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Lipid droplets.in the nervous.s.s.em:involvement in cell metabolic homeos.as.s

Neural Regeneration Res.arch 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing chen cheng Zhuang j.ngxuan Qi Robert Chunhua Zhao j.ao Wang s.hool of Life s.iences Shanghai UniversityShanghaiChina s.hool of Medicine Shanghai UniversityShanghaiChina Ins.itute of Bas.c Medical s.iences.Chines. Academy of Medical s.iences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tis.ue Engineering Chinese Academy of Medical SciencesBeijingChina Beij.ng Key Laboratory of New Drug Development and Clinical Trial of s.em Cell Therapy BeijingChina

Lipid droplets.s.rve as.primary s.orage organelles.for neutral lipids.in neurons.glial cells.and other cells.in the nervous.*** droplet formation begins.with the s.nthes.s.of neutral lipids.in the endoplas.ic ***,lipid droplets.were recognized for their role in maintaining lipid metabolis. and energy homeos.as.s.however,recent res.arch has.s.own that lipid droplets.are highly adaptive organelles.with divers. functions.in the nervous.*** addition to their role in regulating cell metabolis.,lipid droplets.play a protective role in various.cellular s.res. ***,lipid droplets.exhibit s.ecific functions.in neurons.and glial *** of lipid droplet formation leads.to cellular dys.unction,metabolic abnormalities.and nervous.s.s.em *** review aims.to provide an overview of the role of lipid droplets.in the nervous.s.s.em,covering topics.s.ch as.biogenes.s.cellular s.ecificity,and ***,it will explore the as.ociation between lipid droplets.and neurodegenerative *** the involvement of lipid droplets.in cell metabolic homeos.as.s.related to the nervous.s.s.em is.crucial to determine the underlying caus.s.and in exploring potential therapeutic approaches.for thes. dis.as.s.

关键词： Alzheimer's.dis.as. lipid droplet biogenes.s lipid droplets lipid metabolis. nervous.s.s.em neurodegenerative dis.rders oxidative s.res. Parkins.n's.dis.as.

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Probing Co/s. interface behaviour by X-ray photoelectron s.ectros.opy (XPs. and atomic force micros.opy (AFM)

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Nuclear s.ience and Techniques 2006年第4期17卷 202-211页

作者： PAN j. s. LIU R. s. TOK E. s. Ins.itute of Materials.Res.arch and Engineering 3 Research Link Singapore 117602 Department of Phys.cs National University of Singapore Kent Ridge Singapore 119260

In this.work, we inves.igate the Co-s. reaction, the Co growth mode at room temperature, diffus.on be- haviour as.well as.morphology evolution during annealing on both H-terminated and clean s.(001) and s.(111) s.r- faces. From in-s.tu X-ray photoelectron s.ectros.opy (XPs. inves.igation, “Co-s.” reaction appears.to occur on both H-terminated and clean s.rfaces.at room temperature (RT) and the s.licide crys.allinity is.improved upon annealing. Co growth mode on H-terminated s. s.rfaces.occurs.in a ps.udo layer-by-layer manner while s.all clos.-packed is. land growth mode is.obs.rved on the clean s. s.rface. Upon annealing at different temperatures. Co atom concentra- tion decreas.s.vers.s.annealing time, which in part is.attributed to Co atoms.inward diffus.on. The diffus.on behav- iour on both types.of s.rfaces.demons.rates.a s.milar trend. Morphology s.udy us.ng ex-s.tu atomic force micros.opy (AFM) s.ows.that the is.ands.formed on s.(001) s.rface after annealing at 700 °C are elongated with growth direc- tions.alternate between the two perpendicular [ 110 ] and [110] directions. Triangular is.ands.are obs.rved on s. (111) s.rface.

关键词：钴硅金属-半导体界面反应 X射线光电子光谱学原子力显微镜方法表面形态

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s.miconducting Carbon Nanotube/Fullerene Blended Heteroj.nctions.for Photovoltaic Near-Infrared Photon Harves.ing

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Nano Res.arch 2011年第11期4卷 1174-1179页

作者： Dominick j. Bindl Adam s. Brewer Michael s. Arnold 1509 Univers.ty Ave. Materials Science and Engineering Dept. University of Wisconsin-Madison Madison WI 53706 USA

We demons.rate that the near-infrared （NIR） abs.rptivity of s.miconducfing s.ngle-walled carbon nanotubes.（s.s.CNTs. can be harnes.ed in blended heteroj.nctions.with the fullerene derivative [6,6]-phenyl-C61-butyric acid methyl es.er （PCBM）. Photogenerated charge s.paration is.efficiently driven by the ultrahigh interracial area of the blends.and the favorable energy offs.ts.between the two materials. NIR-s.ns.tive photovoltaic and photodetector devices.utilizing the s.ack （indium tin oxide/ca. 10 nm s.s.CNT：PCBM/100 nm Cj.0 nm 2,9- dimethyl-4,7-diphenyl-],10-phenanthroline （BCP）/Ag） were fabricated with NIR power convers.on efficiencies.〉1.3% and peak, zero bias.external quantum efficiency of 18% at λ = 1205 nm.

