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Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1

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Food science and Human Wellness 2024年第2期13卷 932-945页

作者： si Zou Yetao Gong Xiujie li Yanbin Wu Jinzhong Wu Jianguo Wu Ka-Hing Wong College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Research Institute for Future Food The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Food science and Nutrition The Hong Kong Polytechnic UniversityHong Kong 999077China

selenium nanoparticles(seNPs)have been demonstrated potential for use in diseases associated with oxidative *** seNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application ***,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized seNPs(PTR-seNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57Bl/6J mouse *** elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also *** results showed that PTR-seNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting ***-seNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GClC,GClM,HO-1 and NQO-1 ***,PTR-seNPs suppressed the biotransformation of APAP to generate intracellular ROs through CYP 2E1 inhibition,restoring the mitochondrial ***,the protective effect of PTR-seNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-seNPs mediated hepatoprotective *** a potential hepatic protectant,PTR-seNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.

关键词： PTR-seNPs(polysaccharide-proteincomplex functionalized selenium nanoparticles) Acetaminophen-induced hepatotoxicity Nuclear factor erythroid 2-related factor 2 Cytochrome P450 enzyme 2E1 Mitochondria

Research on the solid particle erosion wear of pipe steel for hydraulic fracturing based on experiments and numerical simulations

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Petroleum science 2024年第4期21卷 2779-2792页

作者： si-Qi Yang Jian-Chun Fan Ming-Tao liu De-Ning li Jun-liang li li-Hong Han Jian-Jun Wang shang-Yu Yang si-Wei Dai lai-Bin Zhang state Key laboratory of Oil and Gas Equipment CNPC Tubular Goods Research Institute Key laboratory of Oil and Gas safety and Emergency Technology China University of Petroleum Oil Production Technology Research Institute of liaohe Oilfield Company Tianjin Gas storage Branch PetroChina Dagang Oilfield Company Petroleum Production Engineering Research Institute Daqing Oilfield Company

Erosion wear is a common failure mode in the oil and gas industry. In the hydraulic fracturing, the fracturing pipes are not only in high-pressure working environment, but also suffer from the impact of the high-speed solid particles in the fracturing fluid. Beneath such complex conditions, the vulnerable components of the pipe system are prone to perforation or even burst accidents, which has become one of the most serious risks at the fracturing site. Unfortunately, it is not yet fully understood the erosion mechanism of pipe steel for hydraulic fracturing. Therefore, this article provides a detailed analysis of the erosion behavior of fracturing pipes under complex working conditions based on experiments and numerical simulations. Firstly, we conducted erosion experiments on AIsi 4135 steel for fracturing pipes to investigate the erosion characteristics of the material. The effects of impact angle, flow velocity and applied stress on erosion wear were comprehensively considered. Then a particle impact dynamic model of erosion wear was developed based on the experimental parameters, and the evolution process of particle erosion under different impact angles, impact velocities and applied stress was analyzed. By combining the erosion characteristics, the micro-structure of the eroded area, and the micro-mechanics of erosion damage, the erosion mechanism of pipe steel under fracturing conditions was studied in detail for the first time. Under high-pressure operating conditions, it was demonstrated through experiments and numerical simulations that the size of the micro-defects in the eroded area increased as the applied stress increased, resulting in more severe erosion wear of fracturing pipes.

关键词： Erosion wear Applied stress Particle impact dynamics Erosion mechanism

Association of prealbumin with short-term and long-term outcomes in patients with acute sT-segment elevation myocardial infarction

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Journal of Geriatric Cardiology 2024年第4期21卷 421-430页

作者： Jing TAN Jin si Ke-ling XIAO Ying-Hua ZHANG Qi HUA Jing lI Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Geriatric Medicine Xuanwu Hospital Capital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijingChina

