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Establishment of injury models in studies of biological effects induced by microwave radiation

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Military Medical Research 2021年第2期8卷 253-272页

作者： yun-Fei Lai Hao-Yu Wang rui-yun peng Beijing Institute of Radiation Medicine Beijing 100850China

Microwave radiation has been widely used in various fields,such as communication,industry,medical treatment,and military applications.Microwave radiation may cause injuries to both the structures and functions of various organs,such as the brain,heart,reproductive organs,and endocrine organs,which endanger human health.Therefore,it is both theoretically and clinically important to conduct studies on the biological effects induced by microwave radiation.The successful establishment of injury models is of great importance to the reliability and reproducibility of these studies.In this article,we review the microwave exposure conditions,subjects used to establish injury models,the methods used for the assessment of the injuries,and the indicators implemented to evaluate the success of injury model establishment in studies on biological effects induced by microwave radiation.

关键词： Microwave radiation Injury model Biological effects Methods Biological indicators Review

Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity

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Journal of Medical Colleges of PLA(China) 2016年第4期31卷 212-218页

作者： Hui Wang rui-yun peng Department of Experimental Pathology Beijing Institute of Radiation Medicine

With key roles in essential brain functions ranging from the long-term potentiation(LTP) to synaptic plasticity,the N-methyl-D-aspartic acid receptor(NMDAR) can be considered as one of the fundamental glutamate receptors in the central nervous system.The role of NMDA R was first identified in synaptic plasticity and has been extensively studied.Some molecules,such as Ca^(2+),postsynaptic density 95(PSD-95),calcium/calmodulin-dependent protein kinase II(Ca MK II),protein kinase A(PKA),mitogen-activated protein kinase(MAPK) and cyclic adenosine monophosphate(c AMP) responsive element binding protein(CREB),are of special importance in learning and memory.This review mainly focused on the new research of key molecules connected with learning and memory,which played important roles in the NMDAR signaling pathway.

关键词： N-methyl-D-aspartic acid receptors Long-term potentiation Synaptic plasticity Learning and memory

Detection of hepatitis C virus NS5 protein and genome in Chinese carcinoma of the extrahepatic bile duct and its significance

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World Journal of Gastroenterology 2000年第6期6卷 800-804页

作者： Ming Yi Chen Zhi Qiang Huang Le Zhen Chen Ya Bing Gao rui yun peng De Wen Wang Research Institute of General Surgery Department of Hepatobiliary SurgeryGeneral Hospital of the Chinese Peoples Liberation Army(PLA)Beijing 100853China Department of Pathology General Hospital of PLABeijing 100855China Experimental Pathologic Laboratory Institute of Medical RadiologyAcademy of Military Medical SciencesBeijing 100850China

AIM To investigate the hepatitis C virus(HCV)infection in the tissues of carcinoma ofextrahepatic bile duct and study theircorrelation.METHODS HCV NS5 protein and HCV RNA weredetected by labeled streptavidin biotin(LSAB)method and in situ reverse transcriptionpolymerase chain reaction(IS-RT-PCR)insections of 51 cases of carcinoma ofextrahepatic bile duct and 34 cases of controlgroup(without malignant biliary disease).RESULTS In 51 cases of carcinoma ofextrahepatic bile duct,HCV NS5 protein wasdetected in 14(27.5%),which was clearlystained in the cytoplasm of cancer cell but not inthe nucleus or cell membrane.HCV RNA wasdetected in 18(35.4%),which was located inthe nucleus of cancer cell in 12 cases and in thecytoplasm in 6 cases.HCV NS5 protein and RNAcoexistence was found in 2 cases.In 34 cases ofcontrol group,HCV RNA was detected in 2(5.9%).HCV NS5 protein and RNA positive cellswere found either scattered or in clusters.CONCLUSION The prevalence of hepatitis C viral infection in the tissues of carcinoma ofextrahepatic bile duct was significantly higherthan in control group(X^2=9.808,P=0.002).The findings suggest a correlation between HCVinfection and carcinoma of extrahepatic bileduct,which is different from the traditionalviewpoint.HCV infection might be involved inthe development of carcinoma of extrahepaticbile duct.