关键词： Carbon nanotube bulk heteroj.nction photovoltaic photodetector near-infrared (NIR)

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A modified Muras.ige and s.oog media for efficient multiples.oot induction in G. arborea Roxb.

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j.urnal of Fores.ry Res.arch 2014年第3期25卷 557-564页

作者： s.ilpa s. Madke Konglanth j. Cherian Rupes. s. Badere Department of Botany Hislop College Department of Botany RTM Nagpur University M. J. Phuley Educational Campus

This.paper reports.on the effect of various.micropropagation factors.of Gmelina arborea Roxb. through multiple s.oot induction. Factors.like the s.urce and age of explants. plant growth regulators.（PGRs., media compos.tion, and carbon s.urce affected multiple s.oot-ing in the pres.nt s.udy. Among all the explants.us.d, only s.oot tips.derived from one, two, and three week old s.edlings.could form multiple s.oots. Bes.des. the formation of multiple s.oots.depended on the con-centration and combination of PGRs. Among all the PGRs. BAP （6-benzylaminopurine） alone gave the highes. regeneration efficiency. s.mi-larly, IBA （Indole-3-butyric acid） was.the mos. efficient PGR in inducing root formation in the micros.oots. Media compos.tion and carbon s.urce als. affected the regeneration efficiency. Ms.（Muras.ige and s.oog medium） proved to be the bes. media for regeneration followed by B5, s. （s.0}k and Hilderbrandt medium） and WPM （Woody plant medium） in that order. s.milarly, among s.gars. only s.cros. and glucos. s.p-ported induction of micros.oots. Bas.d on this.s.udy we recommend the us. of glucos. in place of s.cros. in Ms.medium for maximum regenera-tion efficiency.

关键词： agrofores.ry micropropagation plant nutrition s.oot tipexplant timber plant Verbenaceae

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The emerging role of nitric oxide in the s.naptic dys.unction of vas.ular dementia

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Neural Regeneration Res.arch 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying chen Yinyi Xiong Qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina j.uj.ang Clinical Precis.on Medicine Res.arch Center JiujiangJiangxi ProvinceChina Center for Cognitive s.ience and Trans.is.iplinary s.udies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophys.ology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increas. in global aging,the number of people affected by cerebrovas.ular dis.as.s.is.als. increas.ng,and the incidence of vas.ular dementia-clos.ly related to cerebrovas.ular ris.-is.increas.ng at an epidemic ***,few therapeutic options.exis. that can markedly improve the cognitive impairment and prognos.s.of vas.ular dementia *** in Alzheimer’s.dis.as. and other neurological dis.rders.s.naptic dys.unction is.recognized as.the main reas.n for cognitive *** oxide is.one of the ubiquitous.gas.ous.cellular mes.engers.involved in multiple phys.ological and pathological proces.es.of the central nervous.***,nitric oxide has.been implicated in regulating s.naptic plas.icity and plays.an important role in the pathogenes.s.of vas.ular *** review introduces.in detail the emerging role of nitric oxide in phys.ological and pathological s.ates.of vas.ular dementia and s.mmarizes.the divers. effects.of nitric oxide on different as.ects.of s.naptic dys.unction,neuroinflammation,oxidative s.res.,and blood-brain barrier dys.unction that underlie the progres. of vas.ular ***,we propos. that targeting the nitric oxide-s.C-cGMP pathway us.ng certain s.ecific approaches.may provide a novel therapeutic s.rategy for vas.ular dementia.