BACKGROUND Prealbumin is considered to be a useful indicator of nutritional status. Furthermore, it has been found to be associated with severities and prognosis of a range of diseases. However, limited data on the association of baseline prealbumin level with outcomes of patients with acute sT-segment elevation myocardial infarction(sTEMI) are *** We analyzed 2313 patients admitted for acute sTEMI between October 2013 and December 2020. In-hospital outcomes and mortality during the 49 months(interquartile range: 26–73 months) follow-up period were compared between patients with the low prealbumin level(l) and those with the high prealbumin level(≥ 170 mg/l).REsUlTs A total of 114 patients(4.9%) died during hospitalization. After propensity score matching, patients with the low prealbumin level than those with the high prealbumin level experienced higher incidences of heart failure with Killip class Ⅲ(9.9%vs. 4.4%, P = 0.034), cardiovascular death(8.4% vs. 3.4%, P = 0.035) and the composite of major adverse cardiovascular events(19.2%vs. 10.3%, P = 0.012). Multivariate logistic regression analysis identified that the low prealbumin level(l) was an independent predictor of in-hospital major adverse cardiovascular events(odds ratio = 1.918, 95% CI: 1.250–2.942, P = 0.003). The cutoff value of prealbumin level for predicting in-hospital death was 170 mg/l(area under the curve = 0.703, 95% CI: 0.651–0.754, Psensitivity = 0.544, specificity = 0.794). However, after multivariate adjustment of possible confounders, baseline prealbumin level(170 mg/l) was no longer independently associated with 49-month cardiovascular death. After propensity score matching, Kaplan-Meier survival curves revealed consistent *** Decreased prealbumin level closely related to unfavorable short-term outcomes. However, after multivariate adjustment and controlling for baseline differences, baseline prealbumin level was not independently assoc

关键词： patients admitted infarction

Evolution of High-energy Electron Distribution in Pulsar Wind Nebulae

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Research in Astronomy and Astrophysics 2024年第7期24卷 198-214页

作者： Yi-Ming liu Hou-Dun Zeng Yu-liang Xin si-Ming liu Yi Zhang Key laboratory of Dark Matter and space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China school of Astronomy and space science University of Science and Technology of ChinaHefei 230026China school of Physical science and Technology Southwest Jiaotong UniversityChengdu 610031China

In this paper,we analyze the spectral energy distributions of 17 powerful(with a spin-down luminosity greater than10~(35)erg s~(-1))young(with an age less than 15,000 yr)pulsar wind nebulae(PWNe)using a simple timein-dependent one-zone emission *** aim is to investigate correlations between model parameters and the ages of the corresponding PWNe,thereby revealing the evolution of high-energy electron distributions within *** findings are as follows:(1)The electron distributions in PWNe can be characterized by a double power-law with a super-exponential cutoff.(2)As PWNe evolve,the high-energy end of the electron distribution spectrum becomes harder with the index decreasing from approximately 3.5 to 2.5,while the low-energy end spectrum index remains constant near 1.5.(3)There is no apparent correlation between the break energy or cutoff energy and the age of PWNe.(4)The average magnetic field within PWNe decreases with age,leading to a positive correlation between the energy loss timescale of electrons at the break energy or the high-energy cutoff and the age of the PWN.(5)The total electron energy within PWNe remains constant near 2×10~(48)erg,while the total magnetic energy decreases with age.

关键词： radiation mechanisms non-thermal-IsM general-IsM supernova remnants-gamma-rays general

Four late-type Galaxies with Double Radio lobes and Properties of such Galaxies

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Research in Astronomy and Astrophysics 2024年第4期24卷 84-90页

作者： Z.s.Yuan X.Y.Gao Z.l.Wen J.l.Han National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAs Key laboratory of FAsT National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China school of Astronomy and space sciences University of Chinese Academy of SciencesBeijing 100049China

The triggering mechanism for radio lobes from late-type galaxies is not fully *** samples are desired for a thorough investigation and *** utilizing the optical data from the newly released Dark Energy spectroscopic Instrument imaging surveys and the radio sources from the NRAO VlA sky survey and the Faint Images of the Radio sky at Twenty-centimeter,we identify four late-type Galaxies with double Radio lobes(la GRls):J0217-3645,J0947+6220,J1412+3723 and J1736+*** previously known la GRls,we confirm the correlation between radio power P_(1.4GHz)and stellar mass M_(*)of host ***(25/35)la GRls belong to the blue cloud galaxies,while the newly identified cases in this work are located within the region of the red *** find a clear correlation between the differential radio power,i.e.,the offset from the P_(1.4GHz)-M_(*)relation,and the galaxy color,indicating that bluer galaxies at a fixed M_(*)tend to host more powerful radio ***,the majority(31/36)of la GRls are either located in a galaxy group or displaying a disturbed *** suggest that all of the galaxy mass,color and surrounding environment could play important roles in triggering radio lobes in late-type galaxies.

