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Metabolomics for the diagnosis of bladder cancer: A systematic review

Asian Journal of Urology 2024年第2期11卷 221-241页

作者： Herney Andrés García-Perdomo angélica María Dávila-Raigoza Fernando Korkes Division of Urology/Urooncology Department of SurgerySchool of MedicineUniversidad del ValleCaliColombia UROGIV Research Group School of MedicineUniversidad del ValleCaliColombia Urologic Oncology Division of UrologyABC Medical SchoolSao PauloBrazil

Objective: Metabolomics has been extensively utilized in bladder cancer (Bca) research, employing mass spectrometry and nuclear magnetic resonance spectroscopy to compare various variables (tissues, serum, blood, and urine). This study aimed to identify potential biomarkers for early Bca ***: A search strategy was designed to identify clinical trials, descriptive and analytical observational studies from databases such as Medline, Embase, cochrane central Register of controlled Trials, and Latin American and caribbean Literature in Health sciences. Inclusion criteria comprised studies involving Bca tissue, serum, blood, or urine profiling using widely adopted metabolomics techniques like mass spectrometry and nuclear magnetic resonance. Primary outcomes included description of metabolites and metabolomics profiling in Bca patients and the association of metabolites and metabolomics profiling with Bca diagnosis compared to control patients. The risk of bias was assessed using the Quality Assessment of studies of Diagnostic ***: The search strategy yielded 2832 studies, of which 30 case-control studies were included. Urine was predominantly used as the primary sample for metabolite identification. Risk of bias was often unclear inpatient selection, blinding of the index test, and reference standard assessment, but no applicability concerns were observed. Metabolites and metabolomics profiles associated with Bca diagnosis were identified in glucose, amino acids, nucleotides, lipids, and aldehydes ***: The identified metabolites in urine included citric acid, valine, tryptophan, taurine, aspartic acid, uridine, ribose, phosphocholine, and carnitine. Tissue samples exhibited elevated levels of lactic acid, amino acids, and lipids. consistent findings across tissue, urine, and serum samples revealed downregulation of citric acid and upregulation of lactic acid, valine, tryptophan, taurine, glutamine, aspartic acid, uridine, rib

关键词： Metabolite Metabolomics Bladder cancer Metabolomicsprofile

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status and trends of carbon emissions research at the county level in china

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Advances in climate change Research 2024年第2期15卷 338-352页

作者： ang-Zu cAI Ru GUO Yu-Hao ZHang Jiang WU college of Environmental science and Engineering Institute of Environmental Planning and ManagementTongji UniversityShanghai 200092China Institute of carbon Neutrality Tongji UniversityShanghai 200092China shanghai Institute of Pollution control and Ecological security Shanghai 200092China college of Architecture and Urban Planning Tongji UniversityShanghai 200092China Megacity Elaborated Urban Governance Institute Tongji UniversityShanghai 200092China

This study provides a comprehensive overview of the challenges to achieving carbon neutrality at the county level in china and offers targeted recommendations,laying the groundwork for future specialized research in this area.A total of 283 relevant studies(2004-2023)were analyzed to assess county-level carbon emissions through three phases:bibliometric analysis,frontier analysis,and future *** findings reveal that publication trends were largely influenced by domestic and foreign *** cluster discerns ten primary themes,ranging from conceptual frameworks to research *** frontier analysis of the literature highlights the leading research areas,which include carbon neutrality pathway,driving factors,spatiotemporal variation of carbon emissions,the co-effects of pollutants and carbon reduction,and carbon emissions in china's rural *** from the results of bibliometric and frontier analyses,this study elucidates the recommendations for achieving carbon neutrality at the county level from three perspectives:effective regional policy guidance,emphasis on ecological conservation,and the deployment of advanced carbon reduction and sequestration *** study enriches the body of knowledge on carbon emissions at the county level and holds significant implications for china's comprehensive push towards achieving its carbon neutrality objectives.

