In search of a pan-coronavirus vaccine:next-generation vaccine design and immune mechanisms
作者机构：Division of Infection and ImmunityInstitute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2024年第21卷第2期
页 面：103-118页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：funded by a Rosetrees Trust and Pears Foundation Advancement Fellowship,SC is funded by a BBSRC LIDo-DTP PhD studentship(BB/T008709/1) UD is funded by an MRC DTP PhD studentship(MR/W006774/1) funding from the UCL Therapeutic.Acceleration Support scheme supported by funding from MRC IAA 2021 UCL MR/X502984/1
主 题：Vaccine Coronavirus Cross-reactive immunity Cross-protection Universal
摘 要：Members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent *** this review,we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus *** will detail the unmet clinical need associated with the continued transmission of SARS-CoV-2,MERS-CoV and the four seasonal coronaviruses(HCoV-OC43,NL63,HKU1 and 229E)in humans and the potential for future zoonotic *** will highlight how first-generation SARS-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral immunity to coronaviruses and have informed next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of immunity that may offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.
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