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In vitro angiogenesis in response to biomaterial properties for bone tissue engineering:a review of the state of the art

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Regenerative Biomaterials 2023年第1期10卷 744-783页

作者： else ellermann Nima Meyer ruth e.cameron Serena M.Best Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK

Bone tissue engineering(BTe)aims to improve the healing of bone fractures using scaffolds that mimic the native extracellular *** successful bone regeneration,scaffolds should promote simultaneous bone tissue formation and blood vessel growth for nutrient and waste ***,a significant challenge in regenerative medicine remains the development of grafts that can be vascularized *** other things,optimization of physicochemical conditions of scaffolds is key to achieving appropriate angiogenesis in the period immediately following *** phosphates and collagen scaffolds are two of the most widely studied biomaterials for BTe,due to their close resemblance to inorganic and organic components of bone,respectively,and their bioactivity,tunable biodegradability and the ability to produce tailored *** various strategies exist to enhance vascularization of these scaffolds in vivo,further in vitro assessment is crucial to understand the relation between physicochemical properties of a biomaterial and its ability to induce *** mono-culture studies can provide evidence regarding cell-material interaction of a single cell type,a co-culture procedure is crucial for assessing the complex mechanisms involved in angiogenesis.A co-culture more closely resembles the natural tissue both physically and biologically by stimulating natural intercellular interactions and mimicking the organization of the in vivo ***,a co-culture is a complex system requiring optimization of various parameters including cell types,cell ratio,culture medium and seeding *** fundamental knowledge of the mechanism behind the bioactivity of biomaterials and understanding the contribution of surface and architectural features to the vascularization of scaffolds,and the biological response in general,can provide an invaluable basis for future optimization *** review gives an overview of the

关键词： angiogenesis collagen scaffolds hydroxyapatite co-culture architectural features physicochemical properties

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Adjusting the physico-chemical properties of collagen scaffolds to accommodate primary osteoblasts and endothelial cells

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Regenerative Biomaterials 2023年第1期10卷 590-602页

作者： Nima Meyer Daniel V.Bax Jochen Beck ruth e.cameron Serena M.Best Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK Geistlich Pharma AG Product DevelopmentWolhusenSwitzerland

Collagen-based biomaterials are used widely as tissue engineering scaffolds because of their excellent bioactivity and their similarity to the natural *** regeneration of healthy bone tissue requires simultaneous support for both osteoblasts and,where angiogenesis is intended,endothelial *** it is important to tailor carefully the biochemical and structural characteristics of the scaffold to suit the needs of each cell *** work describes for the first time a systematic study to gain insight into the cell type-specific response of primary human osteoblast(hOBs)and human dermal microvascular endothelial cells(HDMeCs)to insoluble collagen-based *** behaviour was evaluated on both 2D films and 3D scaffolds,produced using *** collagen was cross-linked at various eDC/NHS concentrations and mono-cultured with hOBs and HDMeCs to assess the effect of architectural features and scaffold stabilization on cell *** was observed that 3D scaffolds cross-linked at 30%of the standard conditions in literature offered an optimal combination of mechanical stiffness and cellular response for both cell types,although endothelial cells were more sensitive to the degree of cross-linking than *** features have a time-dependent impact on the cell migration profile,with alignment being the most influential parameter overall.

关键词： angiogenesis collagen scaffolds cell migration eDC/NHS cross-linking

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Avoiding artefacts in MicroCT imaging of collagen scaffolds:effect of phosphotungstic acid(PTA)-staining and crosslink density

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Bioactive Materials 2022年第2期7卷 210-219页

作者： Kyung-Ah Kwon Daniel V.Bax Jennifer H.Shepherd ruth e.cameron Serena M.Best Cambridge Centre for Medical Materials Department of Materials Science and MetallurgyUniversity of CambridgeCambridgeUnited Kingdom School of engineering University of LeicesterLeicesterUnited Kingdom

X-ray micro-computed tomography(μ-CT)can be used to provide both qualitative and quantitative information on the structure of three-dimensional(3D)bioactive *** performed in a dry state,μ-CT accurately reflects the structure of collagen-based scaffolds,but imaging in a wet state offers challenges with *** we have used phosphotungstic acid(PTA)as a contrast agent to visualise fully hydrated collagen scaffolds in a physiologically relevant environment.A systematic investigation was performed to understand the effects of PTA on the results of μ-CT imaging by varying sample processing variables such as crosslinking density,hydration medium and staining *** samples in 0.3% PTA solution overnight completely stained the samples and the treatment provided a successful route forμ-CT analysis of crosslinked ***,significant structural artefacts were observed for samples which were either non-crosslinked or had low levels of crosslinking,which had a heterogeneous interior architecture with collapsed pores at the scaffold *** work highlights the importance of optimising the choice of processing and staining conditions to ensure accurate visualisation for hydrated 3D collagen scaffolds in an aqueous medium.