关键词： carbon emissions Emission reduction county carbon neutrality sustainability

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scIRD: Revealing Infection of Malicious software in Edge computing-Enabled IoT Networks

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computers, Materials & continua 2024年第5期79卷 2743-2769页

作者： Jiehao Ye Wen cheng Xiaolong Liu Wenyi Zhu Xuan’ang Wu shigen shen school of Information Engineering Huzhou UniversityHuzhou313000China

The Internet of Things(IoT)has characteristics such as node mobility,node heterogeneity,link heterogeneity,and topology *** the face of the IoT characteristics and the explosive growth of IoT nodes,which brings about large-scale data processing requirements,edge computing architecture has become an emerging network architecture to support IoT applications due to its ability to provide powerful computing capabilities and good service ***,the defense mechanism of Edge computing-enabled IoT Nodes(EcIoTNs)is still weak due to their limited resources,so that they are susceptible to malicious software spread,which can compromise data confidentiality and network service *** this situation,we put forward an epidemiology-based susceptible-curb-infectious-removed-dead(scIRD)***,we analyze the dynamics of EcIoTNs with different infection levels under different initial conditions to obtain the dynamic differential ***,we establish the presence of equilibrium states in the scIRD ***,we conduct an analysis of the model’s stability and examine the conditions under which malicious software will either spread or disappear within Edge computing-enabled IoT(EcIoT)***,we validate the efficacy and superiority of the scIRD model through MATLAB *** research findings offer a theoretical foundation for suppressing the propagation of malicious software in EcIoT *** experimental results indicate that the theoretical scIRD model has instructive significance,deeply revealing the principles of malicious software propagation in EcIoT *** study solves a challenging security problem of EcIoT networks by determining the malicious software propagation threshold,which lays the foundation for buildingmore secure and reliable EcIoT networks.

关键词： Edge computing Internet of Things malicious software propagation model heterogeneity

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Proposal for valleytronic materials:Ferrovalley metal and valley gapless semiconductor

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Frontiers of physics 2024年第2期19卷 131-139页

作者： san-Dong Guo Yu-Ling Tao Guangzhao Wang shaobo chen Dong Huang Yee sin ang school of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology of chongqing School of Electronic Information EngineeringYangtze Normal UniversityChongqing 408100China college of Electronic and Information Engineering Anshun UniversityAnshun 561000China science Mathematics and Technology(SMT)Singapore University of Technology and Design(SUTD)8 Somapah RoadSingapore 487372Singapore

Valleytronic materials can provide new degrees of freedom to future electronic *** this work,the concepts of the ferrovalley metal(FVM)and valley gapless semiconductor(VGs)are proposed,which can be achieved in valleytronic bilayer systems by electric field *** valleytronic bilayer systems,the interaction between out-of-plane ferroelectricity and A-type antiferromagnetism can induce layer-polarized anomalous valley Hall(LP-AVH)*** K and−K valleys of FVM are both metallic,and electron and hole carriers simultaneously *** the extreme case,the FVM can become VGs by analogizing spin gapless semiconductor(sGs).Moreover,it is proposed that the valley splitting enhancement and valley polarization reversal can be achieved by electric field engineering in valleytronic bilayer *** the bilayer RuBr_(2)as an example,our proposal is confirmed by the first-principle *** FVM and VGs can be achieved in bilayer RuBr_(2)by applying electric *** appropriate electric field range,increasing electric field can enhance valley splitting,and the valley polarization can be reversed by flipping electric field *** effectively tune valley properties by electric field in bilayer systems,the parent monolayer should possess out-of-plane magnetization,and have large valley *** results shed light on the possible role of electric field in tuning valleytronic bilayer systems,and provide a way to design the ferrovalley-related material by electric field.

关键词： valleytronics electric field bilayer

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Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma

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Journal of Environmental sciences 2024年第3期137卷 172-180页

作者： Zhiyu chen Fang Li Lei Fu Yu Xia Ying Luo ang Guo Xiaona Zhu Huifang Zhong Qian Luo Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of chinese Academy of sciences Beijing 100049China Rheumatology&Immunology Department of shenzhen children’s Hospital Shenzhen 518038China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic substances Institute of Environment and HealthJianghan UniversityWuhan 430056China

Lipid metabolism play an essential role in occurrence and development of asthma,and it can be disturbed by phthalate esters(PAEs)and organophosphate fame retardants(OPFRs).As a chronic infammatory respiratory disease,the occurrence risk of childhood asthma is increased by PAEs and OPFRs exposure,but it remains not entirely clear how PAEs and OPFRs contribute the onset and progress of the *** have profiled the serum levels of PAEs and OPFRs congeners by liquid chromatography coupled with mass spectrometry,and its relationships with the dysregulation of lipid metabolism in asthmatic,bronchitic(acute infammation)and healthy(non-infammation)*** PAEs and nine OPFRs congeners were found in the serum of children(1–5 years old)from shenzhen,and their total median levels were 615.16 ng/m L and 17.06 ng/m L,***,the serum levels of mono-methyl phthalate(MMP),tri-propyl phosphate(TPP)and tri-n-butyl phosphate(TNBP)were significant higher in asthmatic children than in healthy and bronchitic children as ***-one characteristic lipids and fatty acids of asthma were screened by machine-learning random forest model based on serum lipidome data,and the alterations of infammatory characteristic lipids and fatty acids including palmitic acids,12,13-Di HODE,14,21-Di HDHA,prostaglandin D2 and Lyso PA(18:2)showed significant correlated with high serum levels of MMP,TPP and *** results imply PAEs and OPFRs promote the occurrence of childhood asthma via disrupting infammatory lipid and fatty acid metabolism,and provide a novel sight for better understanding the effects of plastic additives on childhood asthma.

