检索结果-南通市图书馆

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan Daniel Fulton Zubair Ahmed WMatthijs Blankesteijn sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-school for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-school for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(csVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term csVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CsVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

Combinatorial therapies for spinal cord injury repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António J.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang sonata s Y Yau Kwok-Fai so Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNs Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina state Key Laboratory of Brain and Cognitive science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Access to cardiovascular medicines in lowand middle-income countries:a mini review

在线全文

学校读者我要写书评

暂无评论

Global Health Research and Policy 2023年第1期8卷 363-378页

作者： Mark Amankwa Harrison Afia Frimpomaa Asare Marfo Augustine Annan Daniel nii Amoo Ankrah Pharmacy Department Korle Bu Teaching HospitalKorle BuP.O.Box 77AccraGhana Department of Pharmacy Practice Faculty of Pharmacy and Pharmaceutical SciencesCollege of Health SciencesKwame Nkrumah University of Science and TechnologyKumasiGhana

Background Many cardiovascular(CV)medicines are required for long ***,with their limited resources,low-and middle-income countries(LMICs)may have challenges with access to cardiovascular *** aim of this review was to provide a summary of available evidence on access to cardiovascular medicines in *** We searched PubMed and Google scholar for English language articles on access to cardiovascular medicines for the period *** also searched for articles reporting measures for challenges in access to CV medicines from 2007 to *** conducted in LMICs,and reporting availability and affordability were included for *** also reviewed studies reporting affordability or availability using the World Health Organisation/Health Action International(WHO/HAI)*** of affordability and availability were *** Eleven articles met the inclusion criteria for review on availability and *** availability appears to have improved,many countries did not meet the availability target of 80%.Between economies and within countries,there are equity gaps in access to CV *** is lower in public health facilities than private *** out of 11 studies reported availability less than 80%.Eight studies which investigated availability in the public sector reported less than 80%***,CV medicines,especially combined treatments are not affordable in the majority of *** achievement of availability and affordability target is *** the studies reviewed,less than 1-53.5 days wages were required to purchase one month supply of CV *** to meet affordability was 9-75%.Five studies showed that,on average 1.6 days’wages of the Lowest-Paid Government Worker(LPGW)was required to purchase generic CV medicines in the public *** forecasting and procurement,increased public financing and policies to improve generic use,among others are measure

关键词： Cardiovascular medicines Access Low-and middle-income countries Affordability Availability

Marijuana use and repeated attempted suicide among senior high school students in Ghana:Evidence from the WHO Global school-Based student Health survey,2012

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

General Psychiatry 2020年第6期33卷 390-399页

作者： John Tetteh George Ekem-Ferguson swithin Mustapha swaray Nuworza Kugbey Emmanuel nii-Boye Quarshie Alfred Edwin Yawson Department of Community Health University of Ghana Medical SchoolCollege of Health SciencesUniversity of GhanaAccraGhana Department of Psychiatry Korle Bu Teaching HospitalAccraGreater AccraGhana National Cardiothoracic Centre Korle Bu Teaching HospitalAccraGreater AccraGhana Department of Family and Community Health School of Public HealthUniversity of Health and Allied SciencesHohoeVolta RegionGhana Department of Psychology School of Social SciencesUniversity of Ghana College of HumanitiesAccraGreater AccraGhana

Background The association between substance use including marijuana use and attempted suicide has been well ***,little is known about marijuana use and its association with attempted suicide repetition among young people in low-income and middle-income *** This analysis was conducted to assess the factors associated with marijuana use and ascertain marijuana use as a determinant of repeated attempted suicide among senior high school(sHs)students in *** Data from the 2012 Global school-Based student Health survey in Ghana was used for this *** Poisson,Logistic and Probit models weighted with Mahalanobis distance matching within propensity calliper were employed separately to determine the hypothetical association between marijuana use and repeated attempted *** analysis was performed using stata 16 and ps deemed statistically *** The prevalence estimates of marijuana use and repeated attempted suicide among sHs students in Ghana were 3.4%(95%Cl:2.3 to 5.1)and 11.5%(95%Cl:9.1 to 14.4),*** prevalence of marijuana use was significantly associated with school grade,smoking exposure,parent smoker,alcohol intake and *** use was positively associated with repeated attempted suicide among sHs in Ghana correlation=0.23,psuicide among students who use marijuana was approximately threefold and fivefold significant compared with nonmarijuana use students,based on the Poisson(adjusted prevalence ratio:3.02;95%Cl:1.67 to 5.43,pstic(adjusted OR:5.06;95%Cl:3.19 to 11.64,pstimates ***,the Probit model showed that marijuana use significantly increased the log count of repeated attempted suicide by 95%(ap:0.95;95%CI:0.49 to 1.41,psion Marijuana use does not only influence the onset of suicidal attempts but also repeated attempted suicide among sHs students in *** attention is required for suicide

