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The jasmonate pathway promotes nodule symbiosis and suppresses host plant defense in Medicago truncatula

Molecular Plant 2024年第8期17卷 1183-1203页

作者： Da Guo Jingrui Li Peng Liu Yuzhan Wang na Cao Xiangling Fang Tao Wang Jiangli Dong College of Biological sciences China Agricultural UniversityBeijing 100193China state Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBejing 100193China state Key Laboratory of herbage Improvement and Grassland Agro-ecosystems College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou730020China

Root nodule symbiosis(RNs)between legumes and rhizobia is a major source of nitrogen in agricultural *** symbiosis requires precise regulation of plant defense *** role of the defense hormone jasmonic acid(JA)in the immune response has been extensively *** research shows that JA can play either a positive or negative regulatory role in RNs depending on its concentration,but the molecular mechanisms remain to be *** this study,we found that inoculation with the rhizobia sm1021 induces the JA pathway in Medicago truncatula,and blocking the JA pathway significantly reduces the number of infection *** in the MtMYc2 gene,which encodes a JA signaling master transcription factor,significantly inhibited rhizobia infection,terminal differentiation,and symbiotic cell *** Rna sequencing and chromatin immunoprecipitation sequencing,we discovered that MtMYc2 regulates the expression of nodule-specific MtDNF2,MtnaD1,and MtsymCRK to suppress host defense,while it activates MtDNF1 expression to regulate the maturation of MtNCRs,which in turn promotes bacteroid *** importantly,MtMYC2 participates in symbiotic signal transduction by promoting the expression of ***,the MtMYC2-MtiPD3 transcriptional regulatory module is specifically present in legumes,and the Mtmyc2 mutants are susceptible to the infection by the pathogen Rhizoctonia ***,these findings reveal the molecular mechanisms of how the JA pathway regulates RNs,broadening our understanding of the roles of JA in plant-microbe interactions.

关键词： jasmonic acid MYC2 symbiosis defense Medicago truncatula

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salted egg white derived-peptides VF-4 and DR-8 improve Dss-induced colitis in mice by inhibiting NF-κB/MAPK/PI3K-AKT signaling pathways and modulating gut microbiota composition

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Food science and human Wellness 2024年

作者： na Zhou na Wu Yao Yao shuping Chen Mingsheng Xu Zhongping Yin Yan Zhao Yonggang Tu Jiangxi Key Laboratory of natural Products and Functional Food， Jiangxi Agricultural University Agricultural Products Processing and Quality Control Engineering Laboratory of Jiangxi， Jiangxi Agricultural University Jiangxi Experimental Teaching Demonstration Center of Agricultural Products storage and Processing Engineering， Jiangxi Agricultural University

Inflammation underlies many chronic diseases， and inflammatory bowel disease (IBD) is a condition characterized by long-term inflammation of the gut. Egg whites have been shown to contain many beneficial active substances. Therefore， we obtained two peptides from salted egg white: Val-Val-his-Phe (VF-4) and Asp-Thr-Gln-Ala-Met-Pro-Phe-Arg (DR-8). The sodium dextran sulfate (Dss)-induced mice colitis model was used to evaluate its regulatory effect on colitis in vivo. The results showed that VF-4 and DR-8 improved the clinical symptoms of Dss-induced colitis， attenuated colon tissue damage， inhibited the activation of NF-κB/MAPK/PI3K-AKT signaling pathways， and inhibited the expression of inflammatory cytokines. 16s rRna gene sequencing showed that VF-4 and DR-8 administration increased the relative abundance of intestinal beneficial bacteria including Lactobacillus， Blautia， and down-regulated the relative abundance of inflammation-related bacteria including Acinetobacter， Lachnospiraceae＿NK4A136＿group， Klebsiella. Moreover， the degree of correlation between pro-inflammatory cytokines and microbiota was as follows: IL-6 > TNF-α > IL-1β > IFN-γ. In conclusion， this study suggests that salted egg white peptides VF-4 and DR-8 have a significant anti-inflammatory effect in vivo. It also provides a strategy for the treatment of inflammatory bowel disease and a new way for the high-value utilization of salted egg white.