关键词： Phthalate esters Organophosphate fame retardants childhood asthma Lipid and fatty acid metabolism Machine-learning random forest model chronic airway infammation

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Adaptive control of Lower-Limb Exoskeletons for Walking Assistance Based on Inter-Joint coordination

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Journal of Bionic Engineering 2024年第4期21卷 1775-1787页

作者： chaoyang Li Lincong Luo Zhi Liu Tianchi chen songxiang Liu Ye He Xiaoan chen Lei Li Wei Tech ang school of Mechanical Engineering Chongqing UniversityChongqing400044China Rehabilitation Research Institute of singapore Singapore308232Singapore Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China school of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore639798Singapore

Unilateral motor impairment can disrupt the coordination between the joints,impeding the patient’s normal *** assist such patients to walk normally and naturally,an adaptive control algorithm based on inter-joint coordination was proposed in this work for lower-limb *** control strategy can generate the reference trajectory of the affected leg in real time based on a motion coordination model between the joints,and adopt an adaptive controller with virtual windows to track the reference *** short-Term Memory(LsTM)network was also adopted to establish the coordination model between the joints of both lower limbs,which was optimized by preprocessing angle information and adding gait phase *** the adaptive controller,the virtual windows were symmetrically distributed around the reference trajectory,and its width was adjusted according to the gait phase of the auxiliary *** addition,the impedance parameters of the controller were updated online to match the motion capacity of the affected leg based on the spatiotemporal symmetry factors between the bilateral *** LsTM coordination model demonstrated good accuracy and generality in the gait database of seven individuals,with an average root mean square error of 3.5 and 4.1 for the hip and knee joint angle estimation,*** further evaluate the control algorithm,four healthy subjects walked wearing the exoskeleton while additional weights were added around the ankle joint to simulate an asymmetric *** the experimental results,it was shown that the algorithm improved the gait symmetry of the subjects to a normal level while exhibiting great adaptability to different subjects.

关键词： Lower-limb exoskeleton Adaptive control Gait symmetry Inter-joint coordination Motion estimation

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Geochemistry and depositional environment of fuchsite quartzites from sargur Group,western Dharwar craton,India

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Acta Geochimica 2024年第3期43卷 555-570页

作者： c.s.sindhuja G.Harshitha c.Manikyamba K.s.V.subramanyam csIR(council of scientific and Industrial Research)-National Geophysical Research Institute(NGRI) Uppal RoadHyderabad 500007India

Meso-Neoarchean fuchsite quartzites are present in different stratigraphic positions of Dharwar craton including the oldest(~3.3 Ga)sargur Group of western Dharwar *** present study deals with the petro-graphic and geochemical characteristics of the fuchsite quartzites from the Ghattihosahalli belt to evaluate their genesis,depositional setting and the enigma involved in the ancient sedimentation *** major mineral assemblages include quartz,fuchsite,and feldspars along with accessory kyanite and *** geochemical com-positions are characterized by high siO_(2),Al_(2)O_(3),low MgO,caO,strongly enriched cr(1326–6899 ppm),Ba(1165–3653 ppm),sr(46–210 ppm),V(107–868 ppm)and Zn(11–158 ppm)contents compared to the upper continental crust(Ucc).The Ucc normalized rare earth element(REE)patterns are characterized by depleted light REE[(La/sm)Ucc=0.33–0.95]compared to heavy REE[(Gd/Yb)_(Ucc)=0.42–1.65]with conspicuous positive Eu-anomalies(Eu/Eu^(*)=1.35–18.27)characteristic of hydrothermal solutions evidenced through the interlayered *** overall major and trace element systematics reflect a combined mafic-felsic provenance and suggest their deposition at a passive continental margin *** comprehensivefield,petrographic,and geo-chemical studies indicate that these quartzites are infiltrated by cr-richfluids released during high-grade metamorphism of associated ultramafic *** sargur and the subse-quent Dharwar orogeny amalgamated diverse lithounits from different tectonic settings,possibly leading to the release of cr-richfluids and the formation of fuchsite quartzite during or after the *** sug-gest a pre-existing stable crust prior to the sargur Group and the link between orogenic events and various mineral deposits in the Dharwar craton.