关键词： MicroCT crosslinking qualitative

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Targeted protein delivery:carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds

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Regenerative Biomaterials 2019年第5期6卷 279-287页

作者： Constantin edi Tanase Omar Qutachi Lisa J.White Kevin M.Shakesheff Andrew W.McCaskie Serena M.Best ruth e.cameron Department of Materials Science and Metallurgy University of CambridgeCambridge Centre for Medical MaterialsCambridge27Charles Babbage RoadCB30FSUK Centre for Biomolecular Sciences School of PharmacyUniversity of NottinghamUniversity ParkNottingham NG72RDUK Division of Trauma&Orthopaedic Surgery Department of SurgeryUniversity of CambridgeBox 180Addenbrooke’s HospitalHills RoadCambridge CB20QQUK Present address:School of Pharmacy De Montforte UniversityLeicester LE19BHUK

Tissue engineering response may be tailored via controlled,sustained release of active agents from protein-loaded degradable microparticles incorporated directly within three-dimensional(3D)ice-templated collagen ***,the effects of covalent crosslinking during scaffold preparation on the availability and release of protein from the incorporated microparticles have not been ***,we load 3D ice-templated collagen scaffolds with controlled additions of poly-(DL-lactide-co-glycolide)*** probe the effects of subsequent N-(3-dimethylaminopropyl)-N0-ethylcarbodiimide hydrochloride crosslinking on protein release,using microparticles with different internal protein *** isothiocyanate labelled bovine serum albumin is used as a model protein *** scaffolds display a homogeneous microparticle distribution,and a reduction in pore size and percolation diameter with increased microparticle addition,although these values did not fall below those reported as necessary for cell *** protein distribution within the microparticles,near the surface or more deeply located within the microparticles,was important in determining the release profile and effect of crosslinking,as the surface was affected by the carbodiimide crosslinking reaction applied to the *** of microparticles with a high proportion of protein at the surface caused both a reduction and delay in protein *** located within the bulk of the microparticles,was protected from the crosslinking reaction and no delay in the overall release profile was seen.

关键词： collagen scaffolds PLGA microparticles FITC-BSA eDC crosslinking pore size percolation diameter

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effect of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide concentrations on the mechanical and biological characteristics of cross-linked collagen fibres for tendon repair

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Regenerative Biomaterials 2015年第2期2卷 77-85页

作者： Zafar Ahmad Jennifer H.Shepherd David V.Shepherd Siddhartha Ghose Simon J.Kew ruth e.cameron Serena M.Best Roger A.Brooks John Wardale Neil Rushton Orthopaedic Research Unit Department of Surgery University of CambridgeAddenbrooke’s HospitalCambridgeCB20QQUK Department of Materials Science and Metallurgy University of CambridgeCambridgeCB30FSUK Tigenix Ltd CambridgeCB40FYUK

Reconstituted type I collagen fibres have received considerable interest as tendon implant materials due to their chemical and structural similarity to the native *** produced through a semi-continuous extrusion process were cross-linked with different concentrations of the zerolength cross-linker 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(eDC)in combination with N-hydroxysuccinimide(NHS).Tensile properties of the fibres were considered,along with imaging of both surface structure and fibrillar *** of the fibres to bacterial collagenase was investigated and fibre sections seeded with human tendon cells for biological characterization,including cell adhesion and *** work clearly demonstrated that whilst the concentration of eDC and NHS had no significant effect on the mechanics,a higher concentration was associated with higher collagenase resistance,but also provided a less attractive surface for cell adhesion and proliferation.A lower cross-linking concentration offered a more biocompatible material without reduction in mechanics and with a potentially more optimal degradability.