关键词： galaxies:active galaxies:jets galaxies:spiral radio continuum:galaxies

In search of a pan-coronavirus vaccine:next-generation vaccine design and immune mechanisms

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Cellular & Molecular Immunology 2024年第2期21卷 103-118页

作者： s.Cankat M.U.Demael l.swadling Division of Infection and Immunity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

Members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent *** this review,we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus *** will detail the unmet clinical need associated with the continued transmission of sARs-CoV-2,MERs-CoV and the four seasonal coronaviruses(HCoV-OC43,Nl63,HKU1 and 229E)in humans and the potential for future zoonotic *** will highlight how first-generation sARs-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral immunity to coronaviruses and have informed next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of immunity that may offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive immunity Cross-protection Universal

Clinical efficacy of laparoscopic cholecystectomy combined with endoscopic papillary balloon dilation in treatment of gallbladder stones with common bile duct stones: A retrospective study

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World Journal of Gastrointestinal surgery 2024年第6期16卷 1700-1708页

作者： Hong-Dan liu Qi Zhang Wen-si Xu shuang Jin Department of Gastroenterology The Third Affiliated Hospital of Qiqihar Medical UniversityQiqihar 161000Heilongjiang ProvinceChina

BACKGROUND The incidence of cholelithiasis has been on the rise in recent years,but the choice of procedure is *** To investigate the efficacy of laparoscopic cholecystectomy(lC)combined with endoscopic papillary balloon dilation(EPBD)in patients with gallbladder stones(Gs)with common bile duct stones(CBDs).METHODs The clinical data of 102 patients with Gs combined with CBDs were selected for retrospective analysis and divided into either an lC+EPBD group(n=50)or an lC+endoscopic sphincterotomy(EsT)group(n=52)according to surgical ***-related indexes,postoperative recovery,postoperative complications,and expression levels of inflammatory response indexes were compared between the two *** Total surgical time,stone free rate,rate of conversion to laparotomy,and successful stone extraction rate did not differ significantly between the lC+EPBD group and lC+EsT *** hemorrhage,time to ambulation,and length of hospitalization in the lC+EPBD group were lower than those of the lC+EsT group(Pl complications of the two groups was 9.80%and 17.65%,respectively,and the difference was not statistically *** serious complications occurred in either *** 48 h postoperatively,the expression levels of interleukin-6,tumor necrosis factor-α,high-sensitivity Creactive protein,and procalcitonin were lower in the lC+EPBD group than in the lC+EsT group(Pstoperatively,the expression levels of aspartate transaminase,alanine transaminase,and total bilirubin were lower in the lC+EPBD group than in the lC+EsT group(PlUsiON lC combined with EPBD and lC combined with EsT are both effective procedures for the treatment of Gs with CBDs,in which lC combined with EPBD is beneficial to shorten the patient’s hospitalization time,reduce the magnitude of elevated inflammatory response indexes,and promote postoperative recovery.

关键词： Gallbladder stone Common bile duct stone Endoscopic papillary balloon dilation laparoscopic cholecystectomy Endoscopic sphincterotomy

Backward Doubly stochastic Differential Equations with stochastic Non-lipschitz Coefficients

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Acta Mathematicae Applicatae sinica 2024年第4期 908-928页

作者： si-yan XU Yi-dong ZHANG College of science North China University of Technology

In this paper, we prove an existence and uniqueness theorem for backward doubly stochastic differential equations under a new kind of stochastic non-lipschitz condition which involves stochastic and timedependent condition. As an application, we use the result to obtain the existence of stochastic viscosity solution for some nonlinear stochastic partial differential equations under stochastic non-lipschitz conditions.

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Analysis of Two Kinds of stochastic Predator-prey Models with stage structure

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Acta Mathematicae Applicatae sinica 2024年

作者： Xin-qi WANG Tian-si ZHANG College of science University of Shanghai for Science and Technology

In this paper, we studied a stochastic predator-prey model of two predators with stage *** constructing a suitable stochastic lyapunov function, the condition of stationary distribution is verified, and we get the sufficient condition for the model to have ergodic stationary distribution. Then, by using the It?'s formula for the model, the sufficient conditions for the extinction of the predator population are given. Finally,some examples and numerical simulations are illustrated to verify the theoretical results.

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