关键词： hepatitis C virus bile duet neoplasm polymerase chain reaction immunohistochemistry risk factors genes suppressor tumor transfection genome

Effects and mechanisms of a microcurrent dressing on skin wound healing: a review

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Journal of Medical Colleges of PLA(China) 2014年第3期29卷 177-185页

作者： Chao Yu Zong-Qian Hu rui-yun peng Beijing Institute of Radiation Medicine

The variety of wound types has resulted in a wide range of wound dressings, with new products frequently being introduced to target different aspects of the wound healing process. The ideal wound dressing should achieve rapid healing at a reasonable cost, with minimal inconvenience to the patient. Microcurrent dressing, a novel wound dressing with inherent electric activity, can generate low-level microcurrents at the device-wound contact surface in the presence of moisture and can provide an advanced wound healing solution for managing wounds. This article offers a review of the effects and mechanisms of the microcurrent dressing on the healing of skin wounds.

关键词： Microcurrent dressing Electric stimulation Skin wo

Apoptosis of Lewis Lung Carcinoma Cells Induced by Microwave via p53 and Proapoptotic Proteins In vivo

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Chinese Medical Journal 2017年第1期130卷 15-22页

作者： Kou-Dong Zhang Lin-Rong Tong Shui-Ming Wang rui-yun peng Hai-Dong Huang Yu-Chao Dong Xing-Xing Zhang Qiang Li Chong Bai Department of Respiratory and Critical Care Medicine Changhai Hospital The Second Military Medical University Shanghai 200433 China Department of Respiratory Medicine Yancheng First People's Hospital Yancheng Jiangsu 224000 China Department of Respiratory Medicine Chenggong Hospital Xiamen University Xiamen Fujian 361000 China Institute of Radiation Medicine The Academy of Military Medical Sciences Beijing 100850 China

Background： Microwave therapy is a minimal invasive procedure and has been employed in clinical practice for the treatment of various types of cancers. However, its therapeutic application in non-small-cell lung cancer and the underlying mechanism remains to be investigated. This study aimed to investigate its effect on Lewis lung carcinoma （LLC） tumor in vivo. Methods： Fifty LLC tumor-bearing C57BL/6 mice were adopted to assess the effect of microwave radiation on the growth and apoptosis of LLC tumor in vivo. These mice were randomly assigned to 10 groups with 5 mice in each group. Five groups were treated by single pulse microwave at different doses for different time, and the other five groups were radiated by multiple-pulse treatment of a single dose. Apoptosis of cancer cells was determined by terminal deoxynucleotidyl transferase dUTP nick-end labeling assay. Western blotting was applied to detect the expression of proteins. Results： Single pulse of microwave radiation for 5 min had little effect on the mice. Only 15-min microwave radiation at 30 mW/cm2 significantly increased the mice body temperature （2.20 ± 0.82）℃ as compared with the other groups （0.78 ± 0.29 ℃, 1.24 ± 0.52 ℃, 0.78 ± 0.42 ℃, respectively）, but it did not affect the apoptosis of LLC tumor cells significantly. Continous microwave radiation exposure, single dose microwave radiation once per day for up to seven days, inhibited cell division and induced apoptosis of LLC tumor cells in a dose- and duration-dependent manner. It upregulated the protein levels of p53, Caspase 3, Bax and downregulated Bcl-2 protein. Conclusions： Multiple exposures of LLC-bearing mice to microwave radiation effectively induced tumor cell apoptosis at least partly by upregulating proapoptotic proteins and downregulating antiapoptotic proteins. Continuous radiation at low microwave intensity Ibr a short time per day is promising in treating non-small-cell lung cancer.

关键词： Apoptosis Lewis Lung Carcinoma Cells Microwave Radiation Non-small-cell Lung Cancer

Biological effects and mechanisms of shortwave radiation： a review

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Military Medical Research 2018年第1期5卷 79-84页

作者： Chao Yu rui-yun peng Beijing Institute of Radiation Medicine Beijing 100850 China

With the increasing knowledge of shortwave radiation,it is widely used in wireless communications,radar observations,industrial manufacturing,and medical treatments.Despite of the benefits from shortwave,these wide applications expose humans to the risk of shortwave electromagnetic radiation,which is alleged to cause potential damage to biological systems.This review focused on the exposure to shortwave electromagnetic radiation,considering in vitro,in vivo and epidemiological results that have provided insight into the biological effects and mechanisms of shortwave.Additionally,some protective measures and suggestions are discussed here in the hope of obtaining more benefits from shortwave with fewer health risks.