关键词： biopolymer scaffolds soft tissue

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The association between Tai Chi exercise and safe driving performance among older adults： An observational study

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Journal of Sport and Health Science 2018年第1期7卷 83-94页

作者： Sally Miller ruth e.Taylor-Piliae School of Nursing Vanderbilt University Nashville TN 37240 USA College of Nursing The University of Arizona Tucson AZ 85721 USA

Background: Age-related cognitive and physical decline can impair safe driving performance. Tai Chi exercise benefits cognitive and physical function and may influence safe driving performance in older adults. The primary aim of this observational study was to compare cognitive processes and physical function related to safe driving performance among older adult Tai Chi practitioners to normative reference *** aims were to examine relationships between Tai Chi exercise habits, cognitive processes, and physical function related to safe driving performance and to explore potential predictors of safe driving ***: The Driving Health Inventory, the Driving Scenes Test, other driving-related cognitive and physical measures, and self-reported measures including the Mindful Attention Awareness Scale(MAAS) and the Vitality Plus Scale(VPS) were collected from current Tai Chi practitioners(n = 58; age 72.9 ± 5.9 years, mean ± SD) with median >3 years Tai Chi ***: Compared to normative reference values, participants performed better on numerous cognitive measures including the Driving Scenes Test(p e navigation(p = 0.017, d = 0.27), the Useful Field of View Test(p easures including the Rapid Walk Test(p e Right Foot Tapping Test,(p ed higher than normative reference values on MAAS and VPS(p espectively). Statistically significant correlations were found between several study measures. The digit span backward test was the strongest predictor of safe driving performance(β = 0.34,p = 0.009).Conclusion: Tai Chi exercise has the potential to impact cognitive processes and physical function related to safe driving performance. Further study using randomized controlled trials, structured Tai Chi exercise doses, and driving simulator or on-road driving performance as outcome measures

关键词： Automobile driving Driving performance exercise Older adults Physical activity Tai Chi

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Application of nanotechnology to dentistry:Impact of graphene nanocomposites on clinical air quality

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World Journal of Clinical Cases 2025年第8期13卷 1-7页

作者： ruth Rodríguez Montaño Mario A Alarcón-Sánchez Melissa Martínez Nieto Juan J Varela Hernández Sarah M LomelíMartínez Department of Health and Illness as an Individual and Collective Process University Center of TlajomulcoUniversity of GuadalajaraTlajomulco de Zuñiga 45641JaliscoMexico Institute of Research in Dentistry Department of Integral Dental ClinicsUniversity Center of Health SciencesUniversity of GuadalajaraGuadalajara 44340JaliscoMexico Department of Biomedical Science Faculty of Chemical-Biological SciencesAutonomous University of GuerreroGuerrero 39090Mexico Instituto Odontológico del Pacífico Sur Chilpancingo de los Bravo 39022Mexico Independent Researcher Tijuana 22116Baja CaliforniaMexico Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlan 47810JaliscoMexico Master of Public Health Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraOcotlan 46200JaliscoMexico

Concerns about air quality in dental clinics where aerosol generation during procedures poses significant health risks,have prompted investigations on advanced disinfection *** editorial describes the strengths and limitations of ventilation and aerosol control measures in dental offices,especially with respect to the use of graphene *** potential of graphene nanocomposites as an innovative solution to aerosol-associated health risks is examined in this review due to the unique properties of graphene(e.g.,high con-ductivity,mechanical strength,and antimicrobial activity).These properties have produced promising results in various fields,but the application of graphene in dentistry remains *** recent study by Ju et al which was published in World Journal of Clinical Cases evaluated the effectiveness of graphene-based air disinfection systems in dental *** study demonstrated that graphene-based disinfection techniques produced significant reductions in suspended particulate matter and bacterial colony counts,when co-mpared with traditional *** these positive results,challenges such as material saturation,frequency of filter replacement,and associated costs must be addressed before widespread adoption of graphene-based disinfection techniques in clinical ***,there is need for further research on material structure optimization,long-term safety evaluations,and broader clinical applications,in order to maximize their positive impact on public health.

关键词： Graphene Nanocomposites Antibacterial activity Biomedical applications Air disinfection

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Consequences of early life stress on the structure and function of the adult mouse retina

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Neural Regeneration Research 2024年第1期19卷 150-151页

作者： Juan S.Calanni ruth e.Rosenstein Laboratory of Retinal Neurochemistry and experimental Ophthalmology Department of Human BiochemistrySchool of Medicine/CEFyBOUniversity of Buenos Aires/CONICETBuenos AiresArgentina

early-life stress(eLS)refers to a period of environmental/social deprivation,physica l,sexual or emotional abuse,neglect,severe and/or chronic trauma in the prenatal/early postnatal stage,which is closely related to many adverse psychiatric disorders later in life,such as depressive disorder,substance abuse,dysthymia,panic,anxiety,and suicidal behavior in adulthood(Waters and Gould,2022).