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Predicting potential invasion risks of Leucaena leucocephala(Lam.)de Wit in the arid area of saudi Arabia

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Journal of Arid Land 2024年第7期16卷 983-999页

作者： haq s MARIFATUL Darwish MOhAMMED Waheed MUhAMMAD Kumar MANOJ siddiqui h MANZER Bussmann W RAINER Department of Ethnobotany Institute of BotanyIlia State UniversityTbilisi 0162Georgia The Centre of Excellence on sustainable Land Management(CoE-sLM) Indian Council of Forestry Research and EducationDehradun 248006India Department of Botany and Microbiology College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Botany State Museum for Natural HistoryKarlsruhe 76133Germany

The presence of invasive plant species poses a substantial ecological impact,thus comprehensive evaluation of their potential range and risk under the influence of climate change is *** study uses maximum entropy(MaxEnt)modeling to forecast the likelihood of Leucaena leucocephala(Lam.)de Wit invasion in saudi Arabia under present and future climate change *** the MaxEnt modeling,we integrated climatic and soil data to predict habitat suitability for the invasive *** conducted a detailed analysis of the distribution patterns of the species,using climate variables and ecological *** focused on the important influence of temperature seasonality,temperature annual range,and precipitation *** distribution modeling used robust measures of area under the curve(AUC)and receiver-operator characteristic(ROC)curves,to map the invasion extent,which has a high level of accuracy in identifying appropriate *** complex interaction that influenced the invasion of *** was highlighted by the environmental parameters using Jackknife ***,the actual geographic area where *** was found in saudi Arabia was considerably smaller than the theoretical maximum range,suggesting that it had the capacity to expand *** MaxEnt model exhibited excellent prediction accuracy and produced reliable results based on the data from the ROC *** and temperature were the primary factors influencing the potential distribution of ***,an estimated area of 216,342 km^(2)in saudi Arabia was at a high probability of invasion by *** investigated the potential for increased invasion hazards in the future due to climate change scenarios(shared socioeconomic Pathways(ssPs)245 and 585).The analysis of key climatic variables,including temperature seasonality and annual range,along with soil properties such as clay composition and nitrogen content,unveiled their substanti

关键词： area under the curve invasive species invasion risks climate change MaxEnt model

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Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy

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Chinese Chemical Letters 2024年第6期35卷 445-450页

作者： Leichen Wang Anqing Mei na Li Xiaohong Ruan Xu sun Yu Cai Jinjun shao Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211800China school of Chemistry&Materials science Jiangsu Normal UniversityXuzhou 221116China Center for Rehabilitation Medicine Rehabilitation&Sports Medicine Research Institute of Zhejiang ProvinceDepartment of Rehabilitation MedicineZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014China

Introducing heavy halogen atoms into organic small molecules is a practical strategy for efficient singlet oxygen(^(1)O_(2))***,bromine or iodine atoms are introduced on the aza-borondipyrromethene(aza-BODIPY)core,rather than on the periphery aryl rings for efficient~1O_(2) ***,an aza-BODIPY dye NBDPBr with unexpected bromination on the periphery aryl rings was synthesized for photoacoustic(PA)imaging-guided synergistic photothermal therapy(PTT)and photodynamic therapy(PDT)in tumor *** to unexcepted bromination at the periphery aryl rings,NBDPBr demonstrated an outstanding singlet oxygen quantum yield(Φ_(Δ))of 66% which was superior to similar brominated photosensitizers previously *** encapsulation with amphiphilic polymer F-127,hydrophilic NBDPBr nanoparticles(NPs)were fabricated and exhibited an excellent photothermal conversion efficiency(η)of 43.0% under 660 nm *** vivo PA imaging results demonstrated that NBDPBr NPs could specifically accumulate at tumor sites and realized the maximum tumor retention at 7 h *** the in vitro and in vivo results indicated the significant potence of NBDPBr with unexpected bis-bromination for PA imaging-guided synergetic PDT/PTT.