关键词： repetition smoke attempted

Olfactory receptors in neural regeneration in the central nervous system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan serrano-Marín Rafael Rivas-santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain school of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

Prospects of Bioenergy Production for sustainable Rural Development in Ghana

在线全文

学校读者我要写书评

暂无评论

Journal of sustainable Bioenergy systems 2021年第4期11卷 227-259页

作者： nii Nelson Jo Darkwa John Calautit Faculty of Engineering University of Nottingham Nottingham UK

Biomass supplies about 80% of the energy needs for cooking and heating in rural Ghana. It is predominantly used in traditional and inefficient forms (firewood and charcoal), which presents environmental and health concerns. In order to better the living standard in rural Ghana, efforts must be made to provide modern energy services. Most rural communities in Ghana are so remote that an extension of the national grid is uneconomical, hence biomass electricity provides a viable alternative. Biomass is pivotal to the socio-economic development of rural Ghana due to its easy accessibility and enormous potential in the production of varied energy forms. In this paper, a comprehensive review of biomass resources, biomass energy conversion technologies and bioenergy production potential for rural development in Ghana is provided. The most important feedstock from an energy perspective was found to be crop residues. Based on 2017 statistics, Ghana has a theoretical potential of 623.84 PJ of energy from agricultural crop residues and 64.27 PJ of energy from livestock production. Evidence from literature suggests that biomass gasification is the best conversion technology to expand electricity access rate for rural households in Ghana. The paper concludes that although ample biomass resources exist, cocoa pod husks (CPH) which is very common in rural Ghana can be pelletized and used as feedstock for rural power generation systemspan>sspan style="font-family:"">.

关键词： Biomass Bioenergy Biofuel Feedstock Conversion Technologies

Yield of tuberculosis among household contacts of tuberculosis patients in Accra,Ghana

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2018年第1期7卷 155-162页

作者： sally-Ann Ohene Frank Bonsu nii Nortey Hanson-Nortey Adelaide sackey samuel Danso Felix Afutu Paul Klatser Mirjam Bakker World Health Organization Country Office 29 Volta Street AirportAirport Residential AreaP.O.Box MB 142AccraGhana National Tuberculosis Control Program AccraGhana Department of Global Health Academic Medical CentreAmsterdam Institute of Global Health and DevelopmentAmsterdamThe Netherlands KIT Health Royal Tropical Institute(KIT)AmsterdamThe Netherlands

Background:The End TB strategy calls for systematic screening of selected high-risk groups including contacts of tuberculosis(TB)cases to facilitate early TB case *** investigation is not usually routinely practiced in low TB burden countries,such as Ghana,with consequent paucity of data on the yield of TB case detection from such *** study’s objective was to document the outcomes and feasibility of implementing contact investigation activities under programmatic conditions in ***:Retrospective analyses were conducted of abstracted data from the National TB Program,following a contact investigation intervention for TB cases diagnosed in 10 facilities in Accra from June 2010 to December *** proportions and yield from number of contacts needed to screen(NNs)and number needed to test(NNT)to detect a TB case were ***:Overall,out of the 8519 listed contacts of 3267 index cases,8166(96%)were screened and 614(7.5%)were identified as presumptive *** of these,438(71%)underwent sputum smear microscopy/evaluation and 53 TB cases were *** these,56.6%were males,and 49%had sputum smear-positive TB,38%had sputum smear-negative TB,and 7%had extra-pulmonary *** NNs and NNT to detect a TB case of all forms were 154 and 8,*** proportion of TB cases with contacts listed and proportion of contacts screened annually were 88-96%and 83-100%,*** proportion of presumptive TB cases tested and proportion of TB cases diagnosed among contacts tested that were 100%and 36%,respectively,in 2010 dropped to 40%and 14%,respectively,by ***:The study demonstrates that contact identification and prioritization components of a contact investigation were feasible,but overall yield of TB cases may have been lower due to the declining rate of clinical evaluation of presumptive TB contacts over *** barriers to accessing appropriate diagnostic tests may enhance yield from contact inves

关键词： Ghana Tuberculosis Tuberculosis contact investigation screening