation drag forces and flow and vegetation *** using the bulk velocity,U,as the reference velocity scale to define the drag coefficient,C_(d),and stem Reynolds number,the GP runs revealed that the drag coefficient of submerged vegetation is related to submergence ratio(H^(*)),aspect ratio(d^(*)),blockage ratio(ψ^(*)),and vegetation density(λ).The relation between vegetation stem drag forces and flow velocity is implicitly embedded in the definition of C_(d).Comparisons with experimental drag force measurements indicate that using the bulk velocity as the reference velocity,as opposed to using the vegetation layer average velocity,U_(v),eliminates the need for complex iterative processes to estimate U_(v)and avoids introducing additional errors associated with U_(v)*** approach significantly enhances the model’s predictive capabilities and results in a simpler and more user-friendly formula expression.

关键词： Drag coefficient genetic programming algorithm submerged vegetation flow resistance cylinder array