关键词： Unexpected bromination Aza-BODIPY Photodynamic therapy Photothermal therapy synergetic therapy

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The OsBsK1-2-MAPK module regulates blast resistance in rice

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The Crop Journal 2024年第1期12卷 110-120页

作者： shengping Li Xinquan Xiang Zhijuan Diao na Xia Ling Lu Jing Zhang Zhiwei Chen Dingzhong Tang state Key Laboratory of Ecological Control of Fujian-Taiwan Crop Pests Key Laboratory of Ministry of Education for GeneticsBreeding and Multiple Utilization of CropsPlant Immunity CenterFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina College of Life science Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Ministerial and Provincial Joint Innovation Centre for safety Production of Cross-strait Crops Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Provincial Key Laboratory of Crop Breeding by Design Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina

Receptor-like cytoplasmic kinase OsBsK1-2 was reported to play an important role in regulation of response to rice blast,but the signaling pathway remained *** this study,we identified OsMAPKKK18 and previously uncharacterized MAPKKKs OsMAPKKK16 and OsMAPKKK19 that interact with *** of all three MAPKKKs was induced by Magnaporthe oryzae infection,and all three induced cell death when transiently expressed in Nicotiana benthamiana *** of OsMAPKKK16 and OsMAPKKK18 compromised blast resistance and overexpression of OsMAPKKK19 increased blast resistance,indicating that all three MAPKKKs are involved in regulation of rice blast ***,both OsMAPKKK16 and OsMAPKKK19 interacted with and phosphorylated OsMKK4 and OsMKK5,and chitin-induced MAPK activation was suppressed in osmapkkk16 and osbsk1-2 ***18 was earlier reported to interact with and phosphorylate OsMKK4 and affect chitin-induced MAPK activation,suggesting that OsBsK1-2 is involved in regulation of immunity through multiple MAPK signaling *** BsK1 in Arabidopsis,OsBsK1-2 was not involved in response to avirulent *** *** together,our results revealed important roles of OsMAPKKK16/18/19 and a OsBsK1-2-OsMAPKKK16/18/19-OsMKK4/5 module in regulating response to rice blast.

关键词： Disease resistance Magnaporthe oryzae Oriza sativa Rice blast

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MdbhLh162 connects the gibberellin and jasmonic acid signals to regulate anthocyanin biosynthesis in apple

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Journal of Integrative Plant Biology 2024年第2期66卷 265-284页

作者： Jian-Ping An Rui-Rui Xu Xiao-na Wang Xiao-Wei Zhang Chun-Xiang You Yuepeng han Apple technology innovation center of shandong Province College of Horticulture Science and EngineeringShandong Agricultural UniversityTai-An 271018China CAs Key Laboratory of Plant Germplasm Enhancement and specialty Agriculture Wuhan Botanical GardenHubei Hongshan LaboratoryThe Innovative Academy of Seed Design of Chinese Academy of SciencesWuhan 430074China College of Biology and Oceanography Weifang UniversityWeifang 261061China

Anthocyanins are secondary metabolites induced by environmental stimuli and developmental *** positive regulators of anthocyanin biosynthesis have been reported,whereas the anthocyanin repressors have been *** the signal transduction pathways of gibberellin(GA)and jasmonic acid(JA)and their regulation of anthocyanin biosynthesis have been investigated,the cross-talk between GA and JA and the antagonistic mechanism of regulating anthocyanin biosynthesis remain to be *** this study,we identified the anthocyanin repressor MdbhLh162 in apple and revealed its molecular mechanism of regulating anthocyanin biosynthesis by integrating the GA and JA ***162 exerted passive repression by interacting with MdbhLh3 and MdbhLh33,which are two recognized positive regulators of anthocyanin ***162 negatively regulated anthocyanin biosynthesis by disrupting the formation of the anthocyanin-activated MdMYB1-MdbhLh3/33complexes and weakening transcriptional activation of the anthocyanin biosynthetic genes MdDFR and MdUF3GT by MdbhLh3 and *** GA repressor MdRGL2a antagonized MdbhLh162-mediated inhibition of anthocyanins by sequestering MdbhLh162 from the MdbhLh162-MdbhLh3/33 *** JA repressors MdJAZ1 and MdJAZ2 interfered with the antagonistic regulation of MdbhLh162 by MdRGL2a by titrating the formation of the MdRGL2a-MdbhLh162 *** findings reveal that MdbhLh162 integrates the GA and JA signals to negatively regulate anthocyanin *** study provides new information for discovering more anthocyanin biosynthesis repressors and explores the cross-talk between hormone signals.