关键词： endoplas.ic reticulum s.res. endothelial nitric oxide s.nthas. gene therapy nitric oxide NO-s.C-cGMP pathway s.naptic dys.unction vas.ular dementia

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s.licaceae detoxification abilities.in Florida tiger s.allowtail butterflies.（Papilio glaucus.maynardi Gauthier）＂ Novel ability or Pleis.ocene holdover？

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Ins.ct s.ience 2012年第3期19卷 337-345页

作者： Matthew s. Lehnert j. Mark s.riber McGuire Center for Lepidoptera and Biodivers.ty Florida Museum of Natural History University of Florida Gainesville Florida Department of Entomology Soils and Plant Sciences Clemson University Clemson South Carolina Department of Entomology Michigan State University East Lansing Michigan USA

Florida populations.of the eas.ern tiger s.allowtail butterfly, Papilio glaucus.L., have unique morphological features.and ecological adaptations.that have contributed to their s.bs.ecies.s.atus.（P. g. rnaynardi Gauthier）. We des.ribe geographically unique abilities.for detoxification of Carolina willow, s.lix caroliniana Michx. （s.licaceae）, for s.veral Florida populations.of P. g. maynardi. Of all the approximately 570 worldwide s.ecies.of the Papilionidae, s.ch s.licaceae detoxification abilities.exis. only in the allopatric North American wes.ern and northernmos. s.ecies.（P. rutulus.Lucas. R eurymedon Lucas.and P. canadens.s.Roths.hild ＆ j.rdan）. Females.of P. glaucus.collected from populations.in s.utheas.ern Us. were examined for ovipos.tion preference in 5-choice as.ays. and dis.layed a low preference for s.licaceae （〈5%）, but larvae from Florida populations.exhibited a high s.rvival （〉 60%） on thes. plants. Detoxification abilities.have previous.y s.own to be autos.mally inherited, and can be trans.erred via natural or hand-paired inters.ecific hybrid introgres.ion. However, thes. Florida populations.are at leas. 700-1 500 km from the neares. hybrids.or the hybrid s.ecies. 17. appalachiens.s.Pavulaan ＆ Wright, which pos.es. thes. detoxification abilities. In any cas., the Z （ = X）-linked ovipos.tion preferences.for s.licaceae are lacking in thes. Florida populations. illus.rating genetic independence ofovipos.tion preference determination and larval s.rvival/performance abilities. The origins.of detoxification abilities.are unlikely to be due to recent climate-driven introgres.ion, and may repres.nt ances.ral trait carry-overs.from interglacial refugium populations.of the Pleis.ocene epoch.

关键词： eas.ern tiger s.allowtail genetic introgres.ion interglacial is.and refugia,Papilio glaucus.maynardi Papilionidae hos. plants s.licaceae detoxification

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Between a Rock and a Dry Place： The Water-s.res.ed Mos.

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Molecular Plant 2009年第3期2卷 478-486页

作者： Audra j. Charron Ralph s. Quatrano Department of Biology Washington University in St Louis 1 Brookings Dr. St Louis MO 63130 USA

The earlies. land plants.faced a s.ite of abiotic s.res.es.largely unknown to their aquatic algal ances.ors. The des.endants.of thes. plants.evolved two general mechanis.s.for s.rvival in the relatively arid aerial environment. While the vas.ular plants.or ＇tracheophytes. developed tis.ue s.ecializations.to trans.ort and retain water, the other main lineages.of land plants. the bryophytes. retained a s.mple, nonvas.ular morphology. The bryophytes.-mos.es. hornworts. and liverworts.-continually undergo a co-equilibration of their water content with the s.rrounding environment and rely to a great extent on intrins.c cellular mechanis.s.to mitigate damage due to water s.res.. This.s.ort review will focus.on the cellular and molecular res.ons.s.to dehydration and rehydration in mos.es. and offer ins.ghts.into general plant res.ons.s.to water s.res..

关键词： Abiotic/environmental s.res. ABA poikilohydry Tortula ruralis bryophytes Phys.omitrella patens.

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Impacts.of Nutlin-3a and exercis. on murine double minute 2-enriched glioma treatment

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Neural Regeneration Res.arch 2025年第4期20卷 1135-1152页

作者： Yis.eng chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li Weiwei Lin Zhihua Han Beij.e Qi j.nrong Lin Yaying s.n j.ebin Huang Yuzhen Xu s.iyi chen Department of s.ort Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic s.rgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Bas.c Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neuros.rgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious.Dis.as.s Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent res.arch has.demons.rated the impact of phys.cal activity on the prognos.s.of glioma patients.with evidence s.gges.ing exercis. may reduce mortality ris.s.and aid neural *** role of the s.all ubiquitin-like modifier(s.MO)protein,es.ecially pos.-exercis.,in cancer progres.ion,is.gaining attention,as.are the potential anti-cancer effects.of *** us.d machine learning to create the exercis. and s.MO-related gene s.gnature(Es.Rs..This.s.gnature s.ows.how phys.cal activity might help improve the outlook for low-grade glioma and other *** demons.rated the prognos.ic and immunotherapeutic s.gnificance of Es.Rs.markers.s.ecifically highlighting how murine double minute 2(MDM2),a component of the Es.Rs.can be targeted by *** unders.ores.the intricate relations.ip between natural compounds.s.ch as.nutlin-3 and immune *** comprehens.ve CRIs.R s.reening,we validated the effects.of s.ecific Es.Rs.genes.on low-grade glioma *** als. revealed ins.ghts.into the effectivenes. of Nutlin-3a as.a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreas.d with MDM2 overexpres.ion,and this.was.revers.d by Nutlin-3a or *** us.ng a low-grade glioma mous. model highlighted the effect of phys.cal activity on oxidative s.res. and molecular pathway ***,both phys.cal exercis. and Nutlin-3a adminis.ration improved phys.cal function in mice bearing tumors.derived from MDM2-overexpres.ing *** res.lts.s.gges. the potential for Nutlin-3a,an MDM2 inhibitor,with phys.cal exercis. as.a therapeutic approach for glioma *** res.arch als. s.pports.the us. of natural products.for therapy and s.eds.light on the interaction of exercis.,natural products.and immune regulation in cancer treatment.

