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ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/β-Catenin signaling Pathway

Current Medical science 2024年第2期44卷 406-418页

作者： Cheng-cheng ZHU Heng-liang sUN Teng-fei LONG Yuan-yuan LYU Jiang-li LIU Guan-tai ni Anhui Medical University Hefei 230032China Department of Obstetrics and Gynecology The First Affiliated Hospital of Wannan Medical CollegeWuhu 241001China

Objective:Uterine corpus endometrial carcinoma(UCEC),a kind of gynecologic malignancy,poses a significant risk to women’s *** precise mechanism underlying the development of UCEC remains *** finger protein 554(ZNF554),a member of the Krüppel-associated box domain zinc finger protein superfamily,was reported to be dysregulated in various illnesses,including malignant *** study aimed to examine the involvement of ZNF554 in the development of ***:The expression of ZNF554 in UCEC tissues and cell lines were examined by qRT-PCR and Western blot *** with stably overexpressed or knocked-down ZNF554 were established through lentivirus ***-8,wound healing,and Transwell invasion assays were employed to assess cell proliferation,migration,and *** iodide(PI)staining combined with fluorescence-activated cell sorting(FACs)flow cytometer was utilized to detect cell cycle ***-PCR and Western blotting were conducted to examine relative mRNA and protein *** immunoprecipitation assay and luciferase reporter assay were used to explore the regulatory role of ZNF554 in RNA binding motif 5(RBM5).Results:The expression of ZNF554 was found to be reduced in both UCEC samples and cell *** expression of ZNF554 was associated with higher tumor stage,decreased overall survival,and reduced disease-free survival in ***554 overexpression suppressed cell proliferation,migration,and invasion,while also inducing cell cycle *** contrast,a decrease in ZNF554 expression resulted in the opposite ***,ZNF554 transcriptionally regulated RBM5,leading to the deactivation of the Wingless(WNT)/β-catenin signaling ***,the findings from rescue studies demonstrated that the inhibition of RBM5 negated the impact of ZNF554 overexpression onβ-catenin and p-glycogen synthase kinase-3β(p-GsK-3β).similarly,the deliberate activation of RBM5 reduced the increase inβ-catenin and

关键词： zinc finger protein 554 endometrial carcinoma RNA binding motif 5 Wingless/β-catenin signaling pathway

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Research on the Construction of a Comprehensive Teaching Case Library for Ergonomics under the OBE Concept

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Journal of Contemporary Educational Research 2024年第10期8卷 29-34页

作者： Haiyan Tang Wenting ni Chongqing Institute of Engineering Chongqing 400056China

In recent years,case-based teaching has become a hot spot in higher education reform,and the construction of case libraries has received increasing *** development of teaching case libraries not only promotes changes in talent training models but also enhances teaching *** the ergonomics course as an example,this paper explores the construction of a comprehensive teaching case library for ergonomics under the outcome-based education concept,providing a reference for future ergonomics teaching case library development.

关键词： Outcome-based education concept Ergonomics Comprehensive teaching case library

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On the Nature of Online Retrieval of Electronic Data

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The Journal of Human Rights 2024年第4期 876-903页

作者：吴影飞 ni Weisi school of Law People’s Public Security University of China

With the development of information technology, the online retrieval of remote electronic data has become an important method for investigative agencies to collect evidence. In the current normative documents, the online retrieval of electronic data is positioned as a new type of arbitrary investigative measure. However,study of its actual operation has found that the online retrieval of electronic data does not fully comply with the characteristics of arbitrary investigative measures. The root cause is its inaccurately defined nature due to analogy errors, an emphasis on the authenticity of electronic data at the cost of rights protection, insufficient effectiveness of normative documents to break through the boundaries of law, and superficial inconsistency found in the mechanical comparison with the nature of existing investigative measures causes. The nature of electronic data retrieved online should be defined according to different circumstances. The retrieval of electronic data disclosed on the Internet is an arbitrary investigative measure, and following procedural specifications should be sufficient. When investigators conceal their true identities and enter the cyberspace of the suspected crime through a registered account to extract dynamic electronic data for criminal activities, it is essentially a covert investigation in cyberspace, and they should follow the normative requirements for covert investigations. The retrieval of dynamic electronic data from private spaces is a technical investigative measure and should be implemented in accordance with the technical investigative procedures. Retrieval of remote “non-public electronic data involving privacy” is a mandatory investigative measure, and is essentially a search in the virtual ***, procedural specifications should be set in accordance with the standards of searching.