关键词： Dharwar craton Ghattihosahalli Fuchsite quartzite Provenance Depositional setting

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Lightweight and high-security laser-based cotton tip pruning robot

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 98-108页

作者： Xuan'ang Guo Ziyang Mao Zedong shi Wei Lu school of Artificial Intelligence Nanjing Agricultural UniversityNanjing 210031China

considering the current environmental pollution caused by chemical topping,plant damage caused by mechanical topping,and the high cost of manual topping,a laser-based cotton-tip pruning robot for field cotton was designed in this *** main advantages of this robot include its safety,light weight,low cost,and environmental ***,the structural design,measurement,and corresponding control system design of the robot were ***,a precise laser control method based on Yolov5 cotton top identification and the inverse kinematic solution of parallel robot rapid positioning were ***,the optimal laser irradiation wavelength and duration were ***,a laser-topping experiment was conducted,and the overall accuracy and recall rates for cotton identification were 98.3%and 99.3%,*** AP and mAP at the threshold value of 0.5 reached 99.3%and 78.8%,*** maximum positioning error of the jacking system is 2.6 mm,and the repeated positioning error is within±1.2 cm,which meets the accuracy requirements of laser ***-purple laser irradiation at 15 W and 405 nm for 22 s was the best topping *** the effects of cotton topping with and without manual topping,it can be seen that laser topping significantly improved the yield and *** with the photothermal response of the cotton topping,the feasibility of laser topping was verified both theoretically and *** laser-topping scheme proposed in this study exhibits high efficiency,environmental protection,and safety,as well as good application prospects.

关键词： laser topping parallel manipulator photothermal response object detection

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Early Phases of star Formation: Testing chemical Tools

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Research in Astronomy and Astrophysics 2024年第1期24卷 96-118页

作者： N.c.Martinez s.Paron cONIcET-Universidad de Buenos Aires.Instituto de Astronomía y Física del Espacio Ciudad Universitaria(C1428EGA)Ciudad Autónoma de Buenos AiresArgentina

star-forming processes strongly influence the IsM ***,many high-quality databases are available at millimeter *** them,it is possible to carry out studies that review and deepen previous *** these studies involve large samples of sources,it is preferred to use direct tools to study the molecular *** the aim of testing these tools such as the use of the HcN/HNc ratio as a thermometer,and the use of H^(13)cO^(+),Hc_(3)N,N_(2)H^(+) and c_(2)H as "chemical clocks," we present a molecular line study toward 55 sources representing massive young stellar objects at different evolutionary stages:infrared dark clouds(IRDcs),highmass protostellar objects(HMPOs),hot molecular cores(HMcs) and ultracompact H II *** found that the use of the HcN/HNc ratio as a universal thermometer in the IsM should be taken with care because the HcN optical depth is a big issue that can affect the ***,this tool should be utilized only after a careful analysis of the HcN spectrum,checking that no line,neither the main nor the hyperfine ones,presents absorption *** point out that the analysis of the emission of H^(13)cO^(+),Hc_(3)N,N_(2)H^(+) and c_(2)H could be useful to trace and distinguish regions among IRDcs,HMPOs and *** molecular line widths of these four species increase from the IRDc to the HMc stage,which can be a consequence of the gas dynamics related to the starforming processes taking place in the molecular *** results not only contribute with more statistics,acting as a probe of such chemical tools,useful to obtain information in large samples of sources,but also complement previous works through the analysis of other types of sources.

关键词： stars:formation IsM:molecules IsM:clouds

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A 256 Gb/s electronic−photonic monolithically integrated transceiver in 45 nm cMOs

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Journal of semiconductors 2024年第7期45卷 7-10页

作者： ang Li Qianli Ma Yujun Xie Yongliang Xiong Yingjie Ma Han Liu Ye Jin Menghan Yang Guike Li Haoran Yin Minye Zhu Yang Qu Peng Wang Daofa Wang Wei Li Liyuan Liu Nan Qi Ming Li Key Laboratory of Optoelectronic Materials and Devices Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Institute of semiconductors Chinese Academy of SciencesBeijing 100083China center of Materials science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100190China school of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

With the explosive development of artificial intelligence(AI),machine learning(ML),and high-performance comput-ing(HPc),the ever-growing data movement is asking for high density interconnects with higher bandwidth(BW),lower power and lower latency[1−3].The optical I/O leverages silicon photonic(siPh)technology to enable high-density large-scale integrated photonics.

关键词： Gb/s transceiver monolithic

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