关键词： stress life Gould

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Improving the electrochemical performance of α-MoO_(3) electrode using aluminium trifluoromethanesulfonate water-in-salt electrolyte

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Journal of energy Chemistry 2023年第3期78卷 123-134,I0004页

作者： Ayman e.elkholy Timothy T.Duignan ruth Knibbe Xiu Song Zhao School of Chemical engineering The University of QueenslandSt Lucia CampusBrisbane 4072Australia School of Mechanical and Mining engineering The University of QueenslandSt Lucia CampusBrisbane 4072Australia

Orthorhombic molybdenum trioxide(α-MoO_(3)) electrode material experiences severe capacity fading and poor cycling stability in aqueous *** investigated the charge-storage performance of α-MoO_(3) electrode in aluminium trifluoromethanesulfonate(Al(OTf)_(3))-based salt-in-water electrolyte(SiWe) and water-in-salt electrolyte(WiSe).It was found that α-MoO_(3) electrode exhibits significantly different cycling stabilities in both electrolytes with capacity retentions of 8% using the former and87% using the *** is because α-MoO_(3) electrode maintains its crystal structure upon cycling in WiSe,but experiences substantial structural collapses and partial dissolution upon cycling in *** behaviour was inferred from both operando electrogravimetry and ex situ *** results suggest that the predominant charge-storage mechanism in a-MoO_(3) electrode using WiSe is the intercalation of protons produced from electrolyte hydrolysis with some contribution from surface pseudocapacitance enabled by Al3+ions.A two-volt full cell fabricated from α-MoO_(3) electrode as anode and copper hexacyanoferrate(CuHCF) electrode as cathode using WiSe delivers volumetric and gravimetric energies of 10.4 Wh/L and 26.5 Wh/kg,respectively,with 78% capacity retention after 2500 *** study provides an insightful understanding of the electrochemical performance of α-MoO_(3) electrode in Al(OTf)_(3)-based electrolytes.

关键词： Molybdenum oxide Aqueous electrolyte Water-in-salt electrolyte Aqueous batteries Pseudocapacitance

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Collagen scaffolds functionalized with triple-helical peptides support 3D HUVeC culture

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Regenerative Biomaterials 2020年第5期7卷 471-482页

作者： Jean-Daniel Malcor emma J.Hunter Natalia Davidenko Daniel V.Bax ruth cameron Serena Best Sanjay Sinha Richard W.Farndale Department of Biochemistry University of CambridgeCambridge CB21QWUK Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK Division of Medicine and Wellcome Trust Medical Research Council Cambridge Stem Cell InstituteUniversity of CambridgeCambridge CB20AWUK Present address:CambCol Laboratories Ltd Oak Lane Business ParkLittleportElyCambridgeshireCB79RPUK

Porous biomaterials which provide a structural and biological support for cells have immense potential in tissue engineering and cell-based therapies for tissue *** biomaterials that can host endothelial cells represent promising tools for the vascularization of engineered ***-dimensional collagen scaffolds possessing controlled architecture and mechanical stiffness are obtained through freeze–drying of collagen suspensions,followed by chemical cross-linking which maintains their ***,cross-linking scaffolds renders their biological activity suboptimal for many cell types,including human umbilical vein endothelial cells(HUVeCs),by inhibiting cell–collagen ***,we have improved crucial HUVeC interactions with such cross-linked collagen biomaterials by covalently coupling combinations of triple-helical peptides(THPs).These are ligands for collagen-binding cell-surface receptors(integrins or discoidin domain receptors)or secreted proteins(SPARC and von Willebrand factor).THPs enhanced HUVeC adhesion,spreading and proliferation on 2D collagen *** grafted to 3D-cross-linked collagen scaffolds promoted cell survival over seven *** study demonstrates that THP-functionalized collagen scaffolds are promising candidates for hosting endothelial cells with potential for the production of vascularized engineered tissues in regenerative medicine applications.

关键词： collagen biomaterial endothelial cells 3D cell scaffold collagen-mimetic peptides

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