Strain sensor on a chip for quantifying the magnitudes of tensile stress on cells

作     者：Yuyin Zhang Yue Wang Hongze Yin Jiahao Wang Na Liu Songyi Zhong Long Li Quan Zhang Tao Yue 

作者机构：School of Mechatronics Engineering and AutomationShanghai UniversityShanghaiChina School of Future TechnologyShanghai UniversityShanghaiChina Key Laboratory of Advanced Manufacturing Technology of Zhejiang ProvinceSchool of Mechanical EngineeringZhejiang UniversityHangzhouChina Shanghai Key Laboratory of Intelligent Manufacturing and RoboticsShanghai UniversityShanghaiChina Shanghai Institute of Intelligent Science and TechnologyTongji UniversityShanghaiChina 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2024年第10卷第3期

页      面：305-315页

核心收录：

学科分类：0710[理学-生物学] 080202[工学-机械电子工程] 08[工学] 0802[工学-机械工程] 

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.62373235,62303290,and 62073208) the Shanghai Science and Technology Committee Natural Science Foundation(No.23ZR1423700) the Shanghai Municipal Education Innovation Project 2021-09-E00113 

主　　题：stress deformation arrangement 

摘      要：During cardiac development,mechanotransduction from the in vivo microenvironment modulates cardiomyocyte growth in terms of the number,area,and arrangement ***,the response of cells to different degrees of mechanical stimuli is ***-on-a-chip,as a platform for investigating mechanical stress stimuli in cellular mimicry of the in vivo microenvironment,is limited by the lack of ability to accurately quantify externally induced ***,previous technology lacks the integration of external stimuli and feedback sensors in microfluidic platforms to obtain and apply precise amounts of external ***,we designed a cell stretching platform with an in-situ *** in-situ liquid metal sensors can accurately measure the mechanical stimulation caused by the deformation of the vacuum cavity exerted on *** platform was applied to human cardiomyocytes(AC16)under cyclic strain(5%,10%,15%,20 and 25%),and we found that cyclic strain promoted cell growth induced the arrangement of cells on the membrane to gradually unify,and stabilized the cells at 15%amplitude,which was even more effective after 3 days of *** platform’s precise control and measurement of mechanical forces can be used to establish more accurate in vitro microenvironmental models for disease modeling and therapeutic research.