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Vitamin D and selenium for type 2 diabetes mellitus with Hashimoto’s thyroiditis:Dosage and duration insights

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World Journal of Diabetes 2024年第8期15卷 1824-1828页

作者： Yun-Feng Yu Xue-Li shangguan Dan-ni Tan Li-Na Qin Rong Yu school of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

This letter discusses the publication by Feng et ***,selenium,and vitamin D are closely associated with thyroid hormone production in humans;however,the efficacy of selenium and vitamin D supplementation for type 2 diabetes mellitus(T2DM)patients with Hashimoto’s thyroiditis(HT)remains *** the retrospective study we discuss herein,the authors highlighted significant improvements in thyroid function,thyroid antibodies,blood glucose,and blood lipid in T2DM patients with HT following addition of vitamin D and selenium to their antidiabetic regimens,underscoring the value of these *** team is currently engaged in research exploring the relationship between micronutrients and HT,and we have obtained invaluable insights from the aforementioned *** on this research and current literature,we recommend a regimen of 4000 IU/day of vitamin D and 100-200μg/day of selenium for over three months to six months for patients with HT,particularly for those with concurrent T2DM.

关键词： Vitamin D selenium Type 2 diabetes mellitus Hashimoto’s thyroiditis Dosage Duration

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Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GsTs

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Chinese Chemical Letters 2024年第8期35卷 481-485页

作者： Jiaqi Huang Renjiang Kong Yanmei Li ni Yan Yeyang Wu Ziwen Qiu Zhenming Lu Xiaona Rao shiying Li Hong Cheng school of Biomedical Engineering&Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical UniversityGuangzhou 510515China school of Pharmaceutical sciences Guangzhou Medical UniversityGuangzhou 511436China

Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROs)levels at focal sites and the evolvement of antioxidant defense ***,we develop an albumin-based nanomedicine to co-deliver chlorin e6(Ce6)and COH-sR4(Cs),which can simultaneously enhance the yield and lethality of intracellular ROs for amplified photodynamic therapy(PDT).In which,Cs acts as both an activator of AMP-activated protein kinase(AMPK)and an inhibitor of glutathione s-transferases(GsTs).Benefiting from it,the prepared HsA-Ce6@COH-sR4(HCCs)enables positive feed-back uptake by promoting AMPK phosphorylation,leading to rapid and extensive tumor accumulation of *** a result,HCCs obviously increases the ROs production to elevate intracellular oxidative ***,HCCs can inhibit GsTs to disturb the antioxidant defense system of tumor cells,intensifying the oxidative damage of ***,the PDT of HCCs is significantly strengthened by improving the ROs yield and lethality,which greatly declines the proliferation of breast cancer in *** study may open a window in the development of drug co-delivery system for enhanced oxidative therapy of tumors.

关键词： Human serum albumin Drug delivery Reactive oxygen species Positive feedback uptake Oxidative damage

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A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells

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Chinese Chemical Letters 2024年第10期35卷 364-369页

作者： Chuan-Zhi ni Ruo-Ming Li Fang-Qi Zhang Qu-Ao-Wei Li Yuan-Yuan Zhu Jie Zeng shuang-Xi Gu school of Chemistry and Environmental Engineering School of Chemical Engineering&PharmacyPharmaceutical Research InstituteHubei Key Laboratory of Novel Reactor and Green Chemical TechnologyWuhan Institute of TechnologyWuhan 430205China Nanjing Pusheng Biomedical Co. Ltd.Nanjing 210033China

A novel and readily available binaphthyl-based fluorescent probe(s)-1 was designed and synthesized.(s)-1 can be used to not only chemoselectively discriminate 3 basic amino acids out of common amino acids,but also enantioselectively recognize ***,enantioselective imaging of histidine in cells was achieved for the first time by the probe(s)-*** performances endowed it potential application in the chiral analysis of basic amino acids in asymmetric synthesis and cell imaging for diagnosis of diseases caused by racemization of *** magnetic resonance(NMR)and mass spectrometry investigations suggested that different reaction extent of(s)-1 with L/D-histidine and different product structures generated the observed enantioselective fluorescent *** molecular structures and thermodynamic stability of the complexes,formed from(s)-1+Zn2+and enantiomers of histidine,were calculated by Gaussian 16 based on density functional theory(DFT)to validate the above action mechanism.