关键词： exercis. and s.MO-related gene s.gnatures.Es.Rs. glioblas.oma management low-grade glioma natural bioactives neural regeneration phys.cal exercis.

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A s.s.ematic review of progenitor s.rvival and maturation in Parkins.nian models

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Neural Regeneration Res.arch 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís.Dowd Pharmacology&Therapeutics.and Galway Neuros.ience Center University of GalwayGalwayIreland

s.em cell-bas.d brain repair is.a promis.ng emergent therapy for Parkins.n's.dis.as. bas.d on years.of foundational res.arch us.ng human fetal donors.as.a cell *** current therapeutic options.for patients.this.approach has.the potential to provide longterm s.em cell–derived recons.ruction and res.oration of the dopaminergic input to denervated regions.of the brain allowing for res.oration of certain functions.to *** ultimate clinical s.cces. of s.em cell–derived brain repair will depend on both the s.fety and efficacy of the approach and the latter is.dependent on the ability of the trans.lanted cells.to s.rvive and differentiate into functional dopaminergic neurons.in the Parkins.nian *** the pre-clinical literature s.gges.s.that there is.cons.derable variability in s.rvival and differentiation between s.udies.the aim of this.s.s.ematic review was.to as.es. thes. parameters.in human s.em cell-derived dopaminergic progenitor trans.lant s.udies.in animal models.of Parkins.n's.dis.as..A defined s.s.ematic s.arch of the PubMed databas. was.completed to identify relevant s.udies.publis.ed up to March *** s.reening,76 articles.were included in the analys.s.from which 178 s.parate trans.lant s.udies.were *** thes.,graft s.rvival could be as.es.ed in 52 s.udies.and differentiation in 129 ***,we found that graft s.rvival ranged froms.trans.lanted,with a median of 51%of trans.lanted cells.s.rviving in the brain;while dopaminergic differentiation of the cells.ranged from 0% to 46% of cells.trans.lanted with a median of 3%.This.s.s.ematic review s.gges.s.that there is.cons.derable s.ope for improvement in the differentiation of s.em cell-derived dopaminergic progenitors.to maximize the therapeutic potential of this.approach for patients.

关键词： cell replacement therapy differentiation embryonic s.em cells graft induced pluripotent s.em cells Parkins.n's.dis.as. s.rvival trans.lant

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Des.gn and experimental validation of looped-tube thermoacous.ic engine

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j.urnal of Thermal s.ience 2011年第5期20卷 423-429页

作者： Abdulrahman s. Abdulj.lil Zhibin Yu Artur j. j.wors.i Univers.ty of Manches.er School of MACE Sackville Street Manchester M13 9PL UK Univers.ty of Leices.er Department of Engineering University Road Leicester LE1 7RH UK

The aim of this.paper is.to pres.nt the des.gn and experimental validation proces. for a thermoacous.ic looped-tube engine. The des.gn procedure cons.s.s.of numerical modelling of the s.s.em us.ng DELTA EC tool, Des.gn Environment for Low-amplitude ThermoAcous.ic Energy Convers.on, in particular the effects.of mean pres.ure and regenerator configuration on the pres.ure amplitude and acous.ic power generated. This.is.followed by the cons.ruction of a practical engine s.s.em equipped with a ceramic regenerator - a s.bs.rate us.d in auto- motive catalytic converters.with fine s.uare channels. The preliminary tes.ing res.lts.are obtained and compared with the s.mulations.in *** meas.rement res.lts.agree very well on the qualitative level and are reas.nably clos. in the quantitative s.ns..

关键词： Thermoacous.ic engine looped tube modelling s.mulation

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