关键词： anthocyanin biosynthesis bhLh transcription factor gibberellin jasmonic acid regulatory network transcriptional regulation

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Visual test paper based on Au/δ-MnO_(2) hollow nanosphere oxidase-like activity regulation using hexavalent chromium as a smart switch

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Rare Metals 2024年第2期43卷 711-722页

作者： Wen-Chang Zhuang hai-Yue Zhang Zhen-Yang Chen Wen-Jing Cheng Wei-Dan na Zhao Li Lin Tian school of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou221018China school of Chemistry and Environmental science Yili Normal UniversityYining835000China

Paper-based sensing platform is a point of need analytical toolkit for safety ***,the sensitivity,specificity,and simplicity are still ***,we report a novel strategy(Au/δ-MnO_(2) hollow nanosphere and 3,3′,5,5′-tetramethylbenzidine(TMB)induced test strips for signal-on detection)that can be utilized for hexavalent chromium(Cr^(6+))***,Cr^(6+)(CrO_(4)^(2−)) as a smart switch can remarkably enhance the oxidase-like activity of Au/δ-MnO_(2) hollow *** presence of Cr^(6+) can regulate the surface electronic redistribution of Au/δ-MnO_(2) and adjust the geometric configuration,which leads to the improvement in oxidase-like activity of Au/δ-MnO_(2).As a proof-of-concept application,a visual paper-based sensing platform of Cr^(6+) along with quantitative analysis by the test strips was successfully *** paper-based sensing platform exhibits a linear range with excellent selectivity for other interfering substances and lower limit of detection of 0.09μmol·L^(−1),providing a promising toolkit at-home Cr^(6+) measurement and environmental monitoring.

关键词： Point of need Colorimetric biosensing platform Au/δ-MnO_(2) hollow nanosphere Test strip Cr^(6+)

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Risk factors associated with intraoperative persistent hypotension in pancreaticoduodenectomy

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World Journal of Gastrointestinal surgery 2024年第6期16卷 1582-1591页

作者： Xing-Jun Wang Xi-Chen Xuan Zhao-Chu sun shi shen Fan Yu na-na Li Xue-Chun Chu hui Yin You-Li hu Department of Anesthesia and Perioperative Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Intraoperative persistent hypotension(IPh)during pancreaticoduodenectomy(PD)is linked to adverse postoperative outcomes,yet its risk factors remain *** To clarify the risk factors associated with IPh during PD,ensuring patient safety in the perioperative *** A retrospective analysis of patient records from January 2018 to December 2022 at the First Affiliated hospital of nanjing Medical University identified factors associated with IPh in *** factors included age,gender,body mass index,American society of Anesthesiologists classification,comorbidities,medication history,operation duration,fluid balance,blood loss,urine output,and blood gas *** was defined as sustained mean arterial pressurehg,requiring prolonged deoxyepinephrine infusion for>30 min despite additional deoxyepinephrine and fluid *** Among 1596 PD patients,661(41.42%)experienced *** logistic regression identified key risk factors:increased age[odds ratio(OR):1.20 per decade,95%confidence interval(CI):1.08-1.33](Psurgery duration(OR:1.15 per additional hour,95%CI:1.05-1.26)(Pss(OR:1.18 per 250-mL increment,95%CI:1.06-1.32)(Ps the association of arterial blood Ca^(2+)h IPh(OR:2.03,95%CI:1.65-2.50)(PsION IPh during PD is independently associated with older age,prolonged surgery,increased blood loss,and lower plasma Ca^(2+).