关键词： Fluorescent probe Chiral recognition Enantioselectivity Chemoselectivity Basic amino acids Cell imaging

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灌区对塔里木盆地西部极端暴雨的影响

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清华大学学报（自然科学版） 2024年第2期64卷 259-270页

作者：刘家辉倪广恒清华大学土木水利学院水沙科学与水利水电工程国家重点实验室北京100084

塔里木盆地灌区支撑着当地的经济和社会发展,而近年来盆地内部的暴雨事件严重威胁人民群众的生命财产安全。该文通过中尺度气象模式(WRF)设置有无灌区的对比模拟实验,以2021年6月15日盆地西部的暴雨(“6·15”暴雨)为例,发现灌区使暴雨... 详细信息

塔里木盆地灌区支撑着当地的经济和社会发展,而近年来盆地内部的暴雨事件严重威胁人民群众的生命财产安全。该文通过中尺度气象模式(WRF)设置有无灌区的对比模拟实验,以2021年6月15日盆地西部的暴雨(“6·15”暴雨)为例,发现灌区使暴雨强度增加,并揭示了灌区对暴雨水汽输送过程和暴雨形成的影响机制。结果表明:由偏东急流引起的大量水汽向盆地西部输送是“6·15”暴雨形成的主要原因;灌区对水汽输送的阻挡作用使输送区域至暴雨区域的水汽增加,且灌区和山区地形的共同影响使水汽抬升作用增强,导致更多水汽在暴雨落区集中,使暴雨雨量增加。

关键词：塔里木盆地灌区极端暴雨水汽输送

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Enhanced homing of mesenchymal stem cells for in situ niche remodeling and bone regeneration

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Nano Research 2024年第8期17卷 7449-7460页

作者： Yin Yuan Lijun Chen Jing Yang sining Zhou Yangxin Fang Qi Zhang ning Zhang Yifei Li Li Yuan Fan Jia shuo ni Charlie Xiang state Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Biology The David H.Koch Institute for Integrative Cancer Research at MITMassachusetts Institute of TechnologyCambridgeMA 02139USA Research Units of Infectious disease and Microecology Chinese Academy of Medical SciencesHangzhou 310003China Innovative Precision Medicine(IPM)Group Hangzhou 311215China MOE Key Laboratory of Macromolecule synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Cancer Immunology and Virology Dana-Farber Cancer InstituteBostonMA 02215USADepartment of ImmunologyHarvard Medical SchoolBoston MA 02115USA Department of Orthopedic surgery and shanghai Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200233China

Mesenchymal stem cells(MsCs)transplantation is a promising strategy for osteoporosis ***,limited sources and poor tissue-homing efficiency limit their clinical *** this study,we isolated a kind of MsCs from women’s menstrual blood(MensCs)noninvasively and established a novel MsCs bone marrow-targeted delivery system by utilizing waterin-oil-in-water droplet *** were encapsulated withinβ-cyclodextrin-functionalized alginate microcapsules loaded with zoledronates,which has a high affinity for *** this delivery system,MensCs could be preferentially delivered to the bone marrow tissues via intravenous infusion,and restored bone mass by remodeling the bone marrow niche in situ in ovariectomized mouse ***,scRNA-seq analysis demonstrated that those MensCs homed to the bone marrow recruited CD4^(+)FOXP3^(+)natural regulatory T(nT_(reg))cells by secreting *** recruited nTreg promoted CD8^(+)T cells to secret Wnt family member 10B(WNT10B),activating the Wnt signaling in osteoblasts and thus promoting bone formation in situ in the bone *** study reveals a promising application of MensCs in postmenopausal osteoporosis treatment and highlights the clinical value of MensCs by encouraging women to reserve autologous MensCs before menopause to prevent and alleviate postmenopausal osteoporosis.

关键词： mesenchymal stem cells microfluidics bone marrow homing stem cell niche postmenopausal osteoporosis

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Roles of concentration-dependent Cu doping behaviors on the thermoelectric properties of n-type Mg_(3)sb_(1.5)Bi_(0.5)

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Journal of Materiomics 2024年第1期10卷 154-162页