关键词： Shortwave Electromagnetic radiation Biological effects

Effects of microwave radiation on brain energy metabolism and related mechanisms

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Journal of Medical Colleges of PLA(China) 2014年第4期29卷 235-243页

作者： Yan-Hui Hao Li Zhao rui-yun peng Beijing Institute of Radiation Medicine

With the rapid development of electronic technologies, anxiety regarding the potential health hazards induced by microwave radiation(MW) has been growing in recent years. The brain is one of the most sensitive target organs for microwave radiation, where mitochondrial injury occurs earlier and more severely than in other organs. Energy metabolism disorders do play an important role during the process of microwave radiation-induced brain damage. In this paper, we will review the biological effects of microwave radiation, the features of brain energy supply and consumption and the effects of microwave radiation on mitochondrial energy metabolism and potential related mechanisms.

关键词： Microwave radiation Brain Energy metabolism Mitochondria Mechanisms

Advances in the biological effects of terahertz wave radiation

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Journal of Medical Colleges of PLA(China) 2014年第3期29卷 173-176页

作者： Li Zhao Yan-Hui Hao rui-yun peng Department of Experimental Pathology Beijing Institute of Radiation Medicine

The terahertz(THz) band lies between microwave and infrared rays in wavelength and consists of non-ionizing radiation. Both domestic and foreign research institutions, including the army, have attached considerable importance to the research and development of THz technology because this radiation exhibits both photon-like and electron-like properties, which grant it considerable application value and potential. With the rapid development of THz technology and related applications, studies of the biological effects of THz radiation have become a major focus in the field of life sciences. Research in this field has only just begun, both at home and abroad. In this paper, research progress with respect to THz radiation, including its biological effects, mechanisms and methods of protection, will be reviewed.

关键词： Terahertz Radiation Biological effects Progress

A novel microcurrent dressing for wound healing in a rat skin defect model

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Military Medical Research 2020年第2期7卷 190-198页

作者： Chao Yu Zhi-Xiu Xu Yan-Hui Hao Ya-Bing Gao Bin-Wei Yao Jing Zhang Bing Wang Zong-Qian Hu ruiyun peng Department of Experimental Pathology Beijing Institute of Radiation MedicineBeijing 100850China department of Internal Neurology The First Affiliated Hospital/Xinxiang Medical UniversityXinxiang 453100HenanChina department of Biotechnology Beijing Institute of Radiation MedicineBeijing 100850China

Background:The exogenous application of low-intensity electric stimulation(ES)may mimic a natural endogenous bioelectric current and accelerate the repair process of skin wounds.This study designed a novel microcurrent dressing(MCD)and evaluated its potential effects on wound healing in a rat skin defect model.Methods:First,wireless ES was integrated into a medical cotton cushion to fabricate the MCD,and its electrical property was examined by using a universal power meter.Then,animal experiments were conducted to evaluate the MCD’s effect.Forty-five rats were randomized into control(Con)group,Vaseline gauze(VG)group and MCD group.A full-thickness round skin incision 1.5 cm in diameter was made on the back of each animal.Apart from routine disinfection,the Con rats were untreated,whereas the other two groups were treated with VG or MCD.On days 3,7 and 14 post injury,the wound areas were observed and measured using image analysis software following photography,and the skin samples were harvested from wound tissue.Then,histopathological morphology was observed routinely by hematoxylin and eosin(HE)staining;tumor necrosis factorα(TNF-α)and interleukin(IL)-1βexpression were detected by Western blotting.Vascular endothelial growth factor(VEGF)and epidermal growth factor(EGF)expression were detected with immunohistochemistry.Results:The MCD generated a sf electric potential greater than 0.95 V.Animal experiments showed that the woundhealing rate in the MCD group was significantly increased compared with the Con and VG groups(P<0.05 or P<0.01).Histopathological observation revealed an alleviated inflammatory response,induced vascular proliferation and accelerated epithelization in the MCD group.Moreover,samples from the MCD group expressed reduced TNF-αand IL-1βlevels and increased VEGF and EGF levels compared with those of the other two groups(P<0.05 or P<0.01).However,no significant difference was noted between the Con and VG groups at each time point.Conclusions:The MCD generates a stable and lasting ES and significa

关键词： Microcurrent dressing Electric stimulation Skin Wound healing