关键词： Risk factors Pancreaticoduodenectomy Perioperative period Intraoperative persistent hypotension Retrospective cohort study

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Endoscopic treatment of biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants: Lessons learned from single-balloon enteroscopy-assisted ERCP

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hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 509-514页

作者： Rodrigo Garcés-Durán Laurent Monino Pierre h Deprez hubert Piessevaux Tom G Moreels Department of Gastroenterology and hepatology Universitécatholique de LouvainCliniques Universitaires Saint-LucAvenue Hippocrates 101200 BrusselsBelgium

Background: Endoscopic treatment of biliopancreatic pathology is challenging due to surgically altered anatomy after Whipple's pancreaticoduodenectomy. This study aimed to evaluate the feasibility and safety of single-balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography(sBE-ERCP) to treat biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants. Methods: We retrospectively analyzed 106 sBE-ERCP procedures in 46 patients with Whipple's variants. Technical and clinical success rates and adverse events were evaluated. Results: Biliary sBE-ERCP was performed in 34 patients and pancreatic sBE-ERCP in 17, including 5 with both indications. From a total of 106 sBE-ERCP procedures, 76 were biliary indication with technical success rate of 68/76(90%) procedures and clinical success rate of 30/34(88%) patients. Mild adverse event rate was 8/76(11%), without serious adverse events. From a total of 106 sBE-ERCP procedures, 30 were pancreatic indication with technical success rate of 24/30(80%) procedures( P = 0.194 vs. biliary sBEERCP) and clinical success rate of 11/17(65%) patients( P = 0.016 vs. biliary sBE-ERCP). Mild adverse event rate was 6/30(20%)( P = 0.194 vs. biliary sBE-ERCP), without serious adverse events. After sBE-ERCP failure, endoscopic ultrasound-guided drainage, percutaneous drainage and redo surgery were alternative therapeutic options. Conclusions: Biliopancreatic pathology after Whipple's pancreaticoduodenectomy variants can be treated using sBE-ERCP without serious adverse events. Technical and clinical success rates are high for biliary indications, whereas clinical success rate of pancreatic indications is significantly lower. sBE-ERCP can be considered as first-line treatment option in this patient group with surgically altered anatomy.

关键词： Enteroscopy Endoscopic retrograde cholangiopancreatography Pancreaticoduodenectomy surgically altered anatomy Whipple’s procedure

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strain sensor on a chip for quantifying the magnitudes of tensile stress on cells

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Microsystems & nanoengineering 2024年第3期10卷 305-315页

作者： Yuyin Zhang Yue Wang hongze Yin Jiahao Wang na Liu songyi Zhong Long Li Quan Zhang Tao Yue school of Mechatronics Engineering and Automation Shanghai UniversityShanghaiChina school of Future Technology Shanghai UniversityShanghaiChina Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhouChina shanghai Key Laboratory of Intelligent Manufacturing and Robotics Shanghai UniversityShanghaiChina shanghai Institute of Intelligent science and Technology Tongji UniversityShanghaiChina

During cardiac development,mechanotransduction from the in vivo microenvironment modulates cardiomyocyte growth in terms of the number,area,and arrangement ***,the response of cells to different degrees of mechanical stimuli is ***-on-a-chip,as a platform for investigating mechanical stress stimuli in cellular mimicry of the in vivo microenvironment,is limited by the lack of ability to accurately quantify externally induced ***,previous technology lacks the integration of external stimuli and feedback sensors in microfluidic platforms to obtain and apply precise amounts of external ***,we designed a cell stretching platform with an in-situ *** in-situ liquid metal sensors can accurately measure the mechanical stimulation caused by the deformation of the vacuum cavity exerted on *** platform was applied to human cardiomyocytes(AC16)under cyclic strain(5%,10%,15%,20 and 25%),and we found that cyclic strain promoted cell growth induced the arrangement of cells on the membrane to gradually unify,and stabilized the cells at 15%amplitude,which was even more effective after 3 days of *** platform’s precise control and measurement of mechanical forces can be used to establish more accurate in vitro microenvironmental models for disease modeling and therapeutic research.

关键词： stress deformation arrangement

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