作者： Xinxin Yang Heng ni Xiaotong Yu Biao Cao Juanjuan Xing Qiyong Chen Lili Xi Jiandang Liu Jiye Zhang Kai Guo Jing-Tai Zhao school of Materials science and Engineering Shanghai University99 Shangda RoadShanghai200444China Materials Genome Institute Shanghai University99 Shangda RoadShanghai200444China state Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefeiAnhui230026China school of Physics and Materials science Guangzhou UniversityGuangzhou510006China Research Center for Advanced Information Materials(CAIM) Huangpu Research&Graduate School of Guangzhou UniversitySino-Singapore Guangzhou Knowledge CityHuangpu DistrictGuangzhou510555China Key Lab of si-based Information Materials&Devices and Integrated Circuits Design Department of Education of Guangdong ProvinceChina school of Materials science and Engineering Guilin University of Electronic TechnologyGuilin541004China Guangxi Key Laboratory of Information Materials Guilin University of Electronic TechnologyGuilin541004China

Large seebeck coefficients induced by high degeneracy of conduction band minimum,and low intrinsic lattice thermal conductivity originated from large lattice vibrational anharmonicity render Mg_(3)sb_(2)as a promising n-type thermoelectric ***,we demonstrated unique concentration-dependent occupation behaviors of Cu in Mg_(3.4)sb_(1.5)Bi_(0.49)Te_(0.01)matrix,evidenced by structural characterization and transport property *** is found that Cu atoms prefer to enter the interstitial lattice sites in Mg_(3)sb_(2)host with low doping level(Mg_(3.4)sb_(1.5)Bi_(0.49)Te_(0.01)+x%Cu,xs donors for providing additional electrons without deteriorating the carrier *** x is larger than 0.3%,the excessive Cu atoms are inclined to substitute Mg atoms,yielding acceptors to decrease the electron *** a result,the electrical conductivity of the Mg_(3.4)sb_(1.5)Bi_(0.49)Te_(0.01)+0.3%Cu sample reaches 2.3×10^(4)s/m at 300 K,increasing by 300%compared with that of the pristine *** figure of merit zT values in the whole measured temperature range are significantly improved by the synergetic improvement of power factor and reduction of thermal *** average zT∼1.07 from 323 K to 773 K has been achieved for the Mg_(3.4)sb_(1.5)Bi_(0.49)Te_(0.01)+0.3%Cu sample,which is about 30%higher than that of the Mg_(3.4)sb_(1.5)Bi_(0.49)Te_(0.01) sample.

关键词： Mg_(3)sb_(2) Cu doping Concentration-dependent occupation Thermoelectric properties Average zT

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RNA viromes of Dermacentor nuttalli ticks reveal a novel uukuvirus in Qinghai Province,China

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Virologica sinica 2024年第4期39卷 537-545页

作者： Yaohui Fang Jun Wang Jianqing sun Zhengyuan su shengyao Chen Jian Xiao Jun ni Zhihong Hu Yubang He shu shen Fei Deng Key Laboratory of special Pathogens and Biosafety and National Virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of sciences Beijing 101408China Qinghai Lake National Nature Reserve Administration Xining 810000China Hubei Jiangxia Laboratory Wuhan 430200China Xinjiang Key Laboratory of Vector-borne Infectious Diseases Urumqi830002China

Ticks are a major parasite on the Qınghai-Tibet Plateau,western China,and represent an economic burden to agriculture and animal *** research on tick-borne pathogens that threaten humans and animals,the viromes of dominant tick species in this area remain *** this study,we collected Dermacentor nuttalli ticks near Qınghai Lake and identified 13 viruses belonging to at least six families through metagenomic *** viruses were of high abundance in pools,including Xınjiang tick-associated virus 1(XJTAV1),and three novel viruses:Qınghai Lake virus 1,Qınghai Lake virus 2(QHLV1,and QHLV2,unclassified),and Qınghai Lake virus 3(QHLV3,genus Uukuvirus of family Phenuiviridae in order Bunyavirales),which lacks the M *** minimum infection rates of the four viruses in the tick groups were 8.2%,49.5%,6.2%,and 24.7%,respectively,suggesting the prevalence of these viruses in *** ticks.A putative M segment of QHLV3 was identified from the next-generation sequencing data and further characterized for its signal peptide cleavage site,N-glycosylation,and transmembrane ***,we probed the L,M,and s segments of other viruses from sequencing data of other tick pools by using the putative M segment sequence of *** revealing the viromes of *** ticks,this study enhances our understanding of tick-borne viral communities in highland *** putative M segment identified in a novel uukuvirus suggests that previously identified uukuviruses without M segments should have had the same genome organization as typical *** findings will facilitate virus discovery and our understanding of the phylogeny of tick-borne uukuviruses.

关键词： Dermacentor nuttalli Qınghai Province Virome Uukuvirus M segment

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