检索结果-南通市图书馆

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

Revisiting cerebral endothelial cells in Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Modulated Dust-Acoustic Wave Packets in an Opposite Polarity Dusty Plasma system

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2019年第3期71卷 327-333页

作者： s.Jahan N.A.Chowdhury A.mannan A.A.Mamun Department of Physics Jahangirnagar University

The nonlinear propagation of the dust-acoustic bright and dark envelope solitons in an opposite polarity dusty plasma(OPDP) system(composed of non-extensive q-distributed electrons, iso-thermal ions, and positively as well as negatively charged warm dust) has been theoretically investigated. The reductive perturbation method(which is valid for a small, but finite amplitude limit) is employed to derive the nonlinear schr¨odinger equation. Two types of modes, namely, fast and slow dust-acoustic(DA) modes, have been observed. The conditions for the modulational instability(MI) and its growth rate in the unstable regime of the DA waves are significantly modified by the effects of non-extensive electrons, dust mass, and temperatures of different plasma species, etc. The implications of the obtained results from our current investigation in space and laboratory OPDP medium are briefly discussed.

关键词： dust-acoustic waves opposite polarity modulational instability envelope solitons

Rapid,noncontact,sensitive,and semiquantitative characterization of buffered hydrogen-fluoridetreated silicon wafer surfaces by terahertz emission spectroscopy

在线全文

学校读者我要写书评

暂无评论

Light(science & Applications) 2022年第12期11卷 2982-2993页

作者： Dongxun Yang Abdul mannan Fumikazu Murakami Masayoshi Tonouchi Institute of Laser Engineering Osaka University 2-6 YamadaokaSuitaOsaka 565-0871Japan

Advances in modern semiconductor integrated circuits have always demanded faster and more sensitive analytical methods on a large-scale *** surface of wafers is fundamentally essential to start building circuits,and quantitative measures of the surface potential,defects,contamination,passivation quality,and uniformity are subject to *** present study provides a new approach to access those by means of terahertz(THz)emission *** femtosecond laser illumination,THz radiation,which is sensitive to the surface electric fields of the wafer,is ***,we systematically research the THz emission properties of silicon surfaces under different surface conditions,such as the initial surface with a native oxide layer,a fluorine-terminated surface,and a hydrogenterminated ***,a strong doping concentration dependence of the THz emission amplitude from the silicon surface has been revealed in different surface conditions,which implies a semiquantitative connection between the THz emission and the surface band bending with the surface ***-induced THz emission spectroscopy is a promising method for evaluating local surface properties on a wafer scale.

关键词： terminated fluoride fluorine

Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.sARFRAZ Department of Humanities and sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDsolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

关键词：

Optimization of process parameters for the bioconversion of activated sludge by Penicillium corylophilum, using response surface methodology

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental sciences 2007年第1期19卷 23-28页

作者： sarkar mannan Ahmadun Fakhru'l-Razi Md Zahangir Alam Department of Chemical and Environmental Engineering Faculty of Engineering University Putra Malaysia (UPM)43400 UPM SerdangSelangorD.E.Malaysia. Department of Biotechnology Engineering Faculty of Engineering International Islamic University Malaysia (IIUM)Jalan Gombak53100 Kuala LumpurMalaysia.

The optimization of process parameters for the bioconversion of activated sludge by Penicillium corylophilum was investigated using response surface methodology （RsM）. The three parameters namely temperature of 33℃, agitation of 150 r/min, and pH of 5 were chosen as center point from the previous study of fungal treatment. The experimental data on chemical oxygen demand （COD） removal （%） were fitted into a quadratic polynomial model using multiple regression analysis. The optimum process conditions were determined by analyzing response surface three-dimensional surface plot and contour plot and by solving the regression model equation with Design Expert software. Box-Behnken design technique under RsM was used to optimize their interactions, which showed that an incubation temperature of 32.5℃, agitation of 105 r/min, and pH of 5.5 were the best conditions. Under these conditions, the maximum predicted yield of COD removal was 98.43%. These optimum conditions were used to evaluate the trail experiment, and the maximum yield of COD removal was recorded as 98.5%.

关键词： optimization response surface methodology Penicillium activated sludge domestic wastewater sludge

Influence of structural Modification on Work-hardening Behaviour of Type 316 stainless steel

在线全文

学校读者我要写书评

暂无评论

Journal of Materials science & Technology 1998年第5期14卷 399-401页

作者： k.G.samuel s.L.mannan and P.Rodriguez (Metallurgy and Materials Group, Indira Gandhi Centre for Atomic Research, kalpakkam 603 102, India) Metallurgy and Materials Group Indira Gandhi Centre for Atomic Research Kalpakkam 603 102 India

Work-hardening behaviour of type 316 austenitic stainless steel having difFerent initial dislocation structures introduced by swaging to various levels is analysed by a simplified kock's model which takes into account the structural changes through the dislocation accumulation and annihilation process during deformation. The dislocation accumulation and annihilation factors show a temperature and structure dependence. The dislocation annihilation factor shows a plateau or decreasing tendency in the dynamic strain ageing (DsA) temperature range. This is attributed as either due to dislocation accumulation being more pronounced than dislocation annihilation or as due to precipitates being formed at DsA temperatures acting as obstacles to dislocation motion in the DsA temperature range.

关键词： Work Influence of structural Modification on Work-hardening Behaviour of Type 316 stainless steel